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1.发明授权公开(公告)号：US08021874B2
公开(公告)日：2011-09-20
申请号：US12361163
申请日：2009-01-28
CPC分类号： C12P7/649 , A23L33/12 , A61K31/202 , C12P7/6427 , C12P7/6472 , Y02E50/13 , A61K2300/00
摘要： The present invention relates to processes for production of Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs). The present invention also relates to compositions (e.g., nutritional supplements and food products) containing such VLC-PUFAs. In one embodiment, the present invention is directed to methods for biosynthesis and production of the VLC-PUFAs described herein (particularly C28-C38 PUFAs, also referred to herein as supraenes or supraenoics) by the expression, in a production host cell, of the full or partial sequence(s) of Elovl4 DNA/mRNA nucleic acids or ELOVL4 protein sequences encoded thereby, from any species (prokaryotic or eukaryotic) for use in the biosynthesis, production, purification and utilization of VLC-PUFAs in particular by the elongation of C18-C26 saturated fatty acids and PUFAs. The composition of the invention comprises, in various embodiments, a dietary supplement, a food product, a pharmaceutical formulation, a humanized animal milk, an infant formula, a cosmetic item and a biodiesel fuel for example. A pharmaceutical formulation can include, but is not limited to: a drug for treatment of neurodegenerative disease, a retinal disorder, age related maculopathy, a fertility disorder, particularly regarding sperm or testes, or a skin disorder.
摘要翻译： 本发明涉及生产超长链多不饱和脂肪酸（VLC-PUFA）的方法。 本发明还涉及含有这种VLC-PUFA的组合物（例如，营养补充剂和食品）。 在一个实施方案中，本发明涉及通过在生产宿主细胞中表达在本文中描述的VLC-PUFA的生物合成和生产方法（特别是C28-C38 PUFA，本文也称为supraenes或supraenoics） Elovl4 DNA / mRNA核酸或由此编码的ELOVL4蛋白序列的完整或部分序列，用于生物合成，生产，纯化和利用VLC-PUFA的任何物种（原核或真核生物），特别是通过延长 C18-C26饱和脂肪酸和PUFA。 在各种实施方案中，本发明的组合物包含膳食补充剂，食品，药物制剂，人源化动物奶，婴儿配方食品，化妆品和生物柴油燃料。 药物制剂可以包括但不限于：用于治疗神经变性疾病，视网膜病症，年龄相关性黄斑病变，生育障碍，特别是关于精子或睾丸或皮肤病症的药物。
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2.发明申请COMPOSITIONS OF VERY LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF USE 审中-公开非常长链多脂肪酸的组成和使用方法公开(公告)号：US20120071558A1
公开(公告)日：2012-03-22
申请号：US13231649
申请日：2011-09-13
CPC分类号： C12P7/6427 , C12N9/1029
摘要： The present invention relates to processes for production of Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs). The present invention also relates to compositions (e.g., nutritional supplements, food products, and pharmaceutic compositions) containing such VLC-PUFAs. In one embodiment, the present invention is directed to methods for biosynthesis and production of the VLC-PUFAs described herein (particularly C28-C40 PUFAs, also referred to herein as supraenes or supraenoics) by the expression, in a production host cell, of the full or partial sequence(s) of Elovl4 DNA/mRNA nucleic acids or ELOVL4 protein sequences encoded thereby, from any species (prokaryotic or eukaryotic) for use in the biosynthesis, production, purification and utilization of VLC-PUFAs in particular by the elongation of C18-C26 saturated fatty acids and PUFAs. The composition of the invention comprises, in various embodiments, a dietary supplement, a food product, a nutritional formulation, a pharmaceutical formulation, a humanized animal milk, an infant formula, and a cosmetic item and for example. A pharmaceutical formulation can include, but is not limited to: a composition for enhancing neural development and function, a drug for treatment of neurodegenerative disease, an ocular disorder, a retinal disorder, age related maculopathy, a fertility disorder, particularly regarding sperm or testes, or a skin disorder.
摘要翻译： 本发明涉及生产超长链多不饱和脂肪酸（VLC-PUFA）的方法。 本发明还涉及含有这种VLC-PUFA的组合物（例如，营养补充剂，食品和药物组合物）。 在一个实施方案中，本发明涉及通过在生产宿主细胞中表达生物合成和生产本文所述的VLC-PUFA（特别是C28-C40 PUFA，本文也称为supraenes或supraenoics）的方法 Elovl4 DNA / mRNA核酸或由此编码的ELOVL4蛋白序列的完整或部分序列，用于生物合成，生产，纯化和利用VLC-PUFA的任何物种（原核或真核生物），特别是通过延长 C18-C26饱和脂肪酸和PUFA。 本发明的组合物在各种实施方案中包括膳食补充剂，食品，营养制剂，药物制剂，人源化动物奶，婴儿配方食品和化妆品，例如。 药物制剂可以包括但不限于：用于增强神经发育和功能的组合物，用于治疗神经变性疾病，眼部疾病，视网膜病症，年龄相关性黄斑病变，生育障碍，特别是关于精子或睾丸的药物 ，或皮肤病。
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公开(公告)号：US5172969A
公开(公告)日：1992-12-22
申请号：US756742
申请日：1991-09-09
申请人： Robert Reuter , Wallace C. Bullwinkle , Larry L. Hoff , Robert E. Anderson , Arkady Golynsky , Al Schmidt
发明人： Robert Reuter , Wallace C. Bullwinkle , Larry L. Hoff , Robert E. Anderson , Arkady Golynsky , Al Schmidt
CPC分类号： E05D3/18 , A47B96/00 , E05D11/1014 , E05D15/405 , E06B3/40 , E05Y2900/20 , Y10T16/5443
摘要： A cabinet is provided with a curved, upwardly-swinging door and interior shelves. The curved shelf door is mounted on a pair of opposed arms which rotate on a horizontal axis. Each arm is provided with two opposed, circularly arcuate slots and a central ellipsoidal slot, each slot engaging a fixed stud at the side of the cabinet. The ellipsoidal slot and its corresponding stud provide a center pivot for each of the arms. The arms are mounted inside the cabinet on opposed interior side walls. Lighting can be provided in a formed recess in the bottom of the cabinet. The cabinet can also be provided with plural internal shelves supported on planar brackets. The cabinet further can be provided with a pair of side-by-side doors and a center wall. Arms are mounted on each side of the center wall and adjacent the interior side walls of the cabinet, for separately mounting the doors.
摘要翻译： 橱柜设有一个弯曲的向上摆动的门和内部货架。 弯曲的货架门安装在一对在横轴上旋转的相对的臂上。 每个臂设有两个相对的圆弧形槽和中心椭圆形槽，每个槽与机柜侧面的固定螺栓啮合。 椭圆形狭槽及其对应的螺柱为每个臂提供中心枢轴。 手臂安装在机柜内相对的内侧壁上。 照明可以设置在机柜底部的成形凹槽中。 机柜也可以设置有多个支撑在平面支架上的内部货架。 机柜还可以设有一对并排门和中心墙。 臂安装在中心壁的每一侧并且靠近机柜的内侧壁，用于单独安装门。
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公开(公告)号：US5114914A
公开(公告)日：1992-05-19
申请号：US337362
申请日：1989-03-13
IPC分类号： C04B35/45 , C04B35/653 , H01L39/24
CPC分类号： H01L39/2464 , C04B35/4504 , C04B35/653 , Y10S505/739 , Y10S505/74 , Y10S505/741 , Y10S505/742
摘要： An improved method for producing high temperature superconductors comprising sintering ceramic superconductor material in a sealed confinement chamber made of non-reactive impervious material, thereby preventing loss of oxygen from the material during heating and eliminating the need for reoxygenation after sintering.
摘要翻译： 一种用于生产高温超导体的改进方法，包括在由不反应性不透水材料制成的密封限制室中烧结陶瓷超导体材料，从而防止在加热期间材料中的氧损失，并且消除了烧结后再氧化的需要。
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公开(公告)号：USD263237S
公开(公告)日：1982-03-02
申请号：US103166
申请日：1979-12-13
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公开(公告)号：US4117312A
公开(公告)日：1978-09-26
申请号：US707648
申请日：1976-07-22
摘要： An electrical heating cable which limits power output once an established temperature limit is reached. The cable includes a high-resistance element and a temperature-sensitive variable resistance element electrically connected in series between two electrical conductors otherwise insulated from each other by insulating material. The temperature-sensitive resistance undergoes a substantial positive increase in resistivity when the temperature of the cable nears the established temperature limit. The increase in resistivity substantially reduces the heat-generating current flowing in the cable to limit the power output.
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公开(公告)号：US06938301B2
公开(公告)日：2005-09-06
申请号：US10085894
申请日：2002-02-28
申请人： Jason C. Brooke , Kendall O. Shows , William S. Larisey, Jr. , Robert E. Anderson , Daniel C. Hillenbrand , Joe D. McGuinness
发明人： Jason C. Brooke , Kendall O. Shows , William S. Larisey, Jr. , Robert E. Anderson , Daniel C. Hillenbrand , Joe D. McGuinness
CPC分类号： A61G7/0507 , A61G7/012 , A61G7/015 , A61G7/05 , A61G7/0509 , A61G7/0514 , A61G7/0528 , A61G2203/723 , Y10T16/182 , Y10T16/1943 , Y10T16/21
摘要： A bed frame includes a base frame, an articulated support decks, an intermediate frame positioned between the base frame and the articulated support deck, and an auto-contour mechanism. The articulated support deck includes head, seat and foot deck portions. When engaged, the auto-contour mechanism adjusts the elevation of the seat deck portion and the foot deck portion in response to an adjustment of the head deck portion. The auto-contour mechanism is easily engaged/disengaged by manipulating a control lever. The bed frame can include siderails which are provided with a latching mechanism. The bed frame can also include a caster assembly that allows casters to be pivoted in an engaged position in which the bed frame rests on the casters, and a disengaged position in which the bed frame rests on legs.
摘要翻译： 床架包括基架，铰接支撑甲板，定位在基架和铰接支撑甲板之间的中间框架，以及自动轮廓机构。 铰接的支撑甲板包括头部，座椅和脚部部分。 当接合时，自动轮廓机构响应于头甲板部分的调节来调节座椅甲板部分和脚部甲板部分的高度。 自动轮廓机构通过操纵控制杆容易地接合/分离。 床架可以包括设有闩锁机构的挡板。 床架还可以包括脚轮组件，脚轮组件允许脚轮在接合位置枢转，其中床架搁置在脚轮上，以及脱离位置，床架搁置在腿上。
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公开(公告)号：US5057174A
公开(公告)日：1991-10-15
申请号：US547371
申请日：1990-07-05
CPC分类号： B29D24/001 , B24C1/00 , B24C3/325 , B29C33/448 , Y10T156/1003
摘要： A technique is provided for removing foam mandrel material from a stiffener section of a composite structural member as is employed in lightweight aircraft skin structures. The technique involves the direct pressure glass bead blasting of the mandrel material. By mounting a blasting nozzle within a rubber hose of larger diameter, an airstream containing glass beads may be directed outwardly through the nozzle while evacuating pressure is created in an annular passageway between the hose and the nozzle to evacuate mandrel foam particles as well as spent glass beads. The result is a clean channel within the stiffener section.
摘要翻译： 提供了用于从轻型飞机皮肤结构中使用的复合结构构件的加强部分去除泡沫心轴材料的技术。 该技术涉及心轴材料的直接压力玻璃珠喷射。 通过将喷射喷嘴安装在较大直径的橡胶软管内，可以通过喷嘴向外引导包含玻璃珠的气流，同时在软管和喷嘴之间的环形通道中产生压力，以排空心轴泡沫颗粒以及废玻璃 珠子 结果是加强件部分内的干净通道。
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9.发明授权
公开(公告)号：US4925581A
公开(公告)日：1990-05-15
申请号：US221061
申请日：1988-07-19
IPC分类号： C10M135/06 , C10M159/00 , C10M159/02 , C10M163/00
CPC分类号： C10M159/02 , C10M135/06 , C10M159/00 , C10M163/00 , C01P2004/62 , C01P2004/80 , C01P2006/90 , C10M2205/14 , C10M2205/18 , C10M2207/40 , C10M2207/404 , C10M2219/024 , C10M2223/04 , C10M2223/042 , C10M2223/06 , C10M2223/061 , C10M2223/065 , C10M2227/00
摘要： There is disclosed lubricant additives that comprise a combination of meadowfoam oil as a triglyceride or a wax ester, sulfurized triglyceride meadowfoam oil or sulfurized wax ester of meadowfoam oil, and phosphite adducts of triglyceride meadowfoam oil or wax ester of meadowfoam oil. There is also disclosed a process for sulfurizing triglyceride meadowfoam oil that is soluble in a lubricant base, such as mineral oil.
摘要翻译： 公开了包含作为甘油三酯或蜡酯的花旗散发油组合的硫酸甘油三酯草油或硫丹蜡泡沫蜡的硫化蜡酯的组合的润滑剂添加剂，以及草甘膦油的甘油三酯草粉油或蜡酯的亚磷酸酯加成物。 还公开了可溶于诸如矿物油的润滑剂基质中的甘油三酯草聚糖油的硫化方法。
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10.发明授权
公开(公告)号：US4892435A
公开(公告)日：1990-01-09
申请号：US306196
申请日：1989-02-06
申请人： Robert E. Anderson
发明人： Robert E. Anderson
CPC分类号： F16B3/00 , B64C3/26 , F16B2/14 , F16B5/00 , Y10T403/7066 , Y10T403/76
摘要： The invention relates to an expansion fastener device that secures two interlocking members together. The device includes a parallelepiped receptacle having slits along opposite ends. The receptacle is inserted through the interlocking members and double wedges are driven into the receptacle. The double wedges includes a first wedge having tapers in the vertical direction and its insertion into receptacle causes only vertical expansion of the receptacle. A second horizontal tapered wedge is received with a horizontal tapered opening formed in the first wedge to cause independent expansion of the recess in the horizontal direction.
摘要翻译： 本发明涉及将两个互锁构件固定在一起的膨胀紧固装置。 该装置包括具有相对端的狭缝的平行六面体插座。 插座通过互锁构件插入，双楔被驱动进入插座。 双楔子包括在垂直方向上具有锥形的第一楔形物，并且其插入插座仅引起容器的垂直膨胀。 第二水平锥形楔接收有形成在第一楔形件中的水平锥形开口，以引起凹部在水平方向上的独立膨胀。
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