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1.发明授权Implant for the repair of a cartilage defect and method for manufacturing the implant 有权用于修复软骨缺损的植入物和用于制造植入物的方法公开(公告)号：US08945535B2
公开(公告)日：2015-02-03
申请号：US11997769
申请日：2006-09-18
CPC分类号： A61L27/3817 , A61L27/3612 , A61L27/3852
摘要： For the repair of a cartilage defect in a human or animal patient use is made of an implant comprising an implant body including a natural cartilage matrix and being coated with cells having a chondrogenic potential. These cells are produced by in vitro cell proliferation starting from chondrocytes isolated from a cartilage biopsy. The chondrocytes which are de-differentiated during cell proliferation are re-differentiated during tissue culturing and are in particular suitable for producing and maintaining the cartilage matrix of the implant body. The cells adhering to the surface of the implant body are preferably also chondrocytes being de-differentiated by cell proliferation, but not re-differentiated, and are therefore particularly suitable for integrating the implant in the defect. Due to the cells adhering to the surface of the implant body, the implant is successfully integrated in the viable tissue surrounding the defect.
摘要翻译： 为了修复人或动物患者中的软骨缺损，使用植入物包括植入体，其包括天然软骨基质并且具有软骨形成潜能的细胞。 这些细胞通过从软骨活检分离的软骨细胞开始的体外细胞增殖产生。 细胞增殖过程中去分化的软骨细胞在组织培养过程中被重新分化，特别适用于生产和维持植入体本体的软骨基质。 附着在植入体表面的细胞优选也是软骨细胞通过细胞增殖而被去分化，但不再分化，因此特别适用于将植入物整合到缺陷中。 由于细胞粘附到植入体的表面，植入物被成功地整合到围绕缺陷的活组织中。
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公开(公告)号：US5385229A
公开(公告)日：1995-01-31
申请号：US147760
申请日：1993-11-05
申请人： Peter Bittmann , Fredy Tanner , Muller-Glauser
发明人： Peter Bittmann , Fredy Tanner , Muller-Glauser
CPC分类号： A61L2/26 , A61F2/0095 , A61L27/507 , A61B2050/0065 , A61B50/33 , A61F2/062
摘要： The container for packing hollow endoprostheses (8) comprises two germ-proof wrappings (1, 2). In accordance with the invention the inner wrapping (1) consists of a water-tight wall (10, 11) and various connection points (40, 50, 60). At least two of the connection points (40) are provided as access into the cavity of the prosthesis (8) and one is provided as an outlet (50) for liquids for treating the prosthesis. The outer wrapping (2) comprises through-pieces (42, 52, 62), which are associated with the connection points of the inner wrapping. The two wrappings are permeable to gas at least some regions. In accordance with the invention the container has a second application apart from its protective function: for example, in the case of a hybrid prosthesis for vascular replacement, to perform the charging of the prosthesis with the patient's own endothelial cells in the container.
摘要翻译： 用于包装中空内用假体（8）的容器包括两个防菌包装（1,2）。 根据本发明，内包装（1）由防水壁（10,11）和各种连接点（40,50,60）组成。 提供至少两个连接点（40）作为进入假体（8）的空腔的通道，并且一个设置为用于治疗假体的液体的出口（50）。 外包装（2）包括与内包装的连接点相关联的通孔（42,52,62）。 这两个包装对至少一些区域的气体是可渗透的。 根据本发明，容器具有除了其保护功能之外的第二应用：例如在用于血管置换的混合假体的情况下，使用患者自己的内皮细胞在容器中进行假体的充电。
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公开(公告)号：US4932964A
公开(公告)日：1990-06-12
申请号：US278806
申请日：1988-12-01
申请人： Peter Bittmann , Peter Dittes , Werner Muller
发明人： Peter Bittmann , Peter Dittes , Werner Muller
CPC分类号： A61F2/062
摘要： A prosthesis wall for an artificial organ, e.g. an artificial arterial blood vessel, to be coated without gaps on one side with biologically active epithelial, e.g. endothelial cells is provided with a structure of open continuous micropores a few microns in size. The pore size is limited to between 0.1 and 3 microns, at least on the surface to be coated with cells with the thickness of the partitions between the pores being not more than 3 microns to permit a continuous layer of endothelial cells with prolonged and firm adhesion to the prosthesis to be subsequently formed.
摘要翻译： 人造器官的假体壁，例如 人造动脉血管，一侧无间隙地涂覆有生物活性上皮，例如， 提供内皮细胞具有几微米尺寸的开放连续微孔的结构。 孔径限制在0.1和3微米之间，至少在要用细胞涂层的表面上，孔之间的间隔厚度不大于3微米，以允许具有延长和牢固粘附的连续的内皮细胞层 到随后形成的假体。
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4.发明授权Preparation for repairing cartilage tissue, especially articular cartilage defects 有权修复软骨组织，特别是关节软骨缺损的准备公开(公告)号：US08173162B2
公开(公告)日：2012-05-08
申请号：US10547437
申请日：2004-02-23
IPC分类号： A61K9/14
CPC分类号： A61F2/30756 , A61F2/28 , A61F2/30767 , A61F2/30965 , A61F2/3872 , A61F2002/30004 , A61F2002/30006 , A61F2002/30062 , A61F2002/30131 , A61F2002/30224 , A61F2002/30225 , A61F2002/3024 , A61F2002/3092 , A61F2210/0004 , A61F2230/0013 , A61F2230/0069 , A61F2250/0014 , A61F2250/0015 , A61F2310/00293 , A61F2310/00365 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3817 , A61L27/3852 , A61L27/56 , A61L2430/06
摘要： The invention relates to preparations which are suitable for repairing enchondral or osteochondral defects (4) by means of implantation, said preparations comprising a cartilage element (A) and optionally a bone element (B) which is connected to the cartilage element (A). The cartilage element (A) can already contain cells during the implantation or is populated after the implantation with cells migrating from surrounding tissue. The aim of the invention is to better equip the cartilage element (A) of one such preparation for integration into the surrounding tissue and/or for an easy-to-achieve, primary stability. To this end, said cartilage element is not homogeneously embodied but has different characteristics in a peripheral and/or basal region (2, 3) to those in a central region (3). Said differing characteristics (A) relate to the structure and/or composition of the matrix used and/or to the cells established in the matrix, and are in no way used to prevent the migration of cells into the preparation from the surrounding tissue.
摘要翻译： 本发明涉及适于通过植入修复软骨或软骨软骨缺陷（4）的制剂，所述制剂包含软骨元件（A）和任选的与软骨元件（A）连接的骨元素（B）。 软骨元素（A）在植入期间可以含有细胞，或者在植入后填充从周围组织迁移的细胞。 本发明的目的是更好地将一种这样的制剂的软骨元件（A）更好地装配到周围组织中和/或用于易于实现的主要稳定性。 为此，所述软骨元件不是均匀地实施的，而是在外围和/或基部区域（2,3）中具有与中心区域（3）中的区域不同的特征。 所述不同特征（A）涉及使用的基质和/或在基质中建立的细胞的结构和/或组成，并且绝不用于防止细胞从周围组织迁移到制剂中。
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5.发明申请Preparation for repairing cartilage tissue, especially articular cartilage defects 有权修复软骨组织，特别是关节软骨缺损的准备公开(公告)号：US20070148242A1
公开(公告)日：2007-06-28
申请号：US10547437
申请日：2004-02-23
申请人： Simona Vilei , Peter Bittmann , Philipp Wagner , Martin Frenz
发明人： Simona Vilei , Peter Bittmann , Philipp Wagner , Martin Frenz
IPC分类号： A61K9/14
CPC分类号： A61F2/30756 , A61F2/28 , A61F2/30767 , A61F2/30965 , A61F2/3872 , A61F2002/30004 , A61F2002/30006 , A61F2002/30062 , A61F2002/30131 , A61F2002/30224 , A61F2002/30225 , A61F2002/3024 , A61F2002/3092 , A61F2210/0004 , A61F2230/0013 , A61F2230/0069 , A61F2250/0014 , A61F2250/0015 , A61F2310/00293 , A61F2310/00365 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/3817 , A61L27/3852 , A61L27/56 , A61L2430/06
摘要： The invention relates to preparations which are suitable for repairing enchondral or osteochondral defects (4) by means of implantation, said preparations comprising a cartilage element (A) and optionally a bone element (B) which is connected to the cartilage element (A). The cartilage element (A) can already contain cells during the implantation or is populated after the implantation with cells migrating from surrounding tissue. The aim of the invention is to better equip the cartilage element (A) of one such preparation for integration into the surrounding tissue and/or for an easy-to-achieve, primary stability. To this end, said cartilage element is not homogeneously embodied but has different characteristics in a peripheral and/or basal region (2, 3) to those in a central region (3). Said differing characteristics (A) relate to the structure and/or composition of the matrix used and/or to the cells established in the matrix, and are in no way used to prevent the migration of cells into the preparation from the surrounding tissue.
摘要翻译： 本发明涉及适于通过植入修复软骨或软骨软骨缺陷（4）的制剂，所述制剂包含软骨元件（A）和任选的与软骨元件（A）连接的骨元素（B）。 软骨元素（A）在植入期间可以含有细胞，或者在植入后填充从周围组织迁移的细胞。 本发明的目的是更好地将一种这样的制剂的软骨元件（A）更好地装配到周围组织中和/或用于易于实现的主要稳定性。 为此，所述软骨元件不是均匀地实施的，而是在外围和/或基部区域（2,3）中具有与中心区域（3）中的区域不同的特征。 所述不同特征（A）涉及使用的基质和/或在基质中建立的细胞的结构和/或组成，并且绝不用于防止细胞从周围组织迁移到制剂中。
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公开(公告)号：US5658343A
公开(公告)日：1997-08-19
申请号：US472699
申请日：1995-06-06
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61L27/08 , A61L27/16 , A61L27/18 , A61L27/58 , A61F2/38
CPC分类号： A61F2/30756 , A61F2/30965 , A61L27/08 , A61L27/16 , A61L27/18 , A61L27/58 , A61F2/3094 , A61F2002/30008 , A61F2002/30062 , A61F2210/0004 , A61F2250/0017 , A61F2310/00161 , A61L2400/12 , A61L2430/06
摘要： This invention provides an implant (prosthesis) for the replacement of defective biological tissue part. In particular, the implants of this invention are well suited for the replacement of cartilage, more preferably for the replacement of articular cartilage. In one embodiment, the implants comprise a micromatrix constructed from an upper boundary layer and a lower boundary layer where the upper and said lower boundary layers are connected via an intermediate layer with fibers. The implant also includes a nanomatrix situated within the intermediate layer. The nanomatrix contains elements of a size on the order of magnitude of nanometers. The intermediate layer accommodates the nanomatrix such that, for a growing inner pressure the boundary layers are mutually held at a preset distance from one another.
摘要翻译： 本发明提供了用于替换有缺陷的生物组织部分的植入物（假体）。 特别地，本发明的植入物非常适合于替代软骨，更优选用于替代关节软骨。 在一个实施例中，植入物包括由上边界层和下边界层构成的微矩阵，其中上边界层和下边界层通过具有纤维的中间层连接。 植入物还包括位于中间层内的纳米线。 纳米线含有纳米级数量级的元素。 中间层容纳纳米线，使得对于越来越大的内部压力，边界层彼此相互保持在预设的距离。
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公开(公告)号：US4731054A
公开(公告)日：1988-03-15
申请号：US877228
申请日：1986-06-20
申请人： Werner Billeter , Peter Bittmann
发明人： Werner Billeter , Peter Bittmann
CPC分类号： A61L29/16 , A61M31/002 , A61L2300/202 , A61L2300/206 , A61L2300/406
摘要： The repository probe or drug dispenser consists of a tube which is divided into a probe head and a probe end part. In addition, a series of medicine carriers are disposed in the probe head which contain active ingredients and which have an axial length of at most three times the outside diameter of the tube. In addition, openings are provided in the tube transversely of each medicine carrier for the passage of fluids. Joint zones are provided between the segments of the tube in which the medicine carriers are placed. Because of the limitation on the axial length of the medicine carriers and the joint zones, the flexibility of the probe head between the relatively stiff medicine carriers is increased without distortion or a closing of the openings to the medicine carriers when deflecting the probe.
摘要翻译： 储存库探针或药物分配器由分为探头和探头端部的管组成。 此外，一系列药物载体设置在探头中，其含有活性成分，其轴向长度至少为管的外径的三倍。 此外，在管子横向上设置有用于流体通过的药剂载体的开口。 在放置药剂载体的管的段之间提供接合区。 由于药物载体和接合区域的轴向长度受到限制，因此当相对僵硬的药物载体之间的探头的柔性增加时，当偏转探针时，变形或向药物载体关闭开口。
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公开(公告)号：US4318177A
公开(公告)日：1982-03-02
申请号：US105734
申请日：1979-12-20
申请人： Joachim Rapp , Peter Bittmann
发明人： Joachim Rapp , Peter Bittmann
CPC分类号： B28C7/022
摘要： A method of and an apparatus for controlling the water added to concrete batches wherein for a given concrete recipe and batch size, while mixing same, a series of empirical values of water quantity and consistency of the resulting mix are determined by initially feeding a quantity of water to the batch reduced by an amount equivalent to the moisture content of the aggregates of the batch at maximum intrinsic moisture content and thereafter incrementally adding water while measuring the consistency after each water addition, and these values are stored for the respective recipe and batch size. For the addition of water to a further batch of the recipe, while mixing the further batch, an initial quantity of water is added to the further batch which is not reduced by the quantity of water equivalent to the moisture contents of the aggregates and the consistency of the further batch after the initial addition of water thereto is measured. Interpolation between stored water values corresponding to stored consistency values neighboring the measured consistency yields a first water quantity and interpolation between stored water values corresponding to stored consistency values for a set point consistency of the further batch saves a second water quantity. The additional water quantity equal to the difference is added in a single increment.
摘要翻译： 一种用于控制添加到混凝土批料中的水的方法和装置，其中对于给定的混凝土配方和批料尺寸，在混合时，通过初始加入一定量的水，确定所得混合物的水量和稠度的一系列经验值 批量的水减少相当于最大固有水分含量的批料的聚集体的水分含量的量，然后在测量每次加水后的稠度时逐渐加水，并且这些值被存储用于相应的配方和批量 。 为了将水添加到另一批配方中，在混合另外的批料时，将初始量的水添加到另外的批料中，该批次不会减少与聚集体的水分含量相当的水量和稠度 测定其初次添加水后的其他批次。 对应于与所测量的稠度相邻的存储的一致性值的存储水值之间的插值产生第一水量，并且对于与所存储的一致性值相对应的存储的水值之间的插值，用于另一个批次的设定点一致性，从而节省第二水量。 等于差值的附加水量以单个增量加入。
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9.发明申请Implant for the Repair of a Cartilage Defect and Method for Manufacturing the Implant 有权用于修复软骨缺损的植入物和用于制造植入物的方法公开(公告)号：US20080269895A1
公开(公告)日：2008-10-30
申请号：US11997769
申请日：2006-09-18
CPC分类号： A61L27/3817 , A61L27/3612 , A61L27/3852
摘要： For the repair of a cartilage defect in a human or animal patient, e.g. a full thickness articular cartilage defect, use is made of an implant (1) comprising an implant body (2) including a natural cartilage matrix and being coated with cells having a chondrogenic potential, preferably autologous cells. Preferably, the implant body consists of autologous cartilage tissue with viable chondrocytes integrated therein which cartilage tissue is produced by in vitro tissue culturing. Preferably, the cells for producing the cartilage tissue and for coating the implant body surfaces are the same. These cells are produced by in vitro cell proliferation starting from chondrocytes isolated from a cartilage biopsy. The chondrocytes which are de-differentiated during cell proliferation are re-differentiated during tissue culturing and are in particular suitable for producing and maintaining the cartilage matrix of the implant body. The cells adhering to the surface of the implant body are preferably also chondrocytes being de-differentiated by cell proliferation, but not re-differentiated, and are therefore particularly suitable for integrating the implant in the defect. Due to the cells adhering to the surface of the implant body, the implant is successfully integrated in the viable tissue surrounding the defect.
摘要翻译： 为了修复人或动物患者的软骨缺损，例如 全身关节软骨缺损，使用包括植入体（2）的植入物（1），其包括天然软骨基质并且涂覆有具有软骨形成潜能的细胞，优选自体细胞。 优选地，植入体由包含活体软骨细胞的自体软骨组织组成，其中通过体外组织培养产生软骨组织。 优选地，用于产生软骨组织的细胞和用于涂覆植入物体表面的细胞是相同的。 这些细胞通过从软骨活检分离的软骨细胞开始的体外细胞增殖产生。 细胞增殖过程中去分化的软骨细胞在组织培养过程中被重新分化，特别适用于生产和维持植入体本体的软骨基质。 附着在植入体表面的细胞优选也是软骨细胞通过细胞增殖而被去分化，但不再分化，因此特别适用于将植入物整合到缺陷中。 由于细胞粘附到植入体的表面，植入物被成功地整合到围绕缺陷的活组织中。
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公开(公告)号：US5817153A
公开(公告)日：1998-10-06
申请号：US729259
申请日：1996-10-09
CPC分类号： A61L27/3691 , A61L27/24 , A61L27/3604 , A61L27/3687 , C08H1/06 , A61F2310/00365 , Y10S623/915
摘要： In the method of a photo-oxidative treatment of tissue containing collagen tissue, the tissue is pre-treated with an aqueous conditioning solution prior to an irradiation with light. In this pre-treatment the tissue permeable to the solution is loaded with a dye contained in the solution, in particular with methylene blue. This dye, activated by light, catalyzes photo-oxidative reactions. In accordance with the invention a substance is added to the conditioning solution, the refractive index of which is greater than that of water. As a result of this additive, the tissue containing collagen assumes a greater transparency for light during the pre-treatment.
摘要翻译： 在对含有胶原组织的组织进行光氧化处理的方法中，在用光照射之前，用水性调理溶液对组织进行预处理。 在该预处理中，溶液可渗透的组织装载有溶液中所含的染料，特别是用亚甲基蓝。 这种由光激活的染料催化光氧化反应。 根据本发明，将物质加入到其折射率大于水的调理溶液中。 作为这种添加剂的结果，在预处理期间，含有组织的胶原蛋白对于光具有更大的透明度。
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