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公开(公告)号:US6083928A
公开(公告)日:2000-07-04
申请号:US41842
申请日:1993-04-02
申请人: Armelle Bonfils , Pierre Smets , Rene Zalisz
发明人: Armelle Bonfils , Pierre Smets , Rene Zalisz
IPC分类号: C12P19/04 , A61K8/64 , A61K9/06 , A61K31/00 , A61K31/715 , A61K35/74 , A61P17/00 , A61P17/02 , A61Q19/00 , C08B37/00 , C12R1/01 , C12R1/22 , C12R1/385 , A61K47/36 , A61K39/02
摘要: A method for facilitating the healing of skin comprising applying topically to skin a composition containing an amount of a lipopolysaccharide extracted from gram negative bacteria effective to facilitate skin healing.
摘要翻译: 一种促进皮肤愈合的方法,包括将皮肤局部施用含有一定量的从革兰氏阴性细菌提取的脂多糖的组合物,其有效促进皮肤愈合。
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公开(公告)号:US5705389A
公开(公告)日:1998-01-06
申请号:US342338
申请日:1994-11-18
申请人: Abdel Karim Braham , Pierre Smets , Rene Zalisz
发明人: Abdel Karim Braham , Pierre Smets , Rene Zalisz
IPC分类号: C07H21/02 , A61K31/70 , A61K48/00 , A61P37/00 , C07H21/00 , C07K14/525 , C12N15/09 , C12N15/113 , C12N15/28 , H02K3/50 , H02K11/04 , H02K29/00 , C12N5/10 , C12Q1/68
CPC分类号: C12N15/1136 , C07H21/00 , C07K14/525 , C12N2310/315 , C12N2310/321 , H02K2203/03
摘要: A sequence of anti-direction, anti-messenger RNA oligonucleotides of .alpha.-TNF characterized in that it possesses the structure of the formula ##STR1## wherein X is hydrogen, or a sequence of 1 to 17 oligonucleotides in free form, in alkylated form, in sulfurated form or in the form of a poly L-lysine derivative useful for stopping the production of .alpha.-TNF.
摘要翻译: α-TNF的反向,反信使RNA寡核苷酸序列,其特征在于其具有下式的结构:其中X是氢或游离形式的1至17个游离形式的寡核苷酸的烷基化形式的序列 ,以硫化形式或用于停止生产α-TNF的聚L-赖氨酸衍生物的形式。
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公开(公告)号:US5182378A
公开(公告)日:1993-01-26
申请号:US622719
申请日:1990-12-04
申请人: Pierre Smets , Rene Zalisz
发明人: Pierre Smets , Rene Zalisz
IPC分类号: A61K31/715 , A61P37/00 , A61P37/08 , C08B37/00 , C12P19/04
CPC分类号: C12P19/04 , C08B37/0036
摘要: A sulfate derivative of galactan extracted from Klebsiella mainly comprised of sulfate neutral oses in a proportion of 20 to 90% of hydroxyls and their preparation and method of use.
摘要翻译: 从克雷伯杆菌中提取的半乳聚糖的硫酸酯衍生物主要由20至90%的羟基的硫酸酯中和物及其制备方法和使用方法组成。
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公开(公告)号:US5086040A
公开(公告)日:1992-02-04
申请号:US598553
申请日:1990-10-16
申请人: Armelle Bonfils , Pierre Smets , Rene Zalisz
发明人: Armelle Bonfils , Pierre Smets , Rene Zalisz
IPC分类号: C12P21/00 , A61K8/00 , A61K8/64 , A61K8/99 , A61K35/74 , A61K38/00 , A61P17/00 , A61P17/14 , A61Q5/00 , A61Q7/00 , C12R1/01 , C12R1/19 , C12R1/22 , C12R1/37 , C12R1/385
CPC分类号: A61K8/99 , A61K8/64 , A61Q7/00 , Y10S514/88 , Y10S530/825
摘要: A dermatological hair growth stimulating composition containing an effective amount of a glycoprotein extract of gram negative bacteria as the growth stimulant and a method of stimulating hair growth.
摘要翻译: 含有有效量的革兰氏阴性细菌的糖蛋白提取物作为生长刺激剂的皮肤病性毛发生长刺激性组合物和刺激毛发生长的方法。
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公开(公告)号:US4751218A
公开(公告)日:1988-06-14
申请号:US804687
申请日:1985-12-04
申请人: Pierre Smets , Rene Zalisz
发明人: Pierre Smets , Rene Zalisz
IPC分类号: A61K31/715 , A61K35/74 , A61P37/00 , A61P37/08 , C08B37/00 , C12P19/04 , C12P19/26 , C12P21/00 , A61K31/70 , A61K37/10
CPC分类号: C08B37/00 , A61K31/715 , C12P19/04 , C12P19/26 , C12P21/005 , Y10S514/885
摘要: An acylglycan extract of Klebsiella consisting essentially of about 80% of neutral oses, about 20% of lipids and less than 2% of proteins and having a molecular weight of approximately 12,500 and a process for obtining them which have antiallergic and immunomodulating properties.
摘要翻译: 克雷伯菌的酰基甘氨酸提取物基本上由约80%的中性油,约20%的脂质和小于2%的蛋白质组成,分子量约为12,500,以及一种具有抗过敏和免疫调节特性的方法。
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公开(公告)号:US4412946A
公开(公告)日:1983-11-01
申请号:US300910
申请日:1981-09-10
申请人: Rene Zalisz , Marie-France Salles
发明人: Rene Zalisz , Marie-France Salles
IPC分类号: C07K14/195 , A61K35/74 , A61K38/00 , A61K39/108 , A61P37/04 , C07K14/00 , C07K14/26 , C07K14/41 , C12P21/00 , C12R1/22 , A61K37/02 , A61K39/40 , C07G7/00
CPC分类号: C07K14/26 , A61K38/00 , Y10S435/852 , Y10S530/806 , Y10S530/825
摘要: Novel water-soluble, immunostimulating glycoproteins extracted from Klebsiella pneumoniae containing 30 to 45% by weight of proteins, 30 to 40% by weight of neutral saccharides, up to 4% by weight of glucuronic acid, 2 to 5% by weight of osamines and having a molecular weight of about 350,000 daltons.
摘要翻译: 从肺炎克雷伯杆菌提取的新型水溶性免疫刺激性糖蛋白,其含有30至45重量%的蛋白质,30至40重量%的中性糖,至多4重量%的葡萄糖醛酸,2至5重量%的osamine, 分子量约为350,000道尔顿。
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公开(公告)号:US4356171A
公开(公告)日:1982-10-26
申请号:US300928
申请日:1981-09-10
申请人: Rene Zalisz , Marie-France Salles
发明人: Rene Zalisz , Marie-France Salles
IPC分类号: C07K14/195 , A61K38/00 , A61K39/02 , A61K39/108 , A61K39/39 , A61K45/00 , A61P37/04 , C07K1/14 , C07K14/00 , C07K14/26 , C07K14/41 , C12P21/00 , C12R1/22 , A61K37/02 , A61K39/40
CPC分类号: A61K39/39 , A61K39/0266 , A61K45/05 , C07K14/26 , C12P21/005 , A61K2039/55516 , A61K38/00 , Y10S435/852 , Y10S530/825
摘要: Novel water-soluble, immunostimulating glycoproteins extracted from Klebsiella Pneumoniae containing 20 to 35% by weight of proteins, 50 to 70% by weight of neutral monosaccharides, 3 to 8% by weight of glucuronic acid, 1.5 to 3% by weight of osamines and having a molecular weight greater than 100,000 daltons.
摘要翻译: 从肺炎克雷伯氏杆菌提取的新型水溶性免疫刺激性糖蛋白,其含有20〜35重量%的蛋白质,50〜70重量%的中性单糖,3〜8重量%的葡萄糖醛酸,1.5〜3重量%的osamine, 分子量大于100,000道尔顿。
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公开(公告)号:US4870053A
公开(公告)日:1989-09-26
申请号:US567955
申请日:1984-01-04
申请人: Rene Zalisz , Marie-France Salles
发明人: Rene Zalisz , Marie-France Salles
IPC分类号: A61K35/74 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/108 , A61K39/35 , A61K39/39 , A61K45/00 , C07K14/26
CPC分类号: C07K14/26 , A61K39/0266 , A61K39/35 , A61K39/39 , A61K45/05 , A61K2039/55516 , A61K2039/55594 , A61K38/00
摘要: A novel process for the preparation of water-soluble acyl glycoprotein extracted from Klebsiella Pneumoniae containing 30 to 45% by weight of proteins, 30 to 40% by weight of neutral saccharides, less than 4% of glucuronic acid, 2 to 5% by weight of osamines with a molecular weight of about 350,000 daltons and having a polysaccharide chain of n chains of one molecule of glucose and 4 molecules of galactose attached to an asparagine of a proteidic chain by a core formed of heptose and 2-keto-3-deoxy-octulosonic acid followed by an acyl portion containing .beta.-hydroxymyristic acid and then N-acetyl-glucosamine designated herein as F.sub.1 and compositions and a method of inducing antiallergic properties in warm-blooded animals.
摘要翻译: 制备从肺炎克雷伯杆菌提取的水溶性酰基糖蛋白的新方法,其含有30至45重量%的蛋白质,30至40重量%的中性糖,小于4重量%的葡萄糖醛酸,2至5重量% 的分子量为约350,000道尔顿的osamine,并且具有通过由heptose和2-酮-3-脱氧形成的核心连接到蛋白质链的天冬酰胺上的一分子葡萄糖的n链的多糖链和4分子的半乳糖 - 醋酸,然后是含有β-羟基肉豆蔻酸的酰基部分,然后是本文命名为“F1”的N-乙酰葡糖胺,以及在温血动物中诱导抗过敏性质的组合物和方法。
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公开(公告)号:US4596709A
公开(公告)日:1986-06-24
申请号:US543990
申请日:1983-10-20
申请人: Rene Zalisz , Marie-France Salles
发明人: Rene Zalisz , Marie-France Salles
IPC分类号: C07K14/195 , A61K35/74 , A61K38/00 , A61K39/108 , A61P37/04 , C07K14/00 , C07K14/26 , C07K14/41 , C12P21/00 , C12R1/22 , A61K37/02 , A61K39/40 , C07K15/14
CPC分类号: C07K14/26 , A61K38/00 , Y10S435/852 , Y10S530/806 , Y10S530/825
摘要: Novel water-soluble, immunostimulating glycoproteins extracted from Klebsiella pneumoniae containing 30 to 45% by weight of proteins, 30 to 40% by weight of neutral saccharides, up to 4% by weight of glucuronic acid, 2 to 5% by weight of osamines and having a molecular weight of about 350,000 daltons.
摘要翻译: 从肺炎克雷伯杆菌提取的新型水溶性免疫刺激性糖蛋白,其含有30至45重量%的蛋白质,30至40重量%的中性糖,至多4重量%的葡萄糖醛酸,2至5重量%的osamine, 分子量约为350,000道尔顿。
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公开(公告)号:US4154821A
公开(公告)日:1979-05-15
申请号:US871408
申请日:1978-01-23
IPC分类号: A61K35/74 , A61K38/00 , A61P29/00 , A61P31/04 , A61P37/04 , C07K1/14 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/275 , C07K14/41 , C12P21/00 , A61K37/00
CPC分类号: C12P21/005 , C07K14/275 , A61K38/00 , Y10S435/822 , Y10S530/806 , Y10S530/82 , Y10S530/825
摘要: Novel water-soluble glycoproteins isolated from Hafnia strain having remarkable anti-inflammatory and immunostimulating activity with very good tolerance and their preparation.
摘要翻译: 从Hafnia菌株分离的新型水溶性糖蛋白具有显着的抗炎和免疫刺激活性,具有非常好的耐受性及其制备。
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