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    BACTERIOPHAGES EXPRESSING AMYLOID PEPTIDES AND USES THEREOF
    1.
    发明申请
    BACTERIOPHAGES EXPRESSING AMYLOID PEPTIDES AND USES THEREOF 审中-公开
    表达淀粉样蛋白的特异性及其用途

    公开(公告)号：US20120301433A1

    公开(公告)日：2012-11-29

    申请号：US13387888

    申请日：2010-07-29

    申请人： Timothy Kuan-Ta Lu ,  Susan Lindquist ,  Rajaraman Krishnan ,  James Collins ,  Charles W. O'Donnell ,  Bonnie Berger Leighton ,  Srinivas Devadas

    发明人： Timothy Kuan-Ta Lu ,  Susan Lindquist ,  Rajaraman Krishnan ,  James Collins ,  Charles W. O'Donnell ,  Bonnie Berger Leighton ,  Srinivas Devadas

    IPC分类号： C12N7/01 ,  C12S9/00 ,  A61K35/76

    CPC分类号： C07K14/4711 ,  A61K35/76 ,  A61K38/00 ,  C07K2319/735 ,  C12N2795/10232 ,  C12N2795/10243 ,  C12N2795/14132 ,  C12N2795/14143 ,  Y02A50/475 ,  A61K2300/00

    摘要： The present invention generally relates to engineered bacteriophages which express amyloid peptides for the modulation (e.g. increase or decrease) of protein aggregates and amyloid formation. In some embodiments, the engineered bacteriophages express anti-amyloid peptides for inhibiting protein aggregation and amyloid formation, which can be useful in the treatment and prevention of and bacterial infections and biofilms. In some embodiments, the engineered bacteriophages express amyloid peptides for promoting amyloid formation, which are useful for increasing amyloid formation such as promoting bacterial biofilms. Other aspects relate to methods to inhibit bacteria biofilms, and methods for the treatment of amyloid related disorders, e.g., Alzheimer's disease using an anti-amyloid peptide engineered bacteriophages. Other aspects of the invention relate to engineered bacteriophages to express the amyloid peptides on the bacteriophage surface and/or secrete the amyloid peptides, e.g., anti-amyloid peptides and pro-amyloid peptides, and uses thereof for modulation protein aggregates and amyloid formation.

    摘要翻译： 本发明一般涉及表达淀粉样肽用于调节（例如增加或减少）蛋白质聚集体和淀粉样蛋白形成的工程化噬菌体。 在一些实施方案中，工程改造的噬菌体表达用于抑制蛋白质聚集和淀粉样蛋白形成的抗淀粉样肽，其可用于治疗和预防细菌感染和生物膜。 在一些实施方案中，工程改造的噬菌体表达用于促进淀粉样蛋白形成的淀粉样肽，其可用于增加淀粉样蛋白形成，例如促进细菌生物膜。 其它方面涉及抑制细菌生物膜的方法，以及使用抗淀粉样蛋白肽工程化噬菌体治疗淀粉样蛋白相关病症例如阿尔茨海默氏病的方法。 本发明的其它方面涉及在噬菌体表面上表达淀粉样肽和/或分泌淀粉样蛋白肽（例如抗淀粉样蛋白肽和前淀粉样肽）的工程化噬菌体及其用于调节蛋白质聚集体和淀粉样蛋白形成的用途。

    Methods for Identifying Factors That Control the Folding of Amyloid Proteins of Diverse Origin
    3.
    发明申请
    Methods for Identifying Factors That Control the Folding of Amyloid Proteins of Diverse Origin 审中-公开
    识别控制多样性淀粉样蛋白折叠因子的方法

    公开(公告)号：US20120135435A1

    公开(公告)日：2012-05-31

    申请号：US12854608

    申请日：2010-08-11

    申请人： Susan Lindquist

    发明人： Susan Lindquist

    IPC分类号： C12Q1/66 ,  G01N21/64 ,  C12Q1/02

    CPC分类号： C12Q1/025 ,  G01N33/6896

    摘要： The present invention provides a yeast cell based system for determining factors that control the folding of amyloid proteins of diverse origins. Further the present invention provides methods of using such a system to screen for reagents that affect amyloid formation, a process that is integral to several devastating human disease including Creutzfeld-Jacob disease (CJD), fatal familial insomnia (FFI), Gertsmann-Straussler-Scheinker (GSS) syndrome, and kuru. The system of the present invention provides a rapid screening system to quickly and cheaply identify reagents that affect the folding and aggregation properties of the target protein.

    摘要翻译： 本发明提供了用于确定控制不同来源的淀粉样蛋白的折叠的因子的基于酵母细胞的系统。 此外，本发明提供了使用这种系统来筛选影响淀粉样蛋白形成的试剂的方法，该方法是包括Creutzfeld-Jacob病（CJD），致命性家族性失眠（FFI），Gertsmann-Straussler- Scheinker（GSS）综合征和kuru。 本发明的系统提供快速和便宜地识别影响靶蛋白的折叠和聚集性质的试剂的快速筛选系统。

    Methods and compositions of genetic stress response systems
    4.
    发明授权
    Methods and compositions of genetic stress response systems 失效
    遗传应激反应系统的方法和组成

    公开(公告)号：US5827685A

    公开(公告)日：1998-10-27

    申请号：US249380

    申请日：1994-05-25

    申请人： Susan Lindquist

    发明人： Susan Lindquist

    IPC分类号： C07K14/00 ,  C07K16/00 ,  C12C11/00 ,  C12N1/18 ,  C12N15/31 ,  C12N15/67 ,  C12N15/82 ,  C07K14/395 ,  C12N1/16 ,  C12N15/63

    CPC分类号： C07K14/00 ,  C07K16/00 ,  C12C11/003 ,  C12N1/18 ,  C12N15/67 ,  C12N15/8271 ,  C12N15/8273

    摘要： This invention relates to the identification, isolation, purification and manipulation of genetic stress response systems, and more particularly, to genes and expression products of those genes that are components of those systems. These components may be used to protect against potentially toxic stress factors. Stress factors include heat, alcohol and heavy metal ions. A family of stress protector proteins with apparent molecular weights about 100 kd, the hsp100 proteins, are an aspect of this invention. Other stress protector proteins are also within the scope of this invention to enhance or inhibit biological stress response. Applications of this invention to recombinant DNA technology, to commercial methods of food preparation and processing, and to methods of enhancing the stress response of plants and animals, are presented.

    摘要翻译： 本发明涉及遗传胁迫应答系统的鉴定，分离，纯化和操作，更具体地涉及作为那些系统的组分的那些基因的基因和表达产物。 这些组分可用于防止潜在的毒性应激因素。 应激因素包括热，酒精和重金属离子。 具有约100kd（hsp100蛋白）的表观分子量的应激保护蛋白家族是本发明的一个方面。 其他应力保护蛋白也在本发明的范围内，以增强或抑制生物应激反应。 本发明应用于重组DNA技术，食品制备和加工的商业方法，以及增强植物和动物应激反应的方法。

    Yeast ectopically expressing abnormally processed proteins and uses therefor
    7.
    发明申请
    Yeast ectopically expressing abnormally processed proteins and uses therefor 审中-公开
    酵母异位表达异常加工的蛋白质和用途

    公开(公告)号：US20050064548A1

    公开(公告)日：2005-03-24

    申请号：US10826157

    申请日：2004-04-16

    申请人： Susan Lindquist ,  Tiago Outeiro

    发明人： Susan Lindquist ,  Tiago Outeiro

    IPC分类号： A61K20060101 ,  A61K31/00 ,  C07H21/04 ,  C07K14/47 ,  C12N1/18 ,  C12N15/74 ,  G01N33/53 ,  G01N33/569

    CPC分类号： C07K14/47 ,  G01N33/5014

    摘要： Disclosed are yeast ectopically expressing abnormally processed proteins and methods of screening to identify compounds that modulate the function of such abnormally processed proteins in yeast. Compounds identified by such screens can be used to treat or prevent diseases associated with abnormally processed proteins or protein misfolding. Such diseases include Parkinson's Disease, Parkinson's Disease with accompanying dementia, Lewy body dementia, Alzheimer's disease with Parkinsonism, and multiple system atrophy.

    摘要翻译： 公开了异位表达异常加工的蛋白质的酵母和筛选方法，以鉴定调节酵母中异常加工的蛋白质的功能的化合物。 通过这种筛选鉴定的化合物可用于治疗或预防与异常加工的蛋白质或蛋白质错误折叠相关的疾病。 这些疾病包括帕金森病，伴有痴呆的帕金森病，路易体痴呆，帕金森综合征的阿尔茨海默病和多系统萎缩。

    Electrical conductors and devices from prion-like proteins
    9.
    发明申请
    Electrical conductors and devices from prion-like proteins 审中-公开
    来自朊病毒样蛋白的电导体和器件

    公开(公告)号：US20050266242A1

    公开(公告)日：2005-12-01

    申请号：US11089551

    申请日：2005-03-24

    申请人： Susan Lindquist ,  Thomas Scheibel

    发明人： Susan Lindquist ,  Thomas Scheibel

    IPC分类号： D02G3/00

    CPC分类号： G01N33/6896 ,  C07K14/47 ,  G01N2800/2828 ,  Y10T428/2933

    摘要： The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected with such polynucleotides; novel fibrils with specific functionalities and unusually high chemical and thermal stability; and methods of making and using the foregoing.

    摘要翻译： 本发明提供了包含朊病毒聚集域和第二结构域的新型多肽; 编码这种多肽的新型多核苷酸; 用这种多核苷酸转化或转染的宿主细胞; 具有特定功能的新颖纤维和异常高的化学和热稳定性; 以及制作和使用前述的方法。

    Yeast Screens for Treatment of Human Disease
    10.
    发明申请
    Yeast Screens for Treatment of Human Disease 审中-公开
    用于治疗人类疾病的酵母筛

    公开(公告)号：US20110300533A1

    公开(公告)日：2011-12-08

    申请号：US13090653

    申请日：2011-04-20

    申请人： Susan Lindquist ,  Sylvia Krobitsch ,  Tiago Fleming Outeiro

    发明人： Susan Lindquist ,  Sylvia Krobitsch ,  Tiago Fleming Outeiro

    IPC分类号： C12Q1/68 ,  C12Q1/02

    CPC分类号： C12Q1/18 ,  C12Q1/02 ,  C12Q1/025 ,  G01N33/6896 ,  G01N2333/4703 ,  G01N2500/00 ,  G01N2800/2835

    摘要： Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. The methods of the invention provide a rapid and cost-effective method to screen for compounds that prevent protein misfolding and/or protein fibril formation and/or protein aggregation which includes numerous neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, Huntington's disease as well as non-neuronal diseases such as type 2 diabetes.

    摘要翻译： 提供了用于鉴定为与蛋白质错折叠相关的各种疾病提供治疗价值的物质的筛选方法。 使用酵母系统提供遗传和化学筛选方法。 本发明的方法提供了一种快速和具有成本效益的方法来筛选防止蛋白质错折叠和/或蛋白质原纤维形成和/或蛋白质聚集的化合物，其包括许多神经变性疾病，包括帕金森病，阿尔茨海默氏病，亨廷顿氏病以及非 - - 神经性疾病如2型糖尿病。