公开(公告)号：US20180235592A1

公开(公告)日：2018-08-23

申请号：US15749981

申请日：2016-08-03

Applicant: The Penn State Research Foundation ,  The Penn State Research Foundation

Inventor： Rena Kass ,  Kristine Widders ,  Barry M. Fell ,  Randy Haluck ,  Peter Dillon

IPC: A61B17/02

CPC classification number: A61B17/0206 ,  A61B17/0218 ,  A61B17/0293 ,  A61B17/3423 ,  A61B90/30 ,  A61B90/92 ,  A61B90/94 ,  A61B2017/00438 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/00561 ,  A61B2017/00796 ,  A61B2017/00951 ,  A61B2090/0807

Abstract: The device can include a first member connected to a second member via junctions. The members can be statically or pivotally connected at the junctions via arms extending from cross-beams of the members. The junctions can be configured to provide a biasing force. Methods of using the device may include collapsing the device and inserting it through an incision, allowing the biasing force to cause continuous traction and counter-traction adjacent to a leading dissection edge so that retraction of the skin from the tissue can be facilitated during a surgical procedure.

公开(公告)号：US20250108006A1

公开(公告)日：2025-04-03

申请号：US18848678

申请日：2023-03-29

Applicant: The Penn State Research Foundation

Inventor： Amir Sheikhi ,  Arian Jaberi ,  Mohammad Zaman Ataie

IPC: A61K9/06 ,  A61K31/727 ,  A61K38/18 ,  A61K38/30

Abstract: Embodiments relate to a method of forming a granular hydrogel scaffold (GHS). The method comprises converting polymers to form hydrogel microparticles (HMP) via a first crosslinking and assembling the HMP to form GHS via non-light-mediated crosslinking with or without coating or embedding them with any biologies or nanoparticles.

公开(公告)号：US20250102716A1

公开(公告)日：2025-03-27

申请号：US18723219

申请日：2022-12-22

Applicant: THE PENN STATE RESEARCH FOUNDATION

Inventor： Lauren Dell ZARZAR ,  Caleb Huw MEREDITH ,  Nathaniel Erik STURNIOLO

IPC: G02B5/28 ,  G02F1/21

Abstract: Disclosed are articles, embodiments, and methods of formation related substrates which exhibit a tunable interference pattern (e.g., structural color) upon reflection of incident electromagnetic radiation.

公开(公告)号：US20250098650A1

公开(公告)日：2025-03-27

申请号：US18729958

申请日：2023-01-18

Applicant: THE PENN STATE RESEARCH FOUNDATION

Inventor： Chad DECHOW

IPC: A01K67/02 ,  C12Q1/6881

Abstract: Disclosed herein are methods and compositions for identifying domestic livestock having a motor impairment by identifying a motor impairment (MI) haplotype or genotype in the animal. In some embodiments, the methods are used in a selective breeding and mating program, and in some embodiments, the animal is a Holstein bovine, Holstein crossbred, or bovine of another breed with Holstein ancestry.

公开(公告)号：US12261298B2

公开(公告)日：2025-03-25

申请号：US17437202

申请日：2020-03-09

Applicant: THE PENN STATE RESEARCH FOUNDATION

Inventor： Donghai Wang ,  Tom Mallouk ,  Yue Gao

IPC: H01M4/60 ,  H01M4/38 ,  H01M4/86 ,  H01M10/0525 ,  H01M10/0562 ,  H01M10/44

Abstract: Disclosed is a reactive polymer composite comprising a reactive functionalized polymer having a main polymer chain with functionalization along the main polymer chain, wherein the functionalization comprises one or more functional groups that are configured to react with a metal electrode to form a polymeric metal salt and one, or more functional groups configured to electrochemically decompose. Also disclosed are electrodes and batteries comprising the same. Also disclosed are methods of making the same.

公开(公告)号：US20250064580A1

公开(公告)日：2025-02-27

申请号：US18721082

申请日：2022-12-16

Applicant: Robert DOWLING ,  THE PENN STATE RESEARCH FOUNDATION

Inventor： Robert DOWLING ,  William S. PIERCE ,  Gerson ROSENBERG

IPC: A61F2/24

Abstract: A prosthetic anastomosis fixation device comprising an inner support structure and an outer support structure positioned around the inner support structure and coupled to a prosthetic device, wherein the inner support structure comprises an expandable structure radially movable between an unexpanded to an expanded configuration, wherein in the expanded configuration, the inner support structure provides a radially outward force toward an inner surface of the outer support structure, wherein the inner and outer support structures are sized and configured to receive a portion of a biological conduit therebetween such that in the expanded configuration, the portion of a biological conduit is fixedly secured between the inner surface of the outer support structure and an outer surface of the inner support structure.

公开(公告)号：US12233419B2

公开(公告)日：2025-02-25

申请号：US17259136

申请日：2019-07-11

Applicant: The Penn State Research Foundation

Inventor： Pak Kin Wong ,  Hui Li

IPC: B01L3/00 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/689

Abstract: Provided are devices and methods for detecting the presence, absence, and/or characteristics of bacteria. A microfluidic device for characterizing bacteria is provided. The device contains one or more bacteria trapping channels, and one or more pneumatic channels in contact with the bacteria trapping channels, wherein the one or more pneumatic channels are configured to reduce the height of the one or more bacteria trapping channels to thereby trap bacteria in the one or more bacteria trapping channels if said bacteria are present in a liquid biological sample that is introduced into the microfluidic device. Also provided is a method for identifying bacteria that may be used with the microfluidic device.

公开(公告)号：US20250059871A1

公开(公告)日：2025-02-20

申请号：US18938602

申请日：2024-11-06

Applicant: The Penn State Research Foundation

Inventor： Arash Dahi Taleghani

IPC: E21B43/267 ,  C09K8/80

Abstract: Tuning fracture hydraulic conductivity can be provided so that high hydraulic conductivity in high temperature zones and low hydraulic conductivity in low temperature zones can be defined in enhanced geothermal systems (EGS). Uniform thermal gradient along flow paths can be provided or defined to help provide such conductivity zones. Experimentation performed to evaluate embodiments showed that embodiments could prevent appearance of dominant flow paths between the wells and maintain high heat extraction rates. Embodiments can greatly increase cumulative heat extraction. Embodiments can also be provided for application solely to the injection wells. Other embodiments can position tuning agents between the wells and still help provide control of the fluid flow in the reservoir and enhance heat extraction.

公开(公告)号：US12220667B2

公开(公告)日：2025-02-11

申请号：US17645380

申请日：2021-12-21

Applicant: THE PENN STATE RESEARCH FOUNDATION

Inventor： Manish Kumar ,  Tingwei Ren ,  Woochul Song ,  Yu-Ming Tu

IPC: B01D67/00 ,  B01D69/14 ,  B01D71/24 ,  B01D71/26 ,  B01D71/52 ,  B01D71/56 ,  B01D71/80 ,  C07K14/245 ,  C07K14/31 ,  C07K14/47

Abstract: The present disclosure describes compositions and methods for preparing membrane protein nanosheets and two-dimensional crystals. In particular, the methods employ a solvent. A mixture of a polymer and a membrane protein is solubilized in the solvent, applied to a substrate, and subsequently dried to form the nanosheet or two-dimensional crystal. Applicants have surprisingly found that the membrane proteins maintain their structure when exposed to solvents during the short processing time utilized.

公开(公告)号：US20250027858A1

公开(公告)日：2025-01-23

申请号：US18775741

申请日：2024-07-17

Applicant: The Penn State Research Foundation

Inventor： James Charles Slosson ,  Hojae Yi

IPC: G01N3/10 ,  G01N3/24 ,  G01N33/483

Abstract: Methods and systems facilitate measuring flow properties of a material, such as biomass materials, that include different material particles. Sample holding plates securely hold material particles and secure them to sample holders. A normal force actuator applies a normal force between material particles held by the sample holding plates and a sliding force actuator applies a sliding force. Normal and sliding force sensors monitor the transmitted forces, allowing a processor to determine adhesion and friction characteristics between particles held by the first and second sample holding plates.