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    Anti-enterovirus compounds
    1.
    发明授权
    Anti-enterovirus compounds 失效
    抗肠道病毒化合物

    公开(公告)号：US06815444B2

    公开(公告)日：2004-11-09

    申请号：US10444747

    申请日：2003-05-23

    申请人： Jyh-Haur Chern ,  Kak-Shan Shia ,  Shin-Ru Shih ,  Tsu-An Hsu ,  Chia-Liang Tai

    发明人： Jyh-Haur Chern ,  Kak-Shan Shia ,  Shin-Ru Shih ,  Tsu-An Hsu ,  Chia-Liang Tai

    IPC分类号： C07D48704

    CPC分类号： C07D487/04

    摘要： This invention features, among others, a pyrazolopyrimidine compound of formula (A): A is (CH2)q—CHRaRb; each of R1 and R2, independently, is hydrogen, halogen, cyano, nitro, or alkyl; or R1 and R2 taken together is (CH2)r; each of R3 and R4, independently, is hydrogen, halogen, cyano, nitro, or alkyl; each of R5, Ra, and Rb, independently, is aryl, aralkyl, or heteroaryl, optionally substituted with halogen, cyano, nitro, alkyl, aryl, aralkyl, heteroaryl, OR, O(O)CR, C(O)R, C(O)OR, C(O)NRR′, SR, S(O)R, S(O)OR, NRR′, NR(O)CR′, NRC(O)OR′, or NRC(O)NR′R″; each of m, n, o, p, and r, independently, is 0 or 1, and q is 0, 1, or 2; in which each of R, R′, and R″, independently, is hydrogen or alkyl, provided that the sum of m, n, o, and p is 1, 2, 3, or 4.

    摘要翻译： 本发明特别地包括式（A）的吡唑并嘧啶化合物：A是（CH 2）q-CHR a R b; R 1和R 2各自独立地是氢，卤素，氰基，硝基或烷基; 或者R 1和R 2一起是（CH 2）r; R 3和R 4各自独立地是氢，卤素，氰基，硝基或烷基; 氰基，硝基，烷基，芳基，芳烷基，杂芳基，OR，O（O）CR，R 3，R 3和R 4各自独立地是芳基，芳烷基或杂芳基， C（O）OR，NR（O）OR，C（O）NRR'，SR，S（O）R，S（O）OR，NRR' 或NRC（O）NR'R“; m，n，o，p和r各自独立地为0或1，q为0,1或2; 其中R，R'和R“各自独立地是氢或烷基，条件是m，n，o和p的和为1,2,3或4。