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公开(公告)号：US06479250B1
公开(公告)日：2002-11-12
申请号：US09611452
申请日：2000-07-07
申请人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
发明人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
IPC分类号： C12Q148
CPC分类号： C07K14/705 , A61K38/1709 , A61K38/185 , A61K39/00 , C07K14/47 , C07K14/52 , G01N33/566 , G01N33/573 , G01N2500/00 , Y10S514/886 , Y10S514/893 , A61K2300/00
摘要： Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
摘要翻译： 公开了与eck受体结合的配体。 更具体地，公开了与eck受体（eck受体结合蛋白或EBP）特异性结合的多肽和编码所述多肽的DNA序列。 使用eck受体配体和可溶性eck受体的治疗方法，以及包含其的药物组合物。 提供了用于检测粗样品中受体结合活性的快速且灵敏的方法。
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公开(公告)号：US6087167A
公开(公告)日：2000-07-11
申请号：US959524
申请日：1997-10-28
申请人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
发明人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , A61K39/00 , A61P1/16 , A61P7/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/52 , C07K14/705 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12R1/91 , G01N33/566 , G01N33/573 , C12N5/00 , C12N5/06 , C12N5/08
CPC分类号： C07K14/705 , A61K38/1709 , A61K38/185 , C07K14/47 , C07K14/52 , G01N33/566 , G01N33/573 , A61K39/00 , G01N2500/00 , Y10S514/886 , Y10S514/893
摘要： Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
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公开(公告)号：US5824303A
公开(公告)日：1998-10-20
申请号：US445065
申请日：1995-05-19
申请人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
发明人： Timothy D. Bartley , William J. Boyle , Gary M. Fox , Andrew A. Welcher , Ella Magal , Richard A. Lindberg , Vann P. Parker
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , A61K39/00 , A61P1/16 , A61P7/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/52 , C07K14/705 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12R1/91 , G01N33/566 , G01N33/573 , A61K38/45 , C12N9/12
CPC分类号： C07K14/705 , A61K38/1709 , A61K38/185 , C07K14/47 , C07K14/52 , G01N33/566 , G01N33/573 , A61K39/00 , G01N2500/00 , Y10S514/886 , Y10S514/893
摘要： Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
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公开(公告)号：US5716934A
公开(公告)日：1998-02-10
申请号：US452779
申请日：1995-05-30
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , A61P1/16 , A61P7/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/52 , C07K14/705 , C12N15/09 , C12P21/02 , C12Q1/02 , C12R1/91 , G01N33/566 , G01N33/573 , C07K14/435 , C11D00/00
CPC分类号： A61K38/1709 , C07K14/47 , C07K14/52 , C07K14/705 , G01N33/566 , G01N33/573 , A61K39/00 , G01N2500/00
摘要： Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
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公开(公告)号：US5650504A
公开(公告)日：1997-07-22
申请号：US448736
申请日：1995-05-24
IPC分类号： A61K38/00 , A61K38/17 , A61K39/00 , A61P1/16 , A61P7/06 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/52 , C07K14/705 , C12N15/09 , C12P21/02 , C12Q1/02 , C12R1/91 , G01N33/566 , G01N33/573 , C12N15/12
CPC分类号： A61K38/1709 , C07K14/47 , C07K14/52 , C07K14/705 , G01N33/566 , G01N33/573 , A61K39/00 , G01N2500/00
摘要： Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
摘要翻译： 公开了与eck受体结合的配体。 更具体地，公开了与eck受体（eck受体结合蛋白或EBP）特异性结合的多肽和编码所述多肽的DNA序列。 使用eck受体配体和可溶性eck受体的治疗方法，以及包含其的药物组合物。 提供了用于检测粗样品中受体结合活性的快速且灵敏的方法。
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公开(公告)号：US06992175B1
公开(公告)日：2006-01-31
申请号：US09378759
申请日：1999-08-23
申请人： Gary M. Fox , Andrew A. Welcher , Shuqian Jing
发明人： Gary M. Fox , Andrew A. Welcher , Shuqian Jing
IPC分类号： C12P21/08 , C12P21/02 , C07H21/04 , C07K1/00 , G01N33/567
CPC分类号： C07K14/705 , C07K14/71 , C07K16/2863 , C12Q1/485 , G01N33/5082 , G01N33/574
摘要： Four novel members of the EPH sub-family of receptor protein tyrosine kinases are disclosed. Nucleic acid sequences encoding receptor proteins, recombinant plasmids and host cells for expression, and methods of producing and using such receptors are also disclosed.
摘要翻译： 公开了受体蛋白酪氨酸激酶的EPH亚家族的四个新成员。 还公开了编码受体蛋白质的核酸序列，用于表达的重组质粒和宿主细胞，以及产生和使用这些受体的方法。
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公开(公告)号：US5981246A
公开(公告)日：1999-11-09
申请号：US702367
申请日：1996-08-21
申请人： Gary M. Fox , Andrew A. Welcher , Shuqian Jing
发明人： Gary M. Fox , Andrew A. Welcher , Shuqian Jing
IPC分类号： A01K67/027 , A61K31/7088 , A61K38/00 , A61K38/45 , A61K39/395 , A61K48/00 , A61P1/00 , A61P25/00 , A61P43/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12N15/12 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/573
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Four novel members of the EPH sub-family of receptor protein tyrosine kinases are disclosed. Nucleic acid sequences encoding receptor proteins, recombinant plasmids and host cells for expression, and methods of producing and using such receptors are also disclosed.
摘要翻译： 公开了受体蛋白酪氨酸激酶的EPH亚家族的四个新成员。 还公开了编码受体蛋白质的核酸序列，用于表达的重组质粒和宿主细胞，以及产生和使用这些受体的方法。
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公开(公告)号：US5981245A
公开(公告)日：1999-11-09
申请号：US449645
申请日：1995-05-24
申请人： Gary M. Fox , Andrew A. Welcher , Shuqian Jing
发明人： Gary M. Fox , Andrew A. Welcher , Shuqian Jing
IPC分类号： A01K67/027 , A61K31/7088 , A61K38/00 , A61K38/45 , A61K39/395 , A61K48/00 , A61P1/00 , A61P25/00 , A61P43/00 , C07H21/04 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12N15/12 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/573
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/00
摘要： Four novel members of the EPH sub-family of receptor protein tyrosine kinases are disclosed. Nucleic acid sequences encoding receptor proteins, recombinant plasmids and host cells for expression, and methods of producing and using such receptors are also disclosed.
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9.发明申请Human Anti-IFN-gamma Neutralizing Antibodies as Selective IFN-gamma Pathway Inhibitors 有权人抗IFN-γ中和抗体作为选择性IFN-γ途径抑制剂公开(公告)号：US20140004127A1
公开(公告)日：2014-01-02
申请号：US13966185
申请日：2013-08-13
IPC分类号： C07K16/24
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective amount of antibodies to IFN-γ. Methods of detecting the amount of IFN-γ in a sample using antibodies to IFN-γ are also provided.
摘要翻译： 本发明提供了与人类干扰素-γ（IFN-γ）相互作用或与之结合的抗体以及通过向IFN-γ施用药学上有效量的抗体来治疗IFN-γ介导的疾病的方法。 还提供了使用针对IFN-γ的抗体检测样品中IFN-γ量的方法。
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10.发明授权Methods for treating IFN-γ mediated diseases using human anti-IFN-γ neutralizing antibodies as selective IFN-gamma pathway inhibitors 有权使用人抗-γ-γ中和抗体作为选择性IFN-γ途径抑制剂治疗IFN-γ介导的疾病的方法公开(公告)号：US08529893B2
公开(公告)日：2013-09-10
申请号：US13476317
申请日：2012-05-21
IPC分类号： A61K39/395
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective amount of antibodies to IFN-γ. Methods of detecting the amount of IFN-γ in a sample using antibodies to IFN-γ are also provided.
摘要翻译： 本发明提供了与人类干扰素-γ（IFN-γ）相互作用或与之结合的抗体以及通过向IFN-γ施用药学上有效量的抗体来治疗IFN-γ介导的疾病的方法。 还提供了使用针对IFN-γ的抗体检测样品中IFN-γ量的方法。
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