公开(公告)号：US20050113371A1

公开(公告)日：2005-05-26

申请号：US11023131

申请日：2004-12-28

申请人： Seiji Ishiduka ,  Tomohiro Tada ,  Masahide Katayama ,  Satoshi Yanagihara ,  Toshihito Shimizu

发明人： Seiji Ishiduka ,  Tomohiro Tada ,  Masahide Katayama ,  Satoshi Yanagihara ,  Toshihito Shimizu

IPC分类号： A61K31/485 ,  A01N33/04 ,  A01N43/84 ,  A61K31/137 ,  A61K31/537 ,  A61K31/5375 ,  A61P31/10

CPC分类号： A61K31/5375 ,  A61K31/137 ,  A61K2300/00

摘要： The present invention provides an antifungal agent for topical use and remedy for athlete's foot that comprises a new combination of medicines and has a strong antifungal activity against both genus Trichophyton and genus Candida. The antifungal agent for topical use and remedy for athlete's foot contain amorolfine with butenafine or terbinafine.

摘要翻译： 本发明提供一种用于局部使用的抗真菌剂和用于运动员脚的补救剂，其包括药物的新组合，并且对毛癣菌属和念珠菌属具有强烈的抗真菌活性。 用于局部用途的抗真菌剂和运动员脚的补救措施包含含有丁酸钠或特比萘芬的阿莫罗芬。

公开(公告)号：US06525066B2

公开(公告)日：2003-02-25

申请号：US10124485

申请日：2002-04-18

申请人： Ryoichi Fukumoto ,  Hiroyuki Kusakabe ,  Chong Chu ,  Hiroaki Kimura ,  Satoshi Yanagihara ,  Masatoshi Kato ,  Chisato Hirosawa ,  Seiji Ishiduka ,  Fusae Shizume

发明人： Ryoichi Fukumoto ,  Hiroyuki Kusakabe ,  Chong Chu ,  Hiroaki Kimura ,  Satoshi Yanagihara ,  Masatoshi Kato ,  Chisato Hirosawa ,  Seiji Ishiduka ,  Fusae Shizume

IPC分类号： A61K31435

CPC分类号： C07D455/02 ,  A61K31/4375 ,  Y02A50/473 ,  Y02P20/55

摘要： A compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 represents a hydrogen atom or a carboxyl-protecting group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a hydroxyl group, R3 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group, a cyano group, a hydroxyl group or an amino group; R4 represents a hydrogen atom, an amino-protecting group, an alkyl group or a cycloalkyl group, and R5 represents a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a cycloalkyl group, an aryl group, an alkoxy group, an alkylthio group, a hydroxyl group, an imino group or an amino group.

摘要翻译： 由下式（I）表示的化合物或其药学上可接受的盐：其中R1表示氢原子或羧基保护基，R2表示氢原子，卤素原子，低级烷基，低级烷氧基或 羟基，R3表示氢原子，卤素原子，低级烷基，低级烷氧基，低级烷硫基，硝基，氰基，羟基或氨基; R4表示氢原子， 氨基保护基，烷基或环烷基，R 5表示氢原子，卤素原子，烷基，烯基，环烷基，芳基，烷氧基，烷硫基，羟基 基团，亚氨基或氨基。

公开(公告)号：US20090298889A1

公开(公告)日：2009-12-03

申请号：US11917262

申请日：2006-06-30

申请人： Masatoshi Kato ,  Hiroyuki Kusakabe ,  Satoshi Yanagihara ,  Hidenori Akizawa ,  Yushi Tamoto

发明人： Masatoshi Kato ,  Hiroyuki Kusakabe ,  Satoshi Yanagihara ,  Hidenori Akizawa ,  Yushi Tamoto

IPC分类号： A61K31/4412 ,  C07D213/70

CPC分类号： C07D213/70 ,  C07D213/89 ,  C07D401/04 ,  C07D417/04

摘要： The present invention herein provides a 2-pyridone derivative which has a cell adhesion-inhibitory activity and which is useful for preventing and/or treating pathema or disease conditions including, for instance, inflammations which relate to leukocytic infiltration. The 2-pyridone derivative is a compound represented by the following general formula (1). In the formula, R1 represents, for instance, a phenyl or pyridyl group, R2 represents, for instance, a phenyl group, R3 represents, for instance, a lower alkyl group, R4 represents, for instance, a lower alkyl group, R5 represents, for instance, a lower alkyl group, and R6 represents, for instance, a lower alkyl group.

摘要翻译： 本发明提供具有细胞粘附抑制活性的2-吡啶酮衍生物，其可用于预防和/或治疗pathema或疾病状况，包括例如与白细胞浸润有关的炎症。 2-吡啶酮衍生物是由以下通式（1）表示的化合物。 在该式中，R 1表示例如苯基或吡啶基，R 2表示例如苯基，R 3表示例如低级烷基，R 4表示例如低级烷基，R 5表示 ，例如低级烷基，R6表示例如低级烷基。

公开(公告)号：US07223773B2

公开(公告)日：2007-05-29

申请号：US10809874

申请日：2004-03-26

申请人： Ryoichi Fukumoto ,  Yoshimi Niwano ,  Hiroyuki Kusakabe ,  Chong Chu ,  Hiroaki Kimura ,  Koh Nagasawa ,  Satoshi Yanagihara ,  Chisato Hirosawa ,  Seiji Ishiduka

发明人： Ryoichi Fukumoto ,  Yoshimi Niwano ,  Hiroyuki Kusakabe ,  Chong Chu ,  Hiroaki Kimura ,  Koh Nagasawa ,  Satoshi Yanagihara ,  Chisato Hirosawa ,  Seiji Ishiduka

IPC分类号： A61K31/44 ,  C07D455/02

CPC分类号： A61K31/4375 ,  C07D455/02 ,  Y02A50/473 ,  Y02P20/55

摘要： The present invention provides a 4-oxoquinolizine antibacterial agent having a 2-pyridone skeleton as a partial structure and also having a strong antibacterial effect on gram-positive bacteria, gram-negative bacteria or anaerobic bacteria. The compound having the following formula (I) or a pharmaceutically acceptable salt thereof: wherein: R1 represents hydrogen atom or a carboxyl-protecting group, R2 represents hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxyl group or hydroxyl group, R3 represents phenyl group or an aromatic substituent selected from the group consisting of 5-membered and 6-membered heterocyclic groups and R3 has a substituent selected from the group consisting of a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a nitro group, a cyano group, an amino group, an acyl group, a carbamoyl group and a ureido group, and R4 represents a hydrogen atom or a halogen atom.

摘要翻译： 本发明提供了具有2-吡啶酮骨架作为部分结构并且对革兰氏阳性细菌，革兰氏阴性细菌或厌氧细菌具有强抗菌作用的4-氧喹诺酮抗菌剂。 具有下式（I）的化合物或其药学上可接受的盐：其中R 1表示氢原子或羧基保护基，R 2表示氢原子， 卤素原子，低级烷基，低级烷氧基或羟基，R 3表示苯基或选自5元和6元杂环基的芳香族取代基，R 3 3 <3>具有选自氢原子，低级烷基，低级烷氧基，硝基，氰基，氨基，酰基，氨基甲酰基的取代基 和脲基，R 4代表氢原子或卤素原子。

公开(公告)号：US5881116A

公开(公告)日：1999-03-09

申请号：US926038

申请日：1997-09-09

申请人： Mutsuo Hatakeyama ,  Hirokuni Itoh ,  Satoshi Yanagihara

发明人： Mutsuo Hatakeyama ,  Hirokuni Itoh ,  Satoshi Yanagihara

IPC分类号： G01T1/167 ,  G21C17/017 ,  G21C17/00

CPC分类号： G21C17/017

摘要： In a method of measuring the contamination profile of the inner surfaces of a radioactively contaminated pipe embedded within a concrete structure in a nuclear reactor facility, the detecting surface of a detector to be inserted into the contaminated pipe is fitted with a movable shield plate or cover, which is moved by a specified distance and the radioactive contamination profile within a limited area of the inner surfaces of the pipe is measured in terms of the difference in radiation intensity measured in two states, one where the shield plate or cover is in contact with the detecting surface and the other where it is spaced from the latter.

摘要翻译： 在测量核反应堆设备中嵌入在混凝土结构内的放射性污染管的内表面的污染特性的方法中，插入到污染管中的检测器的检测表面装有可移动的屏蔽板或盖 ，其被移动指定的距离，并且在管的内表面的有限区域内的放射性污染特性是根据在两种状态下测量的辐射强度差来测量的，一种是屏蔽板或盖接触的状态 检测表面和与之隔开的另一个。