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1.发明申请公开(公告)号：US20110256631A1
公开(公告)日：2011-10-20
申请号：US13034199
申请日：2011-02-24
Applicant: Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
Inventor： Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
CPC classification number: C12Q1/6874 , C12Q1/6844 , C12Q1/686 , C12Q1/6869 , G01N21/6428 , G01N2021/6421 , G01N2021/6441 , G01N2201/06113 , G01N2201/12 , G06F19/22 , Y10T436/143333 , C12Q2563/107
Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
Abstract translation: 计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或 片段。
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公开(公告)号：US08383369B2
公开(公告)日：2013-02-26
申请号：US12561221
申请日：2009-09-16
Applicant: Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
Inventor： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
CPC classification number: G01N21/6452 , C12Q1/6869 , G01N21/6428 , G01N2201/0635 , Y10T436/143333 , C12Q2525/119 , C12Q2521/125 , C12Q2537/149
Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
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3.发明授权公开(公告)号：US08182993B2
公开(公告)日：2012-05-22
申请号：US12134186
申请日：2008-06-05
Applicant: Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
Inventor： Austin B. Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
CPC classification number: C12Q1/6869 , G06F19/22 , C12Q2563/107
Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
Abstract translation: 计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或 片段。
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公开(公告)号：US08143030B2
公开(公告)日：2012-03-27
申请号：US12413226
申请日：2009-03-27
Applicant: Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers
Inventor： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers
CPC classification number: C12Q1/6869 , G01N2021/7786 , Y10T436/143333 , C12Q2525/301 , C12Q2533/101 , C12Q2537/149 , C12Q2565/631 , C12Q2525/307 , C12Q2525/191
Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
Abstract translation: 提供了在分析反应期间执行间歇检测的方法，装置和系统。 这种方法有助于从不同的反应时间收集反应数据。 此外，这样的方法可用于在给定的反应时间下降低照明分析反应中的一种或多种反应物的光致损伤。 在优选的实施方案中，将反应混合物经受至少一个照明和非照射期，并允许进行，使得反应混合物被照射的时间小于光诱导的损伤阈值期。
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公开(公告)号：US20120015825A1
公开(公告)日：2012-01-19
申请号：US13174089
申请日：2011-06-30
Applicant: Cheng Frank Zhong , Austin B. Tomaney , Patrick Marks , Stuart George Johnson , James N. LaBrenz , Paul Lundquist
Inventor： Cheng Frank Zhong , Austin B. Tomaney , Patrick Marks , Stuart George Johnson , James N. LaBrenz , Paul Lundquist
CPC classification number: G01N21/6428 , G01N21/6452
Abstract: Methods and systems for obtaining and processing optical signal data from analytical reactions, and in processing signal data from arrays of sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof are described. Defining and applying a 2-dimensional software mask allows for obtaining signal data from arrays with higher signal to noise than where the mask is not applied.
Abstract translation: 描述了用于从分析反应获得和处理光信号数据的方法和系统，以及处理来自逐个并入过程的阵列的信号数据以识别模板核酸和较大核酸分子（例如基因组或其片段）的核苷酸序列 。 定义和应用二维软件掩码允许从没有应用掩码的阵列获得具有更高信噪比的阵列的信号数据。
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Patent Agency Ranking
公开(公告)号：US20100075327A1
公开(公告)日：2010-03-25
申请号：US12561221
申请日：2009-09-16
Applicant: Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
Inventor： Kenneth Mark Maxham , Jon Sorenson , John Eid , Patrick Marks , Kevin Travers , Donald Gray , Robin Emig , Mark Chaisson , Benjamin Flusberg
CPC classification number: G01N21/6452 , C12Q1/6869 , G01N21/6428 , G01N2201/0635 , Y10T436/143333 , C12Q2525/119 , C12Q2521/125 , C12Q2537/149
Abstract: Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.
Abstract translation: 提供了在分析反应期间执行间歇检测的方法，装置和系统。 这种方法有助于从不同的反应时间收集反应数据。 此外，这样的方法可用于在给定的反应时间下降低照明分析反应中一种或多种反应物的光诱导损伤。 在优选的实施方案中，将反应混合物经受至少一个照明和非照射期，并允许进行，使得反应混合物被照射的时间小于光诱导的损伤阈值期。
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7.发明授权Rod and groove for sealing or adjusting axial location of turbine parts and methods of use 失效用于密封或调整涡轮机部件的轴向位置的杆和槽以及使用方法公开(公告)号：US06786695B2
公开(公告)日：2004-09-07
申请号：US10293333
申请日：2002-11-14
Applicant: Andrew John Tomko , Brian Patrick Marks
Inventor： Andrew John Tomko , Brian Patrick Marks
IPC: F01D1100
CPC classification number: F01D5/147 , F05D2230/13 , F05D2230/23
Abstract: To accurately axially position and/or seal between axially facing turbine parts, a groove having a cylindrical cross-section is formed in one surface with a centerline offset toward the one surface, the groove opening through the one surface. Rod segments having corresponding cylindrical cross-sections are inserted in the groove. The rod segments have flat surfaces coextensive therewith projecting a predetermined measured distance from the one surface, thereby accurately axially locating the turbine parts relative to one another and forming a seal therebetween. The rod segments have ends abutting one another to seal the segments one to the other.
Abstract translation: 为了准确地轴向地定位和/或密封在轴向面对的涡轮机部件之间，具有圆柱形横截面的凹槽形成在一个表面中，该中心线朝向一个表面偏移，该凹槽通过该一个表面开口。 具有相应圆柱形横截面的杆段插入槽中。 杆段具有共同延伸的平坦表面，其从一个表面突出预定的测量距离，从而相对于彼此精确地轴向定位涡轮机部件并在其间形成密封。 杆段具有彼此邻接的端部，以将片段彼此密封。
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公开(公告)号：US09175338B2
公开(公告)日：2015-11-03
申请号：US12945767
申请日：2010-11-12
Applicant: Benjamin Flusberg , Jonas Korlach , Jeffrey Wegener , Tyson A. Clark , Igor Vilfan , Andrey Kislyuk , Stephen Turner , Jon Sorenson , Kevin Travers , Cheryl Heiner , Austin B. Tomaney , Patrick Marks , Jessica Lee , Lei Jia , Dale Webster , John Lyle , Jeremiah Hanes , Joseph Puglisi
Inventor： Benjamin Flusberg , Jonas Korlach , Jeffrey Wegener , Tyson A. Clark , Igor Vilfan , Andrey Kislyuk , Stephen Turner , Jon Sorenson , Kevin Travers , Cheryl Heiner , Austin B. Tomaney , Patrick Marks , Jessica Lee , Lei Jia , Dale Webster , John Lyle , Jeremiah Hanes , Joseph Puglisi
IPC: C12Q1/68
CPC classification number: C12Q1/6869 , C12Q1/6837 , C12Q1/6858 , C12Q1/6874 , C12Q1/689 , C12Q2600/154 , C12Q2537/164 , C12Q2527/113 , C12Q2521/101 , C12Q2525/307 , C12Q2525/117
Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
Abstract translation: 提供了方法，组合物和系统用于表征修饰的核酸。 在某些优选实施方案中，提供单分子测序方法用于鉴定核酸序列内的修饰的核苷酸。 通过本文提供的方法可检测的修饰物包括化学修饰的碱基，酶修饰的碱基，脱碱基位点，非天然碱基，二级结构和与模板核酸结合的试剂。
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公开(公告)号：US20060283657A1
公开(公告)日：2006-12-21
申请号：US11153688
申请日：2005-06-15
Applicant: Harold Dubensky , Harvey Elder , Patrick Marks , David Michael , Wayne Pierjok , Dennis Runkle , Martin Weatherd
Inventor： Harold Dubensky , Harvey Elder , Patrick Marks , David Michael , Wayne Pierjok , Dennis Runkle , Martin Weatherd
IPC: G10K11/04
CPC classification number: F24F13/20 , F24F5/0075 , Y02A30/26 , Y02B30/92
Abstract: A panel provided for use in an air handling unit includes a skin and a fixture, the fixture and the skin composed of a metal material. The fixture has a base, with an opening formed in the base. The base includes at least one riser extending substantially perpendicular to the base, the at least one riser being secured to the skin to form an enclosed chamber between the skin and the fixture. A perforated sheet is disposed over the opening, a layer of film disposed on a surface of the perforated sheet facing the skin. A first insulating material is disposed on a surface of the film layer opposite the perforated sheet. A second insulating material is disposed in the enclosed chamber between the first insulating material and the skin.
Abstract translation: 提供用于空气处理单元的面板包括皮肤和固定装置，固定装置和由金属材料组成的皮肤。 该固定装置具有基部，其底部形成有开口。 所述底座包括至少一个基本上垂直于所述底座延伸的提升器，所述至少一个提升器固定到皮肤以在皮肤和固定装置之间形成封闭室。 穿孔片设置在开口上方，设置在穿孔片的面向皮肤的表面上的膜层。 第一绝缘材料设置在与穿孔板相对的膜层的表面上。 第二绝缘材料设置在第一绝缘材料和皮肤之间的封闭室中。
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10.发明授权公开(公告)号：US08703422B2
公开(公告)日：2014-04-22
申请号：US13034199
申请日：2011-02-24
Applicant: Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
Inventor： Austin Tomaney , Kenneth Mark Maxham , David Holden , Kevin Hester , Devon Murphy , Patrick Marks
CPC classification number: C12Q1/6874 , C12Q1/6844 , C12Q1/686 , C12Q1/6869 , G01N21/6428 , G01N2021/6421 , G01N2021/6441 , G01N2201/06113 , G01N2201/12 , G06F19/22 , Y10T436/143333 , C12Q2563/107
Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.
Abstract translation: 计算机实现的方法和执行这种方法的系统用于处理来自分析操作和系统的信号数据，特别是处理来自逐个引入过程的信号数据，以鉴定模板核酸和较大核酸分子的核苷酸序列，例如基因组或 片段。
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