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    Cytotoxic conjugates comprising a chemokine receptor targeting agent
    3.
    发明授权
    Cytotoxic conjugates comprising a chemokine receptor targeting agent 失效
    包含趋化因子受体靶向剂的细胞毒性缀合物

    公开(公告)号：US07166702B1

    公开(公告)日：2007-01-23

    申请号：US09453851

    申请日：1999-12-02

    申请人： John R. McDonald ,  Philip J. Coggins

    发明人： John R. McDonald ,  Philip J. Coggins

    IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K16/00

    CPC分类号： C07K14/521 ,  A61K47/62 ,  A61K47/642 ,  A61K47/6425 ,  A61K47/6811 ,  A61K2039/505 ,  C07H21/04 ,  C07K7/06 ,  C07K14/415 ,  C07K2318/20 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/55

    摘要： Conjugates containing as a ligand chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immune effector cells, including leukocyte cell types, neutrophils, macrophages, and eosinophils. The conjugates provided herein are used to lessen or inhibit these processes to prevent or at least lessen the resulting secondary effects. In particular, the conjugates can be used to target toxins to receptors on secondary tissue damage-promoting cells. The ligand moiety can be selected to deliver the cell toxin to such secondary tissue damage-promoting cells as mononuclear phagocytes, leukocytes, natural killer cells, dendritic cells, and T and B lymphocytes, thereby suppressing the proliferation, migration, or physiological activity of such cells. Among preferred conjugates are fusion proteins having a chemokine, or a biologically active fragment thereof, as the ligand moiety linked to a cell toxin via a peptide linker of from 2 to about 60 amino acid residues.

    摘要翻译： 提供含有作为配体趋化因子受体靶向剂（如趋化因子）和靶向药物（如毒素）的缀合物。 这些缀合物用于治疗与免疫效应细胞（包括白细胞细胞类型，嗜中性粒细胞，巨噬细胞和嗜酸性粒细胞）的激活，增殖和迁移相关的炎性反应。 本文提供的缀合物用于减少或抑制这些过程以防止或至少减轻所得到的二次效应。 特别地，缀合物可用于将毒素靶向次级组织损伤促进细胞上的受体。 可以选择配体部分以将细胞毒素递送至作为单核吞噬细胞，白细胞，天然杀伤细胞，树突状细胞和T和B淋巴细胞的次级组织损伤促进细胞，从而抑制这些细胞的增殖，迁移或生理活性 细胞。 优选的缀合物是具有趋化因子或其生物活性片段的融合蛋白，作为通过2至约60个氨基酸残基的肽接头与细胞毒素连接的配体部分。

    Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
    4.
    发明授权
    Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders 失效
    用于治疗次级组织损伤和其他炎性病症和障碍的方法和组合物

    公开(公告)号：US07157418B1

    公开(公告)日：2007-01-02

    申请号：US09360242

    申请日：1999-07-22

    申请人： John R. McDonald ,  Philip J. Coggins

    发明人： John R. McDonald ,  Philip J. Coggins

    IPC分类号： A01N37/18 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  A61K45/00

    CPC分类号： C07K14/521 ,  A61K47/62 ,  A61K47/642 ,  A61K47/6425 ,  A61K47/6811 ,  A61K2039/505 ,  C07H21/04 ,  C07K7/06 ,  C07K14/415 ,  C07K2318/20 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/55

    摘要： Conjugates containing as a ligand a chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immune effector cells, including leukocyte cell types, neutrophiles, macrophages, and eosinophils. The conjugates provided herein are used to lessen or inhibit these processes to prevent or at least lessen the resulting secondary effects. In particular, the conjugates are used to target toxins to receptors on secondary tissue damage-promoting cells. The ligand moiety can be selected to deliver the cell toxin to such secondary tissue damage-promoting cells as mononuclear phagocytes, leukocytes, natural killer cells, dendritic cells, and T and B lymphocytes, thereby suppressing the proliferation, migration, or physiological activity of such cells. Among preferred conjugates are fusion proteins having a chemokine, or a biologically active fragment thereof, as the ligand moiety linked to a cell toxin via a peptide linker of from 2 to about 60 amino acid residues.

    摘要翻译： 提供了含有作为配体趋化因子受体靶向剂（如趋化因子）和靶向药物如毒素的缀合物。 这些缀合物用于治疗与免疫效应细胞（包括白细胞细胞类型，嗜中性细胞，巨噬细胞和嗜酸性粒细胞）的激活，增殖和迁移相关的炎性反应。 本文提供的缀合物用于减少或抑制这些过程以防止或至少减轻所得到的二次效应。 特别地，缀合物用于将毒素靶向次级组织损伤促进细胞上的受体。 可以选择配体部分以将细胞毒素递送至作为单核吞噬细胞，白细胞，天然杀伤细胞，树突状细胞和T和B淋巴细胞的次级组织损伤促进细胞，从而抑制这些细胞的增殖，迁移或生理活性 细胞。 优选的缀合物是具有趋化因子或其生物活性片段的融合蛋白，作为通过2至约60个氨基酸残基的肽接头与细胞毒素连接的配体部分。