利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.014 秒)

    BACTERIOPHAGES EXPRESSING AMYLOID PEPTIDES AND USES THEREOF
    2.
    发明申请
    BACTERIOPHAGES EXPRESSING AMYLOID PEPTIDES AND USES THEREOF 审中-公开
    表达淀粉样蛋白的特异性及其用途

    公开(公告)号：US20120301433A1

    公开(公告)日：2012-11-29

    申请号：US13387888

    申请日：2010-07-29

    申请人： Timothy Kuan-Ta Lu ,  Susan Lindquist ,  Rajaraman Krishnan ,  James Collins ,  Charles W. O'Donnell ,  Bonnie Berger Leighton ,  Srinivas Devadas

    发明人： Timothy Kuan-Ta Lu ,  Susan Lindquist ,  Rajaraman Krishnan ,  James Collins ,  Charles W. O'Donnell ,  Bonnie Berger Leighton ,  Srinivas Devadas

    IPC分类号： C12N7/01 ,  C12S9/00 ,  A61K35/76

    CPC分类号： C07K14/4711 ,  A61K35/76 ,  A61K38/00 ,  C07K2319/735 ,  C12N2795/10232 ,  C12N2795/10243 ,  C12N2795/14132 ,  C12N2795/14143 ,  Y02A50/475 ,  A61K2300/00

    摘要： The present invention generally relates to engineered bacteriophages which express amyloid peptides for the modulation (e.g. increase or decrease) of protein aggregates and amyloid formation. In some embodiments, the engineered bacteriophages express anti-amyloid peptides for inhibiting protein aggregation and amyloid formation, which can be useful in the treatment and prevention of and bacterial infections and biofilms. In some embodiments, the engineered bacteriophages express amyloid peptides for promoting amyloid formation, which are useful for increasing amyloid formation such as promoting bacterial biofilms. Other aspects relate to methods to inhibit bacteria biofilms, and methods for the treatment of amyloid related disorders, e.g., Alzheimer's disease using an anti-amyloid peptide engineered bacteriophages. Other aspects of the invention relate to engineered bacteriophages to express the amyloid peptides on the bacteriophage surface and/or secrete the amyloid peptides, e.g., anti-amyloid peptides and pro-amyloid peptides, and uses thereof for modulation protein aggregates and amyloid formation.

    摘要翻译： 本发明一般涉及表达淀粉样肽用于调节（例如增加或减少）蛋白质聚集体和淀粉样蛋白形成的工程化噬菌体。 在一些实施方案中，工程改造的噬菌体表达用于抑制蛋白质聚集和淀粉样蛋白形成的抗淀粉样肽，其可用于治疗和预防细菌感染和生物膜。 在一些实施方案中，工程改造的噬菌体表达用于促进淀粉样蛋白形成的淀粉样肽，其可用于增加淀粉样蛋白形成，例如促进细菌生物膜。 其它方面涉及抑制细菌生物膜的方法，以及使用抗淀粉样蛋白肽工程化噬菌体治疗淀粉样蛋白相关病症例如阿尔茨海默氏病的方法。 本发明的其它方面涉及在噬菌体表面上表达淀粉样肽和/或分泌淀粉样蛋白肽（例如抗淀粉样蛋白肽和前淀粉样肽）的工程化噬菌体及其用于调节蛋白质聚集体和淀粉样蛋白形成的用途。

    SYSTEM AND METHOD FOR VIRTUAL CONTENT COLLABORATION
    3.
    发明申请
    SYSTEM AND METHOD FOR VIRTUAL CONTENT COLLABORATION 审中-公开
    虚拟内容协作的系统与方法

    公开(公告)号：US20120231441A1

    公开(公告)日：2012-09-13

    申请号：US13393572

    申请日：2010-09-02

    申请人： Sowmya Parthasarathy ,  Rajaraman Krishnan

    发明人： Sowmya Parthasarathy ,  Rajaraman Krishnan

    IPC分类号： G09B7/00 ,  G06F15/16

    CPC分类号： G09B7/02

    摘要： An information sharing system includes a database, an application module, a supervisor module, and a subordinate module. The database stores user data associated with a supervisor and a subordinate, and static data to be shared by them. The static data is associated with a topic for training. The application module is configured to communicate with the database. The supervisor module is configured to enable the supervisor to communicate with the application module and the subordinate module. The subordinate module is configured to enable the subordinate to communicate with the supervisor, enable the subordinate to communicate with the application module via handwritten input, audio input, video input, and image input, provide an electronic prompt to the subordinate that is triggered by the static data, and receive an electronic input comprising at least one of handwritten input, audio input, video input, and image input from the subordinate responsive to the prompt.

    摘要翻译： 信息共享系统包括数据库，应用模块，主管模块和从属模块。 数据库存储与主管和下属相关联的用户数据，以及要由其共享的静态数据。 静态数据与培训主题相关联。 应用模块被配置为与数据库通信。 管理模块被配置为使得主管能够与应用模块和从属模块进行通信。 下属模块被配置为使下属能够与主管进行通信，使下属能够通过手写输入，音频输入，视频输入和图像输入与应用模块通信，向下级提供触发的电子提示， 静态数据，并且响应于提示，从下级接收包括手写输入，音频输入，视频输入和图像输入中的至少一个的电子输入。