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    Compounds consisting in particular of effectors of the central nervous system receptors sensitive excitatory amino acids, preparation and biological applications
    1.
    发明授权
    Compounds consisting in particular of effectors of the central nervous system receptors sensitive excitatory amino acids, preparation and biological applications 有权
    化合物特别包括中枢神经系统受体的敏感兴奋性氨基酸，制剂和生物学应用

    公开(公告)号：US06433014B1

    公开(公告)日：2002-08-13

    申请号：US09367311

    申请日：1999-11-29

    Applicant: Francine Acher ,  Robert Azerad ,  Jean Philippe Pin

    Inventor： Francine Acher ,  Robert Azerad ,  Jean Philippe Pin

    IPC: A61K31195

    CPC classification number: C07C229/48 ,  C07C2601/08

    Abstract: The invention concerns compounds of formula (I): in which: R1 to R4, identical or different, represent hydrogen, alkyl or aryl, themselves substituted if required, R1 and R2 together further capable of representing a bridge —(CH2)m in which m is a whole number from 1 to 5, or a bridge X representing a linear combination of m hydrocarbon groups, m being as defined above and comprising, if required, at least a heteroatom such as O, N or S, or a bridge X representing a linear combination of p heteroatoms O, N and/or S, in which p is a whole number from 1 to 3; A1 and A2 represent —COOH, —SO3H or —PO3H2 radicals, or their derivatives such as esters or amides, or only one of A1 or A2 has these meanings, when R1 and R2 represent a single bond between the carbons in positions 3 and 4, the other of these groups being a hydrogen atom; Y represents a chain —(CH2)n—, n being zero or a whole number from 1 to 5, or represents a linear combination of n hydrocarbon groups and at least a heteroatom O, N or S, or a linear combination of q heteroatoms O, N and/or S, in which q is a whole number from 1 to 3. The invention is applicable as medicines.

    Abstract translation: 本发明涉及式（I）的化合物：其中：R 1至R 4相同或不同，表示氢，烷基或芳基，如果需要，其本身被取代，R 1和R 2一起还可表示桥 - （CH 2）m，其中 m为1至5的整数，或表示m个烃基的线性组合的桥X，m如上所定义，并且如果需要，包含至少一个诸如O，N或S的杂原子或桥X 表示p个杂原子O，N和/或S的线性组合，其中p是1至3的整数; A1和A2表示-COOH，-SO3H或-PO3H2基团，或它们的衍生物如酯或酰胺，或者只有A1或A2中的一个具有这些含义，当R1和R2表示位置3和4之间的碳时，单键 这些基团中的另一个为氢原子; Y表示链 - （CH 2）n - ，n为0或1至5的整数，或表示n个烃基和至少一个杂原子O，N或S或q个杂原子的线性组合的线性组合 O，N和/或S，其中q为1至3的整数。本发明可用作药物。

    Synthesis of chloropentafluoroethane
    2.
    发明授权
    Synthesis of chloropentafluoroethane 失效
    氯五氟乙烷的合成

    公开(公告)号：US4745236A

    公开(公告)日：1988-05-17

    申请号：US931365

    申请日：1986-11-14

    Applicant: Robert Azerad ,  Bernard Cheminal ,  Henri Mathais

    Inventor： Robert Azerad ,  Bernard Cheminal ,  Henri Mathais

    IPC: C07C19/12 ,  B01J27/00 ,  B01J27/12 ,  B01J27/125 ,  C07B61/00 ,  C07C17/00 ,  C07C17/20 ,  C07C67/00 ,  C07C19/08

    CPC classification number: B01J27/125 ,  C07C17/206

    Abstract: The invention relates to a gas phase process for the manufacture of chloropentafluoroethane by the action of hydrofluoric acid on dichlorotetrafluoroethane in the presence of a catalyst, the said catalyst being prepared by reacting, in a gaseous phase, an alumina in which the sodium oxide content is below 300 ppm and the volume of the pores having a radius equal to 40 angstroms or above is greater than 0.7 cm.sup.3 /g, with hydrofluoric acid or with a mixture of hydrofluoric acid and of air, nitrogen or a fluorinated compound.

    Abstract translation: 本发明涉及在催化剂存在下，通过氢氟酸在二氯四氟乙烷上的作用制备氯五氟乙烷的气相方法，所述催化剂是通过使气相中氧化钠含量为 低于300ppm，并且具有等于40埃或以上的半径的孔的体积大于0.7cm 3 / g，与氢氟酸或氢氟酸与空气，氮气或氟化合物的混合物。

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