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    Method of preventing virus: cell fusion by inhibiting the function of the fusion initiation region in rna viruses having class i membrane fusogenic envelope proteins
    2.
    发明申请
    Method of preventing virus: cell fusion by inhibiting the function of the fusion initiation region in rna viruses having class i membrane fusogenic envelope proteins 有权
    防止病毒的方法：通过抑制具有I类膜融合包膜蛋白的rna病毒中的融合起始区的功能来进行细胞融合

    公开(公告)号：US20060280754A1

    公开(公告)日：2006-12-14

    申请号：US10578013

    申请日：2004-11-03

    申请人： Robert Garry

    发明人： Robert Garry

    IPC分类号： A61K39/395 ,  A61K39/12

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K38/04 ,  A61K38/162 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C12N7/00 ,  C12N2760/10022 ,  C12N2760/14122 ,  C12N2760/18422 ,  C12N2760/18433 ,  C12N2770/20022 ,  C12Q1/18 ,  G01N33/56988

    摘要： The present invention relates to a method of preventing or inhibiting viral infection of a cell and/or fusion between the envelope of a virus and the membranes of a cell targeted by the virus (thereby preventing delivery of the viral genome into the cell cytoplasm, a step required for. viral infection). The present invention particularly relates to the families of RNA viruses, including the arenaviruses, coronaviruses, filoviruses, orthomyxoviruses, paramyxoviruses, and retroviruses, having Class I membrane fusion proteins as the fusion proteins that mediate this fusion process. The present invention provides for a method of identifying a conserved motif or domain called the fusion initiation region (FIR) in these viruses. The present invention further provides for methods of preventing infection by such viruses, by interfering with their FIR. The present invention further provides for methods of treatment and prophylaxis of diseases induced by such viruses.

    摘要翻译： 本发明涉及一种预防或抑制病毒感染病毒感染和/或病毒包膜与病毒靶向细胞膜（从而防止病毒基因组递送到细胞质中的融合物）的方法 病毒感染所需的步骤）。 本发明特别涉及RNA病毒家族，其包括具有I类膜融合蛋白作为介导该融合过程的融合蛋白的氨甲威病毒，冠状病毒，弧菌病毒，正粘病毒，副粘病毒和逆转录病毒。 本发明提供了鉴定这些病毒中称为融合起始区（FIR）的保守基序或结构域的方法。 本发明进一步提供了通过干扰它们的FIR来防止这种病毒感染的方法。 本发明还提供了治疗和预防由这些病毒引起的疾病的方法。

    Inhibitors of hepatitis C virus
    3.
    发明申请
    Inhibitors of hepatitis C virus 失效
    丙型肝炎病毒的抑制剂

    公开(公告)号：US20060069027A1

    公开(公告)日：2006-03-30

    申请号：US11235672

    申请日：2005-09-26

    申请人： Robert Garry ,  Jane McKeating

    发明人： Robert Garry ,  Jane McKeating

    IPC分类号： C07K7/08 ,  A61K38/10

    CPC分类号： C07K14/005 ,  A61K38/162 ,  A61K39/12 ,  A61K39/29 ,  C07K7/08 ,  C12N2770/24222 ,  C12N2770/24234

    摘要： The present invention relates to methods that employ peptides or peptide derivatives to inhibit hepatitis C virus infection. The present invention is based in part on the discovery that E2 envelope glycoprotein of hepatitis C virus has previously undescribed domains that are important for interactions with cellular or viral proteins that are necessary for early steps in HCV infection. The present invention provides peptides and methods of treatment and prophylaxis of diseases induced by hepatitis C virus and related viruses.

    摘要翻译： 本发明涉及采用肽或肽衍生物抑制丙型肝炎病毒感染的方法。 本发明部分地基于以下发现：丙型肝炎病毒的E2包膜糖蛋白具有对HCV感染早期步骤所必需的与细胞或病毒蛋白相互作用重要的先前未描述的结构域。 本发明提供治疗和预防由丙型肝炎病毒和相关病毒引起的疾病的肽和方法。

    MINE SITE VEHICLE MOUNTED SAFETY FLAG SYSTEM
    4.
    发明申请
    MINE SITE VEHICLE MOUNTED SAFETY FLAG SYSTEM 审中-公开

    公开(公告)号：US20170186347A1

    公开(公告)日：2017-06-29

    申请号：US14981399

    申请日：2015-12-28

    申请人： Robert Garry Sorensen

    发明人： Robert Garry Sorensen

    IPC分类号： G09F17/00

    CPC分类号： G09F17/00 ,  G09F2017/0075 ,  G09F2017/0083

    摘要： A vehicle mounted flag warning system for mine excavation sites, comprising: a) a base plate comprising a top side and a bottom side and including a plurality of mounting holes; b) an electric hydraulic piston device affixed to a top side of the base plate and engaged with a rotatable cam; d) a spring mounted flag rotatable affixed to the flag cam mount; and e) a switch in electrical communication with the electric hydraulic piston, wherein the flag is rotatably position vertically and rotatably position horizontally when the switch is toggled.

    INSTRUCTIONAL AND COMPUTERIZED SPELLING SYSTEMS, METHODS AND INTERFACES
    6.
    发明申请
    INSTRUCTIONAL AND COMPUTERIZED SPELLING SYSTEMS, METHODS AND INTERFACES 审中-公开
    指令和计算机系统，方法和接口

    公开(公告)号：US20090081623A1

    公开(公告)日：2009-03-26

    申请号：US12237268

    申请日：2008-09-24

    申请人： Tracey Dawn Parkinson ,  Robert Garry Parkinson

    发明人： Tracey Dawn Parkinson ,  Robert Garry Parkinson

    IPC分类号： G09B5/00

    CPC分类号： G09B7/00

    摘要： Methods, systems and interfaces are used in the teaching, practicing, and testing of spelling skills with a computer system. An instructor is provided words, groups of words, and filters for creating word lists to administer to one or more students in a preview. Previews are administered to each of the students for generating individualized word lists that are used to administer practice exercises and practice tests. The individualized word lists can also be used to administer final tests to the students. Some interfaces are used for tracking words passed off by the students as well as words the students fail during the final testing. Graphical user interfaces are provided for instructors and students. Some of the instructor interfaces allow instructors to manage students and student groups and to administer previews, word lists, practice exercises and practice tests, final tests, and reporting.

    摘要翻译： 方法，系统和界面用于使用计算机系统进行拼写技巧的教学，实践和测试。 指导者提供词语，词组和过滤器，用于创建单词列表，以便在预览中管理给一个或多个学生。 对每个学生进行预审，以生成用于管理练习练习和练习测试的个性化单词列表。 个性化单词列表也可用于对学生进行最终测试。 一些接口用于跟踪学生传递的单词以及学生在最终测试期间失败的单词。 为教师和学生提供图形用户界面。 教师的一些界面允许教师管理学生和学生团体，并管理预览，单词列表，练习练习和练习测试，最终测试和报告。

    Seedless grape
    7.
    植物专利
    Seedless grape 有权
    无籽葡萄

    公开(公告)号：USPP18955P3

    公开(公告)日：2008-06-17

    申请号：US10949725

    申请日：2004-09-24

    申请人： Robert Garry Trezise ,  Peter Michael Burne

    发明人： Robert Garry Trezise ,  Peter Michael Burne

    IPC分类号： A01H5/00

    CPC分类号： A01H6/88 ,  A01H5/08

    摘要： The present invention relates to a seedless grape variety, which is a clone of ‘Chardonnay I10V1’ grape. A seedless variety has considerable advantages in wine-making in that the wine being produced can be left on the skins for longer than in the case of conventional cultivars, without developing the bitter taste associated with seeds.

    摘要翻译： 本发明涉及无籽葡萄品种，其是“霞多丽I10V1”葡萄的克隆。 无种子品种在酿酒方面具有相当大的优势，因为所生产的葡萄酒可以比传统品种留在皮肤上更长时间，而不会形成与种子相关的苦味。