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    Liposome for liver-specific delivery and release of therapeutic nucleic acids or drugs
    3.
    发明授权
    Liposome for liver-specific delivery and release of therapeutic nucleic acids or drugs 有权
    用于肝特异性递送和释放治疗性核酸或药物的脂质体

    公开(公告)号：US08318199B2

    公开(公告)日：2012-11-27

    申请号：US12791600

    申请日：2010-06-01

    申请人： Meehyein Kim ,  Soo In Kim ,  Duckhyang Shin ,  Mahnhoon Park

    发明人： Meehyein Kim ,  Soo In Kim ,  Duckhyang Shin ,  Mahnhoon Park

    IPC分类号： A61K9/127 ,  C12N15/88 ,  A61K48/00

    CPC分类号： A61K31/7088 ,  A61K9/1272

    摘要： Disclosed herein is a composite of a nanoscale particle size. The composite is able to specifically deliver therapeutic agents such as therapeutic nucleic acids or drugs to the liver and selectively release them into hepatic cells to manifest potent therapeutic effects of the therapeutic agents. The composite may be comprised of an apolipoprotein A-1 and a liposome-forming material. A composition containing the composite and a pharmaceutically acceptable carrier is disclosed.

    摘要翻译： 本文公开了纳米级粒度的复合材料。 复合材料能够将治疗剂例如治疗性核酸或药物特异性递送至肝脏并选择性地将其释放到肝细胞中以显示治疗剂的有效治疗作用。 复合材料可以由载脂蛋白A-1和脂质体形成材料组成。 公开了含有该复合物和药学上可接受的载体的组合物。

    LINEAR DOUBLE-STRANDED RNA MOLECULE INTERFERING WITH DIFFERENT TARGET GENES
    4.
    发明申请
    LINEAR DOUBLE-STRANDED RNA MOLECULE INTERFERING WITH DIFFERENT TARGET GENES 审中-公开
    线性双链RNA分子与不同目标基因的干扰

    公开(公告)号：US20110008885A1

    公开(公告)日：2011-01-13

    申请号：US12667738

    申请日：2008-07-07

    申请人： Meehyein Kim ,  Duckhyang Shin ,  Hyeon Lee ,  Soo In Kim ,  Yeup Yoon

    发明人： Meehyein Kim ,  Duckhyang Shin ,  Hyeon Lee ,  Soo In Kim ,  Yeup Yoon

    IPC分类号： C12N5/071 ,  C07H21/02 ,  C12N15/63

    CPC分类号： C12N15/111 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/51

    摘要： A linear double-stranded RNA molecule, which comprises two or more consecutively or convergently linked short interfering RNAs (siRNAs) each reducing the expression of one of different target genes, and a recombinant expression vector comprising double-stranded DNA sequence expressing the linear double-stranded RNA molecule are provided. The linear double-stranded RNA molecule or the recombinant expression vector is useful for a method of reducing expression of target genes in a cell, the method comprising introducing the linear double-stranded RNA molecule or the recombinant expression vector into the cell, whereby the encoded siRNAs target different genes and reduce expression of the target genes. It was also proved that effective gene silencing activity can be induced when each siRNA unit within the linear double-stranded RNA molecule has 18 to 24 nucleotides and, additionally, the gene silencing activity is not affected by inverted orientation of an siRNA.

    摘要翻译： 线性双链RNA分子，其包含两个或更多个连续或趋向连接的短干扰RNA（siRNA），每个短干扰RNA减少一个不同靶基因的表达;以及重组表达载体，其包含表达线性双链RNA的双链DNA序列， 提供了双链RNA分子。 线性双链RNA分子或重组表达载体可用于减少细胞中靶基因表达的方法，该方法包括将线性双链RNA分子或重组表达载体引入细胞，由此编码 siRNA靶向不同的基因并减少靶基因的表达。 还证明当线性双链RNA分子内的每个siRNA单元具有18至24个核苷酸时，可以诱导有效的基因沉默活性，此外，基因沉默活性不受siRNA反向取向的影响。

    Plasma generator for generating unipolar plasma
    8.
    发明授权
    Plasma generator for generating unipolar plasma 失效
    用于产生单极等离子体的等离子体发生器

    公开(公告)号：US5909086A

    公开(公告)日：1999-06-01

    申请号：US719057

    申请日：1996-09-24

    申请人： Soo-In Kim ,  Vladimir Nikolaevich Lisin ,  Bekker German ,  Malivanov Sergei

    发明人： Soo-In Kim ,  Vladimir Nikolaevich Lisin ,  Bekker German ,  Malivanov Sergei

    IPC分类号： H01J37/32 ,  H05H1/46 ,  H01J7/24

    CPC分类号： H01J37/32009 ,  H01J37/32045 ,  H05H1/46 ,  H05H2240/20 ,  H05H2277/10

    摘要： The present invention relates to a plasma generator to apply cold plasma in the fields of medicine, biology, ecological recovery, activation, purification, special processing of gases, liquids and solid substances as well as other areas of technology and science. A plasma generator of the invention comprises: a power source; an electronic oscillator constructed on an amplifying (control) element which is connected to a low voltage input section; a resonance transformer having a low voltage input section and a high voltage output section; and, one pin of the high voltage output section of the resonance transformer which is connected to a discharge electrode. The present invention provides a universal plasma generator with decreased mass and dimensions which provides unipolar plasma for plasma therapy and activation of substantial media by virtue of the field.

    摘要翻译： 本发明涉及一种在医药，生物学，生态恢复，活化，纯化，气体，液体和固体物质的特殊处理以及其他技术和科学领域应用冷等离子体的等离子体发生器。 本发明的等离子体发生器包括：电源; 构造在连接到低电压输入部分的放大（控制）元件上的电子振荡器; 具有低电压输入部分和高压输出部分的谐振变压器; 以及连接到放电电极的谐振变压器的高压输出部分的一个引脚。 本发明提供了具有减小的质量和尺寸的通用等离子体发生器，其提供用于等离子体处理的单极等离子体，并且借助该领域激活大量介质。

    Small Interfering RNA Specific For HCV And Therapeutic Agent For Hepatitis C Comprising The Same
    10.
    发明申请
    Small Interfering RNA Specific For HCV And Therapeutic Agent For Hepatitis C Comprising The Same 审中-公开
    丙型肝炎病毒的特异性小干扰RNA和丙型肝炎的治疗剂

    公开(公告)号：US20090318531A1

    公开(公告)日：2009-12-24

    申请号：US11915975

    申请日：2006-05-30

    申请人： Meehyein Kim ,  Duckhyang Shin ,  Mahnhoon Park ,  Soo In Kim

    发明人： Meehyein Kim ,  Duckhyang Shin ,  Mahnhoon Park ,  Soo In Kim

    IPC分类号： A61K48/00 ,  C07H21/02 ,  C12N15/63

    CPC分类号： C12N15/1131 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

    摘要： The present invention relates to a therapeutic reagent for hepatitis C comprising HCV specific short interfering RNA (siRNA) as an effective ingredient. The siRNA of the invention is a double-stranded RNA specific for the nucleotide sequence of HCV which induces viral RNA degradation in mammalian cells and thereby inhibits HCV protein expression and replication. The method of the invention, which includes the step of administrating the synthetic siRNA or a DNA vector encoding the RNA, is thus effective for the treatment of HCV carrier by inhibiting HCV gene expression and replication.

    摘要翻译： 本发明涉及包含HCV特异性短干扰RNA（siRNA）作为有效成分的丙型肝炎治疗试剂。 本发明的siRNA是HCV的核苷酸序列特异性的双链RNA，其在哺乳动物细胞中诱导病毒RNA降解，从而抑制HCV蛋白的表达和复制。 包括给予合成siRNA或编码RNA的DNA载体的步骤的本发明的方法因此通过抑制HCV基因表达和复制而对HCV载体的治疗是有效的。