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1.发明申请PROCESS OF MAKING FLOWABLE HEMOSTATIC COMPOSITIONS AND DEVICES CONTAINING SUCH COMPOSITIONS 有权制备流动性HEMOSTATIC组合物的方法和含有这些组合物的装置公开(公告)号：US20110027378A1
公开(公告)日：2011-02-03
申请号：US12902017
申请日：2010-10-11
申请人： Sanyog M. PENDHARKAR , Anne J. GORMAN , Guanghui ZHANG , Ada RIVERA , Dwayne Lee LOONEY , Thomas Lee CRAVEN
发明人： Sanyog M. PENDHARKAR , Anne J. GORMAN , Guanghui ZHANG , Ada RIVERA , Dwayne Lee LOONEY , Thomas Lee CRAVEN
CPC分类号： A61L26/0095 , A61K31/715 , A61K38/36 , A61K38/363 , A61K38/39 , A61L26/0038 , A61L26/0061 , A61L2400/04 , A61K2300/00
摘要： The present invention includes both sterilized and unsterilized hemostatic compositions that contain a continuous, biocompatible liquid phase having a solid phase of particles of a biocompatible polymer suitable for use in hemostasis and which is substantially insoluble in the liquid phase, and a discontinuous, biocompatible gaseous phase, each of which is substantially homogenously dispersed throughout the continuous liquid phase, methods for making such compositions, medical devices that contain sterilized hemostatic compositions disposed therein and methods of making such devices.
摘要翻译： 本发明包括灭菌和未灭菌的止血组合物，其包含连续的生物相容性液相，其具有适于用于止血并且基本上不溶于液相的生物相容性聚合物颗粒的固相，并且基本上不溶于液相，以及不连续的生物相容性气相 其各自基本均匀地分散在整个连续液相中，制备这种组合物的方法，其中设置有灭菌的止血组合物的医疗装置和制造这种装置的方法。
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2.发明授权Process of making flowable hemostatic compositions and devices containing such compositions 有权制备可流动止血组合物和含有这种组合物的装置的方法公开(公告)号：US07833965B2
公开(公告)日：2010-11-16
申请号：US11348860
申请日：2006-02-07
申请人： Sanyog M. Pendharkar , Anne J. Gorman , Guanghui Zhang , Ada Rivera , Dwayne Lee Looney , Thomas Lee Craven
发明人： Sanyog M. Pendharkar , Anne J. Gorman , Guanghui Zhang , Ada Rivera , Dwayne Lee Looney , Thomas Lee Craven
CPC分类号： A61L26/0095 , A61K31/715 , A61K38/36 , A61K38/363 , A61K38/39 , A61L26/0038 , A61L26/0061 , A61L2400/04 , A61K2300/00
摘要： The present invention includes both sterilized and unsterilized hemostatic compositions that contain a continuous, biocompatible liquid phase having a solid phase of particles of a biocompatible polymer suitable for use in hemostasis and which is substantially insoluble in the liquid phase, and a discontinuous, biocompatible gaseous phase, each of which is substantially homogenously dispersed throughout the continuous liquid phase, methods for making such compositions, medical devices that contain sterilized hemostatic compositions disposed therein and methods of making such devices.
摘要翻译： 本发明包括灭菌和未灭菌的止血组合物，其包含连续的生物相容性液相，其具有适于用于止血并且基本上不溶于液相的生物相容性聚合物颗粒的固相，并且基本上不溶于液相，以及不连续的生物相容性气相 其各自基本均匀地分散在整个连续液相中，制备这种组合物的方法，其中设置有灭菌的止血组合物的医疗装置和制造这种装置的方法。
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公开(公告)号：US06852308B2
公开(公告)日：2005-02-08
申请号：US10288076
申请日：2002-11-05
IPC分类号： A61K9/00 , A61K9/107 , A61K9/127 , A61K9/20 , A61K31/401 , A61K38/00 , A61K47/48 , A61K49/04 , A61L27/00 , C07C235/34 , C08G63/193 , C08G63/682 , C08G64/06 , C08G64/10 , C08G64/12 , C08G64/16 , C08G64/18 , C08G65/331 , C08G65/40 , C08G69/44 , C08K5/13 , C08K5/20 , A61B10/00
CPC分类号： C08G64/12 , A61K9/204 , A61K38/00 , A61K49/0438 , A61K49/0442 , A61K49/0447 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/00 , C08G63/672 , C08G63/6826 , C08G63/6856 , C08G64/10 , C08G64/1633 , C08G64/1641 , C08G64/183 , C08G65/3317 , C08G69/44 , C08K5/13 , C08K5/20
摘要： Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, biocompatible non-toxic additives for other polymeric biomaterials. Radio-opaque medical implants and drug delivery devices for implantation prepared from the polymers of the present invention are also disclosed.
摘要翻译： 制备芳族二羟基单体的碘化和/或溴化衍生物并聚合以形成不透射线的聚合物。 单体也可以与其它二羟基单体共聚。 碘化和溴化芳族二羟基单体可用作其他聚合物生物材料的无光乳化，生物相容性无毒添加剂。 还公开了由本发明的聚合物制备的不透射线的医疗植入物和用于植入的药物递送装置。
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公开(公告)号：US09005609B2
公开(公告)日：2015-04-14
申请号：US12750334
申请日：2010-03-30
IPC分类号： A61K38/00 , A61K38/48 , A61K38/49 , A61K9/00 , A61K9/10 , A61K38/36 , A61K38/39 , A61K47/36 , A61K47/42 , A61L24/10 , A61L26/00 , C12N9/74 , A61K9/19
CPC分类号： A61K9/0019 , A61K9/10 , A61K9/19 , A61K38/36 , A61K38/363 , A61K38/39 , A61K38/4833 , A61K47/36 , A61K47/42 , A61L24/104 , A61L24/108 , A61L26/0028 , A61L26/0042 , A61L26/0095 , A61L2400/04 , C12N9/6429 , C12Y304/21005
摘要： The present invention includes sterilized hemostatic compositions that contain a continuous, biocompatible liquid phase having a solid phase of particles of a biocompatible polymer suitable for use in hemostasis and that is substantially insoluble in the liquid phase, and sterile thrombin, each of which is substantially homogenously dispersed throughout the continuous liquid phase, and methods for making such compositions.
摘要翻译： 本发明包括灭菌的止血组合物，其包含连续的生物相容性液相，其具有适于用于止血并且基本上不溶于液相的生物相容性聚合物颗粒的固相，以及基本均匀的无菌凝血酶 分散在整个连续液相中，以及制备这种组合物的方法。
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5.发明授权Process of making flowable hemostatic compositions and devices containing such compositions 有权制备可流动止血组合物和含有这种组合物的装置的方法公开(公告)号：US08551941B2
公开(公告)日：2013-10-08
申请号：US12902017
申请日：2010-10-11
申请人： Sanyog M. Pendharkar , Anne J. Gorman , Guanghui Zhang , Ada Rivera , Dwayne Lee Looney , Thomas Lee Craven
发明人： Sanyog M. Pendharkar , Anne J. Gorman , Guanghui Zhang , Ada Rivera , Dwayne Lee Looney , Thomas Lee Craven
CPC分类号： A61L26/0095 , A61K31/715 , A61K38/36 , A61K38/363 , A61K38/39 , A61L26/0038 , A61L26/0061 , A61L2400/04 , A61K2300/00
摘要： The present invention includes both sterilized and unsterilized hemostatic compositions that contain a continuous, biocompatible liquid phase having a solid phase of particles of a biocompatible polymer suitable for use in hemostasis and which is substantially insoluble in the liquid phase, and a discontinuous, biocompatible gaseous phase, each of which is substantially homogenously dispersed throughout the continuous liquid phase, methods for making such compositions, medical devices that contain sterilized hemostatic compositions disposed therein and methods of making such devices.
摘要翻译： 本发明包括灭菌和未灭菌的止血组合物，其包含连续的生物相容性液相，其具有适于用于止血并且基本上不溶于液相的生物相容性聚合物颗粒的固相，并且基本上不溶于液相，以及不连续的生物相容性气相 其各自基本均匀地分散在整个连续液相中，制备这种组合物的方法，其中设置有灭菌的止血组合物的医疗装置和制造这种装置的方法。
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公开(公告)号：US07109163B2
公开(公告)日：2006-09-19
申请号：US10768912
申请日：2004-01-30
CPC分类号： A61K47/10 , A61K9/0019 , A61K38/00 , A61K47/186 , A61K47/36 , A61K47/42 , A61L24/0015 , A61L24/0042 , A61L26/0028 , A61L26/0066 , A61L26/009 , A61L2300/208 , A61L2300/404 , A61L2300/418 , A61L2400/04
摘要： The present invention includes both sterilized and unsterilized hemostatic compositions that contain a biocompatible liquid having particles of a biocompatible polymer suitable for use in hemostasis and which is substantially insoluble in the liquid, up to about 20 percent by weight of glycerol and about 1 percent by weight of benzalkonium chloride, each based on the weight of the liquid, all of which are substantially homogenously dispersed throughout the liquid to form a substantially homogenous composition, methods for making such compositions, medical devices that contain such hemostatic compositions disposed therein and methods of making such devices.
摘要翻译： 本发明包括灭菌和未灭活的止血组合物，其包含具有生物相容性聚合物颗粒的生物相容性液体，其适用于止血并且基本上不溶于液体，高达约20重量％的甘油和约1重量％ 的苯扎氯铵，各自基于液体的重量，所有这些基本均匀地分散在整个液体中以形成基本上均匀的组合物，制备这种组合物的方法，包含其中设置的止血组合物的医疗装置及其制备方法 设备。
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公开(公告)号：US06475477B1
公开(公告)日：2002-11-05
申请号：US09554027
申请日：2000-07-03
IPC分类号： A61K3174
CPC分类号： C08G64/12 , A61K9/204 , A61K38/00 , A61K49/0438 , A61K49/0442 , A61K49/0447 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/00 , C08G63/672 , C08G63/6826 , C08G63/6856 , C08G64/10 , C08G64/1633 , C08G64/1641 , C08G64/183 , C08G65/3317 , C08G69/44 , C08K5/13 , C08K5/20
摘要： Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers. The iodinated and brominated aromatic dihydroxy monomers can be employed as radio-opacifying, biocompatible non-toxic additives for other polymeric biomaterials. Radio-opaque medical implants and drug delivery devices for implantation prepared from the polymers of the present invention are also disclosed.
摘要翻译： 制备芳族二羟基单体的碘化和/或溴化衍生物并聚合以形成不透射线的聚合物。 单体也可以与其它二羟基单体共聚。 碘化和溴化芳族二羟基单体可用作其他聚合物生物材料的无光乳化，生物相容性无毒添加剂。 还公开了由本发明的聚合物制备的不透射线的医疗植入物和用于植入的药物递送装置。
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8.发明授权Process of making flowable hemostatic compositions and devices containing such compositions 有权制备可流动止血组合物和含有这种组合物的装置的方法公开(公告)号：US07927626B2
公开(公告)日：2011-04-19
申请号：US10896454
申请日：2004-07-21
CPC分类号： A61K9/0019 , A61K9/10 , A61K9/19 , A61K38/36 , A61K38/363 , A61K38/39 , A61K38/4833 , A61K47/36 , A61K47/42 , A61L24/104 , A61L24/108 , A61L26/0028 , A61L26/0042 , A61L26/0095 , A61L2400/04 , C12N9/6429 , C12Y304/21005
摘要： The present invention is directed to processes of making flowable hemostatic compositions and devices that include the flowable hemostatic composition disposed therein, where a volume of a biocompatible liquid, a volume of a biocompatible gas, and an amount of solid particles of a biocompatible polymer are mixed together to form a substantially homogenous composition including a discontinuous gas phase and the solid particles substantially homogenously dispersed throughout a continuous liquid phase to form a flowable hemostatic composition, and the composition then transferred into a device suitable for applying the flowable hemostatic composition to a site of a body requiring hemostasis under conditions effective to maintain the substantially homogeneous dispersion of the gas phase and the solid particles throughout the liquid phase.
摘要翻译： 本发明涉及制备可流动止血组合物和装置的方法，其包括设置在其中的可流动止血组合物，其中生物相容性液体的体积，生物相容性气体的体积和生物相容性聚合物的固体颗粒的量混合 一起形成基本上均匀的组合物，其包括不连续气相，并且固体颗粒基本均匀地分散在整个连续液相中以形成可流动的止血组合物，然后将组合物转移到适于将可流动止血组合物施用于 在有效维持气相和固体颗粒在整个液相中的基本上均匀分散的条件下需要止血的身体。
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公开(公告)号：US20100183582A1
公开(公告)日：2010-07-22
申请号：US12750334
申请日：2010-03-30
CPC分类号： A61K9/0019 , A61K9/10 , A61K9/19 , A61K38/36 , A61K38/363 , A61K38/39 , A61K38/4833 , A61K47/36 , A61K47/42 , A61L24/104 , A61L24/108 , A61L26/0028 , A61L26/0042 , A61L26/0095 , A61L2400/04 , C12N9/6429 , C12Y304/21005
摘要： The present invention includes sterilized hemostatic compositions that contain a continuous, biocompatible liquid phase having a solid phase of particles of a biocompatible polymer suitable for use in hemostasis and that is substantially insoluble in the liquid phase, and sterile thrombin, each of which is substantially homogenously dispersed throughout the continuous liquid phase, and methods for making such compositions.
摘要翻译： 本发明包括灭菌的止血组合物，其包含连续的生物相容性液相，其具有适于用于止血并且基本上不溶于液相的生物相容性聚合物颗粒的固相，以及基本均匀的无菌凝血酶 分散在整个连续液相中，以及制备这种组合物的方法。
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公开(公告)号：US07718412B2
公开(公告)日：2010-05-18
申请号：US10567388
申请日：2004-07-23
CPC分类号： A61K9/0019 , A61K9/10 , A61K9/19 , A61K38/36 , A61K38/363 , A61K38/39 , A61K38/4833 , A61K47/36 , A61K47/42 , A61L24/104 , A61L24/108 , A61L26/0028 , A61L26/0042 , A61L26/0095 , A61L2400/04 , C12N9/6429 , C12Y304/21005
摘要： The present invention includes sterilized hemostatic compositions that contain a continuous, biocompatible liquid phase having a solid phase of particles of a biocompatible polymer suitable for use in hemostasis and that is substantially insoluble in the liquid phase, and sterile thrombin, each of which is substantially homogenously dispersed throughout the continuous liquid phase, and methods for making such compositions.
摘要翻译： 本发明包括灭菌的止血组合物，其包含连续的生物相容性液相，其具有适于用于止血并且基本上不溶于液相的生物相容性聚合物颗粒的固相，以及基本均匀的无菌凝血酶 分散在整个连续液相中，以及制备这种组合物的方法。
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