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11 条记录 (耗时 0.029 秒)

    LINEAR DOUBLE-STRANDED RNA MOLECULE INTERFERING WITH DIFFERENT TARGET GENES
    2.
    发明申请
    LINEAR DOUBLE-STRANDED RNA MOLECULE INTERFERING WITH DIFFERENT TARGET GENES 审中-公开
    线性双链RNA分子与不同目标基因的干扰

    公开(公告)号：US20110008885A1

    公开(公告)日：2011-01-13

    申请号：US12667738

    申请日：2008-07-07

    申请人： Meehyein Kim ,  Duckhyang Shin ,  Hyeon Lee ,  Soo In Kim ,  Yeup Yoon

    发明人： Meehyein Kim ,  Duckhyang Shin ,  Hyeon Lee ,  Soo In Kim ,  Yeup Yoon

    IPC分类号： C12N5/071 ,  C07H21/02 ,  C12N15/63

    CPC分类号： C12N15/111 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/51

    摘要： A linear double-stranded RNA molecule, which comprises two or more consecutively or convergently linked short interfering RNAs (siRNAs) each reducing the expression of one of different target genes, and a recombinant expression vector comprising double-stranded DNA sequence expressing the linear double-stranded RNA molecule are provided. The linear double-stranded RNA molecule or the recombinant expression vector is useful for a method of reducing expression of target genes in a cell, the method comprising introducing the linear double-stranded RNA molecule or the recombinant expression vector into the cell, whereby the encoded siRNAs target different genes and reduce expression of the target genes. It was also proved that effective gene silencing activity can be induced when each siRNA unit within the linear double-stranded RNA molecule has 18 to 24 nucleotides and, additionally, the gene silencing activity is not affected by inverted orientation of an siRNA.

    摘要翻译： 线性双链RNA分子，其包含两个或更多个连续或趋向连接的短干扰RNA（siRNA），每个短干扰RNA减少一个不同靶基因的表达;以及重组表达载体，其包含表达线性双链RNA的双链DNA序列， 提供了双链RNA分子。 线性双链RNA分子或重组表达载体可用于减少细胞中靶基因表达的方法，该方法包括将线性双链RNA分子或重组表达载体引入细胞，由此编码 siRNA靶向不同的基因并减少靶基因的表达。 还证明当线性双链RNA分子内的每个siRNA单元具有18至24个核苷酸时，可以诱导有效的基因沉默活性，此外，基因沉默活性不受siRNA反向取向的影响。

    Continuous synthetic process of phosphor in supercritical water and apparatus being used therein
    3.
    发明申请
    Continuous synthetic process of phosphor in supercritical water and apparatus being used therein 审中-公开
    超临界水中的荧光粉连续合成工艺及其中使用的设备

    公开(公告)号：US20060097228A1

    公开(公告)日：2006-05-11

    申请号：US11271099

    申请日：2005-11-10

    申请人： Jae Lee ,  Chang Lee ,  Hyeon Lee ,  Jung In ,  Man Han

    发明人： Jae Lee ,  Chang Lee ,  Hyeon Lee ,  Jung In ,  Man Han

    IPC分类号： C09K11/08 ,  B01J19/00

    CPC分类号： B01J19/2415 ,  B01J3/008 ,  B01J2219/00159 ,  Y02P20/544

    摘要： The present invention relates to a method of continuously producing a phosphor at a supercritical water (SCW) condition and an apparatus used in the method. A phosphor produced according to the method of the present invention has similar luminosity to a phosphor produced according to a conventional solid-state method and the size and shape of particles thereof is also uniform. Accordingly, a phosphor according to the method of the present invention is applicable in various fields such as plasma display (PDP) and field emission display (FED). Also, in the method of producing a phosphor according to the present invention, the total reaction time is within about one minute, which is shorter than in the solid-state method. Also, since a separate heat processing process is not needed to obtain crystallized particles, it is efficient in aspects of time and energy.

    摘要翻译： 本发明涉及在超临界水（SCW）条件下连续生产荧光体的方法和该方法中使用的装置。 根据本发明的方法制造的荧光体具有与根据常规固态方法制造的荧光体相似的亮度，并且其颗粒的尺寸和形状也是均匀的。 因此，根据本发明的方法的荧光体可应用于等离子体显示（PDP）和场发射显示（FED）等各种领域。 此外，在本发明的荧光体的制造方法中，总反应时间在比固态方法短的约1分钟内。 此外，由于不需要单独的热处理工艺来获得结晶颗粒，因此在时间和能量方面是有效的。

    Expression vector suitable for expression of a coding sequence for gene therapy
    4.
    发明授权
    Expression vector suitable for expression of a coding sequence for gene therapy 有权
    适用于表达基因治疗编码序列的表达载体

    公开(公告)号：US08309698B2

    公开(公告)日：2012-11-13

    申请号：US12867716

    申请日：2008-02-14

    申请人： Daekyung Koh ,  Kyuhyun Lee ,  Hyeon Lee ,  Seongtae Yun ,  Eui-Cheol Jo

    发明人： Daekyung Koh ,  Kyuhyun Lee ,  Hyeon Lee ,  Seongtae Yun ,  Eui-Cheol Jo

    IPC分类号： C07H21/04 ,  C12N15/63

    CPC分类号： C12N15/63

    摘要： Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.

    摘要翻译： 提供了具有转录调节元件的新组合的基因治疗的表达载体，其包括启动子，增强子，内含子，非翻译区（UTR）和基因座控制区（LCR）。 表达载体能够持续表达肝组织特异性基因，因此可有效用于治疗血栓形成，血友病，肝癌等。

    Method of implementing scatternet in wireless personal area network
    7.
    发明申请
    Method of implementing scatternet in wireless personal area network 审中-公开
    在无线个域网中实现分布式互联网的方法

    公开(公告)号：US20060128402A1

    公开(公告)日：2006-06-15

    申请号：US11271780

    申请日：2005-11-14

    申请人： Hyeon Lee ,  Jin Cho ,  Sun June ,  Kyu Youn ,  Yun Won ,  Tai Kwon

    发明人： Hyeon Lee ,  Jin Cho ,  Sun June ,  Kyu Youn ,  Yun Won ,  Tai Kwon

    IPC分类号： H04Q7/20

    CPC分类号： H04W72/082 ,  H04W36/06 ,  H04W52/0216 ,  H04W52/0219 ,  H04W72/0453 ,  H04W84/20 ,  H04W92/02 ,  Y02D70/142 ,  Y02D70/144

    摘要： The present invention relates to a method of implementing a scatternet over a plurality of piconets using different frequencies in a Wireless Personal Area Network (WPAN). In the scatternet implementation method of the present invention, a master of a first piconet transmits a scatternet request to a shared slave, and the shared slave switches a frequency thereof to a frequency of a second piconet and relays the scatternet request to a master of the second piconet. The master of the second piconet transmits scatternet approval to the shared slave. The shared slave switches the frequency to a frequency of the first piconet, relays the scatternet approval to the master of the first piconet, and is allocated resources, which do not overlap each other, by the masters of the first piconet and the second piconet. The shared slave switches frequencies and relays data between the first piconet and the second piconet while synchronizing with both the first piconet and the second piconet using allocated resources.

    摘要翻译： 本发明涉及一种在无线个人区域网（WPAN）中使用不同频率在多个微微网上实现分散网络的方法。 在本发明的分散网络实现方法中，第一微微网的主机向共享从机发送分散网络请求，并且共享从机将其频率切换到第二微微网的频率，并将分散网络请求中继到主机 第二微微网。 第二个微微网的主机将共同的从站的互联网批准。 共享从站将频率切换到第一微微网的频率，将分机互联网批准中继到第一微微网的主设备，并且由第一微微网和第二微微网的主设备分配不相互重叠的资源。 共享从站在使用分配的资源与第一微微网和第二微微网同步时，切换频率并中继第一微微网和第二微微网之间的数据。

    Expression vector for gene therapy
    9.
    发明授权
    Expression vector for gene therapy 有权
    基因治疗的表达载体

    公开(公告)号：US08569051B2

    公开(公告)日：2013-10-29

    申请号：US13423652

    申请日：2012-03-19

    申请人： Daekyung Koh ,  Kyuhyun Lee ,  Hyeon Lee ,  Seongtae Yun ,  Eui-Cheol Jo

    发明人： Daekyung Koh ,  Kyuhyun Lee ,  Hyeon Lee ,  Seongtae Yun ,  Eui-Cheol Jo

    IPC分类号： C12N15/63 ,  C12N15/113 ,  C07H21/04

    CPC分类号： C12N15/63

    摘要： Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.

    摘要翻译： 提供了具有转录调节元件的新组合的基因治疗的表达载体，其包括启动子，增强子，内含子，非翻译区（UTR）和基因座控制区（LCR）。 表达载体能够持续表达肝组织特异性基因，因此可有效用于治疗血栓形成，血友病，肝癌等。

    EXPRESSION VECTOR SUITABLE FOR EXPRESSION OF A CODING SEQUENCE FOR GENE THERAPY
    10.
    发明申请
    EXPRESSION VECTOR SUITABLE FOR EXPRESSION OF A CODING SEQUENCE FOR GENE THERAPY 有权
    用于表达基因治疗编码序列的表达载体

    公开(公告)号：US20110045584A1

    公开(公告)日：2011-02-24

    申请号：US12867716

    申请日：2008-02-14

    申请人： Daekyung Koh ,  Kyuhyun Lee ,  Hyeon Lee ,  Seongtae Yun ,  Eui-Cheol Jo

    发明人： Daekyung Koh ,  Kyuhyun Lee ,  Hyeon Lee ,  Seongtae Yun ,  Eui-Cheol Jo

    IPC分类号： C12N15/63 ,  C07H21/04

    CPC分类号： C12N15/63

    摘要： Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.

    摘要翻译： 提供了具有转录调节元件的新组合的基因治疗的表达载体，其包括启动子，增强子，内含子，非翻译区（UTR）和基因座控制区（LCR）。 表达载体能够持续表达肝组织特异性基因，因此可有效用于治疗血栓形成，血友病，肝癌等。