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公开(公告)号：US06986837B2
公开(公告)日：2006-01-17
申请号：US10215885
申请日：2002-08-09
IPC分类号： G01N27/453
CPC分类号： G01N27/44721 , B01L3/5027 , B01L9/527 , B01L2200/027 , B01L2200/148 , B01L2400/0415 , G01N27/44791
摘要： A microfluidic controller and detector system and method for performing screening assays are disclosed. The microfluidic controller and detector system comprises a fluidic chip that includes at least two intersecting channels and a detection zone, a fluid direction system comprising an electrical interface configured for electrical contact with the at least two intersecting channels, an optics block having an objective lens disposed adjacent the detection zone, and a control system coupled to the optics block and adapted to receive and analyze data from the optics block. The electrical interface generally includes electrodes configured for electrical contact with the intersecting channels and coupled to electrode channels for supplying electrical input to the electrodes. A reference channel is optionally provided to calibrate the electrode channels.
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公开(公告)号：US4912662A
公开(公告)日：1990-03-27
申请号：US65286
申请日：1987-06-22
摘要： An inclinometer 20 has a sensing unit 40 for providing a varying capacitance signal depending on the orientation of the inclinometer 20. An oscillator circuit unit 82 includes the sensor unit 40 as a capacitive element for providing a signal having a period and a frequency depending on the capacitance of the sensor unit 40. A unit 92 is provided for determining the period of the signal. A look-up table unit 96 stores a predetermined relationship between the period of the signal and the angle of orientation of the inclinometer 20. A comparison unit 94 then compares the period of the signal to the period stored in the look-up table unit 96 and selects the corresponding angle which is the angle of orientation of the inclinometer 20. The angle is then displayed on the inclinometer display 25.
摘要翻译： 倾斜计20具有用于根据倾斜计20的取向提供变化的电容信号的感测单元40.振荡器电路单元82包括作为电容元件的传感器单元40，用于提供具有周期和频率的信号，该周期和频率取决于 传感器单元40的电容。提供用于确定信号周期的单元92。 查找表单元96存储信号的周期和倾斜计20的取向角度之间的预定关系。比较单元94然后将信号的周期与存储在查找表单元96中的周期进行比较 并且选择作为倾斜计20的取向角度的相应角度。然后将该角度显示在倾斜计显示器25上。
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公开(公告)号：US06498497B1
公开(公告)日：2002-12-24
申请号：US09374878
申请日：1999-08-13
IPC分类号： G01R3500
CPC分类号： G01N27/44721 , B01L3/5027 , B01L9/527 , B01L2200/027 , B01L2200/148 , B01L2400/0415 , G01N27/44791
摘要： A microfluidic controller and detector system and method for performing screening assays are disclosed. The microfluidic controller and detector system comprises a fluidic chip that includes at least two intersecting channels and a detection zone, a fluid direction system comprising an electrical interface configured for electrical contact with the at least two intersecting channels, an optics block having an objective lens disposed adjacent the detection zone, and a control system coupled to the optics block and adapted to receive and analyze data from the optics block. The electrical interface generally includes electrodes configured for electrical contact with the intersecting channels and coupled to electrode channels for supplying electrical input to the electrodes. A reference channel is optionally provided to calibrate the electrode channels.
摘要翻译： 公开了用于进行筛选测定的微流控制器和检测器系统和方法。 微流控制器和检测器系统包括流体芯片，其包括至少两个相交通道和检测区域，流体方向系统，包括被配置为与所述至少两个相交通道电接触的电接口， 邻近所述检测区域，以及控制系统，其耦合到所述光学块并适于从所述光学块接收和分析数据。 电接口通常包括被配置为与交叉通道电接触并且耦合到用于向电极提供电输入的电极通道的电极。 可选地提供参考通道以校准电极通道。
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公开(公告)号：US5335190A
公开(公告)日：1994-08-02
申请号：US920395
申请日：1992-07-27
申请人： Robert E. Nagle , Andrew G. Butler
发明人： Robert E. Nagle , Andrew G. Butler
摘要： An inclinometer 300 includes a sensing unit 302 for providing a signal dependent on the orientation of the inclinometer 300. The inclinometer 300 includes a rescaling unit 322 which improves the performance of the inclinometer providing additional compensation for any change in the sensor 302 over time and temperature. The inclinometer 300 further includes an angle offset function 91, 360 which provides a permanent angle offset to any angle determined by the inclinometer.
摘要翻译： 倾斜计300包括用于提供取决于倾斜仪300的取向的信号的感测单元302.倾斜仪300包括重新缩放单元322，其改善了倾斜仪的性能，为传感器302随时间和温度的任何变化提供额外的补偿 。 倾斜计300还包括角度偏移函数91,360，其提供与倾斜计所确定的任何角度的永久角度偏移。
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公开(公告)号：US5590052A
公开(公告)日：1996-12-31
申请号：US227554
申请日：1994-04-14
申请人： Anne R. Kopf-Sill , Steven N. Buhl , Glenda L. Choate , Lloyd A. Schick , Robert E. Nagle , Jenq C. Chang , Daniel Bernstein , Wayne A. Britt
发明人： Anne R. Kopf-Sill , Steven N. Buhl , Glenda L. Choate , Lloyd A. Schick , Robert E. Nagle , Jenq C. Chang , Daniel Bernstein , Wayne A. Britt
CPC分类号： G01N35/00594 , G01N21/253 , G01N35/025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： The present invention provides various methods for detecting errors in a blood analysis system. The system includes a blood analyzer and a molded plastic rotor with a series of chambers and capillary channels through which blood is processed and distributed to cuvettes which contain lyophilized reagents. The rotor is placed in the analyzer which spins the rotor, and an optical system reads the cuvettes as light is flashed through the cuvettes. The invention provides checks for: confirming the presence of a reagent in the cuvettes before a sample is applied to the cuvettes; determining whether a fluid sample has been properly distributed to the cuvettes of the rotor; determining whether an adequate amount of fluid sample was applied to the analytical rotor; determining whether a fluid sample has been properly distributed to a cuvette of an analytical rotor; determining whether a reaction chemistry in a cuvette has reached an end point; checking the noise level and non-linearity of a reaction rate in a cuvette; determining whether an adequate amount of diluent was delivered to the cuvettes of an analytical rotor; determining dilution systematic failure when measuring different reaction chemistries in the cuvettes of the rotor; determining whether a blood sample in a cuvette is hemolyzed, lipemic, or icteric; determining the degradation of a reagent in a cuvette; determining proper light source and light detector operation; and determining proper motor function and cuvette mark detection.
摘要翻译： 本发明提供了用于检测血液分析系统中的错误的各种方法。 该系统包括血液分析仪和具有一系列腔室和毛细通道的模制塑料转子，通过血液分析器和毛细管通道将血液加工并分配到含有冻干试剂的比色皿。 将转子放置在旋转转子的分析仪中，当光通过反应杯闪烁时，光学系统读取比色皿。 本发明提供了以下检查：在将样品施加到比色杯之前，确认试剂在试管中的存在; 确定流体样品是否已经被适当地分配到转子的比色杯中; 确定足够量的流体样品是否被施加到分析转子; 确定流体样品是否已经被适当地分配到分析转子的比色杯中; 确定比色皿中的反应化学物质是否达到终点; 检查反应杯中的反应速率的噪声水平和非线性; 确定足够量的稀释剂是否被输送到分析转子的比色杯中; 测量转子的比色杯中的不同反应化学物质时的稀释系统失效; 确定比色皿中的血液样品是否溶血，脂肪或黄疸; 确定试剂在试管中的降解; 确定适当的光源和光检测器的操作; 并确定适当的运动功能和比色皿标记检测。
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