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1.发明申请NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF 有权新型三亚甲基嘧啶衍生物，其制备方法及其治疗用途公开(公告)号：US20130261106A1
公开(公告)日：2013-10-03
申请号：US13855246
申请日：2013-04-02
申请人： Jean-Christophe CARRY , Fabienne CHATREAUX , Stephanie DEPRETS , Olivier DUCLOS , Vincent LEROY , Sergio MALLART , Dominique MELON-MANGUER , Maria MENDEZ-PEREZ , Fabrice VERGNE
发明人： Jean-Christophe CARRY , Fabienne CHATREAUX , Stephanie DEPRETS , Olivier DUCLOS , Vincent LEROY , Sergio MALLART , Dominique MELON-MANGUER , Maria MENDEZ-PEREZ , Fabrice VERGNE
IPC分类号： C07D495/04
CPC分类号： A61K31/553 , A61K31/519 , A61K31/55 , A61K31/551 , C07D495/04
摘要： The present invention relates to compounds of formula (I): wherein R6 is —CONH2 or a —C(Rα)(Rβ)(OH) group; R is a substituted phenyl or heteroaryl group; R7 is an optionally substituted aryl or heteroaryl group.Process for the preparation thereof and therapeutic use thereof.
摘要翻译： 本发明涉及式（I）化合物：其中R6是-CONH2或-C（Ralpha）（Rbeta）（OH）基团; R是取代的苯基或杂芳基; R 7是任选取代的芳基或杂芳基。 制备方法及其治疗用途。
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2.发明申请Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them 有权二（异）芳基环己烷衍生物，其制备方法，用途和包含它们的药物组合物公开(公告)号：US20100204206A1
公开(公告)日：2010-08-12
申请号：US12630537
申请日：2009-12-03
申请人： Thomas BOHME , Uwe GERLACH , Dirk GRETZKE , Heinz-Werner KLEEMANN , Stefania PFEIFFER-MAREK , Henning VOLLERT , Jean-Michel ALTENBURGER , Sergio MALLART
发明人： Thomas BOHME , Uwe GERLACH , Dirk GRETZKE , Heinz-Werner KLEEMANN , Stefania PFEIFFER-MAREK , Henning VOLLERT , Jean-Michel ALTENBURGER , Sergio MALLART
IPC分类号： A61K31/55 , C07C62/00 , A61K31/19 , C07D213/55 , A61K31/44 , C07D317/46 , A61K31/343 , C07D215/14 , A61K31/47 , C07D213/62 , C07D249/08 , A61K31/4196 , C07D487/02 , C07D231/12 , A61K31/415 , C07D277/30 , A61K31/426 , A61K31/444 , C07D239/02 , A61K31/506 , C07D209/04 , A61K31/404 , C07D235/04 , A61K31/4184 , A61P9/00 , A61P9/06
CPC分类号： C07D317/46 , C07B2200/07 , C07C62/32 , C07C62/34 , C07C255/46 , C07C311/08 , C07C317/46 , C07C323/62 , C07C2601/02 , C07C2601/14 , C07D209/18 , C07D213/30 , C07D213/46 , C07D213/55 , C07D213/57 , C07D213/61 , C07D213/64 , C07D215/14 , C07D217/02 , C07D217/16 , C07D231/12 , C07D231/16 , C07D233/60 , C07D233/64 , C07D233/68 , C07D233/84 , C07D233/90 , C07D235/06 , C07D235/16 , C07D249/08 , C07D277/24 , C07D277/30 , C07D305/04 , C07D305/06 , C07D333/24 , C07D401/12 , C07D405/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising themThe present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
摘要翻译： 二（杂）芳基环己烷衍生物，其制备方法及用途及其组合物本发明涉及式I的二（异）芳基环己烷衍生物，其中Ar 1，Ar 2，R 1和R 2具有权利要求中所示的含义。 式I的化合物是抑制心肌中ATP敏感钾通道的有价值的药物活性化合物，并且适用于例如治疗心血管系统疾病如心律失常或心脏收缩力降低， 例如，可能发生在冠心病，心功能不全或心肌病。 特别是适用于预防心源性猝死。 本发明还涉及用于制备式I化合物的方法和中间体，其用途和包含它们的药物组合物。
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3.发明授权
公开(公告)号：US5324850A
公开(公告)日：1994-06-28
申请号：US835995
申请日：1992-02-21
申请人： Sylvain Juge , Jean-Pierre Genet , Sergio Mallart
发明人： Sylvain Juge , Jean-Pierre Genet , Sergio Mallart
IPC分类号： B01J31/24 , C07C227/32 , C07C229/36 , C07C231/18 , C07F15/00
CPC分类号： B01J31/1875 , B01J31/24 , B01J31/2409 , C07C227/32 , C07C231/18 , B01J2231/643 , B01J2531/821
摘要： Method for the preparation of a chiral catalyst, comprised of an organic complex of ruthenium and phosphorus, consisting in heating a complex of ruthenium with a phosphine, within an organic liquid, inert in relation to substances in presence, the heated complex being based on a diene and an allylic compound; the product obtained following the heating is subjected to the action of an acid in an organic solvent.
摘要翻译： PCT No.PCT / FR90 / 00607 Sec。 一九九二年二月二十一日 102（e）日期1992年2月21日PCT提交1990年8月10日PCT公布。 公开号WO91 / 02588 日本1991年3月7日。用于制备手性催化剂的方法，所述手性催化剂由钌和磷的有机络合物组成，其中包括在有机液体内加热钌与膦的络合物，相对于存在的物质是惰性的， 加热的络合物基于二烯和烯丙基化合物; 在加热后获得的产物在有机溶剂中进行酸的作用。
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4.发明申请公开(公告)号：US20130245006A1
公开(公告)日：2013-09-19
申请号：US13885866
申请日：2011-11-16
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to indolizine derivatives of general formula (I), where A, B, m, W, n and R2 are as defined in claim 1, as well as to the method for preparing same and to the therapeutic use thereof.
摘要翻译： 本发明涉及通式（I）的中氮茚衍生物，其中A，B，m，W，n和R 2如权利要求1所定义，以及其制备方法及其治疗用途。
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5.发明授权Process for the hydrogenation of ethylenically unsaturated organic compounds and ruthenium catalysts for carrying out said process 失效用于进行所述方法的烯属不饱和有机化合物和钌催化剂的氢化方法
公开(公告)号：US5426216A
公开(公告)日：1995-06-20
申请号：US81314
申请日：1993-08-12
IPC分类号： C07B35/02 , C07C51/36 , C07C231/12 , C07F15/00 , C07C229/00 , B01J31/00 , C07F9/00
CPC分类号： C07C51/36 , C07B35/02 , C07C231/12 , C07F15/0046
摘要： The present invention relates to a process for the hydrogenation of ethylenically unsaturated organic compounds. This process is carried out in a homogeneous medium containing a hydrogenation catalyst formed by a complex of ruthenium with a phosphine, which comprises two allylic groups as ligands on the Ru.
摘要翻译： PCT No.PCT / FR91 / 01077 Sec。 371日期：1993年8月12日 102（e）日期1993年8月12日PCT 1991年12月27日PCT PCT。 公开号WO92 / 12110PC 本发明涉及烯属不饱和有机化合物的氢化方法。 该方法在含有钌与膦的络合物形成的氢化催化剂的均匀介质中进行，所述氢化催化剂包含两个烯丙基作为Ru上的配体。
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6.发明授权Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them 有权二（异）芳基环己烷衍生物，其制备方法，用途和包含它们的药物组合物公开(公告)号：US08076324B2
公开(公告)日：2011-12-13
申请号：US12630537
申请日：2009-12-03
申请人： Thomas Bohme , Uwe Gerlach , Dirk Gretzke , Heinz-Werner Kleemann , Stefania Pfeiffer-Marek , Henning Vollert , Jean-Michel Altenburger , Sergio Mallart
发明人： Thomas Bohme , Uwe Gerlach , Dirk Gretzke , Heinz-Werner Kleemann , Stefania Pfeiffer-Marek , Henning Vollert , Jean-Michel Altenburger , Sergio Mallart
IPC分类号： A61P9/00 , A61P9/06 , A61K31/55 , A61K31/444 , A61K31/506 , A61K31/404 , A61K31/19 , A61K31/415 , A61K31/426 , A61K31/4184 , A61K31/44 , A61K31/343 , A61K31/4196 , C07C62/00 , C07D213/55 , C07D317/46 , C07D215/14 , C07D487/02 , C07D231/12 , C07D277/30 , C07D239/02 , C07D209/04 , C07D235/04
CPC分类号： C07D317/46 , C07B2200/07 , C07C62/32 , C07C62/34 , C07C255/46 , C07C311/08 , C07C317/46 , C07C323/62 , C07C2601/02 , C07C2601/14 , C07D209/18 , C07D213/30 , C07D213/46 , C07D213/55 , C07D213/57 , C07D213/61 , C07D213/64 , C07D215/14 , C07D217/02 , C07D217/16 , C07D231/12 , C07D231/16 , C07D233/60 , C07D233/64 , C07D233/68 , C07D233/84 , C07D233/90 , C07D235/06 , C07D235/16 , C07D249/08 , C07D277/24 , C07D277/30 , C07D305/04 , C07D305/06 , C07D333/24 , C07D401/12 , C07D405/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及式I的二（异）芳基环己烷衍生物，其中Ar1，Ar2，R1和R2具有权利要求中所示的含义。 式I的化合物是抑制心肌中ATP敏感钾通道的有价值的药物活性化合物，并且适用于例如治疗心血管系统疾病如心律失常或心脏收缩力降低， 例如，可能发生在冠心病，心功能不全或心肌病。 特别是适用于预防心源性猝死。 本发明还涉及用于制备式I化合物的方法和中间体，其用途和包含它们的药物组合物。
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7.发明授权1-amino-4-(1H-imidazole)- aminobutaneboronic acid derivatives, their preparation and use as synthetic intermediates 失效1-氨基-4-（1H-咪唑） - 氨基丁烷硼酸衍生物，其制备和用作合成中间体
公开(公告)号：US5543526A
公开(公告)日：1996-08-06
申请号：US419923
申请日：1995-04-11
CPC分类号： C07K5/06191 , C07F5/025
摘要： A compound of formula (I) ##STR1## in which R.sub.3 and R.sub.4 together represent the residue of a dihydroxy compound, andR.sub.5 represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group, or a salt thereof, and its use as a synthetic intermediate.
摘要翻译： 式（I）化合物其中R 3和R 4一起代表二羟基化合物的残基，R 5表示氢原子或（C 1 -C 4）烷基或其盐，并且其 用作合成中间体。
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