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1.发明授权Cell lines for the production of monoclonal antibodies to human glycophorin A 失效用于生产人血型糖蛋白A的单克隆抗体的细胞系
公开(公告)号：US4767710A
公开(公告)日：1988-08-30
申请号：US734312
申请日：1985-05-15
申请人： William L. Bigbee , Stella S. N. Fong , Ronald H. Jensen , Martin Vanderlaan , Richard G. Langlois
发明人： William L. Bigbee , Stella S. N. Fong , Ronald H. Jensen , Martin Vanderlaan , Richard G. Langlois
摘要： Cloned mouse hybridoma cell lines have been established which continuously produce antibodies that differentiate between the M and N forms of human glycophorin A. These antibodies have potential application as human blood group reagents, as markers for terminally differentiated erythroid cells and as immunofluorescent labels of somatically variant human erythrocytes.
摘要翻译： 已经建立了克隆的小鼠杂交瘤细胞系，其连续产生区分人血型糖蛋白A的M和N形式的抗体。这些抗体具有作为人血型试剂的潜在应用，作为终末分化的红细胞的标志物和体细胞变异体的免疫荧光标记 人类红细胞。
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2.发明授权Monoclonal antibodies to human glycophorin A and cell lines for the production thereof 失效人血型糖蛋白A的单克隆抗体及其制备的细胞系
公开(公告)号：US4752582A
公开(公告)日：1988-06-21
申请号：US676339
申请日：1984-11-29
申请人： Martin Vanderlaan , William L. Bigbee , Ronald H. Jensen , Stella S. N. Fong , Richard G. Langlois
发明人： Martin Vanderlaan , William L. Bigbee , Ronald H. Jensen , Stella S. N. Fong , Richard G. Langlois
CPC分类号： C07K16/34
摘要： Cloned mouse hybridoma cell lines have been established which continuously produce antibodies that are highly specific to and exhibit high affinity for glycophorin A.sup.N and differentiate between the M and N forms of human glycophorin A.
摘要翻译： 已经建立了克隆的小鼠杂交瘤细胞系，其连续地产生对血型糖蛋白AN高度特异性并表现出高亲和力的抗体，并区分M型和N型人血型糖蛋白A.
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公开(公告)号：US07972818B2
公开(公告)日：2011-07-05
申请号：US11454478
申请日：2006-06-16
CPC分类号： C12Q1/6851 , C12Q1/686 , C12Q2565/626 , C12Q2563/155 , C12Q2561/101 , C12Q2537/143
摘要： Disclosed herein are two methods for rapid multiplex analysis to determine the presence and identity of target DNA sequences within a DNA sample. Both methods use reporting DNA sequences, e.g., modified conventional Taqman® probes, to combine multiplex PCR amplification with microsphere-based hybridization using flow cytometry means of detection. Real-time PCR detection can also be incorporated. The first method uses a cyanine dye, such as, Cy3™, as the reporter linked to the 5′ end of a reporting DNA sequence. The second method positions a reporter dye, e.g., FAM™ on the 3′ end of the reporting DNA sequence and a quencher dye, e.g., TAMRA™, on the 5′ end.
摘要翻译： 本文公开了用于快速多重分析以确定DNA样品中靶DNA序列的存在和身份的两种方法。 两种方法使用报告DNA序列，例如修饰的常规探针，使用流式细胞术检测方法将多重PCR扩增与基于微球的杂交组合。 也可以并入实时PCR检测。 第一种方法使用花青染料，例如Cy3 TM作为与报告DNA序列的5'末端连接的报告物。 第二种方法将报告染料，例如FAM TM置于报告DNA序列的3'末端，并在5'端定位猝灭剂染料，例如TAMRA TM。
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公开(公告)号：US20110027781A1
公开(公告)日：2011-02-03
申请号：US12786248
申请日：2010-05-24
申请人： Richard G. Langlois , Fred P. Milanovich , Billy W. Colston, JR. , Steve B. Brown , Don A. Masquelier , Ray P. Mariella , Kodomudi Venkateswaran
发明人： Richard G. Langlois , Fred P. Milanovich , Billy W. Colston, JR. , Steve B. Brown , Don A. Masquelier , Ray P. Mariella , Kodomudi Venkateswaran
IPC分类号： C12Q1/68 , G01N33/566
CPC分类号： G01N1/2202 , G01N1/2211 , G01N15/1459 , G01N35/08 , G01N2001/2217 , G06F19/00 , Y02A90/26
摘要： An autonomous monitoring system for monitoring for bioagents. A collector gathers the air, water, soil, or substance being monitored. A sample preparation means for preparing a sample is operatively connected to the collector. A detector for detecting the bioagents in the sample is operatively connected to the sample preparation means. One embodiment of the present invention includes confirmation means for confirming the bioagents in the sample.
摘要翻译： 一个用于监测生物标签的自主监测系统。 收集者收集被监测的空气，水，土壤或物质。 用于制备样品的样品制备装置可操作地连接到收集器。 用于检测样品中的生物试剂的检测器可操作地连接到样品制备装置。 本发明的一个实施方案包括用于确认样品中的生物试剂的确认装置。
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公开(公告)号：US09052255B2
公开(公告)日：2015-06-09
申请号：US12786248
申请日：2010-05-24
申请人： Richard G. Langlois , Fred P. Milanovich , Billy W. Colston, Jr. , Steve B. Brown , Don A. Masquelier , Raymond P. Mariella, Jr. , Kodomudi Venkateswaran
发明人： Richard G. Langlois , Fred P. Milanovich , Billy W. Colston, Jr. , Steve B. Brown , Don A. Masquelier , Raymond P. Mariella, Jr. , Kodomudi Venkateswaran
CPC分类号： G01N1/2202 , G01N1/2211 , G01N15/1459 , G01N35/08 , G01N2001/2217 , G06F19/00 , Y02A90/26
摘要： An autonomous monitoring system for monitoring for bioagents. A collector gathers the air, water, soil, or substance being monitored. A sample preparation means for preparing a sample is operatively connected to the collector. A detector for detecting the bioagents in the sample is operatively connected to the sample preparation means. One embodiment of the present invention includes confirmation means for confirming the bioagents in the sample.
摘要翻译： 一个用于监测生物标签的自主监测系统。 收集者收集被监测的空气，水，土壤或物质。 用于制备样品的样品制备装置可操作地连接到收集器。 用于检测样品中的生物试剂的检测器可操作地连接到样品制备装置。 本发明的一个实施方案包括用于确认样品中的生物试剂的确认装置。
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公开(公告)号：US07083951B2
公开(公告)日：2006-08-01
申请号：US10077321
申请日：2002-02-14
CPC分类号： C12Q1/6851 , C12Q1/686 , C12Q2565/626 , C12Q2563/155 , C12Q2561/101 , C12Q2537/143
摘要： Disclosed herein are two methods for rapid multiplex analysis to determine the presence and identity of target DNA sequences within a DNA sample. Both methods use reporting DNA sequences, e.g., modified conventional Taqman® probes, to combine multiplex PCR amplification with microsphere-based hybridization using flow cytometry means of detection. Real-time PCR detection can also be incorporated. The first method uses a cyanine dye, such as, Cy3™, as the reporter linked to the 5′ end of a reporting DNA sequence. The second method positions a reporter dye, e.g., FAM, on the 3′ end of the reporting DNA sequence and a quencher dye, e.g., TAMRA, on the 5′ end.
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