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16 条记录 (耗时 0.022 秒)

    Polymers
    5.
    发明申请
    Polymers 审中-公开
    聚合物

    公开(公告)号：US20020076378A1

    公开(公告)日：2002-06-20

    申请号：US10057943

    申请日：2002-01-29

    申请人： NYCOMED IMAGING AS

    发明人： Henry Wolfe ,  Kenneth Kellar

    IPC分类号： A61K049/04

    CPC分类号： A61K49/14 ,  A61K49/0442 ,  A61K49/085 ,  A61K49/124 ,  A61K49/146 ,  C07F7/025 ,  C07K7/02 ,  C07K14/001

    摘要： The invention provides compounds comprising a linear, branched or dendrimeric polymer backbone with linked thereto at least one reporter moiety, said polymer backbone comprising a plurality of amine-containing acids. Such compounds may be linked to one or more targeting agents and are useful as therapeutic and diagnostic agents, in particular in medical imaging techniques.

    摘要翻译： 本发明提供包含与至少一个报道部分连接的直链，支链或树枝状聚合物主链的化合物，所述聚合物主链包含多个含胺酸。 这样的化合物可以连接到一种或多种靶向剂，并且可用作治疗和诊断剂，特别是在医学成像技术中。

    Contrast agents
    6.
    发明申请
    Contrast agents 审中-公开
    对比剂

    公开(公告)号：US20030059373A1

    公开(公告)日：2003-03-27

    申请号：US10072655

    申请日：2002-02-08

    申请人： Nycomed Imaging AS

    发明人： Jo Klaveness ,  Pal Rongved ,  Lars Stubberud

    IPC分类号： A61K049/04

    CPC分类号： A61K49/1818 ,  A61K49/1821 ,  A61K49/223 ,  A61K49/225

    摘要： Contrast agents comprising microbubble-generating carbohydrate microparticles having a surfactant admixed within the microparticulate structure, with the proviso that the surfactant is not a C10-20 fatty acid, are disclosed. Processes for preparing contrast agents also are disclosed.

    摘要翻译： 公开了包含在微粒结构内具有表面活性剂的产生微泡的碳水化合物微粒的对比剂，前提是表面活性剂不是C10-20脂肪酸。 还公开了制备造影剂的方法。

    Paramagnetic material-containing magnetic resonance external marker or calibration composition
    7.
    发明申请
    Paramagnetic material-containing magnetic resonance external marker or calibration composition 审中-公开
    含顺磁材料的磁共振外部标记物或校准组合物

    公开(公告)号：US20020102214A1

    公开(公告)日：2002-08-01

    申请号：US09983551

    申请日：2001-10-24

    申请人： NYCOMED IMAGING AS.

    发明人： Karen Catherin Briley-Saebo ,  Kenneth Edmund Kellar ,  David Lee Ladd ,  Kenneth Robert Hollister ,  Atle Bjornerud

    IPC分类号： A61K049/00

    CPC分类号： A61K49/128 ,  A61K49/18 ,  A61K49/1803

    摘要： This invention relates to a set of aqueous marker compositions, each composition having a selected 1/Ti value which is substantially invariant over an at least 10null C. temperature range between 15 and 40null C. and preferably over an at least null2% magnetic field strength range about a selected field strength value between 0.01 and 5T and comprising an aqueous matrix material having a non-zero 1/Ti temperature dependence within said temperature range with distributed therein a first paramagnetic material having a Ti relaxivity which is substantially invariant within said range(s) and/or a second paramagnetic material having within said ranges(s) and T1 relaxivity which has a non-zero temperature dependence of opposite polarity to the temperature dependence of 1/Ti of said matrix material, said set containing a plurality of said compositions with different selected 1/Ti values preferably encompassing at least the range 1.0 to 2.5 snull1, said set preferably comprising at least one said composition containing said second paramagnetic material and at least one said composition containing said first paramagnetic material, where i in Ti is 1 or 2.

    摘要翻译： 本发明涉及一组水性标记组合物，每种组合物具有选择的1 / Ti值，其在15至40℃之间的至少10℃的温度范围内基本上不变，优选至少为±2％ 磁场强度范围约0.01至5T之间的所选场强值，并且包括在所述温度范围内具有非零1 / Ti温度依赖性的水性基体材料，其中分布有第一顺​​磁性材料，其具有基本上不变的Ti弛豫度 所述范围和/或第二顺磁材料具有在所述范围和T1弛豫度内，其具有与所述基体材料的1 / Ti的温度依赖性相反极性的非零温度依赖性，所述组包含 具有不同选择的1 / Ti值的多种所述组合物优选包含至少1.0至2.5s -1的范围，所述组优选包含至少一个所述组合物 含有所述第二顺磁性材料和含有所述第一顺磁材料的至少一种所述组合物，其中i在Ti中为1或2。

    Contrast agents
    9.
    发明申请
    Contrast agents 失效
    对比剂

    公开(公告)号：US20010016587A1

    公开(公告)日：2001-08-23

    申请号：US09785177

    申请日：2001-02-20

    申请人： NYCOMED IMAGING AS

    发明人： Jo Klaveness ,  Anne Navested ,  Alan Cuthbertson

    IPC分类号： A61M036/14 ,  A61K051/00 ,  A61B005/055 ,  A61K031/505

    CPC分类号： A61K49/0056 ,  A61K49/0021 ,  A61K49/0043 ,  A61K49/0052 ,  A61K49/0091 ,  A61K49/10 ,  A61K49/103 ,  A61K49/223 ,  A61K51/04 ,  A61K51/0453 ,  A61K51/0478 ,  A61K51/0497 ,  A61K51/1255

    摘要： The invention provides a composition of matter of the formula (I): VnullLnullR where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotensin or a peptidic angiotensin derivative or analog then VnullLnullR is other than a non-metal radionuclide substituted peptide (e.g. 125I substituted angiotensin II) and LnullV is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.

    摘要翻译： 本发明提供了式（I）的物质组合物：VLR，其中V是对血管紧张素II受体位点具有结合亲和力的有机基团，L是连接体部分或键，R是在体内成像中可检测的部分 的条件是V是血管紧张素或肽类血管紧张素衍生物或类似物，则VLR不是非金属放射性核素取代肽（例如125 I取代的血管紧张素II），而LV不仅仅是具有 与侧链结合的螯合剂酰胺。 这种物质的组成可用于影像心血管疾病和病症。

    Process for the crystallisation of sterically hindered compounds
    10.
    发明申请
    Process for the crystallisation of sterically hindered compounds 有权
    空间位阻化合物结晶的方法

    公开(公告)号：US20020072639A1

    公开(公告)日：2002-06-13

    申请号：US09986974

    申请日：2001-11-13

    申请人： NYCOMED IMAGING AS

    发明人： Jan Cervenka

    IPC分类号： C07C017/38

    CPC分类号： C07B63/00 ,  C07C231/24 ,  C07C237/46

    摘要： A process for the crystallisation of a sterically hindered organic compound from a saturated or supersaturated solution of said compound in a solvent therefor, characterised in that crystallisation is effected under elevated pressure at a temperature above the boiling point of said solution at atmospheric pressure and up to the boiling point of said solution at said elevated pressure.

    摘要翻译： 一种用于将空间位阻有机化合物从所述化合物在其溶剂中的饱和或过饱和溶液结晶的方法，其特征在于在高于大气压下所述溶液沸点的温度下在高压下进行结晶，直到 所述溶液在所述升高的压力下的沸点。