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1.发明授权Methods for selecting competent oocytes and competent embryos with high potential for pregnancy outcome 有权选择具有高潜力妊娠结局的感染性卵母细胞和感受态胚胎的方法公开(公告)号：US09121066B2
公开(公告)日：2015-09-01
申请号：US13989423
申请日：2011-11-24
Applicant: Samir Hamamah , Said Assou
Inventor： Samir Hamamah , Said Assou
CPC classification number: C12Q1/6876 , C12N2310/141 , C12N2320/10 , C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention relates to a method for selecting a competent oocyte or a competent embryo by determining the expression level of specific microRNA species in a body fluid or in cumulus cells.
Abstract translation: 本发明涉及通过测定体液或卵丘细胞中特异性微RNA种类的表达水平来选择感受态卵母细胞或感受态胚胎的方法。
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2.发明申请METHODS FOR SELECTING COMPETENT OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME 有权选择具有高潜力的竞争性蛋白质和竞争性胚胎的方法公开(公告)号：US20130316360A1
公开(公告)日：2013-11-28
申请号：US13989423
申请日：2011-11-24
Applicant: Samir Hamamah , Said Assou
Inventor： Samir Hamamah , Said Assou
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , C12N2310/141 , C12N2320/10 , C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention relates to a method for selecting a competent oocyte or a competent embryo by determining the expression level of specific microRNA species in a body fluid or in cumulus cells.
Abstract translation: 本发明涉及通过测定体液或卵丘细胞中特异性微RNA种类的表达水平来选择感受态卵母细胞或感受态胚胎的方法。
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3.发明授权Methods for selecting competent oocytes and competent embryos with high potential for pregnancy outcome 有权选择具有高潜力妊娠结局的感染性卵母细胞和感受态胚胎的方法公开(公告)号：US09090938B2
公开(公告)日：2015-07-28
申请号：US14627394
申请日：2015-02-20
Applicant: Samir Hamamah , Said Assou , John De Vos
Inventor： Samir Hamamah , Said Assou , John De Vos
CPC classification number: C12Q1/6881 , A61B17/43 , C12Q1/66 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , C12Q2600/16 , G01N33/5005 , G01N33/689 , G01N33/6893 , G01N2800/367
Abstract: The present invention relates to a method for selecting a competent oocyte or a competent embryo.
Abstract translation: 本发明涉及一种选择感受态卵母细胞或感受态胚的方法。
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4.发明申请METHODS FOR SELECTING COMPETENT OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME 有权选择具有高潜力的竞争性蛋白质和竞争性蛋白质的方法公开(公告)号：US20150167079A1
公开(公告)日：2015-06-18
申请号：US14627394
申请日：2015-02-20
Applicant: Samir HAMAMAH , Said ASSOU , John DE VOS
Inventor： Samir HAMAMAH , Said ASSOU , John DE VOS
CPC classification number: C12Q1/6881 , A61B17/43 , C12Q1/66 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , C12Q2600/16 , G01N33/5005 , G01N33/689 , G01N33/6893 , G01N2800/367
Abstract: The present invention relates to a method for selecting a competent oocyte or a competent embryo.
Abstract translation: 本发明涉及一种选择感受态卵母细胞或感受态胚的方法。
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公开(公告)号：US08956865B2
公开(公告)日：2015-02-17
申请号：US13816311
申请日：2011-08-11
Applicant: Samir Hamamah , Said Assou
Inventor： Samir Hamamah , Said Assou
IPC: C12N5/02 , C12N5/073 , A61D19/00 , C12N5/0735
CPC classification number: C12N5/0603 , A61D19/00 , C12N5/0604 , C12N5/0605 , C12N5/0606 , C12N2502/02 , C12N2517/10
Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to a novel human embryo co-culture system to improve human embryo growth in vitro and, consequently, increase pregnancy rates in infertile women undergoing in vitro fertilization (IVF) treatment. More particularly, the present invention relates to a method of growing an embryo to a blastocyst stage of development comprising the step of coculturing said embryo in the presence of a population of cumulus cells.
Abstract translation: 本发明一般涉及生殖医学领域。 更具体地说，本发明涉及一种新的人类胚胎共培养系统，用于改善体外受精体外受精（IVF）治疗的不育妇女的体外胚胎生长，从而增加妊娠率。 更具体地，本发明涉及将胚胎生长至囊胚发育阶段的方法，其包括在存在卵丘细胞的情况下共培养所述胚胎的步骤。
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Patent Agency Ranking
6.发明申请METHODS FOR SELECTING COMPETENT OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME 审中-公开选择具有高潜力的竞争性蛋白质和竞争性胚胎的方法公开(公告)号：US20170067105A1
公开(公告)日：2017-03-09
申请号：US15356745
申请日：2016-11-21
Applicant: Samir HAMAMAH , Said ASSOU
Inventor： Samir HAMAMAH , Said ASSOU
IPC: C12Q1/68
CPC classification number: C12Q1/6881 , C12N15/111 , C12N15/113 , C12N2310/141 , C12N2320/10 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention relates to a method for selecting a competent oocyte or a competent embryo by determining the expression level of specific microRNA species in a body fluid or in cumulus cells.
Abstract translation: 本发明涉及通过测定体液或卵丘细胞中特异性微RNA种类的表达水平来选择感受态卵母细胞或感受态胚胎的方法。
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7.发明授权Methods for selecting oocytes and competent embryos with high potential for pregnancy outcome 有权选择具有高潜力妊娠结局的卵母细胞和感受态胚胎的方法公开(公告)号：US08754014B2
公开(公告)日：2014-06-17
申请号：US13264589
申请日：2010-04-09
Applicant: Samir Hamamah , John De Vos , Said Assou
Inventor： Samir Hamamah , John De Vos , Said Assou
CPC classification number: C12Q1/6881 , C12Q2600/156 , C12Q2600/158 , G01N33/689
Abstract: The present invention relates to a method for selecting a competent oocyte or a competent embryo.
Abstract translation: 本发明涉及一种选择感受态卵母细胞或感受态胚的方法。
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公开(公告)号：US20130072748A1
公开(公告)日：2013-03-21
申请号：US13699814
申请日：2011-05-27
Applicant: Samir Hamamah , Delphine Haouzi
Inventor： Samir Hamamah , Delphine Haouzi
IPC: C12Q1/68 , A61B17/435 , C40B40/08
CPC classification number: C12Q1/6837 , A61B17/435 , C12Q1/6883 , C12Q2600/158 , C40B40/08
Abstract: The present invention relates to a method for assessing the endometrium receptivity of a patient, comprising a step consisting of measuring the expression level of eleven genes in an endometrial biopsy sample obtained from said patient wherein said genes are MFAP5, ANGPTL1, PROK1, NLF2, LAMB3, BCL2L10, CD68, TRPC4, SORCS1, FST and KRT80.
Abstract translation: 本发明涉及一种用于评估患者的子宫内膜接受性的方法，包括测量从所述患者获得的子宫内膜活检样品中11种基因的表达水平的步骤，其中所述基因是MFAP5，ANGPTL1，PROK1，NLF2，LAMB3 ，BCL2L10，CD68，TRPC4，SORCS1，FST和KRT80。
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公开(公告)号：US10059994B2
公开(公告)日：2018-08-28
申请号：US15356745
申请日：2016-11-21
Applicant: Samir Hamamah , Said Assou
Inventor： Samir Hamamah , Said Assou
IPC: C07H21/02 , C07H21/04 , C12Q1/68 , C12Q1/6881 , C12N15/11 , C12N15/113 , C12N5/00
CPC classification number: C12Q1/6881 , C12N15/111 , C12N15/113 , C12N2310/141 , C12N2320/10 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention relates to a method for selecting a competent oocyte or a competent embryo by determining the expression level of specific microRNA species in a body fluid or in cumulus cells.
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公开(公告)号：US09481863B2
公开(公告)日：2016-11-01
申请号：US14128946
申请日：2012-06-29
Applicant: Samir Hamamah
Inventor： Samir Hamamah
CPC classification number: C12N5/0605 , C12N5/0682 , C12N2501/115 , C12N2533/54 , C12Q1/6881
Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to a method determining the developmental stage of human cumulus cells issues from MII oocyte.
Abstract translation: 本发明一般涉及生殖医学领域。 更具体地说，本发明涉及确定MII卵母细胞的人卵巢细胞发育发育阶段的方法。
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