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公开(公告)号：US07651851B2
公开(公告)日：2010-01-26
申请号：US11340712
申请日：2006-01-27
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/0295 , G01N21/65 , G01N21/658 , G01N21/8483 , G01N33/52 , G01N2021/656
摘要： Methods and apparatus for in vitro detection of an analyte in a body fluid sample using low resolution Raman spectroscopy are disclosed. The body fluid analyzer includes a disposable strip for receiving a sample of body fluid on a target region, the target region including gold sol-gel to provide surface enhanced Raman scattering. A light source irradiates the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects at least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The results of the processed data are displayed on a screen to inform a user about an analyte within the body fluid sample.
摘要翻译： 公开了使用低分辨率拉曼光谱法体外检测体液样品中分析物的方法和装置。 体液分析仪包括用于接收目标区域上的体液样本的一次性条，所述目标区域包括金溶胶 - 凝胶以提供表面增强的拉曼散射。 光源照射目标区域以产生由分散元件分离成不同波长分量的散射电磁辐射组成的拉曼光谱。 检测阵列检测散射光的至少一些波长分量，并向处理器提供数据以处理数据。 处理数据的结果显示在屏幕上以通知用户体液样品内的分析物。
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公开(公告)号：US07524671B2
公开(公告)日：2009-04-28
申请号：US10905956
申请日：2005-01-27
IPC分类号： C12M1/34
CPC分类号： G01N21/65 , A61B5/14532 , A61B5/1455 , A61B2562/0295 , G01N21/658 , G01N21/8483 , G01N2021/656
摘要： Methods and apparatus for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy are disclosed. The blood analyzer includes a disposable strip for receiving a sample of blood on a target region, the target region including gold sol-gel to provide surface enhanced Raman scattering. A light source irradiates the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects a least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The results of the processed data are displayed on a screen to inform a user about an analyte within the blood sample.
摘要翻译： 公开了使用低分辨率拉曼光谱法体外检测血液样品中分析物的方法和装置。 血液分析仪包括用于接收目标区域上的血液样本的一次性条带，该目标区域包括金溶胶 - 凝胶以提供表面增强的拉曼散射。 光源照射目标区域以产生由分散元件分离成不同波长分量的散射电磁辐射组成的拉曼光谱。 检测阵列检测散射光的至少一些波长分量，并向处理器提供数据以处理数据。 处理数据的结果显示在屏幕上以通知用户血样中的分析物。
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3.发明授权
公开(公告)号：US5750995A
公开(公告)日：1998-05-12
申请号：US601337
申请日：1996-02-16
申请人： Richard H. Clarke
发明人： Richard H. Clarke
CPC分类号： G01N33/2829 , G01N21/3577
摘要： Method and devices for fuel characterization and optimization on-site at a fuel delivery dispenser are disclosed. Fuel properties associated with a fuel sample of a fuel can be measured by mid-infrared analysis and displayed. Pre-determined preferred values for the fuel properties for the particular vehicle can be determined by inputting the model and type of vehicle into a processing means and correlating the vehicle information with the preferred values. The preferred and measured values can be compared and the comparison displayed. A fuel sample rating for the vehicle can be performed based this comparison and displayed. An optimal dispenser fuel for the vehicle can be identified based on a comparison between the preferred values and the values for the fuel properties for each of the dispenser fuels. In one embodiment, driveability index can be the fuel property determined in situ and in real time. In other embodiments, octane number, and Reid vapor pressure can be similarly determined.
摘要翻译： 公开了用于燃料分配器上现场燃料表征和优化的方法和装置。 与燃料燃料样品相关联的燃料性质可以通过中红外分析测量并显示。 可以通过将车辆的型号和类型输入到处理装置中并将车辆信息与优选值相关联来确定用于特定车辆的燃料性质的预定优选值。 可以比较优选和测量值并显示比较。 可以根据这种比较进行车辆的燃油样本评级并显示。 可以基于优选值和每种分配器燃料的燃料性质的值之间的比较来识别用于车辆的最佳分配器燃料。 在一个实施方案中，可驾驶性指数可以是在现场和实时确定的燃料性质。 在其它实施方案中，可以类似地确定辛烷值和Reid蒸气压。
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公开(公告)号：US5264368A
公开(公告)日：1993-11-23
申请号：US822097
申请日：1992-01-17
CPC分类号： G01N21/64 , G01M3/047 , G01M3/38 , G01N2021/6439 , Y10T436/13 , Y10T436/21
摘要： Method and apparatus for detecting and/or monitoring the presence of hydrocarbons in a fluid medium at a remote location, by sensing the presence of hydrocarbon-based fluid in the fluid medium in the remote location, generating a signal indicative of the sensed fluid, and transmitting the signal to monitoring means for indication of hydrocarbon contamination. The apparatus has multiple sensors at different vertical levels for sensing the fluid medium at a plurality of levels within the fluid.
摘要翻译： 通过感测远程位置的流体介质中基于烃的流体的存在，产生指示所检测到的流体的信号，以及用于检测和/或监测位于远程位置的流体介质中烃的存在的方法和装置，以及 将信号发送到用于指示烃污染的监测装置。 该装置具有不同垂直水平的多个传感器，用于感测流体内多个水平的流体介质。
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公开(公告)号：US5246004A
公开(公告)日：1993-09-21
申请号：US929941
申请日：1992-08-14
申请人： Richard H. Clarke , Qian Wang
发明人： Richard H. Clarke , Qian Wang
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61B2562/0233 , A61B2562/043
摘要： Systems and methods for non-invasive blood analysis are disclosed in which blood is illuminated at a plurality of discrete wavelengths selected from the near infrared spectrum. Measurements of the intensity of reflected or transmitted light at such wavelengths are taken, and an analysis of reflectance or transmittance ratios for various wavelengths is performed. Changes in the ratios can be correlated with specific material properties, such as the concentration of cholesterol in a subject's circulatory system.
摘要翻译： 公开了用于非侵入性血液分析的系统和方法，其中以从近红外光谱中选择的多个离散波长照射血液。 对这些波长的反射光或透射光的强度进行测量，并对各种波长的反射率或透射比进行分析。 比例的变化可以与具体的材料性质相关，例如受试者的循环系统中胆固醇的浓度。
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6.发明授权Non-invasive blood analysis by near infrared absorption measurements using two closely spaced wavelengths 失效通过使用两个紧密间隔的波长的近红外吸收测量的非侵入性血液分析
公开(公告)号：US5222495A
公开(公告)日：1993-06-29
申请号：US930070
申请日：1992-08-14
申请人： Richard H. Clarke , Qian Wang
发明人： Richard H. Clarke , Qian Wang
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/0233 , A61B2562/043
摘要： Systems and methods for non-invasive blood analysis are disclosed in which blood is illuminated at a plurality of discrete wavelengths selected from the near infrared spectrum. Measurements of the intensity of transmitted or reflected light at such wavelengths are taken, and an analysis of transmittance or reflectance ratios for various wavelengths is performed. Changes in the ratios can be correlated with specific near infrared (IR) absorption peak for the analyte which varies with concentration of the analyte (the data wavelength) and the a second (reference) wavelength being sufficiently removed from the first so that measurements of light absorption at this second wavelength are relatively insensitive to the concentration of the analyte and yet the second wavelength is sufficiently close to the first wavelength to minimize interference from scattering effects and the like. Typically, the window bracketing these closely spaced wavelengths will be less than about 300 nm and preferably less than about 60 nm wide and, in some instances, more preferably less than about 30 nm wide.
摘要翻译： 公开了用于非侵入性血液分析的系统和方法，其中以从近红外光谱中选择的多个离散波长照射血液。 测量这些波长的透射光或反射光的强度，并对各种波长的透射率或反射率进行分析。 比率的变化可以与分析物的特定近红外（IR）吸收峰相关，分析物的吸收峰随着分析物的浓度（数据波长）而变化，第二（参考）波长从第一个被充分去除，从而测量光 在该第二波长处的吸收对分析物的浓度相对不敏感，而第二波长足够接近第一波长，以最小化来自散射效应等的干扰。 通常，包围这些紧密间隔的波长的窗口将小于约300nm，优选小于约60nm宽，并且在一些情况下更优选小于约30nm宽。
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公开(公告)号：US5982484A
公开(公告)日：1999-11-09
申请号：US31022
申请日：1998-02-26
CPC分类号： G01J3/44 , G01N21/65 , G01N2021/651 , G01N2021/656
摘要： The present invention provides an apparatus for measuring a property of a sample using low resolution Raman spectroscopy. The apparatus includes a multi-mode laser element, a wavelength dispersion element, a detector, and a processor. The multi-mode laser element irradiates a sample with laser radiation to produce a Raman spectrum. The collection element collects the radiation scattered from the molecules of the sample and transmits the scattered radiation to the dispersion element. The dispersion element disperses the scattered radiation into different wavelength components. The detection array detects the different wavelength components. A processor processes data from the detector array to identify a constituent or to measure a property of the sample. The apparatus preferably has a resolution of between 30 cm.sup.-1 and 50 cm.sup.-1. The resolution of the apparatus being determined in part by the spectral full width at half maximum of the multi-mode laser, and, in part, by the dispersion element.
摘要翻译： 本发明提供一种使用低分辨率拉曼光谱测量样品的性质的装置。 该装置包括多模激光元件，波长色散元件，检测器和处理器。 多模激光元件用激光辐射照射样品以产生拉曼光谱。 收集元件收集从样品分子散射的辐射，并将散射的辐射传输到分散元件。 分散元件将散射的辐射分散成不同的波长成分。 检测阵列检测不同的波长分量。 处理器处理来自检测器阵列的数据以识别成分或测量样品的性质。 该装置优选具有在30cm -1和50cm -1之间的分辨率。 该装置的分辨率部分地由多模激光器的半值的光谱全宽确定，部分由色散元件确定。
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公开(公告)号：US5958780A
公开(公告)日：1999-09-28
申请号：US885164
申请日：1997-06-30
CPC分类号： C10L1/14 , C10L1/003 , C10L1/22 , C10L1/2286 , G01N33/2882 , C10L1/1608 , C10L1/188 , C10L1/223 , C10L1/2283 , C10L1/301 , C10L2290/60 , Y10T436/13 , Y10T436/21
摘要： Methods for marking a liquid and methods and systems for identifying marked liquids. A liquid can be marked for identification purposes with at least a first marker and a second marker. Each of the markers is miscible with the liquid. The markers are mixed in the liquid so that the ratio of the concentration of the first marker to the concentration of the second marker is substantially equal to a predetermined value. Thus, when a system according to the invention measures the concentrations of the first and second markers, the system can compare the ratio of the measured concentration of the first marker to the measured concentration of the second marker with a look up table of the predetermined values to provide information concerning the identity of the liquid. In a preferred embodiment, the concentration of the markers is measured using an absorption spectrometer. When using an absorption spectrometer to measure the concentration of the markers, each of the markers has an absorbance spectrum with at least one wavelength range where the marker's absorbance is differentiable from the absorbance of the background liquid and any other marker in the liquid.
摘要翻译： 标记液体的方法和用于识别标记液体的方法和系统。 液体可以用至少第一标记和第二标记进行标识。 每个标记物都与液体混溶。 标记物在液体中混合，使得第一标记物的浓度与第二标记物的浓度之比基本上等于预定值。 因此，当根据本发明的系统测量第一和第二标记的浓度时，系统可以用预定值的查找表来比较第一标记的测量浓度与第二标记的测量浓度的比率 提供关于液体身份的信息。 在优选的实施方案中，使用吸收光谱仪测量标记物的浓度。 当使用吸收光谱仪来测量标记物的浓度时，每个标记物具有至少一个波长范围的吸收光谱，其中标记物的吸光度与背景液体和液体中任何其它标记物的吸光度不同。
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公开(公告)号：US07688440B2
公开(公告)日：2010-03-30
申请号：US11698084
申请日：2007-01-26
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658 , G01N21/8483 , Y10T436/112499
摘要： The invention provides diagnostic apparatuses that are advantageously adapted for the Raman spectroscopic analysis of fluid samples, such as biological fluid samples, deposited on test strip substrates. The tests strips may be include a surface-enhanced Raman spectroscopy (SERS) surface for deposition and analysis of a sample and/or may be lateral flow binding assay type test strips.
摘要翻译： 本发明提供了有利地适用于沉积在测试条基材上的流体样品（例如生物流体样品）的拉曼光谱分析的诊断装置。 测试条可以包括用于样品沉积和分析的表面增强拉曼光谱（SERS）表面和/或可以是侧向流动结合测定型测试条。
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公开(公告)号：US20080158544A1
公开(公告)日：2008-07-03
申请号：US12068269
申请日：2008-02-05
IPC分类号： G01N33/48
CPC分类号： A61B5/14546 , A61B5/0059 , A61M1/14 , A61M1/3609 , A61M1/367 , A61M2230/20 , G01N21/65 , G01N2021/651 , Y10T436/17 , Y10T436/171538 , Y10T436/173845
摘要： Spectroscopic systems and methods are disclosed for determining levels of at least one analyte in blood undergoing hemodialysis. In one aspect, the invention employs Raman spectroscopy to monitor and/or control hemodialysis. In one embodiment, the system uses a laser light directed to circulating blood from a patient undergoing dialysis to make Raman spectral measurements. For example, the laser light can be directed into a segment of the dialysis tubing. The system can utilize unique Raman spectroscopic signature of one or more analytes, e.g., urea, to identify and quantify such analytes against a whole blood background. Based on the spectral response, the concentration of the analytes can be monitored and/or used to control hemodialysis.
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