公开(公告)号：US09035059B2

公开(公告)日：2015-05-19

申请号：US14004950

申请日：2012-03-14

申请人： Tsuyoshi Busujima ,  Takahiro Oi ,  Hiroaki Tanaka ,  Yoshihisa Shirasaki ,  Kanako Iwakiri ,  Nagaaki Sato ,  Shigeru Tokita

发明人： Tsuyoshi Busujima ,  Takahiro Oi ,  Hiroaki Tanaka ,  Yoshihisa Shirasaki ,  Kanako Iwakiri ,  Nagaaki Sato ,  Shigeru Tokita

IPC分类号： C07D401/14 ,  C07D209/44 ,  C07D217/04 ,  C07D223/16 ,  C07D405/12 ,  C07D409/06 ,  C07D413/06 ,  C07D417/10 ,  A61K31/4035 ,  A61K31/454 ,  A61K31/472 ,  A61K31/497 ,  C07D217/18 ,  C07D217/06 ,  C07D217/22 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D413/12 ,  C07D417/06 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  C07D217/20 ,  C07D217/26 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D495/04 ,  C07D217/10 ,  C07D401/08

CPC分类号： C07D217/18 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/4858 ,  C07D209/44 ,  C07D217/04 ,  C07D217/06 ,  C07D217/10 ,  C07D217/20 ,  C07D217/22 ,  C07D217/26 ,  C07D223/16 ,  C07D401/06 ,  C07D401/08 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D495/04

摘要： There are provided compounds represented by the following general formula (I) or pharmaceutically acceptable salts of thereof, which have a superior monoacylglycerol acyltransferase 2 inhibitory action: wherein Ring A represents a partially saturated heteroaryl group, an aryl group or a heteroaryl group, RB represents a C4-18 alkyl group, a C3-8 cycloalkyl group, a partially saturated aryl group, an aryl group, or the following formula (II): wherein V represents the formula —CR11R12—, —CO—, —CO—O—, or —CO—NH—, W represents a single bond or a C1-3 alkylene group, and Ring B represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a partially saturated heteroaryl group, a saturated heterocyclyl group, an aryl group, or a heteroaryl group, Y represents a nitrogen atom or the formula N+(RF), RF represents a C1-4 alkyl group, and m and n, which may be the same or different, each represent an integer of 0 or 1.

摘要翻译： 提供具有优异的单酰基甘油酰基转移酶2抑制作用的由以下通式（I）表示的化合物或其药学上可接受的盐：其中环A表示部分饱和的杂芳基，芳基或杂芳基，RB表示 C4-18烷基，C3-8环烷基，部分饱和芳基，芳基或下式（Ⅱ）表示：其中V表示式-CR11R12-，-CO-，-CO-O- 或-CO-NH-，W表示单键或C1-3亚烷基，环B表示C3-8环烷基，C3-8环烯基，部分饱和杂芳基，饱和杂环基， 芳基或杂芳基，Y表示氮原子或式N +（RF），RF表示C1-4烷基，m和n可相同或不同，分别表示0以上的整数 或1。

公开(公告)号：US08822503B2

公开(公告)日：2014-09-02

申请号：US13081201

申请日：2011-04-06

申请人： Takanori Kawaguchi ,  Kengo Watatani ,  Keiko Fusegi ,  Masahiro Bohno ,  Hajime Asanuma ,  Shoichi Kuroda ,  Yudai Imai ,  Tomomichi Chonan ,  Nagaaki Sato ,  Shigeru Tokita ,  Shigetada Sasako ,  Takumi Okada ,  Keishi Hayashi ,  Shin Itoh ,  Noriko Saito ,  Rui Jibiki ,  Seishi Ishiyama ,  Hirofumi Ota

发明人： Takanori Kawaguchi ,  Kengo Watatani ,  Keiko Fusegi ,  Masahiro Bohno ,  Hajime Asanuma ,  Shoichi Kuroda ,  Yudai Imai ,  Tomomichi Chonan ,  Nagaaki Sato ,  Shigeru Tokita ,  Shigetada Sasako ,  Takumi Okada ,  Keishi Hayashi ,  Shin Itoh ,  Noriko Saito ,  Rui Jibiki ,  Seishi Ishiyama ,  Hirofumi Ota

IPC分类号： A61K31/4439 ,  C07D401/06

CPC分类号： C07D401/10 ,  C07D213/64 ,  C07D401/12 ,  C07D401/14 ,  C07D405/10 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

摘要： A 2-pyridone compound represented by the formula [1]: {wherein in the formula [1], the ring represented by A represents a benzene ring or a pyridine ring, X represents any of the structures represented by the formulas [3] shown below: V represents a single bond or a lower alkylene group, and W represents a single bond, an ether bond or a lower alkylene group (wherein the lower alkylene group may contain an ether bond)}, a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is a compound that has an excellent GK activating effect and is useful as a pharmaceutical.

摘要翻译： 由式[1]表示的2-吡啶酮化合物：其中，在式[1]中，由A表示的环表示苯环或吡啶环，X表示由式[3]表示的任何结构 V表示单键或低级亚烷基，W表示单键，醚键或低级亚烷基（其中低级亚烷基可以含有醚键）}，化合物的互变异构体或立体异构体， 其药学上可接受的盐或其溶剂合物是具有优异的GK活化作用并可用作药物的化合物。

公开(公告)号：US07821125B2

公开(公告)日：2010-10-26

申请号：US12109417

申请日：2008-04-25

申请人： Shigeru Tokita ,  Hiroo Matsue ,  Fumihide Maeda

发明人： Shigeru Tokita ,  Hiroo Matsue ,  Fumihide Maeda

IPC分类号： H01L21/12

CPC分类号： H01L23/433 ,  H01L23/053 ,  H01L23/562 ,  H01L24/32 ,  H01L2224/16225 ,  H01L2224/32057 ,  H01L2224/73253 ,  H01L2224/83385 ,  H01L2924/01006 ,  H01L2924/01033 ,  H01L2924/01082 ,  H01L2924/16152 ,  H01L2924/19041 ,  H05K7/20472 ,  H01L2924/3512 ,  H01L2924/00

摘要： The invention provides a heat radiating structure which reduces a mechanical stress applied to an electronic part mounted on a printed circuit board including a semiconductor package. The heat radiating structure is constructed by a semiconductor package mounted on a printed circuit board, a thermal conduction sheet arranged on an upper surface of the semiconductor package, and a metal case provided with a heat radiating fin for receiving a heat transmitted form the thermal conduction sheet so as to discharge to an atmospheric air, and the metal case is provided with a concavo-convex structure in a contact portion with the thermal conduction sheet.

摘要翻译： 本发明提供了一种减少施加到安装在包括半导体封装的印刷电路板上的电子部件上的机械应力的散热结构。 散热结构由安装在印刷电路板上的半导体封装，布置在半导体封装的上表面上的导热片构成，金属壳由散热片构成，散热片用于接收热传导的热量 片材，以排出到大气中，金属壳体在与导热片的接触部分中设置有凹凸结构。

公开(公告)号：US20090209562A1

公开(公告)日：2009-08-20

申请号：US12378163

申请日：2009-02-11

申请人： Tsuyoshi Nagase ,  Nagaaki Sato ,  Akio Kanatani ,  Shigeru Tokita

发明人： Tsuyoshi Nagase ,  Nagaaki Sato ,  Akio Kanatani ,  Shigeru Tokita

IPC分类号： A61K31/517 ,  C07D239/88 ,  A61P25/00

CPC分类号： C07D239/91 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C07D487/08 ,  A61K2300/00

摘要： The present invention provides a compound represented by formula (I) below, or a pharmaceutically acceptable salt thereof, which, having histamine H3 receptor antagonist or inverse agonist activity, is useful in the prophylaxis or therapy of metabolic diseases, circulatory diseases, or nervous system diseases. [where, for example, Ar is a divalent group formed by eliminating two hydrogen atoms from benzene, X1 is a nitrogen atom, sulfur atom or oxygen atom, R1 is a 5- to 6-membered heteroaryl group, Ring A is a 5- to 6-membered heteroaryl ring, R2 and R3 are amino groups or alkylamino groups, and X2 is represented by formula (II): (where R4 and R5 are lower alkyl groups, and n is an integer from 2 to 4).]

公开(公告)号：US07552872B2

公开(公告)日：2009-06-30

申请号：US11671055

申请日：2007-02-05

申请人： Shigeru Tokita ,  Hiroo Matsue ,  Antony Cleitus ,  Tomonao Kikuchi

发明人： Shigeru Tokita ,  Hiroo Matsue ,  Antony Cleitus ,  Tomonao Kikuchi

IPC分类号： G06K7/00 ,  G06K7/08 ,  G06K19/06 ,  H04Q5/22 ,  G08B13/14

CPC分类号： H04B10/40 ,  H04W4/18

摘要： A reader/writer is provided which is capable of speedily recognizing a correspondence between one end and the other end of a fiber-optic cable when a plurality of fiber-optic cables is laid. The reader/writer according to the present invention reads, on receiving through the fiber-optic cable a signal that is an instruction to read data from a RF tag mounted to an end of the fiber-optic cable, data from the RF tag through radio communication, and transmits the read data through the fiber-optic cable. Also, on receiving through the fiber-optic cable a signal that is an instruction to write data into the RF tag and a signal indicating the write data, the reader/writer writes the write instruction and the write data into the RF tag through radio communication.

摘要翻译： 提供了一种读取器/写入器，其能够在放置多根光纤电缆时能够快速识别光纤电缆的一端与另一端之间的对应关系。 根据本发明的读写器在通过光纤电缆接收作为从安装到光纤电缆的一端的RF标签读取数据的指令的信号时，从RF标签通过无线电 通信，并通过光纤电缆传输读取的数据。 另外，在通过光纤电缆接收作为将数据写入RF标签的指令的信号和表示写入数据的信号时，读取器/写入器通过无线电通信将写入指令和写入数据写入RF标签 。

公开(公告)号：US20090039503A1

公开(公告)日：2009-02-12

申请号：US12109417

申请日：2008-04-25

申请人： Shigeru TOKITA ,  Hiroo Matsue ,  Fumihide Maeda

发明人： Shigeru TOKITA ,  Hiroo Matsue ,  Fumihide Maeda

IPC分类号： H01L23/36

CPC分类号： H01L23/433 ,  H01L23/053 ,  H01L23/562 ,  H01L24/32 ,  H01L2224/16225 ,  H01L2224/32057 ,  H01L2224/73253 ,  H01L2224/83385 ,  H01L2924/01006 ,  H01L2924/01033 ,  H01L2924/01082 ,  H01L2924/16152 ,  H01L2924/19041 ,  H05K7/20472 ,  H01L2924/3512 ,  H01L2924/00

摘要： The invention provides a heat radiating structure which reduces a mechanical stress applied to an electronic part mounted on a printed circuit board including a semiconductor package. The heat radiating structure is constructed by a semiconductor package mounted on a printed circuit board, a thermal conduction sheet arranged on an upper surface of the semiconductor package, and a metal case provided with a heat radiating fin for receiving a heat transmitted form the thermal conduction sheet so as to discharge to an atmospheric air, and the metal case is provided with a concavo-convex structure in a contact portion with the thermal conduction sheet.

摘要翻译： 本发明提供了一种减少施加到安装在包括半导体封装的印刷电路板上的电子部件上的机械应力的散热结构。 散热结构由安装在印刷电路板上的半导体封装，布置在半导体封装的上表面上的导热片构成，金属壳由散热片构成，散热片用于接收热传导的热量 片材，以排出到大气中，金属壳体在与导热片的接触部分中设置有凹凸结构。

公开(公告)号：US20050182045A1

公开(公告)日：2005-08-18

申请号：US11058444

申请日：2005-02-14

申请人： Tsuyoshi Nagase ,  Nagaaki Sato ,  Akio Kanatani ,  Shigeru Tokita

发明人： Tsuyoshi Nagase ,  Nagaaki Sato ,  Akio Kanatani ,  Shigeru Tokita

IPC分类号： A61K31/4725 ,  A61K31/517 ,  A61K31/519 ,  A61K31/55 ,  A61K45/06 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P3/12 ,  A61P5/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P19/06 ,  A61P25/02 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/32 ,  A61P25/36 ,  A61P43/00 ,  C07D217/24 ,  C07D239/70 ,  C07D239/91 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D471/04 ,  C07D487/08 ,  C07D43/02

CPC分类号： C07D239/91 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C07D487/08 ,  A61K2300/00

摘要： The present invention provides a compound represented by formula (I) below, or a pharmaceutically acceptable salt thereof, which, having histamine H3 receptor antagonist or inverse agonist activity, is useful in the prophylaxis or therapy of metabolic diseases, circulatory diseases, or nervous system diseases. [where, for example, Ar is a divalent group formed by eliminating two hydrogen atoms from benzene, X1 is a nitrogen atom, sulfur atom or oxygen atom, R1 is a 5- to 6-membered heteroaryl group, Ring A is a 5- to 6-membered heteroaryl ring, R2 and R3 are amino groups or alkylamino groups, and X2 is represented by formula (II): (where R4 and R5 are lower alkyl groups, and n is an integer from 2 to 4).]

摘要翻译： 本发明提供下述式（I）表示的化合物或其药学上可接受的盐，其具有组胺H3受体拮抗剂或反向激动剂活性，可用于预防或治疗代谢性疾病，循环系统疾病或神经系统 疾病 [其中，例如，Ar为通过从苯中除去两个氢原子形成的二价基团，X 1是氮原子，硫原子或氧原子，R 1是 5-至6-元杂芳基，环A为5-至6-元杂芳基环，R 2和R 3为氨基或烷基氨基，和 X 2由式（II）表示：其中R 4和R 5是低级烷基，n是2的整数 至4）。]

公开(公告)号：US06559997B1

公开(公告)日：2003-05-06

申请号：US09247809

申请日：1999-02-11

申请人： Shigeru Tokita ,  Atsushi Hasegawa ,  Takahiro Hamagishi

发明人： Shigeru Tokita ,  Atsushi Hasegawa ,  Takahiro Hamagishi

IPC分类号： H04B1004

CPC分类号： H04B10/504 ,  H04B10/564

摘要： An optical transmitter for use in an optical transmitting system based on PDS (Passive Double Star) technology, does not erroneously output an optical signal when the optical transmitter is powered on/off. The optical transmitter has a current source 1 for outputting a drive current having a magnitude corresponding to an input control signal, a Laser diode (LD) for generating an optical output signal based on the received drive current, a modulator 9 for controlling the supply and cutoff of the drive current to the Laser diode (LD), a source voltage detector 3 for monitoring a source voltage to detect whether the source voltage is lower than a predetermined voltage, and a switch circuit 4 for outputting a control signal to the current source 1 to stop the supply of the drive current when the source voltage is determined to be lower than the predetermined voltage.

公开(公告)号：US20110237791A1

公开(公告)日：2011-09-29

申请号：US13081201

申请日：2011-04-06

申请人： Takanori KAWAGUCHI ,  Kengo WATATANI ,  Keiko FUSEGI ,  Masahiro BOHNO ,  Hajime ASANUMA ,  Shoichi KURODA ,  Yudai IMAI ,  Tomomichi CHONAN ,  Nagaaki SATO ,  Shigeru TOKITA ,  Shigetada SASAKO ,  Takumi OKADA ,  Keishi HAYASHI ,  Shin ITOH ,  Noriko SAITO ,  Rui JIBIKI ,  Seishi ISHIYAMA ,  Hirofumi OTA

发明人： Takanori KAWAGUCHI ,  Kengo WATATANI ,  Keiko FUSEGI ,  Masahiro BOHNO ,  Hajime ASANUMA ,  Shoichi KURODA ,  Yudai IMAI ,  Tomomichi CHONAN ,  Nagaaki SATO ,  Shigeru TOKITA ,  Shigetada SASAKO ,  Takumi OKADA ,  Keishi HAYASHI ,  Shin ITOH ,  Noriko SAITO ,  Rui JIBIKI ,  Seishi ISHIYAMA ,  Hirofumi OTA

IPC分类号： C07D213/64 ,  C07D401/12 ,  C07D401/06 ,  C07D405/06 ,  C07D413/14

CPC分类号： C07D401/10 ,  C07D213/64 ,  C07D401/12 ,  C07D401/14 ,  C07D405/10 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14

摘要： A 2-pyridone compound represented by the formula [1]: {wherein in the formula [1], the ring represented by A represents a benzene ring or a pyridine ring, X represents any of the structures represented by the formulas [3] shown below: V represents a single bond or a lower alkylene group, and W represents a single bond, an ether bond or a lower alkylene group (wherein the lower alkylene group may contain an ether bond)}, a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof is a compound that has an excellent GK activating effect and is useful as a pharmaceutical.

摘要翻译： 由式[1]表示的2-吡啶酮化合物：其中，在式[1]中，由A表示的环表示苯环或吡啶环，X表示由式[3]表示的任何结构 V表示单键或低级亚烷基，W表示单键，醚键或低级亚烷基（其中低级亚烷基可以含有醚键）}，化合物的互变异构体或立体异构体， 其药学上可接受的盐或其溶剂合物是具有优异的GK活化作用并可用作药物的化合物。

公开(公告)号：US20100210637A1

公开(公告)日：2010-08-19

申请号：US12540534

申请日：2009-08-13

申请人： Norikazu Ohtake ,  Akira Naya ,  Yuji Haga ,  Makoto Jitsuoka ,  Takuya Suga ,  Ryo Yoshimoto ,  Shigeru Tokita ,  Akio Kanatani

发明人： Norikazu Ohtake ,  Akira Naya ,  Yuji Haga ,  Makoto Jitsuoka ,  Takuya Suga ,  Ryo Yoshimoto ,  Shigeru Tokita ,  Akio Kanatani

IPC分类号： A61K31/5377 ,  C07D403/12 ,  A61K31/506 ,  A61P3/10 ,  A61P3/04 ,  A61P1/16 ,  A61P3/06 ,  A61P9/10 ,  C07D401/12 ,  A61K31/4545 ,  C07D413/14 ,  A61K31/501

CPC分类号： C07D401/12 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/506 ,  C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  C07D471/04

摘要： Provided are compounds of a formula (I) and their pharmaceutically-acceptable salts: wherein X1, X2 and X3 each independently represent N or CH; W represents the following formula (II): or the following formula (III): Y represents a group of a formula (IV): The compounds have a histamine-H3 receptor antagonistic or inverse-agonistic activity and are useful for remedy and/or prevention of obesity, diabetes, hormone secretion disorders, sleep disorders, etc.

摘要翻译： 提供式（I）化合物及其药学上可接受的盐：其中X1，X2和X3各自独立地表示N或CH; W表示下式（II）：或下式（III）：Y表示式（IV）的基团：所述化合物具有组胺H3受体拮抗或反向激动活性，可用于治疗和/或 预防肥胖，糖尿病，激素分泌障碍，睡眠障碍等