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1.OMEGA-CARBOXYARL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS 审中-公开
标题翻译: 作为RAF激酶抑制剂的OMEGA-CARBOXYARL替代二苯醚公开(公告)号:US20140329866A1
公开(公告)日:2014-11-06
申请号:US14333533
申请日:2014-07-17
申请人: Bernd RIEDL , Jacques DUMAS , Uday KHIRE , Timothy LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD
发明人: Bernd RIEDL , Jacques DUMAS , Uday KHIRE , Timothy LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD
IPC分类号: C07C275/36 , C07D209/46 , C07D213/82 , C07D213/81 , C07D413/12 , C07D209/48 , C07D213/75
CPC分类号: C07C275/36 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/46 , C07D209/48 , C07D213/75 , C07D213/81 , C07D213/82 , C07D295/13 , C07D295/135 , C07D295/192 , C07D413/12
摘要: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途,以及用于此类治疗的药物组合物。
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公开(公告)号:US20120136157A1
公开(公告)日:2012-05-31
申请号:US13365687
申请日:2012-02-03
申请人: Jacques Dumas , William J. Scott , Du-Shieng Chien , Ala Nassar , Wendy Lee , Susan Bjorge , Laszlo L. Musza , Bernd Riedl
发明人: Jacques Dumas , William J. Scott , Du-Shieng Chien , Ala Nassar , Wendy Lee , Susan Bjorge , Laszlo L. Musza , Bernd Riedl
IPC分类号: C07D213/81
CPC分类号: C07D213/79 , C07D213/81 , C07D213/89
摘要: This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.
摘要翻译: 本发明涉及新的芳基脲及其合成方法。 本发明化合物可用于治疗(i)raf介导的疾病,例如癌症,(ii)p38介导的疾病如炎症和骨质疏松症,和(iii)VEGF介导的疾病如血管生成障碍。
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公开(公告)号:US20120046290A1
公开(公告)日:2012-02-23
申请号:US11932548
申请日:2007-10-31
申请人: Jacques Dumas , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill Wood , Holia Hatoum-Mokdad , Wendy Lee , Aniko Redman , Jeffrey Johnson , Robert Sibley
发明人: Jacques Dumas , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill Wood , Holia Hatoum-Mokdad , Wendy Lee , Aniko Redman , Jeffrey Johnson , Robert Sibley
IPC分类号: A61K31/42 , A61K31/428 , A61K31/422 , A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/5377 , C07D261/14 , C07D231/40 , A61K31/415 , A61P29/00 , A61P19/02 , A61P19/10 , A61P11/06 , A61P1/00 , A61P31/00 , A61K31/4439
CPC分类号: C07D231/40 , A61K31/381 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/428 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/506 , C07D261/14 , Y02A50/411
摘要: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases, other than cancer and proteolytic enzyme mediated diseases, other than cancer, and pharmaceutical compositions for use in such therapy.
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公开(公告)号:US08110587B2
公开(公告)日:2012-02-07
申请号:US10361859
申请日:2003-02-11
申请人: Jacques Dumas , William J. Scott , Bernd Riedl , Du-Schieng Chien , Ala Nassar , Wendy Lee , Susan Bjorge , Laszlo Musza
发明人: Jacques Dumas , William J. Scott , Bernd Riedl , Du-Schieng Chien , Ala Nassar , Wendy Lee , Susan Bjorge , Laszlo Musza
IPC分类号: A61K31/44 , C07D211/72 , C07D211/92
CPC分类号: C07D213/79 , C07D213/81 , C07D213/89
摘要: This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.
摘要翻译: 本发明涉及新的芳基脲及其合成方法。 本发明化合物可用于治疗(i)raf介导的疾病,例如癌症,(ii)p38介导的疾病如炎症和骨质疏松症,和(iii)VEGF介导的疾病如血管生成障碍。
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5.Bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权
标题翻译: 用于治疗癌症和其他疾病的双环脲衍生物公开(公告)号:US08076488B2
公开(公告)日:2011-12-13
申请号:US10788426
申请日:2004-03-01
申请人: Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人: Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号: C07D213/62 , C07D401/00 , C07D417/00
CPC分类号: C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要: This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译: 本发明涉及新的二芳基脲,含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍,作为唯一试剂或与细胞毒性疗法组合的用途。
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6.
公开(公告)号:US07897623B2
公开(公告)日:2011-03-01
申请号:US11845597
申请日:2007-08-27
申请人: Bernd Riedl , Jacques Dumas , Uday R. Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
发明人: Bernd Riedl , Jacques Dumas , Uday R. Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
IPC分类号: A61K31/44
CPC分类号: A61K31/5377 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/473
摘要: This invention relates to the use of a group of aryl ureas in treating p38 mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗p38介导的疾病中的用途,以及用于此类治疗的药物组合物。
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公开(公告)号:US07838541B2
公开(公告)日:2010-11-23
申请号:US10361858
申请日:2003-02-11
IPC分类号: C07D213/02 , A61K31/44
CPC分类号: A61K31/5377 , A61K31/17 , A61K31/40 , A61K31/421 , A61K31/426 , A61K31/44 , A61K31/4436 , A61K31/445 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/54 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/473
摘要: This invention relates to methods of using aryl ureas to treat diseases mediated by the VEGF induced signal transduction pathway characterized by abnormal angiogenesis or hyperpermeability processes.
摘要翻译: 本发明涉及使用芳基脲来治疗由VEGF诱导的信号转导途径介导的疾病的方法,其特征在于异常血管生成或高渗透性过程。
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8.OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS 审中-公开
标题翻译: OMEGA-CARBOXY ARYL替代二苯醚作为p38激酶抑制剂公开(公告)号:US20090118268A1
公开(公告)日:2009-05-07
申请号:US12249386
申请日:2008-10-10
申请人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
发明人: Bernd Riedl , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , Mary-Katherine Monahan , Reina Natero , Joel Renick , Robert N. Sibley
IPC分类号: A61K31/17 , A61K31/4035 , A61K31/4412 , A61K31/5375 , A61K31/495 , A61K31/496 , A61K31/4453 , A61K31/341 , A61K31/40 , A61P35/00 , A61P19/00
CPC分类号: A61K31/5377 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/473
摘要: This invention relates to the use of a group of aryl ureas in treating p38 mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗p38介导的疾病中的用途,以及用于此类治疗的药物组合物。
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9.Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas 失效
标题翻译: 使用对称和不对称二苯脲抑制p38激酶公开(公告)号:US07517880B2
公开(公告)日:2009-04-14
申请号:US10060396
申请日:2002-02-01
申请人: Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
发明人: Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , William J. Scott , Roger A. Smith , Jill E. Wood , David E. Gunn , Holia Hatoum-Mokdad , Marell Rodriguez , Robert Sibley , Ming Wang , Tiffany Turner , Catherine Brennan
IPC分类号: A61K31/40 , A61K31/44 , A61K31/535 , C07D333/22 , C07D233/61
CPC分类号: A61K31/17 , A61K31/341 , A61K31/381 , A61K31/4035 , A61K31/44 , A61K31/5375 , Y02A50/411
摘要: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗细胞因子介导的疾病和蛋白水解酶介导的疾病中的用途,以及用于这种治疗的药物组合物。
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10.Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas 审中-公开
标题翻译: 使用对称和非对称取代的二苯基脲对Raf激酶的抑制公开(公告)号:US20080269265A1
公开(公告)日:2008-10-30
申请号:US12145679
申请日:2008-06-25
申请人: Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , David Gunn , Martha Rodriguez , Ming Wang , Tiffany Turner , Catherine Brennan
发明人: Scott Miller , Martin Osterhout , Jacques Dumas , Uday Khire , Timothy B. Lowinger , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , David Gunn , Martha Rodriguez , Ming Wang , Tiffany Turner , Catherine Brennan
IPC分类号: A61K31/17 , C07D213/70 , C07D213/63 , C07D409/12 , C07D401/12 , C07D277/68 , C07D215/20 , C07D239/38 , A61P35/00 , A61K31/505 , A61K31/47 , A61K31/444 , A61K31/4439 , A61K31/4436 , A61K31/428
CPC分类号: C07D409/12 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/40 , C07D213/40 , C07D213/50 , C07D213/68 , C07D213/69 , C07D213/70 , C07D213/81 , C07D213/89 , C07D215/20 , C07D239/38 , C07D277/68 , C07D317/64 , C07D401/04 , C07D401/12
摘要: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途,以及用于此类治疗的药物组合物。
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