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公开(公告)号:US20080268453A1
公开(公告)日:2008-10-30
申请号:US12068434
申请日:2008-02-06
申请人: Masao Seto , Hiroyuki Tagawa , Yasuko Yoshida , Shigeki Kira
发明人: Masao Seto , Hiroyuki Tagawa , Yasuko Yoshida , Shigeki Kira
CPC分类号: C12Q1/6881 , C12Q1/6886 , C12Q2600/118 , C12Q2600/178
摘要: A method for determining the prognosis of a CD5+DLBCL patient and a CD5-DLBCL patient is provided. It is determined that, in the chromosomal DNA from a patient with lymphoma, (1) the prognosis of the CD5+DLBCL patient with amplification of 13q21.1-q31.3 region is poor; (2) the prognosis of the CD5+DLBCL patient with deletion of 1p36.21-p36.13 region is poor; and (3) the prognosis of the CD5-DLBCL patient with amplification of 5p15.33-p14.2 region is good.
摘要翻译: 提供了一种确定CD5 + DLBCL患者和CD5-DLBCL患者预后的方法。 确定在淋巴瘤患者的染色体DNA中,(1)扩增13q21.1-q31.3区域的CD5 + DLBCL患者的预后差; (2)缺失1p36.21-p36.13区域的CD5 + DLBCL患者的预后差; 和(3)扩增5p15.33-p14.2区域的CD5-DLBCL患者的预后良好。
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公开(公告)号:US20050282177A1
公开(公告)日:2005-12-22
申请号:US10946068
申请日:2004-09-22
申请人: Masao Seto , Hiroyuki Tagawa , Yasuko Yoshida , Shigeki Kira
发明人: Masao Seto , Hiroyuki Tagawa , Yasuko Yoshida , Shigeki Kira
CPC分类号: C12Q1/6881 , C12Q1/6886 , C12Q2600/118 , C12Q2600/178
摘要: A method for determining the prognosis of a CD5+DLBCL patient and a CD5−DLBCL patient is provided. It is determined that, in the chromosomal DNA from a patient with lymphoma, (1) the prognosis of the CD5+DLBCL patient with amplification of 13q21.1-q31.3 region is poor; (2) the prognosis of the CD5+DLBCL patient with deletion of 1p36.21-p36.13 region is poor; and (3) the prognosis of the CD5−DLBCL patient with amplification of 5p15.33-p14.2 region is good.
摘要翻译: 提供了一种确定CD5 + DLBCL患者和CD5-DLBCL患者预后的方法。 确定在淋巴瘤患者的染色体DNA中,(1)扩增13q21.1-q31.3区域的CD5 + DLBCL患者的预后差; (2)缺失1p36.21-p36.13区域的CD5 + DLBCL患者的预后差; 和(3)扩增5p15.33-p14.2区域的CD5-DLBCL患者的预后良好。
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公开(公告)号:US20080004208A1
公开(公告)日:2008-01-03
申请号:US11791839
申请日:2005-12-05
申请人: Masao Seto , Hiroyuki Tagawa , Yasuko Yoshida , Shigeki Kira
发明人: Masao Seto , Hiroyuki Tagawa , Yasuko Yoshida , Shigeki Kira
CPC分类号: G01N33/57426 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/16
摘要: In order to more accurately analyze a change in the complicated gene copy number in malignant lymphoma and identify a region affected by an important genomic aberration in greater detail so that the results can be used in diagnosing the type of disease and performing prognosis, genome-wide array CGH is carried out and thus human chromosome 136.23 to p36.32, human chromosome 1 q42.2 to q43, human chromosome 2 p11.2, human chromosome 2 q13, human chromosome 17 p11.2 to p13.3, and human chromosome 19 p13.2 to p13.3 are identified.
摘要翻译: 为了更准确地分析恶性淋巴瘤中复杂基因拷贝数的变化,并更详细地鉴定受重要基因组畸变影响的区域,使得结果可用于诊断疾病的类型并进行预后,全基因组 进行阵列CGH,因此人染色体136.23至p36.32,人染色体1 q42.2至q43,人染色体2 p11.2,人染色体2 q13,人染色体17 p11.2至p13.3和人染色体 19 p13.2至p13.3。
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公开(公告)号:US20090068716A1
公开(公告)日:2009-03-12
申请号:US12245525
申请日:2008-10-03
CPC分类号: C12Q1/025 , C12Q1/22 , G01N33/54353
摘要: A biological indicator including a carrier and an indicator material, said indicator material adhering on the surface of the carrier, and having a contact portion being contact with the surface of the carrier and a non-contact portion being not in contact with the surface of the carrier, and wherein the carrier includes an adhering area having a adhering portion to which the indicator material adheres and a non-adhering area having an non-adhering portion to which the indicator material does not adhere.
摘要翻译: 一种包括载体和指示剂材料的生物指示剂,所述指示剂材料粘附在载体的表面上,并且具有接触部分与载体的表面接触,并且非接触部分不与所述载体的表面接触 并且其中所述载体包括粘附区域,所述粘附区域具有指示剂材料附着的粘附部分和具有指示材料不粘附到其上的非粘附部分的非粘附区域。
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5.
公开(公告)号:US07200254B2
公开(公告)日:2007-04-03
申请号:US10235999
申请日:2002-09-05
CPC分类号: B82Y30/00 , B01J19/0046 , B01J2219/00529 , B01J2219/0054 , B01J2219/00576 , B01J2219/00677 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , G01N2035/00158 , G01N2035/0494
摘要: Technology is disclosed for highly accurate automated execution of processing for alignment of a detection area to a DNA microarray image file and processing for quantitative determination of success/failure of the alignment during DNA microarray analysis. A probe reactive chip used for the technology comprises a substrate; a spot region wherein spots for fixing a probe capable of specifically reacting to a sample marked so as to be optically detectable are formed in a matrix on a surface of the substrate; and a reference pattern area, which is arranged within the spot region or approximate to the spot region, and comprises a plurality of different alignment marks in order to correct misalignment of the spot during analysis of the sample on the surface of the substrate.
摘要翻译: 公开了用于高精度自动执行用于将检测区域与DNA微阵列图像文件对齐的处理的技术,以及用于在DNA微阵列分析期间定量确定取向成功/失败的处理。 用于该技术的探针反应性芯片包括基底; 斑点区域,其中用于固定探针的斑点能够与标记为可光学检测的样品特异性反应,形成在基底表面上的基质中; 以及布置在斑点区域内或近似于斑点区域的参考图案区域,并且包括多个不同的对准标记,以便在基底表面上的样品分析期间校正斑点的未对准。
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