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1.发明申请公开(公告)号：US20100196452A1
公开(公告)日：2010-08-05
申请号：US12524688
申请日：2008-01-24
申请人： Robson Augusto Souza dos Santos , Ruben Dario Sinisterra Millan , Frederic Jean Georges Frezard , Andrey Christian da Costa Goncalves , Rodrigo Araujo Fraga da Silva
发明人： Robson Augusto Souza dos Santos , Ruben Dario Sinisterra Millan , Frederic Jean Georges Frezard , Andrey Christian da Costa Goncalves , Rodrigo Araujo Fraga da Silva
CPC分类号： A61K38/085 , A61K31/165 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of Ang-(1-7) and/or Ang-(1-7) receptor agonist and/or Ang (1-7) analogue in treating/restoring erectile dysfunction.
摘要翻译： 本发明涉及Ang-（1-7）和/或Ang-（1-7）受体激动剂和/或Ang（1-7）类似物在治疗/恢复勃起功能障碍中的用途。
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2.发明授权公开(公告)号：US08575111B2
公开(公告)日：2013-11-05
申请号：US12524688
申请日：2008-01-24
申请人： Robson Augusto Souza dos Santos , Ruben Dario Sinisterra Millan , Frederic Jean Georges Frezard , Andrey Christian da Costa Goncalves , Rodrigo Araujo Fraga da Silva
发明人： Robson Augusto Souza dos Santos , Ruben Dario Sinisterra Millan , Frederic Jean Georges Frezard , Andrey Christian da Costa Goncalves , Rodrigo Araujo Fraga da Silva
CPC分类号： A61K38/085 , A61K31/165 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of Ang-(1-7) and/or Ang-(1-7) receptor agonist and/or Ang (1-7) analogue in treating/restoring erectile dysfunction.
摘要翻译： 本发明涉及Ang-（1-7）和/或Ang-（1-7）受体激动剂和/或Ang（1-7）类似物在治疗/恢复勃起功能障碍中的用途。
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3.发明申请Inhibitors of Phosphodiesterase Types 1 To 5 Based on Dioclein, Floranol, and Analogs Thereof 审中-公开基于Dioclein，Floranol及其类似物的1型至5型磷酸二酯酶抑制剂公开(公告)号：US20090270495A1
公开(公告)日：2009-10-29
申请号：US11887564
申请日：2006-03-30
申请人： Virginia Soares Lemos , Stayner De Franca Cortes , Bruno Almeida Resende , Roberta Lins Goncalves , Ruben Dario Sinisterra Milan , Martine Schmitt , Claire Lugnier , Jean-Jacques Bourguignon
发明人： Virginia Soares Lemos , Stayner De Franca Cortes , Bruno Almeida Resende , Roberta Lins Goncalves , Ruben Dario Sinisterra Milan , Martine Schmitt , Claire Lugnier , Jean-Jacques Bourguignon
IPC分类号： A61K31/352 , A61P9/10
CPC分类号： A61K9/1647 , A61K31/352 , A61K47/6951 , B82Y5/00
摘要： We disclose substances and a process of developing such substances as potent and selective inhibitors of isoforms of phosphodiesterases of types 1 to 5 (PDE1, PDE2, PDE3, PDE4, PDE5) based on two flavonoids: dioclein, floranol and natural or synthetic analogs thereof. They may be associated with cyclodextrins in inclusion complexes or using a biodegradable or non-biodegradable polymer, such as PLGA, PLA, PGA or mixtures thereof in controlled release devices. Their respective pharmaceutical compositions as well as pharmaceutical and pharmacologically acceptable excipients may be used for the study and treatment of cardiovascular diseases and associated products.
摘要翻译： 我们公开了基于两种类黄酮：二油蛋白，佛罗醇及其天然或合成类似物的物质和开发类型为1至5型（PDE1，PDE2，PDE3，PDE4，PDE5）的磷酸二酯酶的同种型的有效和选择性抑制剂的物质和方法。 它们可以与包合配合物中的环糊精或者在控制释放装置中使用可生物降解或不可生物降解的聚合物如PLGA，PLA，PGA或其混合物相关联。 它们各自的药物组合物以及药物和药理学上可接受的赋形剂可用于心血管疾病和相关产品的研究和治疗。
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4.发明申请公开(公告)号：US20090005303A1
公开(公告)日：2009-01-01
申请号：US11778488
申请日：2007-07-16
CPC分类号： C12N9/6475 , A61K38/00
摘要： Proteases having mitogenic activity isolated from the genus Carica are provided. In particular the proteases are cysteine proteases isolated from Carica candamarcensis. In addition, the recombinant forms of the protease, including fragments and mutants with substantial homology are provided. Also provided are pharmaceutical compositions useful for treating wounds that include the disclosed proteases with mitogenic activity. A method of treating wounds is provided using the disclosed proteases.
摘要翻译： 提供了从卡尼卡酵母属中分离有丝分裂活性的蛋白酶。 特别地，蛋白酶是从卡尼卡酵母（Carica candamarcensis）分离的半胱氨酸蛋白酶。 此外，提供蛋白酶的重组形式，包括具有显着同源性的片段和突变体。 还提供了可用于治疗包括所公开的具有促有丝分裂活性的蛋白酶的伤口的药物组合物。 使用公开的蛋白酶提供治疗伤口的方法。
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5.发明授权Preparation of formulations of angiotensin II AT1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications 有权制备血管紧张素II AT1受体拮抗剂用于治疗动脉高血压，其他心血管疾病及其并发症公开(公告)号：US08293723B2
公开(公告)日：2012-10-23
申请号：US12977402
申请日：2010-12-23
申请人： Ruben Dario Sinisterra Millan , Robson Augusto Souza Dos Santos , Frederic Jean Georges Frezard , Washington Xavier De Paula
发明人： Ruben Dario Sinisterra Millan , Robson Augusto Souza Dos Santos , Frederic Jean Georges Frezard , Washington Xavier De Paula
IPC分类号： C08B37/16 , A61K9/52 , A61K31/00 , A61K31/724
CPC分类号： A61K9/0002 , A61K9/1652 , A61K9/19 , A61K9/5036 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61K38/085
摘要： Inclusion compounds consisting of certain Angiotensin II AT1 receptors antagonist and cyclodextrins are described. These inclusion compounds are useful in the treatment of hypertension.
摘要翻译： 描述了由某些血管紧张素II AT1受体拮抗剂和环糊精组成的包合物。 这些包合物可用于治疗高血压。
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6.发明申请PHARMACEUTICAL COMPOSITIONS COMPRISING SEMICARBAZONES AND THIOSEMICARBAZONES AND METHOD FOR TREATING INFLAMMATORY, PAINFUL AND FEBRILE CONDITIONS AND PREVENTING SIGNS AND SYMPTOMS OF INFLAMMATION 审中-公开包含半胱氨酸和硫代胆碱酯的药物组合物和治疗炎症，阴性和易感条件以及预防感染症状和炎症症状的方法公开(公告)号：US20100249238A1
公开(公告)日：2010-09-30
申请号：US12667351
申请日：2008-01-25
申请人： Ruben Dario Sinisterra , Marcio De Matos Coelho , Heloisa De Oliveira Beraldo , Maria Carolina Doretto , Rafael Pinto Vieira , Leticia Regina De Souza Teixeira , Silvia Passos Andrade
发明人： Ruben Dario Sinisterra , Marcio De Matos Coelho , Heloisa De Oliveira Beraldo , Maria Carolina Doretto , Rafael Pinto Vieira , Leticia Regina De Souza Teixeira , Silvia Passos Andrade
IPC分类号： A61K31/175 , A61P29/00 , C07C281/14
CPC分类号： A61K31/175
摘要： The present patent application refers to pharmaceutical compositions comprising at least a semicarbazone or a thiosemicarbazone, or a pharmaceutically acceptable salt, hydrated or solvated thereof, for the treatment of inflammatory, febrile and painful inflammatory conditions, inflammatory edema and peripheral or central neurophatic painful conditions or prevention of signs and symptoms of inflammation. Claim also pharmaceutical compositions comprising at least a semicarbazone, or a thiosemicarbazone, or a pharmaceutically acceptable salt, hydrated or solvated thereof and a therapeutically effective amount of these compounds, mixed or included in a pharmaceutically acceptable carrier or excipient or a thiosemicarbazone is provided as sustained or controlled release systems for human and veterinary use in solutions or in the solid state.
摘要翻译： 本专利申请是指至少含有缩氨基脲或缩氨基硫脲或其药学上可接受的盐，水合或溶剂化的药物组合物，用于治疗炎性，发热和疼痛的炎性病症，炎性水肿和周围或中枢性神经性疼痛病症或 预防炎症的体征和症状。 还提供包含至少含有缩氨基脲或缩氨基硫脲或其药学上可接受的盐，水合或溶剂化的药物组合物和治疗有效量的这些化合物，其混合或包括在药学上可接受的载体或赋形剂或缩氨基硫脲中作为持续的 或用于人和兽用于溶液或固体状态的控制释放系统。
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7.发明授权Method of increasing the efficacy of antibiotics by compexing with cyclodextrins 失效通过与环糊精混合来提高抗生素疗效的方法公开(公告)号：US06699505B2
公开(公告)日：2004-03-02
申请号：US09981655
申请日：2001-10-17
IPC分类号： A61K914
CPC分类号： A61K31/155 , A61K31/65 , A61K31/7036 , A61K47/6951 , B82Y5/00
摘要： The present invention provides methods of increasing the biological activity of a bioactive agent by complexing the bioactive agent with a complexing agent. In one preferred embodiment, the bioactive agent is an antibiotic and the complexing agent is a cyclodextrin. However, the invention may be extended to include any drugs as bioactive agents. In certain preferred embodiments, the bioactive agent fits into a hydrophobic core of a complexing agent.
摘要翻译： 本发明提供了通过使生物活性剂与络合剂络合来增加生物活性剂的生物活性的方法。 在一个优选的实施方案中，生物活性剂是抗生素，并且络合剂是环糊精。 然而，本发明可以扩展到包括任何药物作为生物活性剂。 在某些优选的实施方案中，生物活性剂适合于络合剂的疏水核心。
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