公开(公告)号：US20210252125A1

公开(公告)日：2021-08-19

申请号：US17049245

申请日：2019-04-25

申请人： Patrick Leonard AHL ,  Akhilesh BHAMBHANI ,  Christopher Jon FARRELL ,  Patrick MCHUGH ,  Morrisa C. JONES ,  Daniel D. ROTH ,  Jessica R. SINACOLA ,  Justin STANBRO ,  Matthew P. WATSON ,  Emily WEN ,  Michael A. WINTERS ,  Merck Sharp & Dohme Corp.

发明人： Patrick Leonard Ahl ,  Akhilesh Bhambhani ,  Christopher Jon Farrell ,  Patrick McHugh ,  Morrisa C. Jones ,  Daniel D. Roth ,  Jessica R. Sinacola ,  Justin Stanbro ,  Matthew P. Watson ,  Emily Wen ,  Michael A. Winters

IPC分类号： A61K39/09 ,  A61K47/62 ,  A61K47/61

摘要： A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.

公开(公告)号：US20210236384A1

公开(公告)日：2021-08-05

申请号：US17053251

申请日：2019-05-02

申请人： Matthew P. WATSON ,  David. A. HAMILTON ,  Scott MCFEATERS ,  Max BLOMBERG ,  Danny ANDRADE ,  Chad CARPENTER ,  Merck Sharp & Dohme Corp. ,  Meissner Filtration Products

发明人： Matthew P. Watson ,  David A. Hamilton ,  Scott McFeaters ,  Max Blomberg ,  Danny Andrade ,  Chad Carpenter

IPC分类号： A61J1/10 ,  A61J1/14 ,  F26B5/06

摘要： A lyophilization bag is provided herein for containing a solution in a lyophilizer during lyophilization. The lyophilization bag includes a body having a flexible base member, and a flexible top member. The base member and the top member, collectively, at least partially encompass an interior volume of the body. A first portion of the interior volume is defined between at least portions of the base member and a reference plane located spaced from the at least portions of the base member, the first portion of the interior volume defining a volume corresponding to the initial volume of the solution. A second portion of the interior volume is defined between the reference plane and at least portions of the top member. At least one port defining an opening is in communication with the second portion of the interior volume.

公开(公告)号：US20130219885A1

公开(公告)日：2013-08-29

申请号：US13881920

申请日：2011-11-03

申请人： John P. Watson ,  David G. Grabowska

发明人： John P. Watson ,  David G. Grabowska

IPC分类号： F04D1/00

CPC分类号： F04D1/00 ,  F01D9/026 ,  F01D17/148 ,  F02B37/025 ,  F02B37/22 ,  F02C6/12 ,  Y02T10/144 ,  Y02T50/671

摘要： A variable geometry turbocharger is simplified yet able to maintain pulse energy. In a first embodiment, a turbine housing is provided with a pivoting flow control valve which pivots about a point near the entry to the turbine housing. By moving the valve about the pivot point, the effective volume of the turbine housing volute is varied, thus effectively reducing the volume of exhaust gas in the volute, allowing control of exhaust gas flowing to the turbine wheel. In the second embodiment of the invention, a rotating wedge segment within the volute is rotated from a first position to a second position, changing the effective volume of the volute and allowing control of exhaust gas flowing to the turbine wheel.

摘要翻译： 可变几何涡轮增压器被简化，但能够维持脉冲能量。 在第一实施例中，涡轮机壳体设置有枢转流量控制阀，枢转流量控制阀围绕靠近涡轮壳体的入口枢转。 通过围绕枢转点移动阀门，涡轮机壳体蜗壳的有效体积是变化的，因此有效地减小了蜗壳中废气的体积，从而允许控制流到涡轮机叶轮的废气。 在本发明的第二实施例中，蜗壳内的旋转楔形段从第一位置旋转到第二位置，改变了蜗壳的有效体积并且允许控制流到涡轮机叶轮的废气。

公开(公告)号：US08246564B2

公开(公告)日：2012-08-21

申请号：US12328635

申请日：2008-12-04

申请人： Stephen E. Myrick ,  Gregory P. Watson ,  John S. Gilkerson ,  John M. Aoki

发明人： Stephen E. Myrick ,  Gregory P. Watson ,  John S. Gilkerson ,  John M. Aoki

IPC分类号： A61M37/00 ,  A61M1/00

CPC分类号： A61M1/32 ,  A61M2205/123 ,  A61M2209/08 ,  B01F3/04758

摘要： This invention discloses a modular system having a base module, a mid-section control module, and a display module for preparing and administering a gas-enriched bodily fluid. Gas-enrichment is achieved by a gas-enriching device which can be in the form of a disposable cartridge. During operation, the gas-enrichment device is placed in an enclosure within the control module to form a fluid pathway for extracorporeal circulation of the bodily fluid. An electronic controller manages the various aspects of the system and executes an automated method for priming the extracorporeal circuit.

摘要翻译： 本发明公开了一种具有基础模块，中段控制模块和用于制备和施用富含气体的体液的显示模块的模块化系统。 气体富集通过可以是一次性药筒形式的气体富集装置实现。 在操作期间，气体富集装置被放置在控制模块内的外壳中以形成用于体液的体外循环的流体通路。 电子控制器管理系统的各个方面，并执行用于引发体外电路的自动化方法。

公开(公告)号：US08192487B2

公开(公告)日：2012-06-05

申请号：US12945618

申请日：2010-11-12

申请人： Mai Nguyen Brooks ,  James P Watson

发明人： Mai Nguyen Brooks ,  James P Watson

IPC分类号： A61F2/12 ,  A61F2/00

CPC分类号： C12N5/0653 ,  A61K35/12 ,  C12N2533/40

摘要： The field of the present invention relates to a novel method for producing tissue or organ in a mammal by implanting in vivo a novel three dimensional biodegradable scaffold. The novel three dimensional biodegradable scaffolds overcome the barrier of developing large organs with tissue engineering.

摘要翻译： 本发明的领域涉及通过在体内植入新的三维可生物降解的支架来在哺乳动物中产生组织或器官的新方法。 新型三维可生物降解支架克服了组织工程开发大器官的障碍。

公开(公告)号：US20120036849A1

公开(公告)日：2012-02-16

申请号：US13264456

申请日：2010-04-19

申请人： John P. Watson ,  Tilman Bernauer ,  Kurtis E. Henderson ,  David G. Grabowska

发明人： John P. Watson ,  Tilman Bernauer ,  Kurtis E. Henderson ,  David G. Grabowska

IPC分类号： F02B37/22 ,  F02B37/00 ,  F02B37/12

CPC分类号： F02B37/22 ,  F01D17/141 ,  F01D17/146 ,  F01D17/148 ,  F02B37/025 ,  F02B37/24 ,  F05D2220/40 ,  F05D2260/53 ,  Y02T10/144

摘要： A variable geometry turbocharger is simplified yet able to maintain pulse energy. In a first embodiment, a turbine housing is provided with a pivoting wall which pivots about a point near the entry to the turbine housing. By moving the wall about the pivot point, the effective volume of the turbine housing volute is varied, thus effectively reducing the volume of exhaust gas in the volute, allowing control of exhaust gas flowing to the turbine wheel. In the second embodiment of the invention, a rotating wedge segment within the volute is rotated from a first position to a second position, changing the effective volume of the volute and allowing control of exhaust gas flowing to the turbine wheel.

摘要翻译： 可变几何涡轮增压器被简化，但能够维持脉冲能量。 在第一实施例中，涡轮机壳体设置有枢转壁，该枢转壁围绕靠近涡轮壳体的入口枢转。 通过围绕枢转点移动壁，涡轮机壳体蜗壳的有效体积是变化的，因此有效地减小了涡卷中的废气体积，从而控制流到涡轮机叶轮的废气。 在本发明的第二实施例中，蜗壳内的旋转楔形段从第一位置旋转到第二位置，改变了蜗壳的有效体积并且允许控制流到涡轮机叶轮的废气。

公开(公告)号：US20110236623A1

公开(公告)日：2011-09-29

申请号：US13150808

申请日：2011-06-01

申请人： Timothy P. WATSON ,  Andrew W. CHRISTIE

发明人： Timothy P. WATSON ,  Andrew W. CHRISTIE

IPC分类号： B29C47/06 ,  B32B5/12

CPC分类号： B32B7/02 ,  B29C48/08 ,  B29C48/19 ,  B29C48/21 ,  B29C48/30 ,  B29C48/305 ,  B29C48/307 ,  B29C48/49 ,  B29C48/705 ,  B29K2105/0032 ,  B29K2995/0092 ,  B32B3/00 ,  B32B27/08 ,  B32B27/308 ,  B32B2307/402 ,  Y10T428/24132 ,  Y10T428/24942 ,  Y10T428/31935

摘要： Co-extrusion apparatus for manufacturing a laminated plastic film or sheet comprises a plug-type layer sequencer including a plurality of channels for conducting a plurality of polymer flows; a transitional aspect ratio block for inducing the plurality of polymer flows to converge; and a flow velocity profiler cartridge for combining the plurality of polymer flows to form the film. In accordance with one embodiment, the layer sequencer includes a tapered selector pin which minimizes mechanical damage when the selector pin is removed. In accordance with another embodiment, the flow velocity profiler cartridge includes inserts fitting within cavities for controlling the polymer flows which form the layers of the film or sheet manufactured by the apparatus. At least one such insert defines lanes within an associated cavity so as to promote the formation of lanes of differing polymer composition within at least one layer of the laminated sheet or film.

摘要翻译： 用于制造层压塑料膜或片材的共挤出设备包括：插塞型层序器，包括用于导入多个聚合物流的多个通道; 用于诱导多个聚合物流会聚的过渡纵横比块; 以及用于组合多个聚合物流以形成膜的流速分析器筒。 根据一个实施例，层序列器包括锥形选择器针，当选择器针被移除时，其最小化机械损伤。 根据另一个实施例，流速分析器筒包括装配在腔内的插入件，用于控制形成由该装置制造的膜或片的层的聚合物流。 至少一个这样的插入件在相关联的空腔内限定通道，以促进层压片材或薄膜的至少一层内形成不同聚合物组成的通道。

公开(公告)号：US20110106250A1

公开(公告)日：2011-05-05

申请号：US12945618

申请日：2010-11-12

申请人： Mai Nguyen Brooks ,  James P. Watson

发明人： Mai Nguyen Brooks ,  James P. Watson

IPC分类号： A61F2/12

CPC分类号： C12N5/0653 ,  A61K35/12 ,  C12N2533/40

摘要： The field of the present invention relates to a novel method for producing tissue or organ in a mammal by implanting in vivo a novel three dimensional biodegradable scaffold. The novel three dimensional biodegradable scaffolds overcome the barrier of developing large organs with tissue engineering.

摘要翻译： 本发明的领域涉及通过在体内植入新的三维可生物降解的支架来在哺乳动物中产生组织或器官的新方法。 新型三维可生物降解支架克服了组织工程开发大器官的障碍。

公开(公告)号：US07926961B2

公开(公告)日：2011-04-19

申请号：US12274574

申请日：2008-11-20

申请人： William E. Shaw ,  Michael E. DeFlumere ,  Brian Foley ,  Walter P Watson

发明人： William E. Shaw ,  Michael E. DeFlumere ,  Brian Foley ,  Walter P Watson

IPC分类号： G02B23/16

CPC分类号： G02B23/06 ,  G02B5/122 ,  G02B27/0018

摘要： A telescope design is disclosed that has at least some of its interior facing surfaces configured with corner reflectors, so that a detector operatively coupled to the telescope views itself, instead of those surfaces. The corner reflectors may be on, for example, interior facing surfaces of a conventional baffle appended to the telescope and/or mirror supports or other structures inside the telescope housing that are within the detector's FOV. Likewise, the corner reflectors may be on interior facing surfaces of a baffle that is integrated into the telescope housing. In some such cases, the integrated baffle can be configured as both a baffle and a mirror support. The integrated baffle can be shaped to the F-cone between mirrors of a given telescope design, and/or configured to minimize or otherwise reduce the total obscuration of the baffle to improve the optical throughput.

摘要翻译： 公开了一种望远镜设计，其具有配置有角反射器的至少一些其内部面对表面，使得可操作地耦合到望远镜的检测器自身而不是那些表面。 角部反射器可以在例如附近到望远镜和/或反射镜支撑件或传感器壳体内的其他结构内的传统挡板的面向内表面处于检测器的FOV内。 同样地，角反射器可以在集成到望远镜壳体中的挡板的面向内表面上。 在一些这样的情况下，集成挡板可以被配置为挡板和反射镜支架。 集成挡板可以被成形为给定望远镜设计的反射镜之间的F锥体，和/或被配置为最小化或以其他方式减少挡板的全部遮蔽以改善光学通过量。

公开(公告)号：US07820102B2

公开(公告)日：2010-10-26

申请号：US10402463

申请日：2003-03-28

申请人： Stephen E. Myrick ,  Gregory P. Watson ,  William R. Patterson ,  Paul J. Zalesky

发明人： Stephen E. Myrick ,  Gregory P. Watson ,  William R. Patterson ,  Paul J. Zalesky

IPC分类号： A61M1/00 ,  A61M37/00

CPC分类号： A61M1/3621 ,  A61M1/32 ,  A61M1/3626 ,  A61M2202/0208 ,  A61M2202/0476 ,  B01F3/04758

摘要： A device generates a gas-enriched physiologic fluid and combines it with a bodily fluid to create a gas-enriched bodily fluid. The device may take the form of a disposable cartridge. The cartridge may include a fluid supply chamber for delivering physiologic fluid under pressure to an atomizer. The atomizer delivers fluid droplets into a gas-pressurized atomization chamber to enrich the physiologic fluid with the gas. The gas-enriched physiologic fluid is delivered to a mixing chamber in the cartridge where the gas-enriched physiologic fluid is mixed with a bodily fluid, such as blood, to create a gas-enriched bodily fluid.

摘要翻译： 装置产生气体富集的生理流体并将其与体液结合以产生富含气体的体液。 该装置可以采取一次性盒式的形式。 药筒可以包括用于将生理液体在压力下输送到雾化器的流体供应室。 雾化器将流体液滴输送到气体加压的雾化室中以与气体一起富集生理液体。 将气体富集的生理液体输送到药筒中的混合室，其中富含气体的生理液体与诸如血液的体液混合，以产生富含气体的体液。