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1.发明申请SUBUNIT VACCINE PLATFORM BASED ON MULTIMERIC RIBONUCLEOPROTEINS COMPRISING NUCLEOPROTEINS OF A NON-SEGMENTED NEGATIVE-STRAND RNA VIRUS AS CARRIERS OF HETEROLOGOUS POLYPEPTIDES 审中-公开基于多重核糖核酸的亚基疫苗平台，其包含作为异源多肽的载体的非分离的阴性RNA病毒的核糖核酸公开(公告)号：US20160271242A1
公开(公告)日：2016-09-22
申请号：US15034870
申请日：2014-09-17
申请人： INSTITUT PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE PARIS DIDEROT - PARIS 7
发明人： Monica SALA , Daria JACOB , Frederic TANGY
IPC分类号： A61K39/165 , C12N7/00 , C12N15/81 , C07K14/445 , A61K39/125 , C07K14/005 , A61K39/015
CPC分类号： A61K39/165 , A61K39/015 , A61K39/125 , A61K2039/521 , A61K2039/523 , A61K2039/542 , A61K2039/545 , A61K2039/57 , A61K2039/575 , A61K2039/6031 , A61K2039/6075 , A61K2039/70 , C07K14/005 , C07K14/445 , C07K2319/85 , C12N7/00 , C12N15/815 , C12N2760/18422 , C12N2760/18434 , C12N2760/18451 , C12N2760/18471 , C12N2770/32322 , C12N2770/32334 , C12N2770/32351 , Y02A50/412
摘要： The present invention relates to a subunit vaccine platform based on multimeric ribonucleoproteins (RNPs) comprising nucleoproteins of a non- segmented negative-strand ribonucleic acid (RNA) virus as carriers of heterologous polypeptides. The present invention also relates to multimeric RNPs resulting from the assembly of at least 200 fusion proteins with a cellular RNA, or to recombinant yeasts or yeast lysates expressing these multimeric RNPs. It also concerns a process for the preparation of these multimeric RNPs or recombinant yeasts or yeast lysates. In particular, the present invention relates to their use as active ingredient for the in vitro production of an immunogenic composition or in eliciting a protective prophylactic or a therapeutic immune response against said heterologous polypeptide in a host in need thereof. Recombinant yeasts or yeast lysates of the invention can also be used as expression and vector systems for delivery to a host.
摘要翻译： 本发明涉及一种基于多聚核糖核蛋白（RNP）的亚单位疫苗平台，其包含非分段负链核糖核酸（RNA）病毒的核蛋白作为异源多肽的载体。 本发明还涉及由至少200个融合蛋白与细胞RNA组装产生的多聚体RNP，或涉及表达这些多聚RNP的重组酵母或酵母裂解物。 它还涉及制备这些多聚RNP或重组酵母或酵母裂解物的方法。 特别地，本发明涉及它们作为体外产生免疫原性组合物的活性成分或在有需要的宿主中引发针对所述异源多肽的保护性预防或治疗性免疫应答的用途。 本发明的重组酵母或酵母裂解物也可用作递送至宿主的表达和载体系统。
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公开(公告)号：US20240294942A1
公开(公告)日：2024-09-05
申请号：US18667718
申请日：2024-05-17
发明人： Kepler MEARS , Robert MANGUSO , Kathleen YATES
IPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C07K16/28
CPC分类号： C12N15/86 , A61K48/0058 , C07K14/005 , C07K16/2803 , C07K16/2812 , C07K16/2815 , C07K16/2833 , C07K16/289 , C07K2317/569 , C07K2317/622 , C07K2319/33 , C12N2740/15042 , C12N2740/15045 , C12N2740/15052 , C12N2740/15062 , C12N2740/15071 , C12N2760/18422 , C12N2760/18471
摘要： The invention features pseudotyped viral particles (e.g., lentiviral or gammaretroviral particles) and compositions and methods of use thereof, where the viral particles comprise a VHH domain.
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公开(公告)号：US11976305B2
公开(公告)日：2024-05-07
申请号：US16954592
申请日：2018-12-20
发明人： Mathieu Mateo , Sylvain Baize , Frédéric Tangy
IPC分类号： A61K39/00 , A61K39/165 , A61P31/14 , C07K14/005 , C12N7/00 , C12N15/86
CPC分类号： C12N7/00 , A61K39/165 , A61P31/14 , C07K14/005 , C12N15/86 , A61K2039/54 , A61K2039/572 , C12N2760/10022 , C12N2760/10023 , C12N2760/10034 , C12N2760/10043 , C12N2760/10052 , C12N2760/10071 , C12N2760/18423 , C12N2760/18434 , C12N2760/18443 , C12N2760/18452 , C12N2760/18471
摘要： The invention relates to recombinant measles virus expressing Lassa virus polypeptides, and concerns in particular immunogenic LASV particles expressed by a measles virus and/or virus like particles (VLPs) that contain proteins of a Lassa virus. These particles are recombinant infectious particles able to replicate in a host after an administration. The invention provides means, in particular nucleic acid constructs, vectors, cells and rescue systems to produce these recombinant infectious particles. The invention also relates to the use of these recombinant infectious particles, in particular under the form of a composition, more particularly in a vaccine formulation, for the treatment or prevention of an infection by Lassa virus.
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公开(公告)号：US20170065650A1
公开(公告)日：2017-03-09
申请号：US15121751
申请日：2015-02-25
IPC分类号： A61K35/768 , A61K39/395 , C12N7/00
CPC分类号： A61K35/768 , A61K39/39558 , C12N7/00 , C12N2760/18432 , C12N2760/18433 , C12N2760/18441 , C12N2760/18471
摘要： The present invention relates to a recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding a secreted activator of the immune response, to a polynucleotide encoding the same, and to a kit comprising the same. Moreover, the present invention relates to a method for treating cancer in a subject afflicted with cancer, comprising contacting said subject with a recombinant virus of the family Paramyxoviridae of the invention, and thereby, treating cancer in a subject afflicted with cancer.
摘要翻译： 本发明涉及副粘病毒科的重组病毒，其包含编码免疫应答分泌的激活剂的至少一种可表达的多核苷酸，以及编码该重组病毒的多核苷酸，以及包含该重组病毒的试剂盒。 此外，本发明涉及在患有癌症的受试者中治疗癌症的方法，包括使所述受试者与本发明的副粘病毒科的重组病毒接触，从而在患有癌症的受试者中治疗癌症。
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公开(公告)号：US20150182619A1
公开(公告)日：2015-07-02
申请号：US14282702
申请日：2014-05-20
申请人： Zoetis LLC
IPC分类号： A61K39/235 , A61K39/23 , C12N7/00 , A61K39/155 , A61K39/02 , A61K39/12 , A61K39/175
CPC分类号： A61K39/235 , A61K39/00 , A61K39/0225 , A61K39/099 , A61K39/12 , A61K39/155 , A61K39/175 , A61K39/23 , A61K2039/525 , A61K2039/5254 , A61K2039/542 , A61K2039/545 , A61K2039/552 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/10034 , C12N2710/10071 , C12N2710/10334 , C12N2750/14034 , C12N2750/14071 , C12N2750/14334 , C12N2760/18034 , C12N2760/18071 , C12N2760/18434 , C12N2760/18471 , C12N2770/20022
摘要： This invention relates to a method of treating a dog for canine diseases comprising administering to the dog therapeutically effective amounts of a vaccine, wherein the vaccine comprises viral antigens, a bacterin, or both, and wherein the vaccine is administered subcutaneously or orally according to the schedules provided herein.
摘要翻译： 本发明涉及一种治疗狗疾病的方法，包括向狗施用治疗有效量的疫苗，其中所述疫苗包含病毒抗原，菌苗或两者，并且其中所述疫苗根据所述疫苗皮下或口服给药 这里提供的时间表。
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公开(公告)号：US20130197612A1
公开(公告)日：2013-08-01
申请号：US13023110
申请日：2011-02-08
IPC分类号： A61N5/06
CPC分类号： A61K39/175 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55522 , A61N5/0613 , C07K14/005 , C07K14/535 , C12N7/00 , C12N2710/24043 , C12N2750/14334 , C12N2760/18422 , C12N2760/18434 , C12N2760/18471 , C12N2800/22
摘要： Apparatuses and methods for the prevention, reduction, or elimination of tissue injury by the application of electromagnetic energy. The apparatuses and methods have application for use in various tissues within diverse regions of the body, including for the prevention, reduction, or elimination of acute kidney injury, kidney failure, and contrast-induced nephropathy.
摘要翻译： 通过施加电磁能量预防，减少或消除组织损伤的装置和方法。 该装置和方法适用于身体不同区域内的各种组织，包括用于预防，减少或消除急性肾损伤，肾衰竭和造影剂引起的肾病。
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公开(公告)号：US20110236419A1
公开(公告)日：2011-09-29
申请号：US13035904
申请日：2011-02-25
IPC分类号： A61K39/145 , C12N15/85 , C12N15/86 , A61K31/7088 , A61K39/00 , A61K39/205 , A61K39/23 , A61K39/215 , A61K39/29 , A61K39/245 , A61K39/002 , A61P37/04 , A61P31/20 , A61P31/14 , A61P31/16 , A61P31/10 , A61P33/02
CPC分类号： A61K39/175 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/552 , A61K2039/55522 , A61N5/0613 , C07K14/005 , C07K14/535 , C12N7/00 , C12N2710/24043 , C12N2750/14334 , C12N2760/18422 , C12N2760/18434 , C12N2760/18471 , C12N2800/22
摘要： The present invention provides vectors that contain and express in vivo or in vitro CDV polypeptides or antigens that elicit an immune response in animal against CDV, compositions comprising said vectors and/or CDV polypeptides, and methods of vaccination against CDV. The invention further provides methods for inducing an immunogenic or protective response against CDV and other canine virus, as well as methods for preventing or treating CDV and other canine virus or disease state(s) caused by CDV and other canine virus.
摘要翻译： 本发明提供载体，其含有体内或体外CDV多肽或在动物体内产生针对CDV的免疫应答的抗原，包含所述载体和/或CDV多肽的组合物，以及针对CDV的疫苗接种方法。 本发明还提供了诱导针对CDV和其他犬病毒的免疫原性或保护性应答的方法，以及用于预防或治疗CDV和其他犬病毒或由CDV和其他犬病毒引起的疾病状态的方法。
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公开(公告)号：US09795643B2
公开(公告)日：2017-10-24
申请号：US14719906
申请日：2015-05-22
申请人： Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Schell , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
发明人： Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Schell , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
IPC分类号： A61K35/768 , C12N9/10 , C12N9/78 , A61K31/7088 , C12N7/00
CPC分类号： A61K35/768 , A61K31/7088 , C07K2319/00 , C12N7/00 , C12N9/1077 , C12N9/78 , C12N2760/18421 , C12N2760/18432 , C12N2760/18443 , C12N2760/18471 , C12N2830/60 , C12Y305/04001
摘要： The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
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公开(公告)号：US09272008B2
公开(公告)日：2016-03-01
申请号：US13818053
申请日：2011-08-19
申请人： Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Zimmermann , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
发明人： Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Zimmermann , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
IPC分类号： C12N7/00 , A61K39/165 , A61K39/00 , A61K35/768 , C12N9/10 , C12N9/78 , A61K31/7088
CPC分类号： A61K35/768 , A61K31/7088 , C07K2319/00 , C12N7/00 , C12N9/1077 , C12N9/78 , C12N2760/18421 , C12N2760/18432 , C12N2760/18443 , C12N2760/18471 , C12N2830/60 , C12Y305/04001
摘要： The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
摘要翻译： 本发明涉及一种药物组合物，其包含编码自杀基因的重组麻疹病毒，所述重组麻疹病毒用于治疗具有抗自由基基因活性的溶瘤性麻疹病毒的一级或二级抗性的恶性细胞。 此外，本发明涉及基于编码自杀基因的麻疹疫苗株Schwarz的重组麻疹病毒，其包含胞嘧啶脱氨酶，特别是酵母胞嘧啶脱氨酶和尿嘧啶磷酸核糖转移酶，特别是酵母尿嘧啶磷酸核糖转移酶的融合物，其方法和 用于制备本文所要求的重组麻疹病毒的试剂盒。
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公开(公告)号：US20150250838A1
公开(公告)日：2015-09-10
申请号：US14719906
申请日：2015-05-22
申请人： Ulrich M. LAUER , Michael BITZER , Johanna LAMPE , Martina ZIMMERMANN , Susanne BERCHTOLD , Sebastian LANGE , Wolfgang J. NEUBERT , Sascha BOSSOW
发明人： Ulrich M. LAUER , Michael BITZER , Johanna LAMPE , Martina ZIMMERMANN , Susanne BERCHTOLD , Sebastian LANGE , Wolfgang J. NEUBERT , Sascha BOSSOW
IPC分类号： A61K35/768 , C12N9/78 , C12N7/00
CPC分类号： A61K35/768 , A61K31/7088 , C07K2319/00 , C12N7/00 , C12N9/1077 , C12N9/78 , C12N2760/18421 , C12N2760/18432 , C12N2760/18443 , C12N2760/18471 , C12N2830/60 , C12Y305/04001
摘要： The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
摘要翻译： 本发明涉及一种药物组合物，其包含编码自杀基因的重组麻疹病毒，所述重组麻疹病毒用于治疗具有抗自由基基因活性的溶瘤性麻疹病毒的一级或二级抗性的恶性细胞。 此外，本发明涉及基于编码自杀基因的麻疹疫苗株Schwarz的重组麻疹病毒，其包含胞嘧啶脱氨酶，特别是酵母胞嘧啶脱氨酶和尿嘧啶磷酸核糖转移酶，特别是酵母尿嘧啶磷酸核糖转移酶的融合物，其方法和 用于制备本文所要求的重组麻疹病毒的试剂盒。
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