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1.Biocompatible crosslinked hydrogels, drug-loaded hydrogels and methods of using the same 有权
标题翻译: 生物相容性交联水凝胶,载药水凝胶及其使用方法公开(公告)号:US09125814B2
公开(公告)日:2015-09-08
申请号:US12428411
申请日:2009-04-22
申请人: Yuehua He , Aniko Takacs-Cox , Anthony Boey , Brent Zaluski , Roger A. Smith , Audrey A. Deschamps , Rui Avelar
发明人: Yuehua He , Aniko Takacs-Cox , Anthony Boey , Brent Zaluski , Roger A. Smith , Audrey A. Deschamps , Rui Avelar
IPC分类号: A61K9/10 , A61K38/20 , A61K38/48 , A61K38/16 , A61K31/445 , A61K31/4025 , A61K31/10 , A61K31/08 , C07D403/14 , C07C317/00 , C07C43/04 , A61K9/06 , A61K9/00 , A61K47/34 , A61L24/00 , A61L26/00 , A61L31/14 , A61L31/16 , C08G65/331 , C08G65/332 , C08G65/333 , C08G65/334 , C08G65/337
CPC分类号: A61L26/0019 , A61K9/0024 , A61K9/06 , A61K47/34 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L26/0066 , A61L26/008 , A61L26/009 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/204 , A61L2300/402 , C07D403/14 , C08G65/00 , C08G65/3312 , C08G65/3324 , C08G65/33317 , C08G65/33337 , C08G65/33368 , C08G65/3342 , C08G65/337 , C08J3/075 , C08J2371/00 , C08L2203/02
摘要: Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.
摘要翻译: 公开了由一个被一个或多个聚乙二醇取代的四甲基甲烷的混合物形成的水凝胶组合物,其中每个聚乙二醇取代基独立地被一个或多个亲电基团进一步取代,和被一个或多个聚乙二醇取代的四甲基甲烷, 聚乙二醇取代基独立地被一个或多个亲核基团进一步取代。 还公开了制备上述水凝胶的方法。 水凝胶组合物可以进一步包含药物,例如止痛剂或局部麻醉剂。 还公开了使用所公开的水凝胶密封伤口,防止手术后粘连和减少手术后疼痛的方法。
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2.Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors 有权
标题翻译: ω-羧基芳基取代的二苯脲作为raf激酶抑制剂公开(公告)号:US08841330B2
公开(公告)日:2014-09-23
申请号:US13368812
申请日:2012-02-08
申请人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood
发明人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood
IPC分类号: A61K31/44
CPC分类号: C07C275/36 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/46 , C07D209/48 , C07D213/75 , C07D213/81 , C07D213/82 , C07D295/13 , C07D295/135 , C07D295/192 , C07D413/12
摘要: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途,以及用于此类治疗的药物组合物。
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3.INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS 审中-公开
标题翻译: 使用取代的杂环类抗生素抑制P38激酶活性公开(公告)号:US20120149706A1
公开(公告)日:2012-06-14
申请号:US13401272
申请日:2012-02-21
申请人: Jacques DUMAS , Uday KHIRE , Timothy B. Lowinger , Holger PAULSEN , Bernd RIEDL , Willian J. SCOTT , Roger A. SMITH , Jill WOOD , Holia HATOUM-MOKDAD , Wendy LEE , Aniko REDMAN , Jeffrey JOHNSON , Robert SIBLEY
发明人: Jacques DUMAS , Uday KHIRE , Timothy B. Lowinger , Holger PAULSEN , Bernd RIEDL , Willian J. SCOTT , Roger A. SMITH , Jill WOOD , Holia HATOUM-MOKDAD , Wendy LEE , Aniko REDMAN , Jeffrey JOHNSON , Robert SIBLEY
IPC分类号: A61K31/42 , C07D413/12 , A61K31/4439 , A61K31/497 , A61K31/506 , A61P37/06 , A61P29/00 , A61P37/02 , A61P19/10 , A61P19/02 , A61P11/06 , A61P1/00 , C07D261/14 , A61K31/5377
CPC分类号: C07D231/40 , A61K31/381 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/428 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/506 , C07D261/14 , Y02A50/411
摘要: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases, other than cancer and proteolytic enzyme mediated diseases, other than cancer, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲处理细胞因子介导的疾病,除了癌症以外的癌症和蛋白水解酶介导的疾病,以及用于这种治疗的药物组合物。
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公开(公告)号:US08013166B2
公开(公告)日:2011-09-06
申请号:US12231878
申请日:2008-09-05
申请人: Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人: Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号: C07D277/42 , C07D277/62 , C07D263/34 , C07D263/58
CPC分类号: C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要: This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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5.Preparation and use of aryl alkyl acid derivatives for the treatment of obesity 失效
标题翻译: 芳基烷基酸衍生物的制备和用途用于治疗肥胖症公开(公告)号:US07968576B2
公开(公告)日:2011-06-28
申请号:US12206721
申请日:2008-09-08
申请人: Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人: Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号: A61K31/4168 , A61K31/421 , A61K31/426 , C07D277/42 , C07D277/82 , C07D263/48 , C07D263/58 , C07D233/88 , C07D235/30
CPC分类号: C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要: This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译: 本发明涉及某些芳基烷基酸化合物,组合物和治疗或预防肥胖症和相关疾病的方法。
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6.2-oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatory disorders 失效
标题翻译: 可用于治疗高增殖性,血管生成和炎症性疾病的2-氧代-1,3,5-三氢三氮杂衍生物公开(公告)号:US07928227B2
公开(公告)日:2011-04-19
申请号:US10788405
申请日:2004-03-01
申请人: Stephen Boyer , Jacques Dumas , Barton Phillips , William J. Scott , Roger A. Smith , Jianqing Chen , Benjamin Jones , Gan Wang
发明人: Stephen Boyer , Jacques Dumas , Barton Phillips , William J. Scott , Roger A. Smith , Jianqing Chen , Benjamin Jones , Gan Wang
IPC分类号: C07D251/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/53 , A61P19/02
CPC分类号: C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要: This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译: 本发明涉及新的二芳基脲,含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍,作为唯一试剂或与细胞毒性疗法组合的用途。
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7.Preparation and Use of Biphenyl Amino Acid Derivatives for the Treatment of Obesity 审中-公开
标题翻译: 联苯氨基酸衍生物治疗肥胖症的制备与应用公开(公告)号:US20100016295A1
公开(公告)日:2010-01-21
申请号:US11989506
申请日:2006-07-31
申请人: Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
发明人: Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
IPC分类号: A61K31/198 , C07D211/60 , A61P3/04 , A61K31/44 , C07C229/02 , C07D207/00 , A61K31/40 , C07D261/18 , A61K31/42 , C07D307/00 , A61K31/34 , C07D209/42 , C07D279/12 , A61K31/54 , C07D265/30 , A61K31/5375 , C07D241/04 , A61K31/4965
CPC分类号: C07D211/60 , C07C237/36 , C07C237/42 , C07C275/42 , C07C311/46 , C07C311/47 , C07D207/16 , C07D207/48 , C07D209/08 , C07D209/42 , C07D213/75 , C07D307/84 , C07D413/12
摘要: This invention relates to certain biphenyl amino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译: 本发明涉及某些联苯氨基酸化合物,组合物和治疗或预防肥胖症和相关疾病的方法。
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8.Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors 有权
标题翻译: ω-羧基芳基取代的二苯脲作为raf激酶抑制剂公开(公告)号:US07235576B1
公开(公告)日:2007-06-26
申请号:US10042203
申请日:2002-01-11
申请人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
发明人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
IPC分类号: A61K31/17 , A61K31/44 , C07D213/30 , C07C275/18 , C07C275/34
CPC分类号: C07D209/48 , C07D213/75 , C07D213/81 , C07D401/12
摘要: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途,以及用于此类治疗的药物组合物。
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公开(公告)号:US06960601B2
公开(公告)日:2005-11-01
申请号:US10255049
申请日:2002-09-24
申请人: Roger A. Smith , Stephen J. O'Connor , Stephan-Nicholas Wirtz , Wai C. Wong , Soongyu Choi , Harold C. E. Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
发明人: Roger A. Smith , Stephen J. O'Connor , Stephan-Nicholas Wirtz , Wai C. Wong , Soongyu Choi , Harold C. E. Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
IPC分类号: A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P15/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P25/30 , A61P35/00 , C07D233/90 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/08 , C07D417/14 , A61K31/445
CPC分类号: C07D401/06 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14
摘要: This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
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10.2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效
标题翻译: 用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号:US06919371B2
公开(公告)日:2005-07-19
申请号:US10666903
申请日:2003-09-17
申请人: Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人: Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号: A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/352
CPC分类号: C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译: 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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