公开(公告)号：US20250082701A1

公开(公告)日：2025-03-13

申请号：US18957210

申请日：2024-11-22

Applicant: SEED HEALTH, INC.

Inventor： Gregor REID ,  Brendan DAISLEY ,  Raja DHIR

IPC: A61K35/747 ,  A23K10/18 ,  A23K10/38 ,  A23K20/163 ,  A23K50/90 ,  A61K9/00 ,  A61K35/00 ,  A61P31/00

Abstract: The present disclosure relates to compositions, methods and systems for the prophylaxis and treatment of honey bees (e.g, Apis mellifera) to protect and/or treat certain diseases, disorders and conditions, e.g., Colony Collapse Disorder and American foulbrood. The present disclosure comprises probiotic compositions, and methods of use thereof, for administration to honey bees for the purposes of treating or preventing disease.

公开(公告)号：US12245673B2

公开(公告)日：2025-03-11

申请号：US17717054

申请日：2022-04-09

Applicant: Seed Health Inc.

Inventor： Joseph E. Kovarik

IPC: A01N25/08 ,  A01N37/18 ,  A01P17/00 ,  A45D29/00 ,  A45D29/17

Abstract: An insect repellent collar for a pet includes an encapsulated insect repellent adjacent to an absorbent material, which is itself adjacent to a skin/fur barrier/odor impervious material, and where at least about 0.5 ml of insect repellent is encapsulated in a frangible enclosure that when fractured, releases a fresh supply of repellent onto the absorbent material for the passive evaporation of the repellent.

公开(公告)号：US20240299470A1

公开(公告)日：2024-09-12

申请号：US18262629

申请日：2022-01-25

Applicant: SEED HEALTH INC.

Inventor： Rajat DHIR ,  Gregor REID ,  Ara KATZ

IPC: A61K35/744 ,  A61K9/00 ,  A61K9/48 ,  A61K31/352 ,  A61K36/185

CPC classification number: A61K35/744 ,  A61K9/0053 ,  A61K9/4808 ,  A61K31/352 ,  A61K36/185

Abstract: Synbiotic compositions including both a prebiotic component and a probiotic component are provided. The prebiotic component includes at least one punicalagin, and the probiotic component includes a rationally defined and assembled consortium of microbial strains. Delivery capsules for oral administration of the synbiotic compositions and methods of using the synbiotic compositions to treat disease are also provided.

公开(公告)号：US20240277780A1

公开(公告)日：2024-08-22

申请号：US18615672

申请日：2024-03-25

Applicant: Seed Health, Inc.

Inventor： Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/00 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/17 ,  C12N1/20

CPC classification number: A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/1709 ,  A61K38/1758 ,  C12N1/20 ,  A61K2035/11 ,  A61K2035/115

Abstract: Various embodiments of the present invention are directed to the field of treating and preventing osteoporosis, with particular embodiments directed to a method of ameliorating, treating, or preventing osteoporosis in a human subject employing tomatidine, xylitol, rapamycin, etc., as well as modifying an individual's microbiome to reduce the likelihood of osteoporosis.

公开(公告)号：US11998479B2

公开(公告)日：2024-06-04

申请号：US18234544

申请日：2023-08-16

Applicant: SEED HEALTH, INC.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61F5/56

CPC classification number: A61F5/566

Abstract: A method and system to address the adverse effects on an individual's oral microbiome with the objective of restoring gingival health caused by exposure to sodium lauryl sulfate. Certain embodiments of the present invention facilitate the growth of desired bacteria in a human's mouth to reduce the likelihood of dental caries, halitosis, canker sores, and other oral diseases. Probiotic bacterial, bioactive flavonoid, xylitol and zinc compound compositions, provide effective prevention and treatment options, especially while precluding the use of sodium lauryl sulfate so as to reduce adverse consequences it has on gingival health.

公开(公告)号：US11833177B2

公开(公告)日：2023-12-05

申请号：US18130946

申请日：2023-04-05

Applicant: Seed Health, Inc.

Inventor： Sheri Simmons ,  Tye Jensen ,  Joseph E. Kovarik

IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17 ,  A61K35/00

CPC classification number: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria, postbiotics, metabolites and other microbe components to foster the growth and maintenance of a healthy skin microbiome. One embodiment includes a topical application of Lactobacillus Crispatus to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, postbiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne, through the production of tryptophan metabolites that act as AHR agonists.

公开(公告)号：US11812835B2

公开(公告)日：2023-11-14

申请号：US17717052

申请日：2022-04-09

Applicant: Seed Health Inc.

Inventor： Joseph E. Kovarik

IPC: A01N25/08 ,  A45D29/00 ,  A45D29/17

CPC classification number: A45D29/007 ,  A01N25/08 ,  A45D29/00 ,  A45D29/17 ,  A45D2200/1018 ,  A45D2200/1036

Abstract: A wearable insect repellent device (such as a wrist/ankle band or adhesive strip) includes an encapsulated insect repellent adjacent to an absorbent material, which is itself adjacent to an odor impervious material, and where at least about 0.5 ml of insect repellent is encapsulated in a frangible enclosure that when fractured, releases a fresh supply of repellent onto said absorbent material for the passive evaporation of the repellent.

公开(公告)号：US20220257410A1

公开(公告)日：2022-08-18

申请号：US17738771

申请日：2022-05-06

Applicant: Seed Health Inc.

Inventor： Joseph E. Kovarik

IPC: A61F5/56

Abstract: A method and system for increasing beneficial bacteria populations in a subject's oral cavity and decreasing pathogenic bacteria to address a variety of diseases and conditions, thereby enhancing a person's oral and overall health, including through the use of oral strips that adhere to surfaces in the oral cavity and that include at least one of xylitol, Lachnospira, Veillonella, Faecalibacterium and/or Rothia bacteria, including bacteria transformed via a CRISPR system. Certain embodiments employ light to modify oral cavity bacterial populations, including the use of bioluminescent oral strips that promote the growth of beneficial bacteria and decrease pathogenic bacteria populations.

公开(公告)号：US20220232944A1

公开(公告)日：2022-07-28

申请号：US17717054

申请日：2022-04-09

Applicant: Seed Health Inc.

Inventor： Joseph E. Kovarik

IPC: A45D29/00 ,  A45D29/17 ,  A01N25/08

Abstract: An insect repellent collar for a pet includes an encapsulated insect repellent adjacent to an absorbent material, which is itself adjacent to a skin/fur barrier/odor impervious material, and where at least about 0.5 ml of insect repellent is encapsulated in a frangible enclosure that when fractured, releases a fresh supply of repellent onto said absorbent material for the passive evaporation of the repellent.

公开(公告)号：US20210128452A1

公开(公告)日：2021-05-06

申请号：US17089469

申请日：2020-11-04

Applicant: SEED HEALTH INC.

Inventor： Rajat Dhir ,  Anthony L. Almada ,  Azza A. Gadir

IPC: A61K8/99 ,  A61Q19/00 ,  A61K8/64 ,  A61K8/49 ,  A61K35/741 ,  A61K31/353 ,  A61K38/16 ,  A61K36/185 ,  A61K31/05 ,  A61K8/34 ,  A61K8/9789 ,  A61K31/436

Abstract: The present invention comprises compositions, systems, and methods of improving the skin and the skin microbiome using bacterial strains and their derivatives, and prebiotics. A useful composition of the invention comprises at least one of (a) a prebiotic that selectively promotes the growth of at least one desirable strain of Cutibacterium acnes (C. acnes); (b) a probiotic comprising at least one desirable strain of C. acnes; and (c) a post-biotic comprising at least one molecule produced by C. acnes.