公开(公告)号：US20090298889A1

公开(公告)日：2009-12-03

申请号：US11917262

申请日：2006-06-30

申请人： Masatoshi Kato ,  Hiroyuki Kusakabe ,  Satoshi Yanagihara ,  Hidenori Akizawa ,  Yushi Tamoto

发明人： Masatoshi Kato ,  Hiroyuki Kusakabe ,  Satoshi Yanagihara ,  Hidenori Akizawa ,  Yushi Tamoto

IPC分类号： A61K31/4412 ,  C07D213/70

CPC分类号： C07D213/70 ,  C07D213/89 ,  C07D401/04 ,  C07D417/04

摘要： The present invention herein provides a 2-pyridone derivative which has a cell adhesion-inhibitory activity and which is useful for preventing and/or treating pathema or disease conditions including, for instance, inflammations which relate to leukocytic infiltration. The 2-pyridone derivative is a compound represented by the following general formula (1). In the formula, R1 represents, for instance, a phenyl or pyridyl group, R2 represents, for instance, a phenyl group, R3 represents, for instance, a lower alkyl group, R4 represents, for instance, a lower alkyl group, R5 represents, for instance, a lower alkyl group, and R6 represents, for instance, a lower alkyl group.

摘要翻译： 本发明提供具有细胞粘附抑制活性的2-吡啶酮衍生物，其可用于预防和/或治疗pathema或疾病状况，包括例如与白细胞浸润有关的炎症。 2-吡啶酮衍生物是由以下通式（1）表示的化合物。 在该式中，R 1表示例如苯基或吡啶基，R 2表示例如苯基，R 3表示例如低级烷基，R 4表示例如低级烷基，R 5表示 ，例如低级烷基，R6表示例如低级烷基。

公开(公告)号：US06525066B2

公开(公告)日：2003-02-25

申请号：US10124485

申请日：2002-04-18

申请人： Ryoichi Fukumoto ,  Hiroyuki Kusakabe ,  Chong Chu ,  Hiroaki Kimura ,  Satoshi Yanagihara ,  Masatoshi Kato ,  Chisato Hirosawa ,  Seiji Ishiduka ,  Fusae Shizume

发明人： Ryoichi Fukumoto ,  Hiroyuki Kusakabe ,  Chong Chu ,  Hiroaki Kimura ,  Satoshi Yanagihara ,  Masatoshi Kato ,  Chisato Hirosawa ,  Seiji Ishiduka ,  Fusae Shizume

IPC分类号： A61K31435

CPC分类号： C07D455/02 ,  A61K31/4375 ,  Y02A50/473 ,  Y02P20/55

摘要： A compound represented by the following Formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 represents a hydrogen atom or a carboxyl-protecting group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a hydroxyl group, R3 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group, a cyano group, a hydroxyl group or an amino group; R4 represents a hydrogen atom, an amino-protecting group, an alkyl group or a cycloalkyl group, and R5 represents a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, a cycloalkyl group, an aryl group, an alkoxy group, an alkylthio group, a hydroxyl group, an imino group or an amino group.

摘要翻译： 由下式（I）表示的化合物或其药学上可接受的盐：其中R1表示氢原子或羧基保护基，R2表示氢原子，卤素原子，低级烷基，低级烷氧基或 羟基，R3表示氢原子，卤素原子，低级烷基，低级烷氧基，低级烷硫基，硝基，氰基，羟基或氨基; R4表示氢原子， 氨基保护基，烷基或环烷基，R 5表示氢原子，卤素原子，烷基，烯基，环烷基，芳基，烷氧基，烷硫基，羟基 基团，亚氨基或氨基。

公开(公告)号：US07223773B2

公开(公告)日：2007-05-29

申请号：US10809874

申请日：2004-03-26

申请人： Ryoichi Fukumoto ,  Yoshimi Niwano ,  Hiroyuki Kusakabe ,  Chong Chu ,  Hiroaki Kimura ,  Koh Nagasawa ,  Satoshi Yanagihara ,  Chisato Hirosawa ,  Seiji Ishiduka

发明人： Ryoichi Fukumoto ,  Yoshimi Niwano ,  Hiroyuki Kusakabe ,  Chong Chu ,  Hiroaki Kimura ,  Koh Nagasawa ,  Satoshi Yanagihara ,  Chisato Hirosawa ,  Seiji Ishiduka

IPC分类号： A61K31/44 ,  C07D455/02

CPC分类号： A61K31/4375 ,  C07D455/02 ,  Y02A50/473 ,  Y02P20/55

摘要： The present invention provides a 4-oxoquinolizine antibacterial agent having a 2-pyridone skeleton as a partial structure and also having a strong antibacterial effect on gram-positive bacteria, gram-negative bacteria or anaerobic bacteria. The compound having the following formula (I) or a pharmaceutically acceptable salt thereof: wherein: R1 represents hydrogen atom or a carboxyl-protecting group, R2 represents hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxyl group or hydroxyl group, R3 represents phenyl group or an aromatic substituent selected from the group consisting of 5-membered and 6-membered heterocyclic groups and R3 has a substituent selected from the group consisting of a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a nitro group, a cyano group, an amino group, an acyl group, a carbamoyl group and a ureido group, and R4 represents a hydrogen atom or a halogen atom.

摘要翻译： 本发明提供了具有2-吡啶酮骨架作为部分结构并且对革兰氏阳性细菌，革兰氏阴性细菌或厌氧细菌具有强抗菌作用的4-氧喹诺酮抗菌剂。 具有下式（I）的化合物或其药学上可接受的盐：其中R 1表示氢原子或羧基保护基，R 2表示氢原子， 卤素原子，低级烷基，低级烷氧基或羟基，R 3表示苯基或选自5元和6元杂环基的芳香族取代基，R 3 3 <3>具有选自氢原子，低级烷基，低级烷氧基，硝基，氰基，氨基，酰基，氨基甲酰基的取代基 和脲基，R 4代表氢原子或卤素原子。

公开(公告)号：US20070147232A1

公开(公告)日：2007-06-28

申请号：US11566310

申请日：2006-12-04

申请人： Jun Takehara ,  Akira Sawada ,  Makoto Toko ,  Hiroyuki Kusakabe ,  Shinya Kono ,  Yuuji Umeda

发明人： Jun Takehara ,  Akira Sawada ,  Makoto Toko ,  Hiroyuki Kusakabe ,  Shinya Kono ,  Yuuji Umeda

IPC分类号： H04L12/26 ,  H04J3/14

CPC分类号： G05B9/02

摘要： An object is to provide a redundant supervisory control system and a redundancy switching method thereof. In the redundant supervisory control system, remote I/O apparatuses are less likely to be inaccessible, even in a case where failures occur in plural locations. Thus, the reliability of the system is enhanced. The redundant supervisory control system including a plurality of first loop interface units in each of a pair of controllers, second loop interface units, and communication cables each connecting the plurality of first and second loop interface units with one another in a circular loop. The redundant supervisory control system is configured by connecting the controllers and the remote I/O units to one another in a plurality of loop networks. In a case where abnormality in the loop networks is detected by use of received data in the networks, the first and second loop interface units that can perform normal reception are automatically selected.

摘要翻译： 目的在于提供一种冗余监控系统及其冗余切换方法。 在冗余监控系统中，即使在多个位置发生故障的情况下，远程I / O设备也不太可能无法访问。 因此，提高了系统的可靠性。 冗余监控系统包括在一对控制器，第二回路接口单元和通信电缆中的每一个中的多个第一回路接口单元，每个控制器，第二回路接口单元和通信电缆中的每一个以圆形回路相互连接多个第一和第二回路接口单元。 冗余监控系统通过在多个环路网络中将控制器和远程I / O单元彼此连接来配置。 在通过使用网络中的接收数据检测到环路网络中的异常的情况下，可以自动选择能够执行正常接收的第一和第二环路接口单元。

公开(公告)号：US5167025A

公开(公告)日：1992-11-24

申请号：US313562

申请日：1989-02-22

申请人： Hiroyuki Kusakabe

发明人： Hiroyuki Kusakabe

IPC分类号： G05B19/05 ,  G05B19/04 ,  G05B19/042 ,  G06F1/04 ,  G06F9/38

CPC分类号： G06F1/04 ,  G05B19/042 ,  G06F9/3867

摘要： A programmable controller is disclosed for controlling a system including a program memory unit for storing a group of sequence instructions including an instruction part and operand part, a data memory unit for storing a plurality of system data, a sequence execution control unit for executing sequence computations based on instructions fetched from the program memory unit and the system data from the data memory unit, and a holding register unit for holding the operand part as address part of the system data when the sequence execution control unit fetches the instruction from the program memory.

摘要翻译： 公开了一种用于控制系统的可编程控制器，该系统包括用于存储包括指令部分和操作数部分的一组序列指令的程序存储器单元，用于存储多个系统数据的数据存储单元，用于执行顺序计算的序列执行控制单元 基于从程序存储器单元提取的指令和来自数据存储单元的系统数据，以及保持寄存器单元，用于当序列执行控制单元从程序存储器取出指令时，将操作数部分保存为系统数据的地址部分。

公开(公告)号：US5586337A

公开(公告)日：1996-12-17

申请号：US869508

申请日：1992-04-16

申请人： Hiroyuki Kusakabe

发明人： Hiroyuki Kusakabe

IPC分类号： G05B19/05 ,  G05B19/04 ,  G05B19/042 ,  G06F1/04 ,  G06F9/38

CPC分类号： G06F1/04 ,  G05B19/042 ,  G06F9/3867

摘要： A programmable controller includes for controlling a system including a program memory unit for storing a group of sequence instructions including an instruction part and operand part, a data memory unit for storing a plurality of system data, a sequence execution control unit for executing sequence computations based on instructions fetched from the program memory unit and the system data from the data memory unit, and a holding register unit for holding the operand part as address part of the system data when the sequence execution control unit fetches the instruction from the program memory.

摘要翻译： 一种可编程控制器，包括用于控制系统，包括用于存储包括指令部分和操作数部分的序列指令组的程序存储器单元，用于存储多个系统数据的数据存储单元，用于执行基于序列计算的序列执行控制单元 从程序存储器单元获得的指令和来自数据存储器单元的系统数据;以及保持寄存器单元，用于当序列执行控制单元从程序存储器取出指令时，将操作数部分保存为系统数据的地址部分。

公开(公告)号：US5165026A

公开(公告)日：1992-11-17

申请号：US417039

申请日：1989-10-04

申请人： Hiroyuki Kusakabe

发明人： Hiroyuki Kusakabe

IPC分类号： G05B19/05

CPC分类号： G05B19/05

摘要： A program memory and a data memory are independently arranged, and a holding register is arranged between the program memory and the data memory. The program memory and the holding register, the holding register and the data memory, and the data memory, a bit computation unit, and a numerical computation unit are respectively connected to each other through independent buses. After an operand address output from the program memory is latched by the holding register, the content of an instruction pointer for the program memory is updated. As a result, since an operand of the next instruction is set in a register file upon completion of execution of the first instruction, a processing speed can be increased.

公开(公告)号：US07613108B2

公开(公告)日：2009-11-03

申请号：US11566310

申请日：2006-12-04

申请人： Jun Takehara ,  Akira Sawada ,  Makoto Toko ,  Hiroyuki Kusakabe ,  Shinya Kono ,  Yuuji Umeda

发明人： Jun Takehara ,  Akira Sawada ,  Makoto Toko ,  Hiroyuki Kusakabe ,  Shinya Kono ,  Yuuji Umeda

IPC分类号： G06F11/16

CPC分类号： G05B9/02

摘要： An object is to provide a redundant supervisory control system and a redundancy switching method thereof. In the redundant supervisory control system, remote I/O apparatuses are less likely to be inaccessible, even in a case where failures occur in plural locations. Thus, the reliability of the system is enhanced. The redundant supervisory control system including a plurality of first loop interface units in each of a pair of controllers, second loop interface units, and communication cables each connecting the plurality of first and second loop interface units with one another in a circular loop. The redundant supervisory control system is configured by connecting the controllers and the remote I/O units to one another in a plurality of loop networks. In a case where abnormality in the loop networks is detected by use of received data in the networks, the first and second loop interface units that can perform normal reception are automatically selected.

摘要翻译： 目的在于提供一种冗余监控系统及其冗余切换方法。 在冗余监控系统中，即使在多个位置发生故障的情况下，远程I / O设备也不太可能无法访问。 因此，提高了系统的可靠性。 冗余监控系统包括在一对控制器，第二回路接口单元和通信电缆中的每一个中的多个第一回路接口单元，每个控制器，第二回路接口单元和通信电缆中的每一个以圆形回路彼此连接多个第一和第二回路接口单元。 冗余监控系统通过在多个环路网络中将控制器和远程I / O单元彼此连接来配置。 在通过使用网络中的接收数据检测到环路网络中的异常的情况下，可以自动选择能够执行正常接收的第一和第二环路接口单元。