公开(公告)号：US11633716B2

公开(公告)日：2023-04-25

申请号：US16638586

申请日：2018-09-07

Applicant: TORAY INDUSTRIES, INC. ,  NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE

Inventor： Junichi Kasuya ,  Ryo Matsunaga ,  Yoshiyuki Ueno ,  Yuji Ueda ,  Kazuo Teramoto ,  Kazumasa Ogasawara

IPC: B01J20/26 ,  A61M1/36 ,  B01J20/28 ,  B01J20/32 ,  C07K14/495

Abstract: An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 μmol and 2500 μmol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 μmol or less per 1 g.

公开(公告)号：US20220409229A1

公开(公告)日：2022-12-29

申请号：US17620765

申请日：2020-06-20

Applicant: National University Corporation Shiga University of Medical Science

Inventor： Tohru TANI ,  Shigeyuki NAKA ,  Atsushi YAMADA

IPC: A61B17/3201 ,  A61B18/18

Abstract: Provided is a scissors-type medical treatment tool capable of not only local tissue fixation in an incision/cutting part but also heating on side surfaces of electrodes of a forceps/tweezers type. It has been found out that a tissue part in which tissue is nipped between blades and a tissue part which is brought into abutment against side surfaces of the blades can be heated simultaneously or sequentially by optimizing arrangement of microwave application electrodes and microwave receiver electrodes in a blade pair (in particular, by causing coagulation to be performed evenly on the left and right of the blades), and the present invention has therefore been achieved.

公开(公告)号：US11464441B2

公开(公告)日：2022-10-11

申请号：US16829858

申请日：2020-03-25

Applicant: SHIGA UNIVERSITY OF MEDICAL SCIENCE ,  NIHON KOHDEN CORPORATION ,  Takeshi Tsuchiya ,  NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER

Inventor： Takashi Ashihara ,  Koji Takizawa ,  Tatsuo Nishihara ,  Nobuhiro Suzuki ,  Yuuho Iwanaga ,  Akio Ota ,  Takeshi Tsuchiya ,  Kazuo Nakazawa ,  Shin Inada

IPC: A61B5/361 ,  A61B5/25 ,  A61B5/318 ,  A61B5/349 ,  A61B5/352 ,  A61B5/00 ,  A61B5/322 ,  A61B5/02 ,  A61B18/14

Abstract: A myocardial excitation complementation/visualization apparatus includes an acquiring section that acquires intracardiac electrocardiograms of a subject, the intracardiac electrocardiograms being recorded by a recording unit having a plurality of electrodes, a processing section that performs a computation for completing and visualizing a state of excitation in a myocardium of the subject based on the intracardiac electrocardiograms, and a displaying section that displays the state of excitation in the myocardium of the subject based on an output of the processing section. The processing section includes a first generating section, a correcting section, a second generating section, and a third generating section. The displaying section displays a change of the state of excitation in the myocardium of the subject based on the visualized data.

公开(公告)号：US20220175410A1

公开(公告)日：2022-06-09

申请号：US17554386

申请日：2021-12-17

Applicant: NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE

Inventor： Tohru TANI ,  Shigeyuki NAKA ,  Atsushi YAMADA ,  Tsuyoshi NAKAKUBO

IPC: A61B17/3201 ,  A61B17/28 ,  A61B17/29 ,  A61B34/30

Abstract: A cutting device including a first contact member and at second contact member assembled so as to be openable and closable, a contact mechanism that rotates the first contact member toward the second contact member to bring the first contact member and the second contact member into contact with a target portion, and a cutting mechanism for cutting the target portion in a state where the first contact member and the second contact member are in contact with the target portion by the contact mechanism.

公开(公告)号：US10890513B2

公开(公告)日：2021-01-12

申请号：US15759719

申请日：2016-09-14

Applicant: NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE ,  JAPAN VILENE COMPANY, LTD.

Inventor： Ken-ichi Mukaisho ,  Takanori Hattori ,  Takuya Iwasa ,  Masaaki Kawabe ,  Satoshi Kumagai

IPC: G01N1/31 ,  G01N1/30 ,  G02B21/34 ,  G01N1/40 ,  G01N33/483 ,  G01N1/28

Abstract: Provided are a cell-holding substrate holder for preparing an observation specimen, and a cell-holding substrate kit, wherein the cell-holding substrate can be easily attached and detached. Also provided is a method of preparing an observation specimen, wherein cell organelles can be satisfactorily observed using an optical microscope, while three problems of cell detachment, drying, and loss of the three-dimensional properties can be simultaneously solved. The cell-holding substrate holder comprises (1) a support plate 1 having a cell-holding substrate arrangement portion 12 having a window portion through which water can pass; and (2) a removable sandwiching plate 2, 3 which has a window portion through which water can pass, and is capable of working in conjunction with the support plate 1 to sandwich and fix a cell-holding substrate 9 in the cell-holding substrate arrangement portion 12. The cell-holding substrate kit 10 comprises the cell-holding substrate holder and a cell-holding substrate 9. In the preparation method, cells are collected with an inorganic fiber aggregate, wet-fixed as they are, stained, and mounted with a mounting medium having a refractive index equivalent to that of the inorganic fiber.

公开(公告)号：US20190335977A1

公开(公告)日：2019-11-07

申请号：US16343990

申请日：2017-10-24

Applicant: NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE

Inventor： Atsushi YAMADA ,  Tohru TANI ,  Shigeyuki NAKA ,  Shigehiro MORIKAWA

IPC: A61B1/008 ,  A61M25/01 ,  A61B34/00

Abstract: A bending and extending device 1 comprises an elastic hollow guide unit 2 and a movable part 3 to be movably inserted into the guide unit 2. The movable part 3 is constituted, either partially or entirely, of a plurality of belt-like flexible parts 30a and 30b, which extend in the axial direction of the guide unit 2 and the flexible parts 30a and 30b are connected at distal ends. The bending and extending device 1 is characterized in that, when, by the sliding operation of the flexible parts 30a and 30b, a cross-section in which a contact point T of the flexible part 30a and the inner surface of the guide unit 2 is present on an extending line Y extending from a line segment connecting the centroid P of the flexible part 30b and the axial center G of the guide unit 2 and in which the flexible part 30a and the second flexible part 30b are in contact with each other is generated, and when the cross-section is divided into two ranges by a predetermined straight line X, the centroid P of the flexible part 30b is not positioned in a range in which the contact point T is present; and the predetermined straight line X is a line that passes through the axial center G of the guide unit 2, and that orthogonally crosses the extending line Y.

公开(公告)号：US20180303883A1

公开(公告)日：2018-10-25

申请号：US15769278

申请日：2016-10-19

Applicant: Meiji Co., Ltd. ,  SHIGA UNIVERSITY OF MEDICAL SCIENCE

Inventor： Shigeki KOSHIDA ,  Masaki TERAHARA

IPC: A61K35/745 ,  A61K9/00 ,  A61K47/36 ,  A61P37/08 ,  A23L33/00 ,  A23L33/135

CPC classification number: A61K35/745 ,  A23L33/135 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/304 ,  A23V2250/5114 ,  A23Y2300/25 ,  A61K9/0053 ,  A61K9/0095 ,  A61K35/74 ,  A61K47/36 ,  A61P37/08

Abstract: Provided herein is an anti-allergic agent for ameliorating an allergic disease in infants, particularly newborns, without causing side effects. The anti-allergic agent for infants comprises a bifidobacterium.

公开(公告)号：US20170290623A1

公开(公告)日：2017-10-12

申请号：US15512647

申请日：2015-07-13

Applicant: TOCALO CO., LTD. ,  NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE

Inventor： Shinya MIKI ,  Megumi ADACHI ,  Toru TANI ,  Shigeyuki NAKA ,  Tomoharu SHIMIZU

IPC: A61B18/14 ,  A61L31/08 ,  A61L31/10 ,  A61B18/18 ,  A61B17/32

CPC classification number: A61B18/1445 ,  A61B17/320068 ,  A61B18/1402 ,  A61B2017/00849 ,  A61B2017/320069 ,  A61B2017/320082 ,  A61B2018/0013 ,  A61B2018/00601 ,  A61B2018/00607 ,  A61B2018/0097 ,  A61B2018/1412 ,  A61B2018/1452 ,  A61B2018/1462 ,  A61L31/088 ,  A61L31/10 ,  A61L2420/08

Abstract: There is provided an energy device for surgical operation capable of suppressing fixation of body tissue, wherein a coating layer is formed on an outer periphery of a base material constituting an operational area portion transmitting energy in an energy device for surgical operation operating in the operational area portion, and is comprised of a base coating formed on the base material and an outermost coating formed on the base coating. The base coating is made from silicon oxide or a compound containing silicon oxide, and the outermost coating is made from polysiloxane or a compound containing polysiloxane or a compound containing a partly fluorinated polysiloxane, and the coating layer has a good adhesiveness and is applicable to a complicated form.

公开(公告)号：US20150031054A1

公开(公告)日：2015-01-29

申请号：US14374181

申请日：2013-01-23

Applicant: Panasonic Healthcare Co., Ltd. ,  Shiga University of Medical Science

Inventor： Takaomi Fukuhara ,  Toshifumi Nanjo ,  Ikuo Tooyama

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2333/47 ,  G01N2333/4709 ,  G01N2800/2821

Abstract: Disclosed herein is a method for diagnosing Alzheimer's disease capable of minimizing invasiveness to reduce the risk of infection. The method for diagnosing Alzheimer's disease includes the steps of: pretreating an intranasal specimen; detecting tau protein or amyloid beta peptide (Aβ) in the pretreated intranasal specimen; comparing a value of the tau protein or the Aβ obtained in the detection step with a predetermined value; and displaying a comparison result obtained in the comparison step.

Abstract translation: 本文公开了一种用于诊断能够最小化侵入性以降低感染风险的阿尔茨海默氏病的方法。 用于诊断阿尔茨海默氏病的方法包括以下步骤：预处理鼻内标本; 在预处理的鼻内标本中检测tau蛋白或淀粉样蛋白β肽（A＆bgr）; 比较tau蛋白或A蛋白的值; 在所述检测步骤中以预定值获得; 并显示在比较步骤中获得的比较结果。

公开(公告)号：US12048548B2

公开(公告)日：2024-07-30

申请号：US17691385

申请日：2022-03-10

Applicant: NIHON KOHDEN CORPORATION ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE

Inventor： Kunihiko Kiuchi ,  Takashi Ashihara ,  Kaori Uchiyama ,  Akio Ota ,  Naoki Koura ,  Koji Takizawa

IPC: A61B5/347 ,  A61B5/0245 ,  A61B5/308 ,  A61B5/339

CPC classification number: A61B5/339 ,  A61B5/0245 ,  A61B5/308 ,  A61B5/347

Abstract: A display control device includes processing circuitry configured to: obtain an intracardiac electrocardiogram of a subject; generate visualization data representing an excitation state of a myocardium based on the intracardiac electrocardiogram; determine a type of excitation dynamics of the myocardium based on the visualization data; and display, on a stereoscopic image of a heart of the subject, a site from which the intracardiac electrocardiogram is obtained with a color in accordance with a ratio of the determined type of the excitation dynamics.