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公开(公告)号:US20180148481A2
公开(公告)日:2018-05-31
申请号:US15507947
申请日:2015-09-01
申请人: Stefan Howorka , Han Remaut , Lakmal Jayasinghe , Elizabeth Jayne Wallace , James Anthony Clarke , Richard George Hambley , Jonathan Bankes Pugh
发明人: Stefan Howorka , Han Remaut , Lakmal Jayasinghe , Elizabeth Jayne Wallace , James Anthony Clarke , Richard George Hambley , Jonathan Bankes Pugh
IPC分类号: C07K14/245 , C12Q1/68 , G01N27/447
CPC分类号: C07K14/245 , C07K2319/22 , C12Q1/68 , C12Q1/6869 , C12Q1/6874 , C12Q2565/631 , G01N27/447
摘要: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.
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公开(公告)号:US20050208574A1
公开(公告)日:2005-09-22
申请号:US11129917
申请日:2005-05-16
申请人: Hagan Bayley , Stefan Howorka , Liviu Movileanu
发明人: Hagan Bayley , Stefan Howorka , Liviu Movileanu
IPC分类号: C07K14/31 , C12Q1/68 , C12Q1/6816 , C12Q1/6834 , C12Q1/6837 , C12Q1/6874 , G01N33/531 , G01N33/543 , G01N33/92
CPC分类号: C12Q1/6837 , C07K14/31 , C12Q1/6816 , C12Q1/6834 , C12Q1/6874 , G01N33/531 , G01N33/5438 , G01N33/92 , Y10S530/825 , C12Q2565/607
摘要: Provided are pore-subunit polypeptides covalently linked to one or more sensing moieties, and uses of these modified polypeptides to detect and/or measure analytes or physical characteristics within a given sample.
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公开(公告)号:US20070087382A1
公开(公告)日:2007-04-19
申请号:US10571456
申请日:2004-09-10
申请人: Stefan Howorka , Patrick Pammer
发明人: Stefan Howorka , Patrick Pammer
CPC分类号: B82Y30/00 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00459 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , C40B40/06 , C40B40/10 , C40B60/14
摘要: The invention relates to assemblies for bonding molecules comprising bondable functional groups, which are present on a solid supporting material as individual molecular functional groups or multiple identical functional groups. Said assemblies are characterised in that the density of the individual functional groups or multiple functional groups on the solid supporting material is between 104 and 1010 individual or multiple functional groups per cm2 and that there are no additional bondable functional groups within a selected distance d from any individual bondable functional group or multiple functional group for at least 95% and in particular at least 99% of the individual or multiple functional groups.
摘要翻译: 本发明涉及用于结合包含可结合官能团的分子的组合物,其作为单独的分子官能团或多个相同的官能团存在于固体支持材料上。 所述组件的特征在于,固体支持材料上的各个官能团或多个官能团的密度为每厘米10个至10个/个以上的单个或多个官能团 并且在单个或多个功能的至少95%,特别是至少99%的任何个别可结合官能团或多官能团的选定距离d内不存在额外的可结合的官能团 团体
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公开(公告)号:US06777202B2
公开(公告)日:2004-08-17
申请号:US09117447
申请日:1998-12-02
申请人: Werner Lubitz , Uwe Sleytr , Beatrix Kuen , Michaela Truppe , Stefan Howorka , Stepanka Resch , Gerhard Schroll , Margit Sara
发明人: Werner Lubitz , Uwe Sleytr , Beatrix Kuen , Michaela Truppe , Stefan Howorka , Stepanka Resch , Gerhard Schroll , Margit Sara
IPC分类号: C12P2126
CPC分类号: C12N9/1029 , A61K39/00 , C07K14/005 , C07K14/32 , C07K14/415 , C07K2319/02 , C07K2319/40 , C07K2319/735 , C12N15/62 , C12N2710/16722
摘要: The invention concerns a process for the recombinant production of S-layer proteins in gram-negative host cells. Furthermore the nucleotide sequence of a new S-layer gene and processes for the production of modified S-layer proteins are disclosed.
摘要翻译: 本发明涉及在革兰氏阴性宿主细胞中重组生产S层蛋白的方法。 此外,公开了新的S层基因的核苷酸序列和生产修饰的S层蛋白的方法。
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