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    Method of preventing virus: cell fusion by inhibiting the function of the fusion initiation region in rna viruses having class i membrane fusogenic envelope proteins
    4.
    发明申请
    Method of preventing virus: cell fusion by inhibiting the function of the fusion initiation region in rna viruses having class i membrane fusogenic envelope proteins 有权
    防止病毒的方法：通过抑制具有I类膜融合包膜蛋白的rna病毒中的融合起始区的功能来进行细胞融合

    公开(公告)号：US20060280754A1

    公开(公告)日：2006-12-14

    申请号：US10578013

    申请日：2004-11-03

    申请人： Robert Garry

    发明人： Robert Garry

    IPC分类号： A61K39/395 ,  A61K39/12

    CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K38/04 ,  A61K38/162 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C12N7/00 ,  C12N2760/10022 ,  C12N2760/14122 ,  C12N2760/18422 ,  C12N2760/18433 ,  C12N2770/20022 ,  C12Q1/18 ,  G01N33/56988

    摘要： The present invention relates to a method of preventing or inhibiting viral infection of a cell and/or fusion between the envelope of a virus and the membranes of a cell targeted by the virus (thereby preventing delivery of the viral genome into the cell cytoplasm, a step required for. viral infection). The present invention particularly relates to the families of RNA viruses, including the arenaviruses, coronaviruses, filoviruses, orthomyxoviruses, paramyxoviruses, and retroviruses, having Class I membrane fusion proteins as the fusion proteins that mediate this fusion process. The present invention provides for a method of identifying a conserved motif or domain called the fusion initiation region (FIR) in these viruses. The present invention further provides for methods of preventing infection by such viruses, by interfering with their FIR. The present invention further provides for methods of treatment and prophylaxis of diseases induced by such viruses.

    摘要翻译： 本发明涉及一种预防或抑制病毒感染病毒感染和/或病毒包膜与病毒靶向细胞膜（从而防止病毒基因组递送到细胞质中的融合物）的方法 病毒感染所需的步骤）。 本发明特别涉及RNA病毒家族，其包括具有I类膜融合蛋白作为介导该融合过程的融合蛋白的氨甲威病毒，冠状病毒，弧菌病毒，正粘病毒，副粘病毒和逆转录病毒。 本发明提供了鉴定这些病毒中称为融合起始区（FIR）的保守基序或结构域的方法。 本发明进一步提供了通过干扰它们的FIR来防止这种病毒感染的方法。 本发明还提供了治疗和预防由这些病毒引起的疾病的方法。

    Inhibitors of hepatitis C virus
    5.
    发明申请
    Inhibitors of hepatitis C virus 失效
    丙型肝炎病毒的抑制剂

    公开(公告)号：US20060069027A1

    公开(公告)日：2006-03-30

    申请号：US11235672

    申请日：2005-09-26

    申请人： Robert Garry ,  Jane McKeating

    发明人： Robert Garry ,  Jane McKeating

    IPC分类号： C07K7/08 ,  A61K38/10

    CPC分类号： C07K14/005 ,  A61K38/162 ,  A61K39/12 ,  A61K39/29 ,  C07K7/08 ,  C12N2770/24222 ,  C12N2770/24234

    摘要： The present invention relates to methods that employ peptides or peptide derivatives to inhibit hepatitis C virus infection. The present invention is based in part on the discovery that E2 envelope glycoprotein of hepatitis C virus has previously undescribed domains that are important for interactions with cellular or viral proteins that are necessary for early steps in HCV infection. The present invention provides peptides and methods of treatment and prophylaxis of diseases induced by hepatitis C virus and related viruses.

    摘要翻译： 本发明涉及采用肽或肽衍生物抑制丙型肝炎病毒感染的方法。 本发明部分地基于以下发现：丙型肝炎病毒的E2包膜糖蛋白具有对HCV感染早期步骤所必需的与细胞或病毒蛋白相互作用重要的先前未描述的结构域。 本发明提供治疗和预防由丙型肝炎病毒和相关病毒引起的疾病的肽和方法。