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    FEDERATED LEARNING OF MEDICAL VALIDATION MODEL
    1.
    发明申请
    FEDERATED LEARNING OF MEDICAL VALIDATION MODEL 有权

    公开(公告)号：US20250037861A1

    公开(公告)日：2025-01-30

    申请号：US18696634

    申请日：2021-11-01

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Yi YAO ,  Wei Bin XING ,  Xiao Jun TAO ,  Jing QIAN ,  Qi ZHOU ,  Chenxi ZHANG ,  Yin QIAN

    IPC: G16H50/20 ,  G16H10/40 ,  G16H15/00 ,  H04W84/02

    Abstract: A computer-implemented method is provided that includes transmitting, by a master node to a plurality of computing nodes, definition information about an initial medical validation model (410): performing, by the master node, a federated learning process together with the plurality of computing nodes (420), to jointly train the initial medical validation model using respective processed local training datasets available at the plurality of computing nodes, the respective local training datasets being processed by the plurality of computing nodes based on the definition information; and determining, by the master node, a final medical validation model based on a result of the federated learning process (430). Through the solution, by means of federated learning, it addresses the data security and privacy concerns from local sites owning.

    MR-PROADM MARKER PANELS FOR EARLY DETECTION OF SEPSIS
    2.
    发明申请
    MR-PROADM MARKER PANELS FOR EARLY DETECTION OF SEPSIS 有权

    公开(公告)号：US20250035629A1

    公开(公告)日：2025-01-30

    申请号：US18696730

    申请日：2022-09-28

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Felix Gruenewald ,  Victor Johann Raul Jeger ,  Martin Klammer ,  Philipp Schuetz ,  Maria von Holtey ,  Stephen Weber ,  Heike Wegmeyer ,  Ursula-Henrike Wienhues-Thelen

    IPC: G01N33/573 ,  G01N33/68

    Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being MR-proADM, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: sFlt-1, GDF15 and ESM1, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being MR-proADM and a second biomarker selected from the group consisting of: sFlt-1, GDF15 and ESM1, or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.

    Method and system to localize a carrier on a laboratory transport system
    4.
    发明授权
    Method and system to localize a carrier on a laboratory transport system 有权

    公开(公告)号：US12196772B2

    公开(公告)日：2025-01-14

    申请号：US17008778

    申请日：2020-09-01

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Riccardo Leone Benedetti ,  Reto Huesser ,  Goran Savatic ,  Norbert Schmitt

    IPC: H04W4/80 ,  G01N35/00 ,  G01N35/04

    Abstract: A method to localize a carrier on a laboratory transport system is presented. The laboratory transport system comprises a carrier associated with an identity, a multi-lane transport module, and a control unit. The carrier comprises a signal transmitter configured to transmit a signal comprising information about the identity. The multi-lane transport module comprises a transport surface comprising a first and a second transport lane as well as a first signal receiver and a second signal receiver each configured to receive the transmitted signal. Based on received signal strengths, the control unit localizes the carrier on one of the transport lanes of the multi-lane transport module.

    DETECTION OF AIR BUBBLES IN OPTICAL DETECTION UNIT
    5.
    发明申请
    DETECTION OF AIR BUBBLES IN OPTICAL DETECTION UNIT 有权

    公开(公告)号：US20240426765A1

    公开(公告)日：2024-12-26

    申请号：US18755464

    申请日：2024-06-26

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Juergen Hildenbrand ,  Alexander Kramlich ,  Michael Lambertson

    IPC: G01N21/94

    Abstract: An in-vitro diagnostic (IVD) analyzer 200 comprising an optical detection unit 217 comprising a cuvette 214 for the optical measurement of a biological sample 2, 2′ is herein disclosed. The IVD analyzer 200 further comprises a piezo actuator 218 arranged on one side of the cuvette 214 configured to transmit ultrasonic waves 254, 254′ through the cuvette 214, a piezo receiver 218′ arranged on the opposite side of the cuvette 214 configured to receive ultrasonic waves 255, 255′, 255″ transmitted through the cuvette 214 and a controller 250 configured to operate according to either a lysis operating mode (L) or an air-detection operating mode (AD). According to the lysis operating mode (L) the piezo actuator 218 is configured to transmit ultrasonic waves 254′ through the cuvette 214 for disrupting cellular particles contained in the biological sample 2. According to the air-detection operating mode (AD) the piezo actuator 218 is configured to transmit ultrasonic waves 254 through the cuvette 214 and the controller 250 is configured to correlate changes in amplitude and/or shifts of phase of the ultrasonic waves 255, 255′, 255″ received by the piezo receiver 218′ relative to reference values with an eventual presence and quantity of air 3 in the cuvette 214, in order to determine if the optical measurement of the biological sample 2, 2′ is affected by the presence of air 3. A respective automated method of operating the in-vitro diagnostic analyzer 200 in order to determine if the optical measurement of the biological sample 2, 2′ is affected by the presence of air is herein also disclosed.

    METHOD FOR IMPROVING CROSS-FLOW FILTRATION AND CROSS-FLOW FILTRATION SYSTEM
    6.
    发明申请
    METHOD FOR IMPROVING CROSS-FLOW FILTRATION AND CROSS-FLOW FILTRATION SYSTEM 有权

    公开(公告)号：US20240409436A1

    公开(公告)日：2024-12-12

    申请号：US18810797

    申请日：2024-08-21

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Carlos Munoz ,  Hans Zahn

    IPC: C02F1/00 ,  C02F103/00

    Abstract: A method of cross-flow filtering wastewater from a diagnostic apparatus or a laboratory analyser, wherein the wastewater comprises nanoparticles and/or microparticles, and the wastewater is streaming in a laminar flow across a surface of a filter membrane, the method comprising: (a) streaming the wastewater across the surface of the filter membrane with a flow rate, so that the flow of the wastewater is a laminar flow with a Reynolds number (Re) of smaller than 500; (b) streaming the wastewater in pulse cycles across the surface of the filter membrane, wherein each pulse cycle comprises one active phase in which the wastewater is under a duty pressure and one inactive phase in which the wastewater is under an inactive pressure, wherein the inactive pressure is no more than 10% of the duty pressure and the active phases have a duration of greater than 50% of the corresponding pulse cycles; and (c) separating the nanoparticles and/or microparticles from the wastewater when the wastewater passes through the filter membrane. Also described is a cross-flow filtration system configured for performing the method.

    HEALTHCARE DATA SYSTEM
    7.
    发明申请
    HEALTHCARE DATA SYSTEM 有权

    公开(公告)号：US20240406146A1

    公开(公告)日：2024-12-05

    申请号：US18421536

    申请日：2024-01-24

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Domenico de Luca

    IPC: H04L9/40

    Abstract: A healthcare data system. The system comprises a data protection entity configured to: sign at least a portion of a routing header of a data packet with a private key held by the data protection entity, the data packet including a payload and a routing header, the payload including healthcare data and the routing header indicating an intended consumer of the data packet; and transmit the data packet on towards the intended consumer. The healthcare data system further comprises one or more data receivers, each configured to: receive the data packet; and verify the signed routing header.

    Calibration management of an in-vitro diagnostic system
    8.
    发明授权
    Calibration management of an in-vitro diagnostic system 有权

    公开(公告)号：US12140601B2

    公开(公告)日：2024-11-12

    申请号：US16714865

    申请日：2019-12-16

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Juliane Drobnik ,  Mirko Klingauf ,  Regula Krieg

    IPC: G01N35/00 ,  G01N35/04

    Abstract: A computer-implemented method of automatically managing calibration of an in-vitro diagnostic system is provided comprising determining a lot calibration time period in which a lot calibration is applicable to reagent containers of the same lot, having a predefined time length starting from the time when the lot calibration becomes available, upon making a reagent container of the lot available to the system, determining whether a lot calibration that has not exceeded the lot calibration time period is available and linking the reagent container to the available lot calibration or most recent available lot calibration if more than one lot calibration is available, wherein if a new lot calibration for the same lot becomes available the method comprises replacing the existing link to the previous lot calibration with a link to the new lot calibration.

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