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公开(公告)号：US20120148601A1
公开(公告)日：2012-06-14
申请号：US13304835
申请日：2011-11-28
申请人： ROBERT G. ULRICH , Mark A. Olson , Sina Bavari
发明人： ROBERT G. ULRICH , Mark A. Olson , Sina Bavari
IPC分类号： A61K39/085 , C07K2/00 , A61K39/116 , A61K35/16 , C12N1/21 , A61P31/04 , C12N15/70 , C12P21/00 , C12Q1/04 , C12N15/31 , A61K39/40
CPC分类号： C07K14/31
摘要： The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.
摘要翻译： 本发明涉及遗传减毒的超抗原毒素疫苗改变，使得超抗原属性不存在，然而有效识别超抗原并产生适当的免疫应答。 显示减毒的超抗原毒素保护动物免受野生型毒素的攻击。 描述了生产和使用改变的超抗原毒素的方法。
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公开(公告)号：US07374931B2
公开(公告)日：2008-05-20
申请号：US10405871
申请日：2003-04-02
申请人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
发明人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
IPC分类号： A01N43/04 , A01N63/00 , A01N65/00 , A61K48/00 , A61K31/70 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C07H21/02 , C07H21/04
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C12N2799/021
摘要： Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus, compositions and methods for use in inducing an immune response which is protective against staphylococcal aureus intoxication in subjects is described.
摘要翻译： 描述了使用编码来自金黄色葡萄球菌的突变体SEA和SEB外毒素的核酸，用于诱导在受试者中保护葡萄球菌金黄色葡萄球菌中毒的免疫应答的组合物和方法。
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公开(公告)号：US07378257B2
公开(公告)日：2008-05-27
申请号：US10767687
申请日：2004-01-29
申请人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
发明人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
IPC分类号： C12N15/09
CPC分类号： C07K14/31
摘要： The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.
摘要翻译： 本发明涉及遗传减毒的超抗原毒素疫苗改变，使得超抗原属性不存在，然而有效识别超抗原并产生适当的免疫应答。 显示减毒的超抗原毒素保护动物免受野生型毒素的攻击。 描述了生产和使用改变的超抗原毒素的方法。
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公开(公告)号：US06632640B1
公开(公告)日：2003-10-14
申请号：US09350755
申请日：1999-07-09
申请人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
发明人： John S. Lee , Peter Pushko , Jonathan F. Smith , Robert G. Ulrich
IPC分类号： C12N1509
CPC分类号： C07K14/32 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/31 , C12N2799/021
摘要： Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus, compositions and methods for use in inducing an immune response which is protective against staphylococcal aureus intoxication in subjects is described.
摘要翻译： 使用编码来自
金黄色葡萄球菌 的突变体SEA和SEB外毒素的核酸，用于诱导免疫应答的组合物和方法，其用于保护金黄色葡萄球菌 描述了ITALIC> 中毒。 -
公开(公告)号：US06399332B1
公开(公告)日：2002-06-04
申请号：US09144776
申请日：1998-09-01
申请人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
发明人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
IPC分类号： C12N1509
CPC分类号： C07K14/31
摘要： The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.
摘要翻译： 本发明涉及遗传减毒的超抗原毒素疫苗改变，使得超抗原属性不存在，然而有效识别超抗原并产生适当的免疫应答。 显示减毒的超抗原毒素保护动物免受野生型毒素的攻击。 描述了生产和使用改变的超抗原毒素的方法。
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公开(公告)号：US08067202B2
公开(公告)日：2011-11-29
申请号：US12151497
申请日：2008-05-07
申请人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
发明人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
IPC分类号： C12N15/09
CPC分类号： C07K14/31
摘要： The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.
摘要翻译： 本发明涉及遗传减毒的超抗原毒素疫苗改变，使得超抗原属性不存在，然而有效识别超抗原并产生适当的免疫应答。 显示减毒的超抗原毒素保护动物免受野生型毒素的攻击。 描述了生产和使用改变的超抗原毒素的方法。
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公开(公告)号：US07750132B2
公开(公告)日：2010-07-06
申请号：US11333682
申请日：2006-01-17
申请人： Robert G. Ulrich
发明人： Robert G. Ulrich
CPC分类号： C07K14/31
摘要： The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.
摘要翻译： 本发明涉及遗传减毒的超抗原毒素疫苗改变，使得超抗原属性不存在，然而有效识别超抗原并产生适当的免疫应答。 显示减毒的超抗原毒素保护动物免受野生型毒素的攻击。 描述了生产和使用改变的超抗原毒素的方法。
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公开(公告)号：US06713284B2
公开(公告)日：2004-03-30
申请号：US08882431
申请日：1997-06-25
申请人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
发明人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
IPC分类号： C12N1509
CPC分类号： C07K14/31
摘要： The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.
摘要翻译： 本发明涉及遗传减毒的超抗原毒素疫苗改变，使得超抗原属性不存在，然而有效识别超抗原并产生适当的免疫应答。 显示减毒的超抗原毒素保护动物免受野生型毒素的攻击。 描述了生产和使用改变的超抗原毒素的方法。
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公开(公告)号：US20120094861A1
公开(公告)日：2012-04-19
申请号：US13282290
申请日：2011-10-26
CPC分类号： G01N33/6845 , C07K14/35
摘要： The present invention provides compositions and methods for identifying molecules in samples that bind to molecules associated with pathogenic agents (e.g., infectious agents). In certain aspects, the invention may be used to identify individuals that have been exposed to one or more pathogenic agent or have generated antibodies in response to one or more pathogenic agent. In other aspects, the invention is directed to the identification of molecules of one or more pathogenic agent that may be used to generate immune responses in other individuals.
摘要翻译： 本发明提供用于鉴定与病原体（例如感染因子）相关的分子结合的样品中的分子的组合物和方法。 在某些方面，本发明可用于鉴定已经暴露于一种或多种病原体或已响应于一种或多种病原体产生抗体的个体。 在其他方面，本发明涉及鉴定可用于在其他个体中产生免疫应答的一种或多种病原体的分子。
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公开(公告)号：US20090305899A1
公开(公告)日：2009-12-10
申请号：US12313086
申请日：2008-11-17
CPC分类号： G01N33/6845 , C07K14/35
摘要： The present invention provides compositions and methods for identifying molecules in samples that bind to molecules associated with pathogenic agents (e.g., infectious agents). In certain aspects, the invention may be used to identify individuals that have been exposed to one or more pathogenic agent or have generated antibodies in response to one or more pathogenic agent. In other aspects, the invention is directed to the identification of molecules of one or more pathogenic agent that may be used to generate immune responses in other individuals.
摘要翻译： 本发明提供用于鉴定与病原体（例如感染因子）相关的分子结合的样品中分子的组合物和方法。 在某些方面，本发明可用于鉴定已经暴露于一种或多种病原体或已响应于一种或多种病原体产生抗体的个体。 在其他方面，本发明涉及鉴定可用于在其他个体中产生免疫应答的一种或多种病原体的分子。
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