摘要:
A manufacturing method of a tape for manufacturing a curved tape curving in the width direction along the longitudinal direction of the tape, wherein, in a cutting process which cuts an original tape with a wide width into a plurality of tapes with a predetermined width by continuously passing the original tape between a rotary blade and a rotary bed knife having a receiving portion for receiving the rotary blade, an edge which has a shorter edge length between both edges in the width direction of the tape is to become a cut side by being pushed into the receiving portion of the rotary bed knife.
摘要:
Penem-3-carboxylic acid derivatives of formula (I): ##STR1## (wherein: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group, a hydroxyalkyl group, an acyloxyalkyl group, an alkylsulphonyloxyalkyl group, an arylsulphonyloxyalkyl group or a trialkylsilyloxyalkyl group;R.sup.2 represents a hydrogen atom or an alkyl group;R.sup.3 represents a hydrogen atom, an amino-protecting group or a group of formula ##STR2## in which R.sup.5 and R.sup.6 are the same or different and each represents a hydrogen atom or an alkyl group;A represents a branched-chain alkylene group; andR.sup.4 represents a carboxy group or a protected carboxy group)and pharmaceutically acceptable salts thereof, may be prepared by heating a corresponding phosphorus-ylide compound or by reacting a corresponding azetidin-2-one with a suitable phosphorous acid triester or triamide, and have been found to have excellent antibacterial activity accompanied by a very low acute toxicity.
摘要翻译:(I)的半酯-3-羧酸衍生物:其中:R1表示氢原子,烷基,烷氧基,羟烷基,酰氧基烷基,烷基磺酰氧基烷基,芳基磺酰氧基烷基 基团或三烷基甲硅烷氧基烷基; R 2表示氢原子或烷基; R 3表示氢原子,氨基保护基或式“IMAGE”基团,其中R 5和R 6相同或不同,并且各自表示氢 原子或烷基; A表示支链亚烷基; R4表示羧基或保护的羧基)及其药学上可接受的盐可以通过加热相应的磷内酯化合物或通过使相应的氮杂环丁烷 -2-酮与合适的亚磷酸三酯或三酰胺,发现具有优异的抗菌活性,伴随着非常低的急性毒性。
摘要:
Novel cephalosporin derivatives having a (1-alkyl-1H-tetrazol-5-yl)vinyl group at the 3-position of the cephem nucleus and showing an excellent antibacterial activity are disclosed. A process for preparing the cephalosporin derivatives is also disclosed.
摘要:
A compound of the formula ##STR1## wherein A represents acetoxy group, carbamoyloxy group or (1-metyl-1H-tetrazol-5-yl)thio group and Y represents propargylthio group, azidomethylthio group, 2-hydroxyethylthio group, 3-isoxazolyloxy group, 3-isoxazolylthio group, methylsulfonyl group, ethylsulfonyl group, 2-cyanoethyl-sulfonyl group or sydnon-3-yl group and nontoxic pharmaceutically acceptable salts thereof are prepared by a process which comprises reacting a compound of the formula ##STR2## wherein R represents a protective group for a carboxyl group and A has the same meaning as defined above with a carboxylic acid of the formulaY - CH.sub.2 COOHwherein Y has the same meaning as defined above or a reactive derivative thereof to give a compound having the formula ##STR3## wherein A, R and Y have the same meanings as defined above and removing the protective group for the carboxyl group from said compound.The compounds are antibacterial agents.
摘要:
A manufacturing method of a tape-form recoding medium in the present invention is configured with a raw web winding process of winding on a winding core raw web having a support body, a data recoding layer laminated on one side of the support body, and a minute convexity laminated on the other side thereof; a raw web rewinding process of rewinding on other winding cores the raw web wound on the winding core in the raw web winding core; and a heat treatment process of heating the rewound raw web and decreasing a number of a concavity not less than 30 nm in depth formed in the data recording layer in the raw web winding process to not more than 80 pieces/mm2.
摘要翻译:在本发明的带状记录介质的制造方法中,将卷绕在具有支撑体的卷绕芯部原料网上的原料卷绕过程,层叠在支撑体一侧的数据记录层,以及 其另一侧层叠有微小凸起; 在其他卷绕芯上卷绕卷绕在原料卷绕芯中的卷绕芯上的原料卷的原料卷筒卷绕过程; 以及在原料卷绕过程中将数据记录层中形成的深度不小于30nm的多个凹面加热到不超过80个/ mm 2的热卷绕处理过程, / SUP>。
摘要:
An error factor estimating method estimates a factor of an error occurring when information recorded on a digital recording medium is reproduced by a digital recording and reproducing apparatus. The error factor estimating method includes the steps of: recording error factor estimation data on a digital recording medium; reproducing the error factor estimation data from the digital recording medium to obtain an error factor estimation signal; and estimating the factor of the error based on the factor estimation. The error factor estimating method can estimate the factor of occurrence of the error based on a factor estimation signal obtained by reproducing the error factor estimation data from the recording medium by the digital recording and reproducing device without affecting user data recorded on the recording medium at all.
摘要:
Compounds of formula (I): ##STR1## in which: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;R.sup.2 represents a hydrogen atom, a group of formula ##STR2## (in which R.sup.5 and R.sup.6 each represents an alkyl group, an aralkyl group or an aryl group, or R.sup.5 and R.sup.6 together represent a nitrogen-containing heterocyclic group) or a group of formula ##STR3## (in which R.sup.7 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted amino group, a cyclic amino group, a hydroxy group, an alkoxy group, an aryloxy group, an aralkyloxy group, a substituted or unsubstituted hydrazino group or a guanidino group, and A' represents a bivalent saturated aliphatic hydrocarbon group); andR.sup.3 represents a carboxy group or a protected carboxy group; and pharmaceutically acceptable salts thereof are valuable antibiotics and may be prepared from the corresponding 1-(protected carboxymethyl)-4-alkylthio-azetidin-2-one.
摘要:
Compounds of formula (I): ##STR1## (wherein R.sup.1 represents a C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.3 alpha-hydroxyalkyl group;R.sup.2 represents a hydrogen atom, a substituted or unsubstituted alkyl group or a cycloalkyl group;R.sup.3 represents a hydrogen atom or an alkyl group; and n is 1 or 2) and their salts and esters have valuable antibiotic activity and can be used for the treatment of diseases caused by a wide range of pathogenic microorganisms.
摘要翻译:式(I)化合物:其中R 1表示C 1 -C 4烷基或C 1 -C 3α-羟基烷基; R 2表示氢原子,取代或未取代的烷基或环烷基; R 3表示 氢原子或烷基; n为1或2),其盐和酯具有有价值的抗生素活性,可用于治疗由广泛的致病微生物引起的疾病。
摘要:
Compounds of formula (I): ##STR1## [wherein: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;R.sup.2 represents a group of formula ##STR2## in which ##STR3## represents an alicyclic amine group having from 4 to 8 ring atoms, optionally having a single double bond, optionally containing an additional hetero-atom and optionally having an oxo group on the ring;X represents a hydrogen atom, an alkyl group, an alkoxy group, an alkylthio group, an alkylsulphinyl group, an alkylsulphonyl group, a hydroxy group, a halogen atom or various substituted alkyl groups;Y represents a hydrogen atom, an alkyl group, an aliphatic acyl group or an acylimidoyl group; andR.sup.3 represents a carboxy group or a protected carboxy group]and pharmaceutically acceptable salts thereof have valuable antibacterial activity, especially in vivo.
摘要:
Compounds of formula (I): ##STR1## .[.[.]. wherein: R.sup.1 .[.represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups.]. .Iadd.is hydroxyethyl; .Iaddend.R.sup.2 represents a group of formula ##STR2## in which ##STR3## .[.represents an alicyclic amine group having from 4 to 8 ring atoms, optionally having a single double bond, optionally containing an additional hetero-atom and optionally having an oxo group on the ring;.]. .Iadd.is a 3-pyrrolidinyl group; .Iaddend.X represents a hydrogen atom.[.; an alkyl group, an alkoxy group, an alkylthio group, an alkylsulphinyl group, an alkylsulphonyl group, a hydroxy group, a halogen atom or various substituted alkyl groups.].;Y represents .[.a hydrogen atom, an alkyl group, an aliphatic acyl group or an acylimidoyl.]. .Iadd.an acetylimidoyl .Iaddend.group; andR.sup.3 represents a carboxy group or a protected carboxy group.[.].].and pharmaceutically acceptable salts thereof have valuable antibacterial activity, especially in vivo.