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公开(公告)号：US20090291854A1
公开(公告)日：2009-11-26
申请号：US12307524
申请日：2007-07-05
CPC分类号： C12Q1/689 , C12Q1/6837 , C12Q1/6895 , C12Q2600/16 , G16B25/00
摘要： Disclosed is a method for identification of microbial pathogens in a body fluid sample comprising the following steps: a) providing a body fluid sample; b) lysing the microbial pathogens and performing a nucleic acid amplification reaction on the microbial DNA encoding 16S or 18S rRNA wherein or whereafter the amplified nucleic acids are labelled; c) contacting the labelled amplified nucleic acids of step b) with a microarray comprising on defined areas on the microarray's surface immobilised probes for microbial DNA encoding 16S or 18S rRNA from microbial pathogens; d) detecting the binding of one or more species of the labelled amplified nucleic acids to a probe by detecting a labelled amplified nucleic acid being specifically bound to the microarray; and e) identifying a microbial pathogen in the body fluid sample by correlating the detected binding of the labelled amplified nucleic acids with the defined areas of the immobilised probes for microbial DNA encoding 16S or 18S rRNA from microbial pathogens.
摘要翻译： 公开了一种用于鉴定体液样品中微生物病原体的方法，包括以下步骤：a）提供体液样品; b）裂解微生物病原体并对编码16S或18S rRNA的微生物DNA进行核酸扩增反应，其中扩增的核酸被标记; c）将步骤b）的标记的扩增的核酸与包含在微阵列表面上的限定区域上的微阵列接触，用于从微生物病原体编码16S或18S rRNA的微生物DNA的固定化探针; d）通过检测与微阵列特异性结合的标记的扩增核酸，检测一种或多种标记的扩增核酸与探针的结合; 和e）通过将检测到的标记的扩增的核酸的结合与来自微生物病原体的编码16S或18S rRNA的微生物DNA的固定化探针的限定区域相关联来鉴定体液样品中的微生物病原体。
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公开(公告)号：US10718026B2
公开(公告)日：2020-07-21
申请号：US13146903
申请日：2010-01-28
IPC分类号： C12Q1/6886
摘要： The present invention discloses a method of generating subsets of methylation specific markers from a set, having diagnostic power for various diseases, e.g. cancer of thyroid, breast, colon, or leukemia, in diverse samples; identified subsets of that set, as well as methods for the prognosis and diagnosis of diseases.
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3.发明申请Apparatus For Increasing The Reaction Efficiency, Especially The Binding Efficiency, Between Molecules And Molecular Moieties 审中-公开用于增加反应效率的装置，特别是分子和分子之间的结合效率公开(公告)号：US20090325822A1
公开(公告)日：2009-12-31
申请号：US12296524
申请日：2007-04-11
申请人： Rudolf Heer , Christa Noehammer , Joerg Schotter , Moritz Eggeling , Rudolf Pichler , Markus Mansfeld
发明人： Rudolf Heer , Christa Noehammer , Joerg Schotter , Moritz Eggeling , Rudolf Pichler , Markus Mansfeld
IPC分类号： C40B60/00
CPC分类号： B01F13/0809 , B01F13/0059 , B01L3/5027
摘要： An apparatus for enhancing the contact frequency between two reactants capable of binding to one another, preferably between an analyzer molecule and an analyte molecule, especially for enhancing the binding effectiveness in bioanalysis arrays with the aid of micro- or nanomagnetic particles (75) set in motion in a controlled manner in the fluid reaction medium by means of magnetic fields generated by variably feedable electromagnets (3, 2, 20) arranged on both sides of the reaction fluid film. On one side of a reaction fluid film, especially of a microscope slide (4) comprising the reactants (63), the reaction liquid (70) comprising the reactants (73) and preferably a glass plate (5) covering the microbioanalysis array (6), is arranged close to a two-dimensional matrix (20) having a multitude of miniature or millimagnetic coils (2) feedable individually with magnetization current of variable strength and/or voltage as a function of time—corresponding to a time-dependent variable magnetization pattern desired in each case—and, on the other side of the reaction vessel, especially the microscope slide (4) with the (micro)bioanalysis array (6), in whose vicinity is positioned only one magnetic coil (3) likewise feedable with variable magnetization current and whose magnetic field permeates the entire reaction vessel, especially the microbioanalysis array (6).
摘要翻译： 一种用于增强能够彼此结合的两种反应物之间的接触频率的装置，优选在分析器分子和分析物分子之间，特别是借助于设置在微生物或纳米磁性颗粒中的增强生物分析阵列的结合效果 通过设置在反应流体膜两侧的可变输入电磁体（3,2,20）产生的磁场，在流体反应介质中以受控的方式运动。 在反应流体膜的一侧，特别是包含反应物（63）的显微镜载片（4）的一侧，包含反应物（73）的反应液（70）和优选覆盖微生物分析阵列（6）的玻璃板（5） ）布置成靠近二维矩阵（20），该二维矩阵（20）具有多个微型或微电磁线圈（2），该二维矩阵能够单独地馈送作为时间的函数的可变强度和/或电压的磁化电流 - 对应于时间因变量 在每种情况下都需要磁化图案，并且在反应容器的另一侧，特别是具有（微）生物分析阵列（6）的显微镜载玻片（4），其附近仅定位一个电磁线圈（3），同样可进给 具有可变的磁化电流并且其磁场渗透整个反应容器，特别是微量分析阵列（6）。
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公开(公告)号：US4457149A
公开(公告)日：1984-07-03
申请号：US351650
申请日：1982-02-24
申请人： Hans J. Weinzinger , Rudolf Pichler
发明人： Hans J. Weinzinger , Rudolf Pichler
摘要： To permit a planar strip to be unwound from a reel, the strip to be coiled up has imparted to it a progressively decreasing curvature in a sense which is opposite to the longitudinal curvature of the coiled strip.
摘要翻译： 为了允许平面条从卷轴展开，要卷起的条带在与线圈条的纵向曲率相反的意义上赋予它逐渐减小的曲率。
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公开(公告)号：US20110287967A1
公开(公告)日：2011-11-24
申请号：US13146901
申请日：2010-01-28
CPC分类号： C12Q1/6886 , C12Q2523/125 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16
摘要： The present invention discloses a method of diagnosing lung cancer by using methylation specific markers from a set, having diagnostic power for lung cancer diagnosis and distinguishing lung cancer types in diverse samples; as well as methods to identify sets of prognostic and diagnostic value.
摘要翻译： 本发明公开了一种通过使用来自一组的甲基化特异性标志物来诊断肺癌的方法，具有用于肺癌诊断的诊断力并区分不同样品中的肺癌类型; 以及确定预后和诊断价值的方法。
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公开(公告)号：US6164103A
公开(公告)日：2000-12-26
申请号：US300840
申请日：1999-04-28
申请人： Rudolf Pichler , Sonja Tichy , Franz Holy , Alois Seilinger
发明人： Rudolf Pichler , Sonja Tichy , Franz Holy , Alois Seilinger
CPC分类号： B21B37/40
摘要： A method for improving the contour of rolled material over at least one segment of a rolling schedule including a plurality of rolling processes. The method includes associating at least one quality criterion with at least one rolling stand of at least one of the plurality of rolling processes, optimizing the at least one quality criterion using a mathematical formula, predetermining at least one work roll shift for the plurality of rolling processes over the at least one segment of the rolling schedule based on an optimization of the at least one quality criterion, and axially shifting at least one work roll of the at least one rolling stand.
摘要翻译： 一种用于在包括多个轧制过程的滚动调度的至少一个段上改进轧制材料轮廓的方法。 该方法包括将至少一个质量标准与多个轧制过程中的至少一个轧制过程的至少一个轧制机架相关联，使用数学公式优化至少一个质量标准，预先确定用于多个轧制的至少一个轧辊位移 基于所述至少一个质量标准的优化，以及轴向移动所述至少一个轧制机架的至少一个工作轧辊，在所述轧制进度的所述至少一个部分上的过程。
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公开(公告)号：US20110287968A1
公开(公告)日：2011-11-24
申请号：US13146903
申请日：2010-01-28
摘要： The present invention discloses a method of generating subsets of methylation specific markers from a set, having diagnostic power for various diseases, e.g. cancer of thyroid, breast, colon, or leukemia, in diverse samples; identified subsets of that set, as well as methods for the prognosis and diagnosis of diseases.
摘要翻译： 本发明公开了一种从一组产生甲基化特异性标志物亚群的方法，其具有各种疾病的诊断能力，例如， 不同样本的甲状腺癌，乳腺癌，结肠癌或白血病; 确定该组的亚组，以及预后和诊断疾病的方法。
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8.发明授权Process for monitoring and controlling the quality of rolled products from hot-rolling processes 失效用于监控和控制热轧工艺轧制产品质量的工艺公开(公告)号：US06430461B1
公开(公告)日：2002-08-06
申请号：US09302577
申请日：1999-04-30
申请人： Josef Andorfer , Dietmar Auzinger , Rudolf Pichler
发明人： Josef Andorfer , Dietmar Auzinger , Rudolf Pichler
IPC分类号： G06F1900
摘要： Process to monitor and control the quality of rolled products from hot-rolled processes which produce products such as sheets, rods, etc., from input stock such as slabs, billets, etc. The process estimates in advance the expected material properties of the end product at each step of the hot-rolling production process. The process further provides that conditions, such as temperature, reduction depth, etc., are detected on-line throughout the entire rolling process and from the values obtained, via interrelated physical—metallurgical and/or statistical models describing the whole rolling process, the mechanical/technical material properties to be expected, particularly the yield point, the tensile strength and the breaking elongation point of the rolled product, are calculated. On-line detection of the actual and momentary production conditions is necessary to allow the material properties to always be estimated in advance.
摘要翻译： 监控和控制轧制产品的质量的过程，这些轧制产品从生产诸如板材，坯料等输入材料的产品（例如板材，棒材等）的热轧工艺中。该工艺预先提前终了预期的材料性能 产品在热轧生产过程的每个步骤。 该方法进一步提供了在整个轧制过程中在线检测诸如温度，还原深度等的条件，以及通过描述整个轧制过程的相互关联的物理 - 冶金和/或统计模型所获得的值， 计算预期的机械/技术材料性能，特别是轧制品的屈服点，拉伸强度和断裂伸长点。 在线检测实际和瞬间的生产条件是必要的，以使材料属性能够提前估计。
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公开(公告)号：US4516368A
公开(公告)日：1984-05-14
申请号：US06287737
申请日：1980-11-10
申请人： Rudolf Pichler
发明人： Rudolf Pichler
IPC分类号： E04F11/02 , E04F20060101 , E04F11/00 , E04F11/116 , E04F11/14
CPC分类号： E04F11/116 , E04F11/1041
摘要： A construction element having a bridge-like portion of which first and second pillars are provided on the lower part thereof with a plurality of steps. The second pillar being connected by an inclined part to a channel-like portion provided with an outer edge.
摘要翻译： PCT No.PCT / CH80 / 00134 Sec。 371日期1981年8月3日 102（e）日期1981年8月3日PCT提交1980年11月10日PCT公布。 公开号WO81 / 01584 日期：1981年6月11日。具有桥状部分的构造元件，其第一和第二柱在其下部设置有多个台阶。 第二柱由倾斜部分连接到设有外边缘的通道状部分上。
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