公开(公告)号：US08962854B2

公开(公告)日：2015-02-24

申请号：US14240144

申请日：2012-08-22

Applicant: Shigeru Nishiyama ,  Tsuyoshi Saito ,  Shojiro Maki ,  Haruki Niwa

Inventor： Shigeru Nishiyama ,  Tsuyoshi Saito ,  Shojiro Maki ,  Haruki Niwa

IPC: C07D417/04 ,  C07D417/06 ,  C07D277/10 ,  C07D277/66 ,  C12Q1/66 ,  C07D277/12 ,  A61K49/00

CPC classification number: C12Q1/66 ,  A61K49/003 ,  C07D277/12 ,  C07D277/66 ,  C07D417/04 ,  C07D417/06

Abstract: An object of the present invention to provide a firefly luciferin and firefly luciferin analog that are modified to maintain luminescent activity by luciferase in a firefly bioluminescent system. In particular, it is an object of the present invention to provide a new luminescent substrate for which the emission wavelength in a firefly bioluminescent system is shifted to a longer wavelength than that of a conventional luminescent substrate. The present invention provides a luciferin in which the benzothiazole ring moiety has been modified at the 7-position, a luciferin analog in which the benzene ring moiety has been modified at the 6-position, and a luciferin analog in which the 6-(dialkylamino)-2-naphthalenyl moiety has been modified at the 5-position.

Abstract translation: 本发明的目的是提供萤火虫荧光素和萤火虫萤光素类似物，其被修饰以通过荧光素酶在萤火虫生物发光系统中维持发光活性。 特别地，本发明的目的是提供一种荧光生物发光系统的发光波长比现有的发光基板移动到更长的波长的新的发光基板。 本发明提供了其中苯并噻唑环部分在7位被修饰的荧光素，其中苯环部分已经在6位被修饰的萤光素类似物和其中6-（二烷基氨基 ）-2-萘基部分已经在5位修饰。

公开(公告)号：US20140221665A1

公开(公告)日：2014-08-07

申请号：US14240144

申请日：2012-08-22

Applicant: Shigeru Nishiyama ,  Tsuyoshi Saito ,  Shojiro Maki ,  Haruki Niwa

Inventor： Shigeru Nishiyama ,  Tsuyoshi Saito ,  Shojiro Maki ,  Haruki Niwa

IPC: C12Q1/66

CPC classification number: C12Q1/66 ,  A61K49/003 ,  C07D277/12 ,  C07D277/66 ,  C07D417/04 ,  C07D417/06

Abstract: An object of the present invention to provide a firefly luciferin and firefly luciferin analog that are modified to maintain luminescent activity by luciferase in a firefly bioluminescent system. In particular, it is an object of the present invention to provide a new luminescent substrate for which the emission wavelength in a firefly bioluminescent system is shifted to a longer wavelength than that of a conventional luminescent substrate. The present invention provides a luciferin in which the benzothiazole ring moiety has been modified at the 7-position, a luciferin analog in which the benzene ring moiety has been modified at the 6-position, and a luciferin analog in which the 6-(dialkylamino)-2-naphthalenyl moiety has been modified at the 5-position.

Abstract translation: 本发明的目的是提供萤火虫荧光素和萤火虫萤光素类似物，其被修饰以通过荧光素酶在萤火虫生物发光系统中维持发光活性。 特别地，本发明的目的是提供一种荧光生物发光系统的发光波长比现有的发光基板移动到更长的波长的新的发光基板。 本发明提供了其中苯并噻唑环部分在7位被修饰的荧光素，其中苯环部分已经在6位被修饰的萤光素类似物和其中6-（二烷基氨基 ）-2-萘基部分已经在5位修饰。

公开(公告)号：US08557167B2

公开(公告)日：2013-10-15

申请号：US13122571

申请日：2009-11-18

Applicant: Masayuki Kanemasu ,  Shigeru Nishiyama ,  Hideki Horizono

Inventor： Masayuki Kanemasu ,  Shigeru Nishiyama ,  Hideki Horizono

IPC: B28B3/00

CPC classification number: B29C43/3642 ,  B29C43/12 ,  B29C73/025 ,  B29C73/10 ,  B29C2043/3644 ,  B29K2105/0002 ,  B29K2105/0872

Abstract: In manufacturing composite material by curing fluid, strength deterioration of the composite material due to repair before the fluid is cured is reduced. A suction hole is formed in a bag film (3) for sealing a space for fibers being impregnated with resin, after start of impregnation. The suction hole is covered by a plate (56) with holes (57). The resin is sucked from the space through the plate (56). According to such composite material manufacturing method, a defect, which occurs during fibers are impregnated with resin, can be repaired before the resin is cured without causing disorder and damage in the fibers. In a composite material formed from one repaired in the above way, the repaired portion is strong, namely, there is no strength deterioration due to repair after curing, and thus, the material is preferred as compared with a composite material which is repaired after resin is cured.

公开(公告)号：US20120244302A1

公开(公告)日：2012-09-27

申请号：US13425559

申请日：2012-03-21

Applicant: Tetsuro HIROKAWA ,  Shigeru Nishiyama

Inventor： Tetsuro HIROKAWA ,  Shigeru Nishiyama

IPC: B32B5/12 ,  B32B27/04 ,  B32B5/26 ,  B29C53/56 ,  B32B1/00

CPC classification number: B64C1/061 ,  B29B11/16 ,  B29C53/588 ,  B29C70/32 ,  B64C2001/0072 ,  Y02T50/43 ,  Y10T428/13 ,  Y10T428/1369

Abstract: Provided is a first reinforcing fiber layer (11) formed of reinforcing fibers which are wound around an outer periphery of a mandrel (20), aligned in parallel to a direction (+θ direction) in which the reinforcing fibers intersect with an annular direction (0° direction) of the mandrel (20), and seamlessly continue in the annular direction of the mandrel (20) by an amount of at least one rotation.

Abstract translation: 提供了一种由增强纤维形成的第一增强纤维层（11），该增强纤维缠绕在心轴（20）的外周上，该心轴（20）的平行于与增强纤维相交的方向（+＆amp; （0°方向），并且在心轴（20）的环形方向上以至少一个旋转的量无缝地继续。

公开(公告)号：US08123158B2

公开(公告)日：2012-02-28

申请号：US12693465

申请日：2010-01-26

Applicant: Ren Ishikawa ,  Yosuke Sumiya ,  Shigeru Nishiyama ,  Kazuo Hiraguchi

Inventor： Ren Ishikawa ,  Yosuke Sumiya ,  Shigeru Nishiyama ,  Kazuo Hiraguchi

IPC: B65H75/18

CPC classification number: G11B23/043 ,  B65H75/30 ,  B65H2601/254 ,  B65H2701/378 ,  B65H2701/5122 ,  G11B23/107

Abstract: A reel includes a hub formed in a cylindrical-tube-shape with a base portion, on an outer peripheral surface of which a recording tape is wound; a base side flange portion that projects-out to a radial direction outer side of a base portion side of the hub; a flange member configured in a disc-shape or an annular-plate-shape of a material with an elastic modulus at least equal to a material that constitutes the hub, the flange member being coaxially joined to an opening end portion of the hub; a metal plate formed in a circular-plate-shape or an annular-plate-shape, which is fixed coaxially to the base portion of the hub; and a groove wall that is formed integrally with the base portion of the hub and forms a groove portion which is continuous around the entire periphery between the groove wall and an outer peripheral surface of the metal plate.

Abstract translation: 卷轴包括形成为具有基部的圆筒形状的轮毂，在其外周表面上缠绕有记录带; 基部侧凸缘部，其突出到所述轮毂的基部侧的径向外侧; 凸缘构件，其构造为具有至少等于构成轮毂的材料的弹性模量的材料的盘形或环形板状，所述凸缘构件同轴地接合到所述轮毂的开口端部; 形成为与所述毂的基部同轴地固定的圆板状或环状板状的金属板， 以及与所述毂的基部一体形成的槽壁，并且形成在所述槽壁与所述金属板的外周面之间的整个周边上连续的槽部。

公开(公告)号：US20110241250A1

公开(公告)日：2011-10-06

申请号：US13129886

申请日：2009-11-18

Applicant: Hideki Horizono ,  Shigeru Nishiyama

Inventor： Hideki Horizono ,  Shigeru Nishiyama

IPC: B29C70/06 ,  B29C43/34

CPC classification number: B29C70/467 ,  B29C43/36 ,  B29C70/48 ,  B29C70/541 ,  B29C2043/3444 ,  B29K2105/0002 ,  B29K2105/0872

Abstract: A manufacturing method and a manufacturing apparatus of a fiber reinforced composite material are provided, in which the whole fiber-based material is impregnated with a resin and a molding can be performed with high dimensional accuracy. A manufacturing method of a fiber reinforced composite material according to the present invention includes fixing a fiber-based material having a first surface to a first mold to provide an opening for the first surface; setting a second mold having a second surface such that the first surface faces the second surface through a space; filling resin into the space; and relatively moving the second mold and the first mold to bring the second surface closer to the first surface, such that the fiber-based material is impregnated with the resin.

Abstract translation: 提供了一种纤维增强复合材料的制造方法和制造装置，其中整个纤维基材料用树脂浸渍，并且可以以高尺寸精度进行成型。 根据本发明的纤维增强复合材料的制造方法包括将具有第一表面的纤维基材料固定到第一模具以提供第一表面的开口; 设置具有第二表面的第二模具，使得第一表面通过空间面向第二表面; 将树脂填充到空间中; 并且相对移动第二模具和第一模具以使第二表面更靠近第一表面，使得纤维基材料被树脂浸渍。

公开(公告)号：US20110204534A1

公开(公告)日：2011-08-25

申请号：US13122571

申请日：2009-11-18

Applicant: Masayuki Kanemasu ,  Shigeru Nishiyama ,  Hideki Horizono

Inventor： Masayuki Kanemasu ,  Shigeru Nishiyama ,  Hideki Horizono

IPC: B29C45/02 ,  B29C70/00 ,  B29C73/02

CPC classification number: B29C43/3642 ,  B29C43/12 ,  B29C73/025 ,  B29C73/10 ,  B29C2043/3644 ,  B29K2105/0002 ,  B29K2105/0872

Abstract: In manufacturing composite material by curing fluid, strength deterioration of the composite material due to repair before the fluid is cured is reduced. A suction hole is formed in a bag film (3) for sealing a space for fibers being impregnated with resin, after start of impregnation. The suction hole is covered by a plate (56) with holes (57). The resin is sucked from the space through the plate (56). According to such composite material manufacturing method, a defect, which occurs during fibers are impregnated with resin, can be repaired before the resin is cured without causing disorder and damage in the fibers. In a composite material formed from one repaired in the above way, the repaired portion is strong, namely, there is no strength deterioration due to repair after curing, and thus, the material is preferred as compared with a composite material which is repaired after resin is cured.

Abstract translation: 在通过固化流体制造复合材料时，由于在流体固化之前修复而导致的复合材料的强度劣化降低。 在开始浸渍之后，在袋膜（3）中形成有用于密封浸渍有树脂的纤维空间的吸孔。 抽吸孔由具有孔（57）的板（56）覆盖。 树脂通过板（56）从空间吸入。 根据这样的复合材料制造方法，在树脂浸渍之前，在树脂浸渍的纤维中发生的缺陷可以在树脂固化之前被修复，而不会引起纤维的紊乱和损坏。 在以上述方式修复的复合材料中，修复部分强，即固化后的修复没有强度劣化，因此与树脂后修复的复合材料相比，材料优选 被治愈

公开(公告)号：US07954750B2

公开(公告)日：2011-06-07

申请号：US12509502

申请日：2009-07-27

Applicant: Ren Ishikawa ,  Yosuke Sumiya ,  Shigeru Nishiyama

Inventor： Ren Ishikawa ,  Yosuke Sumiya ,  Shigeru Nishiyama

IPC: B65H75/18

CPC classification number: G11B23/107 ,  B65H75/30 ,  B65H2601/254 ,  B65H2701/378 ,  B65H2701/5122 ,  G11B23/043

Abstract: A reel comprising a hub formed in the shape of a cylindrical tube with a base, on an outer peripheral surface of which a recording tape is wound; a base side flange portion that projects-out to a radial direction outer side of a base portion side of the hub; a flange member configured in a disc shape or an annular plate shape of a material with an elastic modulus at least equal to a material that constitutes the hub, the flange member being coaxially joined to an opening end portion of the hub; a metal plate formed in a circular plate shape or an annular plate shape, which is fixed coaxially to the base portion of the hub; and plate retention portions that are formed integrally with the base portion of the hub and touch an outer peripheral surface of the metal plate at at least four locations, which are at equal intervals in a circumferential direction of the hub.

Abstract translation: 一种卷轴，其包括形成为具有基部的圆柱形管形式的轮毂，在其外周表面上缠绕有记录带; 基部侧凸缘部，其突出到所述轮毂的基部侧的径向外侧; 凸缘构件，其被构造成具有至少等于构成轮毂的材料的弹性模量的材料的盘形或环形板形状，所述凸缘构件同轴地接合到所述毂的开口端部; 形成为与所述毂的基部同轴地固定的圆板状或环状板状的金属板， 以及板保持部，其与轮毂的基部一体形成，并且在轮毂的圆周方向上以等间隔的至少四个位置接触金属板的外周面。

公开(公告)号：US20100123036A1

公开(公告)日：2010-05-20

申请号：US12693465

申请日：2010-01-26

Applicant: Ren ISHIKAWA ,  Yosuke SUMIYA ,  Shigeru NISHIYAMA ,  Kazuo HIRAGUCHI

Inventor： Ren ISHIKAWA ,  Yosuke SUMIYA ,  Shigeru NISHIYAMA ,  Kazuo HIRAGUCHI

IPC: B65H75/18 ,  B65H75/14 ,  G11B23/107

CPC classification number: G11B23/043 ,  B65H75/30 ,  B65H2601/254 ,  B65H2701/378 ,  B65H2701/5122 ,  G11B23/107

Abstract: A reel includes a hub formed in a cylindrical-tube-shape with a base portion, on an outer peripheral surface of which a recording tape is wound; a base side flange portion that projects-out to a radial direction outer side of a base portion side of the hub; a flange member configured in a disc-shape or an annular-plate-shape of a material with an elastic modulus at least equal to a material that constitutes the hub, the flange member being coaxially joined to an opening end portion of the hub; a metal plate formed in a circular-plate-shape or an annular-plate-shape, which is fixed coaxially to the base portion of the hub; and a groove wall that is formed integrally with the base portion of the hub and forms a groove portion which is continuous around the entire periphery between the groove wall and an outer peripheral surface of the metal plate.

Abstract translation: 卷轴包括形成为具有基部的圆筒形状的轮毂，在其外周表面上缠绕有记录带; 基部侧凸缘部，其突出到所述轮毂的基部侧的径向外侧; 凸缘构件，其构造为具有至少等于构成轮毂的材料的弹性模量的材料的盘形或环形板状，所述凸缘构件同轴地接合到所述轮毂的开口端部; 形成为与所述毂的基部同轴地固定的圆板状或环状板状的金属板， 以及与所述毂的基部一体形成的槽壁，并且形成在所述槽壁与所述金属板的外周面之间的整个周边上连续的槽部。

公开(公告)号：US20100019077A1

公开(公告)日：2010-01-28

申请号：US12509502

申请日：2009-07-27

Applicant: Ren ISHIKAWA ,  Yosuke SUMIYA ,  Shigeru NISHIYAMA

Inventor： Ren ISHIKAWA ,  Yosuke SUMIYA ,  Shigeru NISHIYAMA

IPC: B65H75/18 ,  B65H75/14 ,  G11B23/107

CPC classification number: G11B23/107 ,  B65H75/30 ,  B65H2601/254 ,  B65H2701/378 ,  B65H2701/5122 ,  G11B23/043

Abstract: A reel comprising a hub formed in the shape of a cylindrical tube with a base, on an outer peripheral surface of which a recording tape is wound; a base side flange portion that projects-out to a radial direction outer side of a base portion side of the hub; a flange member configured in a disc shape or an annular plate shape of a material with an elastic modulus at least equal to a material that constitutes the hub, the flange member being coaxially joined to an opening end portion of the hub; a metal plate formed in a circular plate shape or an annular plate shape, which is fixed coaxially to the base portion of the hub; and plate retention portions that are formed integrally with the base portion of the hub and touch an outer peripheral surface of the metal plate at at least four locations, which are at equal intervals in a circumferential direction of the hub.

Abstract translation: 一种卷轴，其包括形成为具有基部的圆柱形管形式的轮毂，在其外周表面上缠绕有记录带; 基部侧凸缘部，其突出到所述轮毂的基部侧的径向外侧; 凸缘构件，其被构造成具有至少等于构成轮毂的材料的弹性模量的材料的盘形或环形板形状，所述凸缘构件同轴地接合到所述毂的开口端部; 形成为与所述毂的基部同轴地固定的圆板状或环状板状的金属板， 以及板保持部，其与轮毂的基部一体形成，并且在轮毂的圆周方向上以等间隔的至少四个位置接触金属板的外周面。