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公开(公告)号：US5593992A
公开(公告)日：1997-01-14
申请号：US472366
申请日：1995-06-07
IPC分类号： A61K8/19 , A61K8/00 , A61K8/20 , A61K8/23 , A61K31/00 , A61K31/165 , A61K31/4168 , A61K31/4178 , A61K31/44 , A61K31/4409 , A61K31/4427 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/12 , A61P31/16 , A61P31/18 , A61P35/00 , A61P37/00 , A61P39/00 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q19/00 , C07B61/00 , C07C20060101 , C07C231/12 , C07C231/14 , C07C233/05 , C07C233/36 , C07C311/30 , C07C315/00 , C07C315/02 , C07C317/28 , C07C317/32 , C07C317/40 , C07C319/14 , C07C319/20 , C07C323/25 , C07C323/29 , C07C323/31 , C07C323/41 , C07C323/45 , C07D213/00 , C07D213/53 , C07D213/61 , C07D215/12 , C07D233/54 , C07D239/02 , C07D239/38 , C07D239/42 , C07D295/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/00 , C07D409/14 , C07D413/00 , C07D413/04 , C07D413/14
CPC分类号： C07D401/04 , C07C315/00 , C07D239/38 , C07D401/14 , C07D403/04 , C07D405/14 , Y10S514/866 , Y10S514/903
摘要： Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
摘要翻译： 新型1,4,5-取代的咪唑化合物和用作治疗作为细胞因子抑制剂的组合物。
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公开(公告)号：US6103936A
公开(公告)日：2000-08-15
申请号：US819619
申请日：1997-03-17
申请人： Jerry Leroy Adams , Peter William Sheldrake , Timothy Francis Gallagher , Ravishanker Garigipati , Paul Elliot Bender , Jeffrey Charles Boehm , Joseph Sisko , Zhi-Qiang Peng , John C. Lee
发明人： Jerry Leroy Adams , Peter William Sheldrake , Timothy Francis Gallagher , Ravishanker Garigipati , Paul Elliot Bender , Jeffrey Charles Boehm , Joseph Sisko , Zhi-Qiang Peng , John C. Lee
IPC分类号： A61K8/19 , A61K8/00 , A61K8/20 , A61K8/23 , A61K31/00 , A61K31/165 , A61K31/4168 , A61K31/4178 , A61K31/44 , A61K31/4409 , A61K31/4427 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/12 , A61P31/16 , A61P31/18 , A61P35/00 , A61P37/00 , A61P39/00 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q19/00 , C07B61/00 , C07C20060101 , C07C231/12 , C07C231/14 , C07C233/05 , C07C233/36 , C07C311/30 , C07C315/00 , C07C315/02 , C07C317/28 , C07C317/32 , C07C317/40 , C07C319/14 , C07C319/20 , C07C323/25 , C07C323/29 , C07C323/31 , C07C323/41 , C07C323/45 , C07D213/00 , C07D213/53 , C07D213/61 , C07D215/12 , C07D233/54 , C07D239/02 , C07D239/38 , C07D239/42 , C07D295/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/00 , C07D409/14 , C07D413/00 , C07D413/04 , C07D413/14
CPC分类号： C07D401/04 , C07C315/00 , C07D239/38 , C07D401/14 , C07D403/04 , C07D405/14 , Y10S514/866 , Y10S514/903
摘要： The present invention is to a novel process for the preparation of a compound of the formula: ##STR1## wherein p is 0, or 2;Ar is an optionally substituted phenyl or naphtyl; andinter alia R4 is an optionally susbtituted phenyl, naphth-1-yl, naphth-2-yl, or a heteroaryl ring;which process comprises reacting together an aldehyde of the formula:R.sub.4 --CHO;wherein R.sub.4 is as defined above;a compound of the formula:ArS(O)pH;wherein Ar, and p are as defined above;with formamide, an acid catalyst, and optionally a dehydrating agent.
摘要翻译： 本发明涉及制备下式化合物的新方法：其中p为0或2; Ar是任选取代的苯基或萘基; 尤其是R4是任选被取代的苯基，萘-1-基，萘-2-基或杂芳基环; 该方法包括使下式的醛反应：R4-CHO;其中R4如上定义; 下式的化合物：ArS（O）pH;其中Ar和p如上所定义; 与甲酰胺，酸催化剂和任选的脱水剂。
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