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    Cyan coupler and combination solvent-containing photographic element and process
    2.
    发明授权
    Cyan coupler and combination solvent-containing photographic element and process 失效
    青色耦合剂和组合溶剂的照相元件和工艺

    公开(公告)号：US6110658A

    公开(公告)日：2000-08-29

    申请号：US266234

    申请日：1999-03-10

    申请人： James S. Honan ,  Raymond P. Scaringe ,  Thomas A. Rosiek

    发明人： James S. Honan ,  Raymond P. Scaringe ,  Thomas A. Rosiek

    IPC分类号： G03C7/388 ,  G03C1/06 ,  G03C5/30 ,  G03C7/30 ,  G03C7/34 ,  G03C7/392 ,  G03C1/38

    CPC分类号： G03C7/39296 ,  G03C7/3006 ,  G03C7/346 ,  G03C7/39232 ,  G03C7/39256

    摘要： Disclosed is a photographic element having a reduced rate of crystal formation comprising a silver halide emulsion layer having associated therewith:(a) a phenolic cyan dye-forming "NB coupler";(b) a first high boiling solvent having Formula (IV):G--C--OO--R.sup.1 (IV) wherein:R.sup.1 is an alkyl or aryl groups; andG is an alkyl (including cycloalkyl and aralkyl) containing linking group; and(c) one or more second high boiling solvents selected from phosphates, phosphonates, phosphine oxides, sulfoxides, and carbonamides, said second high boiling solvent being present in amounts (by weight) sufficient to reduce crystal formation in a dispersion of the coupler compared to a dispersion of the same coupler in a dispersion where the second solvent is replaced with a like amount of the first solvent.

    摘要翻译： 公开了具有降低的晶体形成速率的照相元件，其包含与之相关的卤化银乳剂层：（a）形成苯酚青色染料的“NB成色剂”; （b）具有式（IV）的第一高沸点溶剂：G-C-OO-R 1（IV）其中：R 1是烷基或芳基; 并且G是含有连接基团的烷基（包括环烷基和芳烷基） 和（c）选自磷酸盐，膦酸盐，氧化膦，亚砜和碳酰胺的一种或多种第二高沸点溶剂，所述第二高沸点溶剂以足以减少成色剂分散体中的结晶形成的量（重量比） 到相同成色剂在分散体中的分散体，其中第二溶剂被等量的第一溶剂代替。

    Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers
    3.
    发明授权
    Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers 失效
    纳米颗粒药剂与晶体生长改性剂的共沉淀

    公开(公告)号：US5665331A

    公开(公告)日：1997-09-09

    申请号：US370998

    申请日：1995-01-10

    申请人： Pranab Bagchi ,  Raymond P. Scaringe ,  H. William Bosch

    发明人： Pranab Bagchi ,  Raymond P. Scaringe ,  H. William Bosch

    IPC分类号： A61K9/14 ,  A61K49/04

    CPC分类号： B82Y5/00 ,  A61K49/0485 ,  A61K9/145 ,  Y10S977/745 ,  Y10S977/881 ,  Y10S977/915 ,  Y10S977/927 ,  Y10S977/928

    摘要： This invention describes the coprecipitation of nanoparticulate pharmaceutical agent dispersion via a process that comprises the dissolution of the said pharmaceutical agent in combination with a crystal growth modifier (CGM) in an alkaline solution and then neutralizing the said solution with an acid in the presence of suitable surface-modifying surface-active agent or agents to form a fine particle dispersion of the said pharmaceutical agent, followed by steps of diafiltration clean-up of the dispersion and then concentration of it to a desired level. This process of dispersion preparation leads to microcrystalline particles of Z-average diameters smaller than 400 nm as measured by photon correlation spectroscopy. Various modification of precipitation schemes are described, many of which are suitable for large-scale manufacture of these agent dispersions. It has been discovered that coprecipitation with CGM leads to smaller particle size compared to a case where precipitation is carried out using the pharmaceutical agent alone. Thus, this dispersion of instant invention is expected to have greater bioavailability. The CGM compound is a compound that has at least about 75% of its chemical structure identical to that of the pharmaceutical agent.

    摘要翻译： 本发明描述了纳米颗粒药剂分散体的共沉淀，该方法包括在碱性溶液中将所述药剂与晶体生长调节剂（CGM）组合溶解，然后在适当的存在下用酸中和所述溶液 表面改性表面活性剂或试剂以形成所述药剂的细颗粒分散体，然后将分散体进行渗滤清洗，然后将其浓缩至期望水平。 这种分散制备过程导致通过光子相关光谱测量的Z平均直径小于400nm的微晶颗粒。 描述了各种改性的沉淀方案，其中许多适用于这些试剂分散体的大规模制造。 已经发现，与仅使用药剂进行沉淀的情况相比，CGM的共沉淀导致较小的粒度。 因此，本发明的这种分散体预期具有更大的生物利用度。 CGM化合物是其化学结构的至少约75％与药剂相同的化合物。