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公开(公告)号：US11046760B2
公开(公告)日：2021-06-29
申请号：US15889532
申请日：2018-02-06
发明人： Christopher Lamond Murriel , Timothy Charles Hoey , Austin L. Gurney , Julie Michelle Roda , Minu K. Srivastava , Inkyung Park , Jakob Dupont
IPC分类号： A61K39/395 , C12N15/11 , C12N15/113 , C07K16/28 , A61K31/282 , A61K31/519 , C07K14/475 , C07K16/22 , A61K39/00
摘要： The present invention provides methods comprising combination therapy for modulating immune responses, for inhibiting tumor growth, and/or for treating cancer. In particular, the present invention provides Notch pathway inhibitors in combination with immunotherapeutic agents for the treatment of cancer and other diseases.
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公开(公告)号：US09987357B2
公开(公告)日：2018-06-05
申请号：US15147521
申请日：2016-05-05
发明人： Jakob Dupont , Robert J. Stagg
IPC分类号： A61K38/17 , G01N33/68 , A61K39/395 , C07K16/30 , A61K31/675 , C07K16/28 , A61K45/06 , G01N33/574 , A61K39/00 , C07K14/72
CPC分类号： A61K39/39558 , A61K31/675 , A61K38/177 , A61K39/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/545 , A61K2039/585 , C07K14/723 , C07K16/2863 , C07K16/2869 , C07K16/2875 , C07K16/30 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2319/30 , G01N33/574 , G01N33/6887 , G01N2333/78 , G01N2800/108 , G01N2800/52 , G01N2800/7028 , A61K2300/00
摘要： Methods for treating diseases such as cancer comprising administering a Wnt pathway inhibitor, either alone or in combination with other anti-cancer agents, and monitoring for skeletal-related side effects and/or toxicity.
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公开(公告)号：US20170022289A1
公开(公告)日：2017-01-26
申请号：US15123864
申请日：2015-03-04
发明人： Jakob Dupont , Ann M. Kapoun , Belinda Cancilla
IPC分类号： C07K16/32 , C12Q1/68 , G01N33/574 , A61K39/395 , A61K45/06
CPC分类号： C07K16/32 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/53 , G01N33/57407 , G01N2333/705 , G01N2800/52
摘要： The present invention provides methods for treating cancer. More particularly, the invention provides methods for treating cancer comprising administrating doses of an anti-Notch 1 antibody.
摘要翻译： 本发明提供了治疗癌症的方法。 更具体地，本发明提供了治疗癌症的方法，包括施用剂量的抗Notch1抗体。
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4.发明申请公开(公告)号：US20150232570A1
公开(公告)日：2015-08-20
申请号：US14429497
申请日：2013-09-20
发明人： Timothy C. Hoey , Ann M. Kapoun , Min Wang , Tzu-Ling Tang Lin , Jennifer Anne Cain , Jakob Dupont
IPC分类号： C07K16/30 , A61K45/06 , C12Q1/68 , A61K39/395
CPC分类号： C07K16/3061 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： NOTCH1-binding antibodies and methods of using the antibodies for treating hematologic cancers are disclosed. Methods of using antibodies that bind to a non-ligand binding membrane proximal region of the extracellular domain of human NOTCH1 and methods of treating chronic lymphocytic leukemia (CLL), hairy cell leukemia, chronic myelogenous leukemia (CML), nonHodgkin lymphoma, diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), or cutaneous T-cell lymphoma (CTCL) in a subject, comprising administering a therapeutically effective amount of a NOTCH1-binding antibody to the subject are also disclosed. Methods of identifying subjects suitable for such treatment methods are further disclosed.
摘要翻译： 公开了NOTCH1结合抗体和使用该抗体治疗血液癌症的方法。 使用结合人NOTCH1细胞外结构域的非配体结合膜近端区域的抗体的方法和治疗慢性淋巴细胞白血病（CLL），毛细胞白血病，慢性骨髓性白血病（CML），非霍奇金淋巴瘤，弥漫性大B 细胞淋巴瘤（DLBCL），套细胞淋巴瘤（MCL）或皮肤T细胞淋巴瘤（CTCL），包括向受试者施用治疗有效量的NOTCH1结合抗体。 还公开了鉴定适合于这种治疗方法的受试者的方法。
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公开(公告)号：US20210403553A1
公开(公告)日：2021-12-30
申请号：US17330716
申请日：2021-05-26
发明人： Christopher Lamond Murriel , Timothy Charles Hoey , Austin L. Gurney , Julie Michelle Roda , Minu K. Srivastava , Inkyung Park , Jakob Dupont
IPC分类号： C07K16/28 , A61K39/395 , C12N15/113 , A61K31/282 , A61K31/519
摘要： The present invention provides methods comprising combination therapy for modulating immune responses, for inhibiting tumor growth, and/or for treating cancer. In particular, the present invention provides Notch pathway inhibitors in combination with immunotherapeutic agents for the treatment of cancer and other diseases.
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公开(公告)号：US20170299598A1
公开(公告)日：2017-10-19
申请号：US15421635
申请日：2017-02-01
IPC分类号： G01N33/574 , A61K31/403 , A61K31/4045 , A61K31/519 , G01N33/74 , C07K16/30 , A61K31/282 , A61K39/395 , A61K31/7068 , A61K31/706 , A61K45/06 , G01N33/68 , A61K39/00
CPC分类号： G01N33/57488 , A61K31/282 , A61K31/403 , A61K31/4045 , A61K31/519 , A61K31/706 , A61K31/7068 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/30 , G01N33/6893 , G01N33/74 , G01N2333/58 , G01N2800/32 , G01N2800/52
摘要： Methods for treating diseases such as cancer comprising administering a DLL4 antagonist, either alone or in combination with other anti-cancer agents, and monitoring for cardiovascular side effects and/or toxicity.
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公开(公告)号：US09599620B2
公开(公告)日：2017-03-21
申请号：US14068910
申请日：2013-10-31
IPC分类号： G01N33/50 , A61K39/395 , C07K16/30 , G01N33/574 , G01N33/68 , A61K31/282 , A61K31/706 , G01N33/74 , A61K31/4045
CPC分类号： G01N33/57488 , A61K31/282 , A61K31/403 , A61K31/4045 , A61K31/519 , A61K31/706 , A61K31/7068 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/30 , G01N33/6893 , G01N33/74 , G01N2333/58 , G01N2800/32 , G01N2800/52
摘要： Methods for treating diseases such as cancer comprising administering a DLL4 antagonist, either alone or in combination with other anti-cancer agents, and monitoring for cardiovascular side effects and/or toxicity.
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公开(公告)号：US20160334423A1
公开(公告)日：2016-11-17
申请号：US15070373
申请日：2016-03-15
IPC分类号： G01N33/74 , A61K39/395 , C07K16/30 , G01N33/574 , A61K31/282 , A61K31/519 , A61K31/7068 , G01N33/68 , A61K45/06 , A61K31/403
CPC分类号： G01N33/57488 , A61K31/282 , A61K31/403 , A61K31/4045 , A61K31/519 , A61K31/706 , A61K31/7068 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/30 , G01N33/6893 , G01N33/74 , G01N2333/58 , G01N2800/32 , G01N2800/52
摘要： Methods for treating diseases such as cancer comprising administering a DLL4 antagonist, either alone or in combination with other anti-cancer agents, and monitoring for cardiovascular side effects and/or toxicity.
摘要翻译： 用于治疗诸如癌症的疾病的方法包括单独或与其它抗癌剂组合施用DLL4拮抗剂，以及监测心血管副作用和/或毒性。
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9.发明申请公开(公告)号：US20160235844A1
公开(公告)日：2016-08-18
申请号：US14993775
申请日：2016-01-12
发明人： Robert Joseph Stagg , Jakob Dupont
IPC分类号： A61K39/395 , C07K14/705 , C07K16/28 , A61K38/17 , A61K45/06
CPC分类号： A61K39/39558 , A61K38/177 , A61K45/06 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K16/2863 , C07K16/3053 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2319/02 , C07K2319/30 , C07K2319/32 , A61K39/395 , A61K2300/00
摘要： Novel methods of treating neuroendocrine tumors are provided. In one embodiment, the method comprises administering to a subject in need thereof a therapeutically effective dose of a Wnt antagonist. In one embodiment, the Wnt antagonist is an anti-FZD antibody. In another embodiment, the Wnt antagonist is a soluble FZD receptor polypeptide. In a further embodiment, the Wnt antagonist is an anti-Wnt antibody.
摘要翻译： 提供治疗神经内分泌肿瘤的新方法。 在一个实施方案中，所述方法包括向有需要的受试者施用治疗有效剂量的Wnt拮抗剂。 在一个实施方案中，所述Wnt拮抗剂是抗FZD抗体。 在另一个实施方案中，Wnt拮抗剂是可溶性FZD受体多肽。 在另一个实施方案中，Wnt拮抗剂是抗Wnt抗体。
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公开(公告)号：US20160176962A1
公开(公告)日：2016-06-23
申请号：US14928271
申请日：2015-10-30
发明人： Christopher Lamond Murriel , Timothy Charles Hoey , Austin L. Gurney , Julie Michelle Roda , Minu K. Srivastava , Inkyung Park , Jakob Dupont
IPC分类号： C07K16/28 , A61K31/519 , A61K31/282 , A61K39/395
CPC分类号： C07K16/28 , A61K31/282 , A61K31/519 , A61K39/39558 , A61K2039/507 , A61K2039/572 , C07K16/2803 , C07K16/2827 , C07K2317/24 , C07K2317/31 , C07K2317/76 , A61K39/395 , A61K2300/00
摘要： The present invention provides methods comprising combination therapy for modulating immune responses, for inhibiting tumor growth, and/or for treating cancer. In particular, the present invention provides Notch pathway inhibitors in combination with immunotherapeutic agents for the treatment of cancer and other diseases.
摘要翻译： 本发明提供了包括用于调节免疫应答，抑制肿瘤生长和/或治疗癌症的组合疗法的方法。 特别地，本发明提供Notch途径抑制剂与用于治疗癌症和其它疾病的免疫治疗剂的组合。
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