公开(公告)号：US09145583B2

公开(公告)日：2015-09-29

申请号：US13391167

申请日：2010-08-18

申请人： Sang Yup Lee ,  So Young Yoo ,  Do Kyun Kim ,  Tae Jung Park ,  Jung Kuk Yun ,  Gene Lee

发明人： Sang Yup Lee ,  So Young Yoo ,  Do Kyun Kim ,  Tae Jung Park ,  Jung Kuk Yun ,  Gene Lee

IPC分类号： C12Q1/68 ,  C12M1/36 ,  B82Y30/00

CPC分类号： C12Q1/6837 ,  B01J2219/00509 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00614 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00722 ,  B82Y30/00 ,  C12Q1/6883 ,  C12Q2600/158

摘要： A multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing corneal dystrophy, and more particularly to a multi-spot metal-capped nanostructure array nucleic acid chip capable of employing LSPR (localized surface plasmon resonance) optical properties, a preparation method thereof, and a multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations, which can diagnose various corneal dystrophies. The metal-capped nanostructure array nucleic acid chip can be combined with analysis devices, including a light source, a detector, a spectrophotometer and a computer, to provide an LSPR optical property-based optical biosensor, and the use of the multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations allows the simultaneous diagnosis of various corneal dystrophies that are genetic ocular diseases.

摘要翻译： 一种用于诊断角膜营养不良的多点金属帽纳米结构阵列核酸芯片，更具体地涉及能够使用LSPR（局部表面等离子共振）光学性质的多点金属封端的纳米结构阵列核酸芯片，其制备方法 ，以及用于诊断BIGH3基因突变的多点金属帽纳米结构阵列核酸芯片，其可以诊断各种角膜营养不良。 金属封端的纳米结构阵列核酸芯片可以与包括光源，检测器，分光光度计和计算机的分析装置组合，以提供基于LSPR光学性质的光学生物传感器，并且使用多点金属 用于诊断BIGH3基因突变的封闭的纳米结构阵列核酸芯片允许同时诊断作为遗传性眼部疾病的各种角膜营养不良。

公开(公告)号：US20140243222A1

公开(公告)日：2014-08-28

申请号：US13391167

申请日：2010-08-18

申请人： Sang Yup Lee ,  So Young Yoo ,  Do Kyun Kim ,  Tae Jung Park ,  Jung Kuk Yun ,  Gene Lee

发明人： Sang Yup Lee ,  So Young Yoo ,  Do Kyun Kim ,  Tae Jung Park ,  Jung Kuk Yun ,  Gene Lee

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6837 ,  B01J2219/00509 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00614 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00722 ,  B82Y30/00 ,  C12Q1/6883 ,  C12Q2600/158

摘要： A multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing corneal dystrophy, and more particularly to a multi-spot metal-capped nanostructure array nucleic acid chip capable of employing LSPR (localized surface plasmon resonance) optical properties, a preparation method thereof, and a multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations, which can diagnose various corneal dystrophies. The metal-capped nanostructure array nucleic acid chip can be combined with analysis devices, including a light source, a detector, a spectrophotometer and a computer, to provide an LSPR optical property-based optical biosensor, and the use of the multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations allows the simultaneous diagnosis of various corneal dystrophies that are genetic ocular diseases.

摘要翻译： 一种用于诊断角膜营养不良的多点金属帽纳米结构阵列核酸芯片，更具体地涉及能够使用LSPR（局部表面等离子共振）光学性质的多点金属封端的纳米结构阵列核酸芯片，其制备方法 ，以及用于诊断BIGH3基因突变的多点金属帽纳米结构阵列核酸芯片，其可以诊断各种角膜营养不良。 金属封端的纳米结构阵列核酸芯片可以与包括光源，检测器，分光光度计和计算机的分析装置组合，以提供基于LSPR光学性质的光学生物传感器，并且使用多点金属 用于诊断BIGH3基因突变的封闭的纳米结构阵列核酸芯片允许同时诊断作为遗传性眼部疾病的各种角膜营养不良。

公开(公告)号：US09970051B2

公开(公告)日：2018-05-15

申请号：US13876603

申请日：2011-09-30

申请人： Gene Lee ,  Jung Kuk Yun

发明人： Gene Lee ,  Jung Kuk Yun

IPC分类号： C12Q1/68

CPC分类号： C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/156

摘要： The present invention relates to a system for diagnosing Avellino corneal dystrophy, and more particularly to a system for diagnosing Avellino corneal dystrophy, in which whether a sample is normal or Avellino corneal dystrophy is determined based on the ratio of the input first PCR amplification value and the second PCR amplification value. The system makes it possible to diagnosis Avellino corneal dystrophy in a simpler and accurate manner without being influenced by the doctor's skill. Particularly, the inventive system makes the overall process systematic, and thus provides accurate diagnosis. In addition, the system can also easily administer a number of test subjects.

公开(公告)号：US20130302811A1

公开(公告)日：2013-11-14

申请号：US13876603

申请日：2011-09-30

申请人： Gene Lee ,  Jung Kuk Yun

发明人： Gene Lee ,  Jung Kuk Yun

IPC分类号： C12Q1/68

CPC分类号： C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/156

摘要： The present invention relates to a system for diagnosing Avellino corneal dystrophy, and more particularly to a system for diagnosing Avellino corneal dystrophy, in which whether a sample is normal or Avellino corneal dystrophy is determined based on the ratio of the input first PCR amplification value and the second PCR amplification value. The system makes it possible to diagnosis Avellino corneal dystrophy in a simpler and accurate manner without being influenced by the doctor's skill. Particularly, the inventive system makes the overall process systematic, and thus provides accurate diagnosis. In addition, the system can also easily administer a number of test subjects.

摘要翻译： 本发明涉及Avellino角膜营养不良症诊断系统，更具体地说，涉及一种诊断Avellino角膜营养不良的系统，其中判定样本是正常还是Avellino角膜营养不良是基于输入的第一PCR扩增值和 第二个PCR扩增值。 该系统可以以更简单准确的方式诊断Avellino角膜营养不良，而不受医生的技能影响。 特别地，本发明的系统使整个过程系统化，从而提供准确的诊断。 此外，系统还可以轻松管理多个测试对象。

公开(公告)号：US20120077200A1

公开(公告)日：2012-03-29

申请号：US13264784

申请日：2009-12-01

申请人： Gene Lee ,  Jung Kuk Yun

发明人： Gene Lee ,  Jung Kuk Yun

IPC分类号： C12Q1/68 ,  C07H21/00

CPC分类号： C12Q1/6883 ,  C12Q1/686 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2561/113

摘要： The present invention relates to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, and more particularly to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, which can accurately diagnose the presence or absence of a mutation in exon 4 of BIGH3 gene, which is responsible for Avellino corneal dystrophy. The use of the primer pair and probe according to the invention can diagnose Avellino corneal dystrophy in a more rapid and accurate manner than a conventional method that uses a DNA chip or PCR.

摘要翻译： 本发明涉及用于诊断Avellino角膜营养不良的实时PCR引物对和探针，更具体地涉及用于诊断Avellino角膜营养不良的实时PCR引物对和探针，其可以准确地诊断突变的存在或不存在 在BIGH3基因的外显子4中，其负责Avellino角膜营养不良症。 根据本发明的引物对和探针的使用可以比使用DNA芯片或PCR的常规方法更快速和准确地诊断Avellino角膜营养不良症。

公开(公告)号：US20080193386A1

公开(公告)日：2008-08-14

申请号：US11909461

申请日：2006-03-24

申请人： Won-Min Yoo ,  Nae-Choon Yoo ,  Ki-Chang Keum ,  Sang-Yup Lee ,  Gene Lee

发明人： Won-Min Yoo ,  Nae-Choon Yoo ,  Ki-Chang Keum ,  Sang-Yup Lee ,  Gene Lee

IPC分类号： A61K8/98 ,  A61K35/14 ,  A61P17/14 ,  A61K35/16

CPC分类号： A61K35/16 ,  A61K8/983 ,  A61Q7/00

摘要： The present invention relates to a composition for treating alopecia or promoting hair growth, which contains the blood plasma or serum as an active ingredient. The inventive composition is effective in hair growth, hair growth promotion and hair loss prevention.

摘要翻译： 本发明涉及一种治疗脱发或促进毛发生长的组合物，其含有血浆或血清作为活性成分。 本发明的组合物在毛发生长，促进毛发生长和脱发中是有效的。

公开(公告)号：US08017157B2

公开(公告)日：2011-09-13

申请号：US11638056

申请日：2006-12-12

申请人： Won Min Yoo ,  Kyung Hee Chang ,  Nae Choon Yoo ,  Ki Chang Keum ,  Sang Yup Lee ,  Gene Lee

发明人： Won Min Yoo ,  Kyung Hee Chang ,  Nae Choon Yoo ,  Ki Chang Keum ,  Sang Yup Lee ,  Gene Lee

IPC分类号： A61K35/16

CPC分类号： A61K35/16

摘要： The present invention relates to a pharmaceutical composition for the treatment of wounds containing blood plasma or serum and a method for treating wounds effectively by applying said composition to the wound site to normalize the tissue-environment around the site.

摘要翻译： 本发明涉及用于治疗含有血浆或血清的伤口的药物组合物和通过将所述组合物施用于伤口部位来有效地治疗伤口的方法，以使得围绕该部位周围的组织环境归一化。

公开(公告)号：US20070065817A1

公开(公告)日：2007-03-22

申请号：US10514072

申请日：2003-05-09

申请人： Sang-Yup Lee ,  Seung Yoo ,  Kyung Chang ,  So Yoo ,  Nae Yo ,  Won Yoo ,  Ki Keum ,  June Kim ,  Gene Lee

发明人： Sang-Yup Lee ,  Seung Yoo ,  Kyung Chang ,  So Yoo ,  Nae Yo ,  Won Yoo ,  Ki Keum ,  June Kim ,  Gene Lee

IPC分类号： C12Q1/68 ,  C12M3/00 ,  C12M1/34 ,  C07H21/04

CPC分类号： C12Q1/689 ,  C12Q2600/16

摘要： The present invention relates to nucleic acid probes which are derived from rRNA genes of non-virus organisms and are useful for the detection of said non-virus infectious organisms in a biological sample. In addition, the present invention relates to compositions and chips useful for the diagnosis of one or more types of infectious diseases comprising said nucleic acid probes.

摘要翻译： 本发明涉及衍生自非病毒生物体的rRNA基因的核酸探针，并且可用于检测生物样品中的所述非病毒感染性生物体。 此外，本发明涉及可用于诊断包含所述核酸探针的一种或多种感染性疾病的组合物和碎片。

公开(公告)号：US20090136587A1

公开(公告)日：2009-05-28

申请号：US11995901

申请日：2006-08-08

申请人： Won Min Yoo ,  Nae Choon Yoo ,  Ki Chang Keum ,  Sang Yup Lee ,  Gene Lee

发明人： Won Min Yoo ,  Nae Choon Yoo ,  Ki Chang Keum ,  Sang Yup Lee ,  Gene Lee

IPC分类号： A61K35/16

CPC分类号： A61K35/16 ,  Y02A50/401

摘要： The present invention relates to a pharmaceutical composition for the treatment of nerve damage, and more particularly to a pharmaceutical composition for the treatment of nerve damage, which contains blood plasma or serum as an active ingredient. The inventive composition regenerates nerve cells after spinal nerve damage and provides complete structural continuity in the spinal nerve lesion sites. Thus, the composition is useful for the treatment of nerve damage.

摘要翻译： 本发明涉及用于治疗神经损伤的药物组合物，更具体地涉及含有血浆或血清作为活性成分的用于治疗神经损伤的药物组合物。 本发明组合物在脊髓神经损伤后再生神经细胞，并在脊神经损伤部位提供完整的结构连续性。 因此，该组合物可用于治疗神经损伤。

公开(公告)号：US09892485B2

公开(公告)日：2018-02-13

申请号：US12420014

申请日：2009-04-07

申请人： Clay Kaytis ,  John Edgar Park ,  Gene Lee ,  Philippe Brochu ,  Hidetaka Yosumi

发明人： Clay Kaytis ,  John Edgar Park ,  Gene Lee ,  Philippe Brochu ,  Hidetaka Yosumi

IPC分类号： G06T15/00 ,  G06T3/40

CPC分类号： G06T3/40

摘要： A method of manipulating at least a portion of a character model into a pose involving a library data having a plurality of deformations, where each deformation is associated with index values of one or more distance measurement nodes. One or more distance measurement nodes are defined for the portion of the character model, wherein each distance measurement node comprises a number of points on a surface defined by the geometry of the character model, wherein the points are separated by a distance value. A particular pose is selected for the character model portion to establish an initial model by selecting values for the pose controls. For the particular pose, a value of the distance measurement nodes is determined. At least one deformation is selected from the library data based in the value of the distance measurement nodes and applied to the initial model to generate a deformed model.