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    Genetic alterations associated with prostate cancer
    1.
    发明授权
    Genetic alterations associated with prostate cancer 有权
    与前列腺癌相关的遗传改变

    公开(公告)号：US06451529B1

    公开(公告)日：2002-09-17

    申请号：US09294535

    申请日：1999-04-19

    申请人： Ronald H. Jensen ,  Michael L. Cher

    发明人： Ronald H. Jensen ,  Michael L. Cher

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6841 ,  C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/156

    摘要： The present invention provides new probes for the detection of prostate cancer cells. The probes bind selectively with target polynucleotide sequences selected from the group consisting of 2q, 4q, 5q, 6q, 10p, 15q, 1q, 2p, 3q, 3p, 4q, 6p, 7p, 7q, 9q, 11p, 16p, and 17q.

    摘要翻译： 本发明提供了用于检测前列腺癌细胞的新探针。 探针与选自2q，4q，5q，6q，10p，15q，1q，2p，3q，3p，4q，6p，7p，7q，9q，11p，16p和17q的靶多核苷酸序列选择性结合 。

    Monoclonal antibodies to human hemoglobin S and cell lines for the production thereof
    4.
    发明授权
    Monoclonal antibodies to human hemoglobin S and cell lines for the production thereof 失效
    人血红蛋白S的单克隆抗体及其制备的细胞系

    公开(公告)号：US4752583A

    公开(公告)日：1988-06-21

    申请号：US676162

    申请日：1984-11-29

    申请人： Ronald H. Jensen ,  Martin Vanderlaan ,  William L. Bigbee ,  Larry H. Stanker ,  Elbert W. Branscomb ,  Robert J. Grabske

    发明人： Ronald H. Jensen ,  Martin Vanderlaan ,  William L. Bigbee ,  Larry H. Stanker ,  Elbert W. Branscomb ,  Robert J. Grabske

    IPC分类号： G01N33/72 ,  C12N5/00 ,  C07K15/04

    CPC分类号： G01N33/721 ,  Y10S530/861

    摘要： The present invention provides monoclonal antibodies specific to and distinguish between hemoglobin S and hemoglobin A and methods for their production and use. These antibodies are capable of distinguishing between two hemoglobin types which differ from each other by only a single amino acid residue. The antibodies produced according to the present method are useful as immunofluorescent markers to enumerate circulating red blood cells which have the property of altered expression of the hemoglobin gene due to somatic mutation in stem cells. Such a measurement is contemplated as an assay for in vivo cellular somatic mutations in humans. Since the monoclonal antibodies produced in accordance with the instant invention exhibit a high degree of specificity to and greater affinity for hemoglobin S, they are suitable for labeling human red blood cells for flow cytometric detection of hemoglobin genotype.

    摘要翻译： 本发明提供对血红蛋白S和血红蛋白A特异性和区别的单克隆抗体及其生产和使用方法。 这些抗体能够通过仅一个氨基酸残基来区分彼此不同的两种血红蛋白类型。 根据本方法制备的抗体可用作免疫荧光标记物，以列举由于干细胞中的体细胞突变而导致血红蛋白基因表达改变的性质的循环红细胞。 这样的测量被认为是人体内体内细胞体细胞突变的测定。 由于根据本发明产生的单克隆抗体对血红蛋白S表现出高度的特异性和更高的亲和力，所以它们适用于标记人红细胞用于血红蛋白基因型的流式细胞检测。

    Quantitative PCR method to enumerate DNA copy number
    6.
    发明授权
    Quantitative PCR method to enumerate DNA copy number 有权
    定量PCR方法列举DNA拷贝数

    公开(公告)号：US06180349B2

    公开(公告)日：2001-01-30

    申请号：US09314246

    申请日：1999-05-18

    申请人： David G. Ginzinger ,  Tony E. Godfrey ,  Ronald H. Jensen ,  Joe W. Gray

    发明人： David G. Ginzinger ,  Tony E. Godfrey ,  Ronald H. Jensen ,  Joe W. Gray

    IPC分类号： C07H2102

    CPC分类号： C07H21/00

    摘要： The present invention provides rapid and inexpensive methods for determining the copy number of a test locus of interest. The methods generally involve monitoring the formation of amplification product using real time amplification detection systems to quantify the amount of test locus and reference loci in a test subject and the amount of test locus and reference loci in at least one control subject. The methods can be used to interrogate the copy number of loci containing simple sequence repeats. Since such sequences are ubiquitous in eukaryotic genomes, the present methods have wide-ranging applicability. The methods of the present invention can be used as diagnostic and prognostic tools and in correlating abnormal copy number values for specific loci with disease and effectiveness of different treatment options.

    摘要翻译： 本发明提供用于确定感兴趣的测试轨迹的拷贝数的快速和便宜的方法。 所述方法通常涉及使用实时放大检测系统来监测扩增产物的形成，以量化测试受试者中的测试基因座和参考基因座的数量以及至少一个对照受试者中的测试基因座和参考基因座的量。 该方法可用于询问含有简单序列重复序列的拷贝数。 由于这些序列在真核基因组中普遍存在，因此本方法具有广泛的适用性。 本发明的方法可用作诊断和预后工具，并将特定基因座的异常拷贝数值与疾病和不同治疗方案的有效性相关联。