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10 条记录 (耗时 0.026 秒)

    Determination of bone-sialoprotein in bodily fluids for oncological problems
    3.
    发明授权
    Determination of bone-sialoprotein in bodily fluids for oncological problems 有权
    测定体液中骨涎蛋白的肿瘤学问题

    公开(公告)号：US07790853B2

    公开(公告)日：2010-09-07

    申请号：US10480441

    申请日：2002-06-06

    申请人： Franz Paul Armbruster ,  Markus Karmatschek ,  Mats Paulsson

    发明人： Franz Paul Armbruster ,  Markus Karmatschek ,  Mats Paulsson

    IPC分类号： C07K16/00 ,  G01N33/53 ,  G01N33/574

    CPC分类号： C07K16/18 ,  A01K2217/05 ,  A61K2039/505 ,  C07K14/51 ,  C07K16/24 ,  C07K16/30 ,  C07K2317/11 ,  C07K2317/21

    摘要： The invention relates to antibodies or a plurality of antibodies against human bone sialoprotein (BSP), characterized in that the antibodies bind to epitopes which are present only in human bone sialoprotein from tumor cells, the post-translational glycosylation of which is modified or incomplete in the region of amino acids of 120 to 135, containing the amino acids TGLAA (SEQ ID NO: 2), in comparison with normal bone sialoprotein from bones. The antibodies are put to use in an immunoassay for the diagnosis and prognosis of tumor diseases, in particular the diagnosis and prognosis of bone metastases in the case of primary breast carcinoma.

    摘要翻译： 本发明涉及针对人骨涎蛋白（BSP）的抗体或多种抗体，其特征在于所述抗体结合仅存在于来自肿瘤细胞的人骨涎蛋白的表位，其翻译后糖基化被修饰或不完全 与来自骨骼的正常骨涎蛋白相比，含有氨基酸TGLAA（SEQ ID NO：2）的氨基酸的区域为120至135。 在免疫测定中使用抗体用于肿瘤疾病的诊断和预后，特别是在原发性乳腺癌的情况下的骨转移的诊断和预后。

    Diagnosis of gluten sensitive enteropathy and other autoimmunopathies
    9.
    发明授权
    Diagnosis of gluten sensitive enteropathy and other autoimmunopathies 有权
    诊断面筋敏感性肠病和其他自身免疫病

    公开(公告)号：US07781169B1

    公开(公告)日：2010-08-24

    申请号：US10019067

    申请日：2000-06-28

    申请人： Mats Paulsson ,  Uwe Odenthal ,  Neil Smyth ,  Daniel Aeschlimann ,  Sarolta Karpati ,  Miklos Sardy

    发明人： Mats Paulsson ,  Uwe Odenthal ,  Neil Smyth ,  Daniel Aeschlimann ,  Sarolta Karpati ,  Miklos Sardy

    IPC分类号： G01N33/53

    CPC分类号： G01N33/564 ,  G01N2333/9108 ,  G01N2800/202 ,  G01N2800/24 ,  Y10S436/811

    摘要： Method for diagnosis of autoimmune diseases of the GSE-type or associated with gluten sensitive enteropathy comprising taking a sample and testing the sample for antibodies against human tissue transglutaminase, tissue-specific transglutaminases, or other transglutaminases. It was found that autoimmune diseases other than celiac disease can be diagnosed and distinguished in this way, notably, dermatitis herpetiformis Duhring, Crohn's disease, Addison's disease, AI hemolytic anemia, AI thrombocytopenic purpura, AI thyroid diseases, atrophic gastritis—pernicious anemia, IgA nephropathy or IgA glomerulonephritis, myasthenia gravis, partial lipodystrophy, polymyositis, primary biliary cirrhosis, primary sclerosing cholangitis, recurrent pericarditis, relapsing polychondritis, rheumatoid arthritis, rheumatism, sarcoidosis, Sjögren's syndrome, SLE, splenic atrophy, type I (insulin-dependent) diabetes mellitus, diabetes mellitus of other types, ulcerative colitis, vasculitis (both systemic and cutaneous), vitiligo as well as autoimmune diseases associated with infertility, increased risk of abortion, or reduced fetal growth.

    摘要翻译： 用于诊断GSE型自身免疫性疾病或与麸质敏感性肠病相关的方法，包括取样并测试样品以获得针对人组织转谷氨酰胺酶，组织特异性转谷氨酰胺酶或其他转谷氨酰胺酶的抗体。 发现腹腔疾病以外的自身免疫性疾病可以以这种方式进行诊断和鉴别，特别是疱疹性疱疹性杜氏病，克罗恩病，艾迪生病，溶血性贫血，AI血小板减少性紫癜，AI甲状腺疾病，萎缩性胃炎恶性贫血，IgA 肾病或IgA肾小球肾炎，重症肌无力，部分脂肪营养不良，多发性肌炎，原发性胆汁性肝硬化，原发性硬化性胆管炎，复发性心包炎，复发性多软骨炎，类风湿性关节炎，风湿病，结节病，Sjögren综合征，SLE，脾萎缩，I型（胰岛素依赖型） 其他类型的糖尿病，溃疡性结肠炎，全身和皮肤的血管炎，白癜风以及与不孕不育相关的自身免疫性疾病，流产风险增加或胎儿生长减少。