摘要:
This invention features, among others, a pyrazolopyrimidine compound of formula (A): A is (CH2)q—CHRaRb; each of R1 and R2, independently, is hydrogen, halogen, cyano, nitro, or alkyl; or R1 and R2 taken together is (CH2)r; each of R3 and R4, independently, is hydrogen, halogen, cyano, nitro, or alkyl; each of R5, Ra, and Rb, independently, is aryl, aralkyl, or heteroaryl, optionally substituted with halogen, cyano, nitro, alkyl, aryl, aralkyl, heteroaryl, OR, O(O)CR, C(O)R, C(O)OR, C(O)NRR′, SR, S(O)R, S(O)OR, NRR′, NR(O)CR′, NRC(O)OR′, or NRC(O)NR′R″; each of m, n, o, p, and r, independently, is 0 or 1, and q is 0, 1, or 2; in which each of R, R′, and R″, independently, is hydrogen or alkyl, provided that the sum of m, n, o, and p is 1, 2, 3, or 4.
摘要翻译:本发明特别地包括式(A)的吡唑并嘧啶化合物:A是(CH 2)q-CHR a R b; R 1和R 2各自独立地是氢,卤素,氰基,硝基或烷基; 或者R 1和R 2一起是(CH 2)r; R 3和R 4各自独立地是氢,卤素,氰基,硝基或烷基; 氰基,硝基,烷基,芳基,芳烷基,杂芳基,OR,O(O)CR,R 3,R 3和R 4各自独立地是芳基,芳烷基或杂芳基, C(O)OR,NR(O)OR,C(O)NRR',SR,S(O)R,S(O)OR,NRR' 或NRC(O)NR'R“; m,n,o,p和r各自独立地为0或1,q为0,1或2; 其中R,R'和R“各自独立地是氢或烷基,条件是m,n,o和p的和为1,2,3或4。
摘要:
A compound of the following formula: in which R1, R2, R3, U, V, T, W, X, Y, Z, m, n, p, x, y, and z are as defined herein. Also disclosed are (1) a pharmaceutical composition containing such a compound, and (2) a method for treating Hepatitis C virus infection using such a compound.
摘要:
A compound of the following formula: in which R1, R2, R3, U, V, T, W, X, Y, Z, m, n, p, x, y, and z are as defined herein. Also disclosed are (1) a pharmaceutical composition containing such a compound, and (2) a method for treating Hepatitis C virus infection using such a compound.
摘要:
Thiourea compounds of the following formula: wherein n, R1, R2, R3, A1, A2, X, Y, and Z are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.
摘要:
Imidazolidinone and imidazolinethione compounds of formula (I): wherein R1, R2, R3, A1, A2, X, Y, Z, m, n, p, x, and y are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.
摘要:
Imidazolidinone and imidazolinethione compounds of formula (I): wherein R1, R2, R3, A1, A2, X, Y, Z, m, n, p, x, and y are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.
摘要:
Thiourea compounds of the following formula: wherein n, R1, R2, R3, A1, A2, X, Y, and Z are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.
摘要:
This invention relates to thiourea compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.
摘要:
This invention relates to thiourea compounds of formula (II) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.
摘要:
The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV or EMCV infection.