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1.
公开(公告)号:US5705389A
公开(公告)日:1998-01-06
申请号:US342338
申请日:1994-11-18
申请人: Abdel Karim Braham , Pierre Smets , Rene Zalisz
发明人: Abdel Karim Braham , Pierre Smets , Rene Zalisz
IPC分类号: C07H21/02 , A61K31/70 , A61K48/00 , A61P37/00 , C07H21/00 , C07K14/525 , C12N15/09 , C12N15/113 , C12N15/28 , H02K3/50 , H02K11/04 , H02K29/00 , C12N5/10 , C12Q1/68
CPC分类号: C12N15/1136 , C07H21/00 , C07K14/525 , C12N2310/315 , C12N2310/321 , H02K2203/03
摘要: A sequence of anti-direction, anti-messenger RNA oligonucleotides of .alpha.-TNF characterized in that it possesses the structure of the formula ##STR1## wherein X is hydrogen, or a sequence of 1 to 17 oligonucleotides in free form, in alkylated form, in sulfurated form or in the form of a poly L-lysine derivative useful for stopping the production of .alpha.-TNF.
摘要翻译: α-TNF的反向,反信使RNA寡核苷酸序列,其特征在于其具有下式的结构:其中X是氢或游离形式的1至17个游离形式的寡核苷酸的烷基化形式的序列 ,以硫化形式或用于停止生产α-TNF的聚L-赖氨酸衍生物的形式。
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2.
公开(公告)号:US5182378A
公开(公告)日:1993-01-26
申请号:US622719
申请日:1990-12-04
申请人: Pierre Smets , Rene Zalisz
发明人: Pierre Smets , Rene Zalisz
IPC分类号: A61K31/715 , A61P37/00 , A61P37/08 , C08B37/00 , C12P19/04
CPC分类号: C12P19/04 , C08B37/0036
摘要: A sulfate derivative of galactan extracted from Klebsiella mainly comprised of sulfate neutral oses in a proportion of 20 to 90% of hydroxyls and their preparation and method of use.
摘要翻译: 从克雷伯杆菌中提取的半乳聚糖的硫酸酯衍生物主要由20至90%的羟基的硫酸酯中和物及其制备方法和使用方法组成。
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公开(公告)号:US5086040A
公开(公告)日:1992-02-04
申请号:US598553
申请日:1990-10-16
申请人: Armelle Bonfils , Pierre Smets , Rene Zalisz
发明人: Armelle Bonfils , Pierre Smets , Rene Zalisz
IPC分类号: C12P21/00 , A61K8/00 , A61K8/64 , A61K8/99 , A61K35/74 , A61K38/00 , A61P17/00 , A61P17/14 , A61Q5/00 , A61Q7/00 , C12R1/01 , C12R1/19 , C12R1/22 , C12R1/37 , C12R1/385
CPC分类号: A61K8/99 , A61K8/64 , A61Q7/00 , Y10S514/88 , Y10S530/825
摘要: A dermatological hair growth stimulating composition containing an effective amount of a glycoprotein extract of gram negative bacteria as the growth stimulant and a method of stimulating hair growth.
摘要翻译: 含有有效量的革兰氏阴性细菌的糖蛋白提取物作为生长刺激剂的皮肤病性毛发生长刺激性组合物和刺激毛发生长的方法。
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公开(公告)号:US4751218A
公开(公告)日:1988-06-14
申请号:US804687
申请日:1985-12-04
申请人: Pierre Smets , Rene Zalisz
发明人: Pierre Smets , Rene Zalisz
IPC分类号: A61K31/715 , A61K35/74 , A61P37/00 , A61P37/08 , C08B37/00 , C12P19/04 , C12P19/26 , C12P21/00 , A61K31/70 , A61K37/10
CPC分类号: C08B37/00 , A61K31/715 , C12P19/04 , C12P19/26 , C12P21/005 , Y10S514/885
摘要: An acylglycan extract of Klebsiella consisting essentially of about 80% of neutral oses, about 20% of lipids and less than 2% of proteins and having a molecular weight of approximately 12,500 and a process for obtining them which have antiallergic and immunomodulating properties.
摘要翻译: 克雷伯菌的酰基甘氨酸提取物基本上由约80%的中性油,约20%的脂质和小于2%的蛋白质组成,分子量约为12,500,以及一种具有抗过敏和免疫调节特性的方法。
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公开(公告)号:US6083928A
公开(公告)日:2000-07-04
申请号:US41842
申请日:1993-04-02
申请人: Armelle Bonfils , Pierre Smets , Rene Zalisz
发明人: Armelle Bonfils , Pierre Smets , Rene Zalisz
IPC分类号: C12P19/04 , A61K8/64 , A61K9/06 , A61K31/00 , A61K31/715 , A61K35/74 , A61P17/00 , A61P17/02 , A61Q19/00 , C08B37/00 , C12R1/01 , C12R1/22 , C12R1/385 , A61K47/36 , A61K39/02
摘要: A method for facilitating the healing of skin comprising applying topically to skin a composition containing an amount of a lipopolysaccharide extracted from gram negative bacteria effective to facilitate skin healing.
摘要翻译: 一种促进皮肤愈合的方法,包括将皮肤局部施用含有一定量的从革兰氏阴性细菌提取的脂多糖的组合物,其有效促进皮肤愈合。
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