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1.发明授权Polynucleotides and related nanoassemblies, structures, arrangements, methods and systems 有权多核苷酸和相关的纳米组件，结构，布置，方法和系统公开(公告)号：US09340416B2
公开(公告)日：2016-05-17
申请号：US12540052
申请日：2009-08-12
Applicant: Hareem T. Maune , Si-Ping Han , Robert D. Barish , Marc W. Bockrath , William A. Goddard, III , Paul W. K. Rothemund , Erik Winfree
Inventor： Hareem T. Maune , Si-Ping Han , Robert D. Barish , Marc W. Bockrath , William A. Goddard, III , Paul W. K. Rothemund , Erik Winfree
Abstract: A linker polynucleotide for attaching a nanomaterial to a polynucleotidic platform and related nanoassemblies, arrangements, structures, methods and systems.
Abstract translation: 用于将纳米材料附着到多核苷酸平台和相关纳米组件，布置，结构，方法和系统的接头多核苷酸。
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公开(公告)号：US09029524B2
公开(公告)日：2015-05-12
申请号：US12316372
申请日：2008-12-10
Applicant: Si-Ping Han , Robert D. Barish , William A. Goddard, III
Inventor： Si-Ping Han , Robert D. Barish , William A. Goddard, III
CPC classification number: C12N15/113 , C07H21/02 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/3517 , C12N2310/3519 , C12N2310/53 , C12N2320/10
Abstract: The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form and an active form upon covalent or non-covalent interaction with one or more specific chemical signals, such as disease-specific mRNA, miRNA, or other cellular RNA products with sequences that characterize diseased states of the cell. The interaction between the subject polynucleotides and the signals is preferably mediated by hybridization, which exposes, facilitates the formation, and/or allows the formation of a substrate that can be processed by proteins of the RNAi pathway (such as Dicer). The input and output of multiple different polynucleotides of the invention can form an in vivo signaling network. In addition, the multiple input signals can be integrated to modulate the activity of the subject polynucleotides.
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3.发明申请公开(公告)号：US20140141211A1
公开(公告)日：2014-05-22
申请号：US11978219
申请日：2007-10-26
Applicant: Si-Ping Han , Robert Barish , Michael J. Hochberg , Saurabh Vyawahare , Hareem Maune
Inventor： Si-Ping Han , Robert Barish , Michael J. Hochberg , Saurabh Vyawahare , Hareem Maune
IPC: C23C18/31
CPC classification number: C23C18/1635 , B82Y40/00 , C23C18/1608 , C23C18/1641 , C23C18/1646 , C23C18/2086 , C23C18/30 , Y10T428/24851
Abstract: The present invention relates to methods for self-assembly of arbitrarily-shaped metal nanostructures using specifically-designed patterns on nucleic acid scaffolds. The methods involve using the nucleic acid scaffolds as templates on which a second material patterned, as seed nuclei. The patterns are then selectively plated with metal using an electro-less plating process to create arbitrarily-shaped metal nanostructures that are not constrained by the structure of the scaffold. The methods herein use controlled-growth processes to actively select the dimensions, positions, and alignments of the patterns to create different arbitrary shapes of metal nanostructures.
Abstract translation: 本发明涉及在核酸支架上使用特定设计的图案自组装任意形状的金属纳米结构的方法。 所述方法包括使用核酸支架作为其上构图的第二材料作为种子核的模板。 然后使用无电镀方法将图案用金属选择性地镀覆以产生不受支架结构约束的任意形状的金属纳米结构。 本文的方法使用受控生长过程来主动地选择图案的尺寸，位置和对准以产生不同的任意形状的金属纳米结构。
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公开(公告)号：US20100048421A1
公开(公告)日：2010-02-25
申请号：US12540027
申请日：2009-08-12
Applicant: Si-Ping HAN , Hareem Maune , Robert D. Barish , William A. Goddard, III
Inventor： Si-Ping HAN , Hareem Maune , Robert D. Barish , William A. Goddard, III
Abstract: The disclosure relates to nanotube composite structures and related methods and systems. In particular, structures, methods and systems are provided herein to allow for precise, tunable separation between nanomaterials such as carbon nanotubes.
Abstract translation: 本公开涉及纳米管复合结构及相关方法和系统。 特别地，本文提供了结构，方法和系统，以允许诸如碳纳米管之类的纳米材料之间的精确的，可调节的分离。
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Patent Agency Ranking
公开(公告)号：US20120022146A1
公开(公告)日：2012-01-26
申请号：US13167672
申请日：2011-06-23
Applicant: Si-Ping HAN , William A. GODDARD, III , Lisa SCHERER , John J. ROSSI
Inventor： Si-Ping HAN , William A. GODDARD, III , Lisa SCHERER , John J. ROSSI
IPC: A61K31/711 , C07H21/02
CPC classification number: C12N15/87 , C12N15/111 , C12N2310/14 , C12N2310/3519 , C12N2320/32 , C12N2320/50
Abstract: Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain, compositions, methods and systems.
Abstract translation: 本文提供了用于酶辅助递送分子和相关组分的信号激活分子构建体，例如传感器结构域，组合物，方法和系统。
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6.发明申请POLYNUCLEOTIDES AND RELATED NANOASSEMBLIES, STRUCTURES, ARRANGEMENTS, METHODS AND SYSTEMS 有权多核苷酸和相关纳米生物，结构，安排，方法和系统公开(公告)号：US20100069621A1
公开(公告)日：2010-03-18
申请号：US12540052
申请日：2009-08-12
Applicant: Hareem T. MAUNE , Si-Ping Han , Robert D. Barish , Marc W. Bockrath , William A. Goddard , Paul W.K. Rothemund , Erik Winfree
Inventor： Hareem T. MAUNE , Si-Ping Han , Robert D. Barish , Marc W. Bockrath , William A. Goddard , Paul W.K. Rothemund , Erik Winfree
Abstract: A linker polynucleotide for attaching a nanomaterial to a polynucleotidic platform and related nanoassemblies, arrangements, structures, methods and systems.
Abstract translation: 用于将纳米材料附着到多核苷酸平台和相关纳米组件，布置，结构，方法和系统的接头多核苷酸。
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公开(公告)号：US20090234109A1
公开(公告)日：2009-09-17
申请号：US12316372
申请日：2008-12-10
Applicant: Si-Ping Han , Robert D. Barish , William A. Goddard
Inventor： Si-Ping Han , Robert D. Barish , William A. Goddard
IPC: C07H21/02
CPC classification number: C12N15/113 , C07H21/02 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/3517 , C12N2310/3519 , C12N2310/53 , C12N2320/10
Abstract: The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form and an active form upon covalent or non-covalent interaction with one or more specific chemical signals, such as disease-specific mRNA, miRNA, or other cellular RNA products with sequences that characterize diseased states of the cell. The interaction between the subject polynucleotides and the signals is preferably mediated by hybridization, which exposes, facilitates the formation, and/or allows the formation of a substrate that can be processed by proteins of the RNAi pathway (such as Dicer). The input and output of multiple different polynucleotides of the invention can form an in vivo signaling network. In addition, the multiple input signals can be integrated to modulate the activity of the subject polynucleotides.
Abstract translation: 本发明提供了用于信号激活的RNA干扰（saRNAi）的组合物和方法，优选在体内。 本发明提供了在与一种或多种特定化学信号共价或非共价相互作用之间切换无活性形式和活性形式的多核苷酸，例如疾病特异性mRNA，miRNA或具有表征患病状态的序列的其它细胞RNA产物 细胞。 本发明多核苷酸与信号之间的相互作用优选通过杂交介导，其通过暴露，促进形成和/或允许形成可由RNAi途径的蛋白质（例如Dicer）处理的底物。 本发明的多个不同多核苷酸的输入和输出可以形成体内信号传导网络。 此外，多个输入信号可以被整合以调节受试多核苷酸的活性。
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公开(公告)号：US08710199B2
公开(公告)日：2014-04-29
申请号：US13167672
申请日：2011-06-23
Applicant: Si-Ping Han , William A. Goddard, III , Lisa Scherer , John J. Rossi
Inventor： Si-Ping Han , William A. Goddard, III , Lisa Scherer , John J. Rossi
IPC: C07H21/00 , C12N15/113
CPC classification number: C12N15/87 , C12N15/111 , C12N2310/14 , C12N2310/3519 , C12N2320/32 , C12N2320/50
Abstract: Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain, compositions, methods and systems.
Abstract translation: 本文提供了用于酶辅助递送分子和相关组分的信号激活分子构建体，例如传感器结构域，组合物，方法和系统。
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公开(公告)号：US09102520B2
公开(公告)日：2015-08-11
申请号：US12540027
申请日：2009-08-12
Applicant: Si-Ping Han , Hareem Maune , Robert D. Barish , William A. Goddard, III
Inventor： Si-Ping Han , Hareem Maune , Robert D. Barish , William A. Goddard, III
Abstract: The disclosure relates to nanotube composite structures and related methods and systems. In particular, structures, methods and systems are provided herein to allow for precise, tunable separation between nanomaterials such as carbon nanotubes.
Abstract translation: 本公开涉及纳米管复合结构及相关方法和系统。 特别地，本文提供了结构，方法和系统，以允许诸如碳纳米管之类的纳米材料之间的精确的，可调节的分离。
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