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1.发明授权公开(公告)号：US07928239B2
公开(公告)日：2011-04-19
申请号：US09777920
申请日：2001-02-07
申请人： Jacques Dumas , Bernd Riedl , Uday Khire , Jill E. Wood , Robert N. Sibley , Mary-Katherine Monahan , Joel Renick , David E. Gunn , Timothy B. Lowinger , William J. Scott , Roger A. Smith
发明人： Jacques Dumas , Bernd Riedl , Uday Khire , Jill E. Wood , Robert N. Sibley , Mary-Katherine Monahan , Joel Renick , David E. Gunn , Timothy B. Lowinger , William J. Scott , Roger A. Smith
IPC分类号： C07D401/02 , A61K31/44 , A61K31/47
CPC分类号： C07D213/75 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/36 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/48 , C07D213/81 , C07D213/82 , C07D215/38 , C07D217/22 , C07D295/13 , C07D295/135 , C07D295/192 , C07D307/14 , C07D401/12
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途，以及用于此类治疗的药物组合物。
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2.发明申请Inhibition Of Raf Kinase Using Quinolyl, Isoquinolyl Or Pyridyl Ureas 审中-公开使用喹啉基，异喹啉基或吡啶基脲进行Raf激酶的抑制公开(公告)号：US20080194580A1
公开(公告)日：2008-08-14
申请号：US11932269
申请日：2007-10-31
申请人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert N. Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David E. Gunn , Timotthy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood
发明人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert N. Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David E. Gunn , Timotthy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood
IPC分类号： A61K31/496 , A61K31/444 , A61K31/44 , A61P35/00 , A61K31/47
CPC分类号： C07D213/40
摘要： This invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.
摘要翻译： 本发明涉及一组喹啉基，异喹啉基和吡啶基脲，它们在治疗raf介导的疾病中的用途，以及包含用于这种治疗的这些尿素的药物组合物。
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公开(公告)号：US20080108672A1
公开(公告)日：2008-05-08
申请号：US11768104
申请日：2007-06-25
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
IPC分类号： A61K31/44 , C07C275/40 , A61P35/00 , C07C275/38
CPC分类号： C07C275/40 , C07C275/30 , C07C275/34 , C07D213/81 , C07D401/12
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
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4.发明申请SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY 审中-公开取代的吡啶类和吡嗪类与成血活性抑制活性公开(公告)号：US20110263597A1
公开(公告)日：2011-10-27
申请号：US13177833
申请日：2011-07-07
申请人： Jacques P. Dumas , Stephen James Boyer , Julie A. Dixon , Teddy Kite Joe , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
发明人： Jacques P. Dumas , Stephen James Boyer , Julie A. Dixon , Teddy Kite Joe , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
IPC分类号： A61K31/5377 , A61K31/5025 , A61P17/06 , A61P27/02 , A61P19/02 , A61K31/4725 , A61P35/00
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： Methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using substituted pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents.
摘要翻译： 使用具有血管生成抑制活性的取代哒嗪治疗具有异常血管生成或超渗性过程特征的哺乳动物的方法及其广泛结构式，其中含有A，B，D，E和L的环是苯基或含氮杂环; 基团X和Y可以是各种定义的连接单元中的任何一种; R 1和R 2可以被定义为独立的取代基或一起可以是环定义的桥; 环J可以是芳基，吡啶基或环烷基; 和G基团可以是各种定义的取代基中的任何一种。
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5.发明授权公开(公告)号：US07977333B2
公开(公告)日：2011-07-12
申请号：US10720702
申请日：2003-11-24
申请人： Jacques P. Dumas , Stephen J. Boyer , Julie A. Dixon , Teddy K. Joe , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
发明人： Jacques P. Dumas , Stephen J. Boyer , Julie A. Dixon , Teddy K. Joe , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
IPC分类号： A61K31/535 , A61K31/50 , C07D237/30 , C07D237/32 , C07D237/34 , C07D413/14
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： Substituted and pyridines and pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
摘要翻译： 具有血管生成抑制活性的取代的吡啶和哒嗪和广义结构式，其中含有A，B，D，E和L的环是苯基或含氮杂环; 基团X和Y可以是各种定义的连接单元中的任何一种; R 1和R 2可以被定义为独立的取代基或一起可以是环定义的桥; 环J可以是芳基，吡啶基或环烷基; 和G基团可以是各种定义的取代基中的任何一种。 还公开了含有这些材料的药物组合物，以及使用这些材料治疗具有异常血管生成或超敏性过程特征的病症的哺乳动物的方法。
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6.发明授权公开(公告)号：US07235576B1
公开(公告)日：2007-06-26
申请号：US10042203
申请日：2002-01-11
申请人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
发明人： Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
IPC分类号： A61K31/17 , A61K31/44 , C07D213/30 , C07C275/18 , C07C275/34
CPC分类号： C07D209/48 , C07D213/75 , C07D213/81 , C07D401/12
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途，以及用于此类治疗的药物组合物。
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7.发明申请OMEGA CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS 审中-公开OMEGA CARBOXYARYL替代二苯醚作为RAF激酶抑制剂公开(公告)号：US20120040986A1
公开(公告)日：2012-02-16
申请号：US13208010
申请日：2011-08-11
申请人： Bernd RIEDL , Jacques DUMAS , Uday KHIRE , Timothy B. LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD , Mary-Katherine MONAHAN , Reina NATERO , Joel RENICK , Robert N. SIBLEY
发明人： Bernd RIEDL , Jacques DUMAS , Uday KHIRE , Timothy B. LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD , Mary-Katherine MONAHAN , Reina NATERO , Joel RENICK , Robert N. SIBLEY
IPC分类号： A61K31/5377 , A61K31/17 , C07D209/44 , A61K31/4035 , C07D211/70 , A61P35/00 , C07D213/63 , C07D413/12 , C07D403/04 , A61K31/497 , C07D241/04 , A61K31/4965 , C07C275/28 , A61K31/44
CPC分类号： C07C275/40 , C07C275/30 , C07C275/34 , C07D213/81 , C07D401/12
摘要： This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途，以及用于此类治疗的药物组合物。
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8.发明授权Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity 失效取代哒嗪和熔融哒嗪与血管生成抑制活性公开(公告)号：US06903101B1
公开(公告)日：2005-06-07
申请号：US09636519
申请日：2000-08-10
申请人： Jacques P. Dumas , Stephen James Boyer , Teddy Kite Joe , Holia N. Hatoum-Mokdad , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
发明人： Jacques P. Dumas , Stephen James Boyer , Teddy Kite Joe , Holia N. Hatoum-Mokdad , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
IPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D401/08 , A61K31/502 , A61P35/00
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12
摘要： Substituted and Fused pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
摘要翻译： 具有血管发生抑制活性的取代和稠合的哒嗪和广义结构式，其中含有A，B，D，E和L的环是含氮杂环; 基团X和Y可以是各种定义的连接单元中的任何一种; R 1和R 2可以是独立的取代基或一起可以是环定义的桥; 环J可以是芳基，吡啶基或环烷基; 和G基团可以是各种定义的取代基中的任何一种。 还公开了含有这些材料的药物组合物，以及使用这些材料治疗具有异常血管生成或超敏性过程特征的病症的哺乳动物的方法。
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9.发明授权公开(公告)号：US06689883B1
公开(公告)日：2004-02-10
申请号：US09672294
申请日：2000-09-28
申请人： Jacques P. Dumas , Stephen James Boyer , Julie A. Dixon , Teddy Kite Joe , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
发明人： Jacques P. Dumas , Stephen James Boyer , Julie A. Dixon , Teddy Kite Joe , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
IPC分类号： C07D23714
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： Substituted pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
摘要翻译： 含有A，B，D，E和L的环的具有血管生成抑制活性的取代的哒嗪和广泛结构的哒嗪是苯基或含氮杂环; 基团X和Y可以是各种定义的连接单元中的任何一种; R 1和R 2可以被定义为独立的取代基或一起可以是环定义的桥; 环J可以是芳基，吡啶基或环烷基; 和G基团可以是各种定义的取代基中的任何一种。 还公开了含有这些材料的药物组合物，以及使用这些材料治疗具有异常血管生成或超敏性过程特征的病症的哺乳动物的方法。
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10.发明授权公开(公告)号：US07897623B2
公开(公告)日：2011-03-01
申请号：US11845597
申请日：2007-08-27
申请人： Bernd Riedl , Jacques Dumas , Uday R. Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
发明人： Bernd Riedl , Jacques Dumas , Uday R. Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
IPC分类号： A61K31/44
CPC分类号： A61K31/5377 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/473
摘要： This invention relates to the use of a group of aryl ureas in treating p38 mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗p38介导的疾病中的用途，以及用于此类治疗的药物组合物。
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