中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

15 records (took 0.015 seconds)

    Process for the depletion or removal of endotoxins
    4.
    发明授权
    Process for the depletion or removal of endotoxins 失效
    内毒素消耗或去除的过程

    公开(公告)号：US07510826B2

    公开(公告)日：2009-03-31

    申请号：US11412130

    申请日：2006-04-27

    Applicant: Metin Colpan ,  Peter Moritz ,  Joachim Schorr

    Inventor： Metin Colpan ,  Peter Moritz ,  Joachim Schorr

    IPC: C12Q1/00 ,  G01N30/02 ,  G01N31/00 ,  G01N33/48

    CPC classification number: B01D15/363 ,  B01D15/3804 ,  C12N15/101 ,  C12N15/87 ,  Y10S435/81 ,  Y10S435/82 ,  Y10S436/808 ,  Y10T436/10 ,  G01N30/461

    Abstract: A process for the depletion or removal of endotoxins from preparations containing active ingredients designated for therapeutical use which are obtained from natural sources by genetic engineering and/or biotechnology by treatment with chromatographic material wherein said natural sources are lysed, the fractions obtained are optionally centrifuged, filtrated or treated with affinity chromatographic methods; said fractions are preincubated with an aqueous salt solution and detergents, treated with anion exchange material and then washed with another salt solution, and the active ingredients are eluted from the anion exchanger, followed by further purification in a per se known manner.

    Abstract translation: 从含有指定用于治疗用途的活性成分的制剂中消耗或除去内毒素的方法，其通过遗传工程和/或生物技术从天然来源获得，其中所述天然来源被裂解，所得的级分任选地离心， 用亲和层析法过滤或处理; 所述级分用盐水溶液和洗涤剂预先加热，用阴离子交换材料处理，然后用另一种盐溶液洗涤，活性成分从阴离子交换剂中洗脱，然后以本身已知的方式进一步纯化。

    Differentiated threshold value behavior in prepaid services
    6.
    发明授权
    Differentiated threshold value behavior in prepaid services 失效
    预付费服务中的差异化阈值行为

    公开(公告)号：US07123703B2

    公开(公告)日：2006-10-17

    申请号：US10474674

    申请日：2002-02-27

    Applicant: Rüdiger Hausmann ,  Peter Moritz

    Inventor： Rüdiger Hausmann ,  Peter Moritz

    IPC: H04M11/00 ,  H04M15/00

    CPC classification number: G07F7/1008 ,  G06Q20/341 ,  G06Q20/4093 ,  H04M15/88 ,  H04M17/00 ,  H04M17/201 ,  H04M2017/22 ,  H04M2215/0116 ,  H04M2215/22

    Abstract: The invention relates to a method for threshold value relates control of at least one service in a data or telecommunication system, comprising the following steps: a) defining at least one threshold value for a prepaid credit for the payment of said service; b) defining at least one action, especially control of the scope of said service, in the framework of said service, said action being able to be triggered at said threshold value; c) signalling if the threshold value(s) is/are exceeded or not respected; and d) triggering the action in response to the signal.

    Abstract translation: 本发明涉及一种用于门限值的方法，涉及对数据或电信系统中的至少一个服务的控制，包括以下步骤：a）定义用于支付所述服务的预付信用的至少一个阈值; b）在所述服务的框架中定义至少一个动作，特别是对所述服务的范围的控制，所述动作能够以所述阈值触发; c）信号是否超过或不超过阈值; 以及d）响应该信号触发动作。

    Process for the preparation of endotoxin-free or endotoxin-depleted nucleic acids and/or oligonucleotides for gene therapy
    7.
    发明授权
    Process for the preparation of endotoxin-free or endotoxin-depleted nucleic acids and/or oligonucleotides for gene therapy 有权
    用于制备用于基因治疗的无内毒素或缺乏内毒素的核酸和/或寡核苷酸的方法

    公开(公告)号：US06297371B1

    公开(公告)日：2001-10-02

    申请号：US09253702

    申请日：1999-02-22

    Applicant: Metin Colpan ,  Joachim Schorr ,  Peter Moritz

    Inventor： Metin Colpan ,  Joachim Schorr ,  Peter Moritz

    IPC: C07H2100

    CPC classification number: B01D15/363 ,  B01D15/3804 ,  C12N15/101 ,  C12N15/87 ,  Y10S435/81 ,  Y10S435/82 ,  Y10S436/808 ,  Y10T436/10 ,  G01N30/461

    Abstract: A process for the isolation and purification of nucleic acids and/or oligonucleotides for use in gene therapy wherein said nucleic acids and/or oligonucleotides are isolated or purified from an essentially biological source, characterized in that said essentially biological sources are lysed, the fractions obtained are optionally freed or depleted from the remainder of said biological sources by per se known mechanical methods, such as centrifugation, filtration; the fractions thus treated are subsequently treated with affinity chromatographic material or with inorganic chromatographic material for the removal of endotoxins; followed by isolation of said nucleic acids and/or oligonucleotides on an anion exchanger which is designed such that DNA begins to desorb from the anion exchanger only at an ionic strength corresponding to a sodium chloride solution of a concentration higher by at least 100 mM than one corresponding to the ionic strength at which RNA begins to desorb from the anion exchanger material.

    Abstract translation: 用于分离和纯化用于基因治疗的核酸和/或寡核苷酸的方法，其中所述核酸和/或寡核苷酸从基本上生物来源分离或纯化，其特征在于基本上生物来源被裂解，获得的级分为 通过本身已知的机械方法，例如离心，过滤，任选地从所述生物源的剩余部分中释放或消耗;随后用亲和层析材料或用无机色谱材料处理如此处理的级分以除去内毒素; 然后在阴离子交换器上分离所述核酸和/或寡核苷酸，所述阴离子交换器被设计为使得DNA开始从阴离子交换剂解吸离子，其离子强度对应于浓度高于一个相应浓度至少100mM的氯化钠溶液 到RNA开始从阴离子交换材料解吸的离子强度。

    Process for the separation and purification of nucleic acids from biological sources
    8.
    发明授权
    Process for the separation and purification of nucleic acids from biological sources 失效
    从生物来源分离和纯化核酸的方法

    公开(公告)号：US5990301A

    公开(公告)日：1999-11-23

    申请号：US687529

    申请日：1996-10-18

    Applicant: Metin Colpan ,  Joachim Schorr ,  Peter Moritz

    Inventor： Metin Colpan ,  Joachim Schorr ,  Peter Moritz

    IPC: C12N15/10 ,  C12N15/87 ,  C07H21/00 ,  C12N1/08

    CPC classification number: C12N15/87 ,  C12N15/101 ,  Y10S435/81

    Abstract: A process for the isolation and purification of nucleic acids and/or oligonucleotides for use in gene therapy wherein nucleic acids and/or oligonucleotides are isolated or purified from an essentially biological source, characterized in thatessentially biological sources are lysed, the fractions obtained are optionally freed or depleted from the remainder of biological sources by per se known mechanical methods, such as centrifugation, filtration;the fractions thus treated are subsequently treated with affinity chromatographic material or with inorganic chromatographic material for the removal of endotoxins; followed byisolation of nucleic acids and/or oligonucleotides on an anion exchanger which is designed such that DNA begins to desorb from the anion exchanger only at an ionic strength corresponding to a sodium chloride solution of a concentration higher by at least 100 mM than one corresponding to the ionic strength at which RNA begins to desorb from the anion exchanger material.

    Abstract translation: PCT No.PCT / EP95 / 00389 371日期：1996年10月18日 102（e）日期1996年10月18日PCT提交1995年2月3日PCT公布。 第WO95 / 21177号公报 日期1995年8月10日一种用于分离和纯化用于基因治疗的核酸和/或寡核苷酸的方法，其中从基本上生物来源分离或纯化核酸和/或寡核苷酸，其特征在于基本上生物来源被裂解， 通过本身已知的机械方法，例如离心，过滤，任选地从所述生物来源的其余部分中释放或消耗所得的级分。 随后用亲和层析材料或用无机色谱材料处理如此处理的级分以除去内毒素; 随后在阴离子交换器上分离核酸和/或寡核苷酸，其被设计为使得DNA开始从阴离子交换剂解吸，仅在对应于浓度高于一个浓度的至少100mM的氯化钠溶液的离子强度 到RNA开始从阴离子交换材料解吸的离子强度。

    Guillotine knife sharpener
    9.
    发明授权
    Guillotine knife sharpener 失效
    GUILLOTINE KNIFE SHARPENER

    公开(公告)号：US3683563A

    公开(公告)日：1972-08-15

    申请号：US3683563D

    申请日：1970-08-06

    Applicant: WALTER PETER MORITZ

    Inventor： MORITZ WALTER PETER

    IPC: B24B3/38 ,  B24B3/36

    CPC classification number: B24B3/38

    Abstract: A device for sharpening the knife of a guillotine in which one or preferably two grinding wheels are driven by an electric motor, the arrangement being mounted on a base which can be moved over the surface of a guillotine table, the grinding wheel or wheels being capable of being sset at an angle to the surface of the table corresponding to the angle at which the blade is to be sharpened. Sharpening is carried out simply by moving the device backwards and forwards along the length of the blade. It is to be preferred that the device is constructed in such a way that the grinding wheel or grinding wheels may be set either in a high position or a low position to enable the whole length of the guillotine blade to be sharpened.

    Abstract translation: 一种用于磨削闸刀的刀具的装置，其中一个或优选两个砂轮由电动机驱动，该装置安装在可在闸刀台的表面上移动的基座上，砂轮或轮具有能力 相对于刀刃要锐化的角度与桌子表面成一定角度。 通过沿着刀片的长度向前和向后移动设备来进行锐化。 优选地，该装置被构造成使得砂轮或砂轮可以设置在高位置或低位置，以使切割刀片的整个长度能够被磨削。

Patent Agency Ranking